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Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells

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成果类型:
期刊论文
作者:
Liu, Yan-ping;Yuan, Xiao-yan;Li, Xun-ya;Wang, Ye;Sun, Zhan-bing;...
通讯作者:
Zhang, Z.-H.
作者机构:
[Wang, Ye; Deng, Wei-hua; Yuan, Xiao-yan; Zhang, Zhao-hui; Jiang, Tian-yi; Liu, Yan-ping; Huang, Lian; Li, Xun-ya; Sun, Zhan-bing; Lei, Yuan-di] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
[Yuan, Xiao-yan; Zhang, Zhao-hui; Liu, Yan-ping] Univ South China, Hunan Prov Key Lab Typ Environm Pollut & Hlth, Hengyang, Peoples R China.
通讯机构:
School of public health, University of South China, Hengyang, China
语种:
英文
关键词:
*16HBE cell;*apoptosis;*autophagy;*beryllium sulfate;*hydrogen sulfide
期刊:
Journal of Applied Toxicology
ISSN:
0260-437X
年:
2022
卷:
42
期:
2
页码:
230-243
基金类别:
Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ4082]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573193]
机构署名:
本校为第一机构
院系归属:
公共卫生学院
摘要:
Beryllium and its compounds are systemic toxicants that are widely applied in many industries. Hydrogen sulfide has been found to protect cells. The present study aimed to determine the protective mechanisms involved in hydrogen sulfide treatment of 16HBE cells following beryllium sulfate-induced injury. 16HBE cells were treated with beryllium sulfate doses ranging between 0 and 300 μM BeSO4. Additionally, 16HBE cells were subjected to pretreatment with either a 300 μM dose of sodium hydrosulfide (a hydrogen sulfide donor) or 10 mM DL-proparg...

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