作者机构：
[Fang, Xuexian] Hangzhou Normal Univ, Sch Publ Hlth, Dept Nutr & Toxicol, State Key Lab Expt Hematol, Hangzhou, Peoples R China.;[Min, Junxia; Wang, Fudi; Fang, Xuexian] Zhejiang Univ, Affiliated Hosp 4, Affiliated Hosp 1,State Key Lab Expt Hematol, Canc Ctr,Sch Med,Inst Translat Med,Sch Publ Hlth, Hangzhou, Peoples R China.;[Wang, Fudi; Fang, Xuexian] Univ South China, Affiliated Hosp 1, Affiliated Hosp 2, Sch Publ Hlth,Basic Med Sci,Hengyang Med Sch, Hengyang, Peoples R China.;[Ardehali, Hossein] Northwestern Univ, Feinberg Cardiovasc & Renal Res Inst, Chicago, IL 60611 USA.
通讯机构：
[Junxia Min; Fudi Wang] T;The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, China<&wdkj&>The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, China<&wdkj&>The First Affiliated Hospital, The Second Affiliated Hospital, Basic Medical Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China
关键词：
Functional nucleic acids;Biosensors;Isothermal amplification strategies;Heavy metal ions;Ultrasensitive detection
摘要：
Heavy metal ions are a class of pollutant with serious threat to ecosystem and human health. To recognize effectively heavy metal ions, some functional nucleic acids (FNAs) are fabricated to serve as recognition element in biosensors. However, there are some challenges that limit the sensitivity of FNAs-based biosensors for the detection of heavy metal ions, such as extremely low abundance and wide concentration range. Nucleic acid amplification is an effective signal amplification technique. Among these methods, alternative to polymerase chain reaction (PCR) acting as gold standard, isothermal amplification strategies have been applied widely in FNAs-based biosensors due to the charming property of lower costs, higher robustness, better reproducibility and more comfortable conditions. In this review, we firstly summarize the different types of FNAs-based biosensors for heavy metal ions detection. Then, we focus on isothermal amplification strategies applied in heavy metal ions FNAs-based biosensors. Finally, we present our perspectives on future advances and challenges of the biosensors with isothermal amplification for heavy metal ions detection.
作者：
Du, Can;Zheng, Shuilin;Yang, Yue;Feng, Xiangling;Chen, Jihua;...
期刊：
Ecotoxicology and Environmental Safety,2022年239:113649 ISSN：0147-6513
通讯作者：
Yang, Fei
作者机构：
[Yang, Fei] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410078, Peoples R China.;[Wang, Hui; Yang, Fei] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;[Yang, Fei] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing 210009, Peoples R China.;[Yang, Fei] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Crit Human Dis Prevent Hunan Prov Dept Educ, Hengyang 421001, Peoples R China.
通讯机构：
[Fei Yang] H;Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, China<&wdkj&>Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China<&wdkj&>Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China<&wdkj&>The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China
期刊：
Journal of Radioanalytical and Nuclear Chemistry,2022年331(2):655-664 ISSN：0236-5731
通讯作者：
He, Shuya;Xiao, Fangzhu
作者机构：
[He, Shuya; Xiao, Fangzhu; Chen, Luyao; Cheng, Conghui; Guo, Kexin; He, SY; Xiao, FZ; Li, Shanshan] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.;[Xie, Jingxi] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[Xiao, Fangzhu] Univ South China, Hunan Engn Res Ctr Safety Control & Recycling Rad, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[He, SY; Xiao, FZ; Xiao, Fangzhu] U;Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hunan Engn Res Ctr Safety Control & Recycling Rad, Hengyang 421001, Hunan, Peoples R China.
关键词：
Deinococcus radiodurans;Heavy metal contamination;Radionuclide contamination;Biosorption
摘要：
This review thoroughly presents the recent progress of Deinococcus radiodurans, recombinant D. radiodurans and immobilized D. radiodurans as superior adsorbents to efficiently remove toxic heavy metals ions and radionuclides. Finally, a summary and prospect on the opportunities and challenges of D. radiodurans are provided.
期刊：
Journal of Fluorescence,2022年32(5):1651-1660 ISSN：1053-0509
通讯作者：
Liang, Hao;Chen, Lili
作者机构：
[Bai, Qinqin; Liang, Hao; Liu, Luyao; Chen, Lili; Zhang, Xuebing] Univ South China, Dept Publ Hlth Lab Sci, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Bai, Qinqin; Liang, Hao; Liu, Luyao; Chen, Lili; Zhang, Xuebing] Univ South China, Hunan Key Lab Typical Environm Pollut & Hlth Haza, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Bai, Qinqin; Liang, Hao; Liu, Luyao; Chen, Lili; Zhang, Xuebing] Hengyang Engn Technol Res Ctr, Hengyang 421001, Hunan, Peoples R China.;[Li, Zhongyu; Lu, Chunxue] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Liang, Hao; Chen, Lili] D;Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.;Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.;Hengyang Engineering Technology Research Center, Hengyang, 421001, Hunan, China.
关键词：
Chlamydia trachomatis;CuNCs;Detection;Hairpin DNA
期刊：
BIOCHEMISTRY AND CELL BIOLOGY,2022年100(1):9-16 ISSN：0829-8211
通讯作者：
Zhang, C
作者机构：
[Yang, Chen; Li, Yong-Zhen; Qu, Shun-Lin; Zhang, Chi; Zhao, Yu-Yan; Chen, Lin-Hui] Univ South China, Hengyang Med Coll, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.;[Huang, Liang] Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Hunan, Peoples R China.;[Zhu, Ying] Univ South China, Coll Publ Hlth, Dept Hlth Inspect & Quarantine, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zhang, C ] U;Univ South China, Hengyang Med Coll, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
关键词：
glucagon-like peptide 1;type 2 diabetes;mitogen-activated protein kinase pathway;cardiovascular disease;peptide GLP-1;diabète de type2;voie de la MAPK;maladies cardiovasculaires
作者机构：
[Cao, Yi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
通讯机构：
[Yi Cao] H;Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China
关键词：
3D human brain organoids;Neurotoxicity
摘要：
Neurotoxicity studies aim at understanding the toxic effects and mechanisms of toxicants to human central nervous systems (CNS). However, human brains are the most complex organs, whereas the most commonly used models, such as 2D cell cultures and animal brains, are probably too simple to predict the responses of human brains. Embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs)-based 3D human brain organoids hold unprecedented promise for the understanding of neurodevelopment and brain disease development. This review summarizes recent advances of using 3D human brain organoids for neurotoxicity studies. Comparative studies showed that 3D human brain organoids could support the findings obtained by animal or cohort studies, indicating that 3D human brain organoids are reliable models to evaluate the developmental neurotoxicity. 3D human brain organoids have been used to understand the toxicological mechanisms by using both conventional toxicological methods to investigate the signaling pathway changes as well as single cell RNA-sequencing to understand the neuron diversity. Some studies also used brain organoids carrying gene mutations or with virus infections to understand the toxicological responses of brains under diseased conditions. Although there are still limitations associated, 3D human brain organoids are promising tools for future neurotoxicity studies.
作者机构：
[Jiang, Miao; Jiang, Zhi-Sheng] Univ South China, Inst Cardiovasc Dis, Dept Pathophysiol,Postdoctoral Res Stn Basic Med, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, Hengyang 421001, Peoples R China.;[Jiang, Miao; Wang, Gui-Xue] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Bioengn Coll, Chongqing 400030, Peoples R China.;[Zhao, Xiao-Mei] Univ South China, Coll Publ Hlth, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Da-wei] Univ Alberta, Fac Med & Dent, Dept Pediat, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.
通讯机构：
[Jiang, Zhi-Sheng] I;[Wang, Gui-Xue] K;Institute of Cardiovascular Disease, Department of Pathophysiology, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic disease, Postdoctoral Research Station of Basic Medicine, University of South China, Hengyang, 421001, China. Electronic address:;Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering Collage of Chongqing University, Chongqing, 400030, China. Electronic address:
作者机构：
[Pan, Jianming; Liu, Bangxiang; Hu, Panwang; Wang, Mengzhu; Niu, Xiangheng; Zhu, Hengjia] Jiangsu Univ, Inst Green Chem & Chem Technol, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China.;[Niu, Xiangheng] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.
通讯机构：
[Xiangheng Niu] I;Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China<&wdkj&>School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China
摘要：
Non-alcoholic fatty liver disease (NAFLD), recently re-defined and re-classified as metabolic dysfunction-associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD/MAFLD. As a newly discovered form of iron-dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that link MAFLD and ferroptosis have not been fully elucidated. The main characteristics of ferroptosis are the accumulation of lipid peroxides and reactive oxygen species. In this brief narrative review, the mechanisms of ferroptosis and its putative pathogenic role in MAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.
作者机构：
[Chu, Hanyu; Yang, Fei] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;[Chen, Jihua; Du, Can; Feng, Xiangling; Yang, Fei; Yang, Yue] Cent South Univ, Xiangya Sch Publ Hlth, Changsha 410078, Peoples R China.;[Zhu, Lemei] Changsha Med Univ, Sch Publ Hlth, Changsha 410219, Peoples R China.;[Yang, Fei] Univ South China, Sch Basic Med Sci, Key Lab Ecol Environm & Crit Human Dis Prevent Hun, Dept Educ,Hengyang Med Sch, Hengyang 421001, Peoples R China.
通讯机构：
[Jihua Chen; Fei Yang] A;Authors to whom correspondence should be addressed.<&wdkj&>Xiangya School of Public Health, Central South University, Changsha 410078, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province, Department of Education, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Xiangya School of Public Health, Central South University, Changsha 410078, China<&wdkj&>Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China
摘要：
Obesity, a metabolic disease caused by excessive fat accumulation in the body, has attracted worldwide attention. Microcystin-LR (MC-LR) is a hepatotoxic cyanotoxin which has been reportedly to cause lipid metabolism disorder. In this study, C57BL/6J mice were fed a high-fat diet (HFD) for eight weeks to build obese an animal model, and subsequently, the obese mice were fed MC-LR for another eight weeks, and we aimed to determine how MC-LR exposure affects the liver lipid metabolism in high-fat-diet-induced obese mice. The results show that MC-LR increased the obese mice serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), indicating damaged liver function. The lipid parameters include serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and liver TG, which were all increased, whilst the high-density lipoprotein cholesterol (HDL-c) was decreased. Furthermore, after MC-LR treatment, histopathological observation revealed that the number of red lipid droplets increased, and that steatosis was more severe in the obese mice. In addition, the lipid synthesis-related genes were increased and the fatty acid beta-oxidation-related genes were decreased in the obese mice after MC-LR exposure. Meanwhile, the protein expression levels of phosphorylation phosphatidylinositol 3-kinase (p-PI3K), phosphorylation protein kinase B (p-AKT), phosphorylation mammalian target of rapamycin (p-mTOR), and sterol regulatory element binding protein 1c (SREBP1-c) were increased; similarly, the p-PI3K/PI3K, p-AKT/AKT, p-mTOR/mTOR, and SREBP1/beta-actin were significantly up-regulated in obese mice after being exposed to MC-LR, and the activated PI3K/AKT/mTOR/SREBP1 signaling pathway. In addition, MC-LR exposure reduced the activity of superoxide dismutase (SOD) and increased the level of malondialdehyde (MDA) in the obese mice's serum. In summary, the MC-LR could aggravate the HFD-induced obese mice liver lipid metabolism disorder by activating the PI3K/AKT/mTOR/SREBP1 signaling pathway to hepatocytes, increasing the SREBP1-c-regulated key enzymes for lipid synthesis, and blocking fatty acid beta-oxidation.
通讯机构：
[Yang, SY; Xiao, FB] U;[Yang, SY; Xiao, FB] H;Univ South China, Coll Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Hunan, Peoples R China.
摘要：
Iron-doped carbon dots (Fe-CDs) were greenly synthesized via a one-step hydrothermal method using the eco-friendly materials milk powder and FeCl3. It was found that the synthesized biomass Fe-CDs have photoluminescence properties and strong mimetic oxidase activity, which enables catalysis of the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce a blue product, oxidized TMB (oxTMB). The presence of ascorbic acid (AA) could reduce the oxTMB and make the solution color lighter to realize the colorimetric determination of AA. In addition, the absorption peak of the oxTMB generated at 370 nm overlaps with the excitation spectrum of Fe-CDs, and oxTMB quenched the fluorescence of Fe-CDs based on the internal filtration effect (IFE). The presence of AA will reduce oxTMB and restore the fluorescence of Fe-CDs, and the change of fluorescence intensity is positively correlated with the concentration of AA. Accordingly, a novel method for colorimetric/fluorometric dual-signal detection of AA was developed. The linear range of the colorimetric assay was 25.0–500.0 μM, and the detection limit was 8.59 μM. The linear range of the fluorometric assay was 20.0–500.0 μM with an LOD of 5.13 μM. The method took advantage of different signals to achieve complementarity and eliminate false positives of single signals and improve the accuracy with great application prospects in the detection of AA.
期刊：
Human Vaccines & Immunotherapeutics,2022年18(6):Article: 2110799 ISSN：2164-5515
通讯作者：
Zhengrong Yang
作者机构：
[Yang, Zhengrong; Zeng, Guang; Wang, Xiaohui] Shenzhen Ctr Dis Control & Prevent, Dept HIV AIDS Prevent & Control, Shenzhen, Peoples R China.;[Yang, Zhengrong; Zeng, Guang; Feng, Shuidong; Tang, Jie] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.;[Xu, Liumei] Third Peoples Hosp Shenzhen, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China.
通讯机构：
[Zhengrong Yang] D;Department of HIV/AIDS Prevention and Control, Shenzhen Center for Disease Control and Prevention, Shenzhen, China<&wdkj&>School of Public Health, Hengyang Medical School, University of South China, Hengyang, China
关键词：
CD4+T cell count;HIV/HBV co-infection;inactivated COVID-19 vaccine;people living with HIV;spike receptor binding domain IgG (S-RBD-IgG) antibody;viral load (VL)
摘要：
In the global context of the COVID-19 pandemic, the overall benefits of getting any COVID-19 vaccine approved by the World Health Organization for emergency use outweigh the potential risks, even in people with weakened immune systems, including people living with HIV (PLWH). At present, there are no reports of HIV/hepatitis B virus (HBV) co-infected patients receiving a booster dose of the inactivated COVID-19 vaccine. Here, we describe a patient with HIV/HBV co-infection who did not seroconvert to three doses of the inactivated COVID-19 vaccine.
