作者机构：
[Liu, Ming-Xuan] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: mingxuanliu@ntu.edu.cn;[Zhou, Meng-Zhu; Tao, Yi-Tong; Wu, Wei; Zhang, Su-Yun; Zhu, Ya-Qi; Yang, Yue] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China;[Liu, Yong-Hong] School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225001, Jiangsu, PR China;[Yang, Yuan] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address: 2023010013@usc.edu.cn;[Zhang, Xiao-Ling] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: Zhangxiaoling@ntu.edu.cn
通讯机构：
[Yang, Yuan] D;[Zhang, Xiao-Ling; Liu, Ming-Xuan] S;School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address:;Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address:
摘要：
Hepatic fibrosis impacts millions of patients globally suffering from various liver diseases. Therefore, development of novel therapeutic strategies is urgently required. Since macrophage recruitment increases during liver fibrosis progression, macrophage membrane-coated biomimetic complexes can be designed for targeted anti-liver fibrosis therapy. In this study, a biomimetic “gas-gene” strategy was proposed to enhance anti-liver fibrosis efficacy. A macrophage membrane-coated carbon nitride-based biomimetic delivery platform loaded with DNA nanoparticles (M-PEISeCCNs@DNA) was developed. The macrophage membrane coating facilitated the delivery of M-PEISeCCNs@SBP1 to the liver fibrosis site and reversed the positive charge of the carriers to avoid cation-induced cytotoxicity. Under near-infrared (NIR) irradiation, M-PEISeCCNs@SBP1 could trigger water splitting to produce O 2 , thereby mitigating hypoxia and alleviating liver fibrosis. The light-responsive release of the SBP1-DNA plasmid was also achieved through carrier photolysis. The delivered SBP1-DNA and the Se element within the vectors synergistically upregulated the expression of selenium-binding protein-1 (SBP1). Additionally, we demonstrated for the first time that SBP1 is an effective therapeutic target for liver fibrosis, and its overexpression inhibits epithelial-mesenchymal transition (EMT) and attenuates CCl 4 -induced liver fibrosis in mice. In this experiment, M-PEISeCCNs@SBP1 effectively treated liver fibrosis in mice through the SBP1-mediated NOTCH2/Wnt pathway.
Hepatic fibrosis impacts millions of patients globally suffering from various liver diseases. Therefore, development of novel therapeutic strategies is urgently required. Since macrophage recruitment increases during liver fibrosis progression, macrophage membrane-coated biomimetic complexes can be designed for targeted anti-liver fibrosis therapy. In this study, a biomimetic “gas-gene” strategy was proposed to enhance anti-liver fibrosis efficacy. A macrophage membrane-coated carbon nitride-based biomimetic delivery platform loaded with DNA nanoparticles (M-PEISeCCNs@DNA) was developed. The macrophage membrane coating facilitated the delivery of M-PEISeCCNs@SBP1 to the liver fibrosis site and reversed the positive charge of the carriers to avoid cation-induced cytotoxicity. Under near-infrared (NIR) irradiation, M-PEISeCCNs@SBP1 could trigger water splitting to produce O 2 , thereby mitigating hypoxia and alleviating liver fibrosis. The light-responsive release of the SBP1-DNA plasmid was also achieved through carrier photolysis. The delivered SBP1-DNA and the Se element within the vectors synergistically upregulated the expression of selenium-binding protein-1 (SBP1). Additionally, we demonstrated for the first time that SBP1 is an effective therapeutic target for liver fibrosis, and its overexpression inhibits epithelial-mesenchymal transition (EMT) and attenuates CCl 4 -induced liver fibrosis in mice. In this experiment, M-PEISeCCNs@SBP1 effectively treated liver fibrosis in mice through the SBP1-mediated NOTCH2/Wnt pathway.
摘要：
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
作者机构：
[Xiaoyuan Ye; Xiangjiu Guan; Liejin Guo] International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China;School of Civil Engineering, University of South China, Hengyang 421001, China;School of Electrical Engineering, Xi'an University of Technology, Xi'an 710054, China;[Wengao Zeng] International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China<&wdkj&>School of Civil Engineering, University of South China, Hengyang 421001, China;[Tuo Zhang] International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China<&wdkj&>School of Electrical Engineering, Xi'an University of Technology, Xi'an 710054, China
通讯机构：
[Xiangjiu Guan; Liejin Guo] I;International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China
摘要：
Biomass represents a complex yet abundant resource. The reforming of biomass promises a potentially ideal low-carbon technology route to produce fuels and high-value chemicals. Thermo-photo catalysis, as an emerging technology, demonstrates the capacity to simultaneously harness light and heat energy for efficient biomass conversion. This approach integrates the individual advantages of photocatalysis and thermal catalysis, concurrently reducing the energy consumption of thermal catalysis and enhancing the efficiency of photocatalysis. This review introduces the primary types and pretreatment of biomass, together with advancements in the photoreforming of typical biomass and derivatives. By categorizing thermo-photo catalysis into three types, i.e., thermo-assisted photocatalysis, photo-promoted thermal catalysis, and thermo-photo cocatalysis, the roles of light energy and heat energy within the reaction system and the thermo-photo synergistic mechanisms are analyzed, with the applications in biomass reforming detailedly discussed. Key challenges including design of catalyst, investigation of mechanism, development of reactor, and thermal measurement at nanoscale are highlighted, emphasizing potential research directions in thermo-photo catalytic biomass reforming. This review aims to guide research and suggest innovations in materials and sustainable energy systems for the production of green fuels and high-value chemicals with potential practical adoption at an industrial scale.
Biomass represents a complex yet abundant resource. The reforming of biomass promises a potentially ideal low-carbon technology route to produce fuels and high-value chemicals. Thermo-photo catalysis, as an emerging technology, demonstrates the capacity to simultaneously harness light and heat energy for efficient biomass conversion. This approach integrates the individual advantages of photocatalysis and thermal catalysis, concurrently reducing the energy consumption of thermal catalysis and enhancing the efficiency of photocatalysis. This review introduces the primary types and pretreatment of biomass, together with advancements in the photoreforming of typical biomass and derivatives. By categorizing thermo-photo catalysis into three types, i.e., thermo-assisted photocatalysis, photo-promoted thermal catalysis, and thermo-photo cocatalysis, the roles of light energy and heat energy within the reaction system and the thermo-photo synergistic mechanisms are analyzed, with the applications in biomass reforming detailedly discussed. Key challenges including design of catalyst, investigation of mechanism, development of reactor, and thermal measurement at nanoscale are highlighted, emphasizing potential research directions in thermo-photo catalytic biomass reforming. This review aims to guide research and suggest innovations in materials and sustainable energy systems for the production of green fuels and high-value chemicals with potential practical adoption at an industrial scale.
期刊：
European Journal of Mechanics - A/Solids,2026年115:105822 ISSN：0997-7538
通讯作者：
Jiu-Jiu Chen
作者机构：
[Shao-Yong Huo; Qiu-Shuang Yang; Zhi-Peng Jin; Shu-xin Zhang; Chun-Ming Fu] College of Mechanical Engineering, University of South China, Hengyang, 421001, China;[Jiu-Jiu Chen] State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China;[Rong-hua Chen] School of Aeronautics and Mechanical Engineering, Jiangsu College Key Laboratory of Non-Traditional Machining, Changzhou Institute of Technology, Changzhou, Jiangsu, 213032, China
通讯机构：
[Jiu-Jiu Chen] S;State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China
摘要：
Manipulation of elastic waves to achieve rainbow trapping effect has attracted wide attention. However, most of the current researches achieve rainbow trapping effect by changing the structural parameters, which means that the structure and mechanical properties are always fixed. Realizing the actively tunable working frequency range in elastic topological systems and obtain multi-dimensional rainbow trapping is still a challenge. In this paper, we design a topologically protected second-order thermostatic phononic crystal (PC) plate by using ferroelectric ceramic materials. By adjusting the rotation angle of the T-shaped scatterer, we can realize the multi-dimensional topological phase transition between the bulk and edge bands of elastic wave. Then, a “trivial-nontrivial-trivial” (TNT) heterostructure is constructed to obtain the coupled topological edge states of elastic wave, and the influence of intermediate coupling layer number on the edge states is investigated, which exhibits a multi-mode interference effect. Furthermore, the tunable topological edge states and corner states of elastic wave are obtained based on the temperature control of the ferroelectric materials. In addition, by employing the active tunability of the coupled edge states and corner states, the multi-dimensional topological rainbow trapping of elastic wave in ferroelectric PC plates is demonstrated. The edge and corner states of different frequencies are well separated and captured in different spatial positions, and the working frequency range of the PC plate can be easily tuned by controlling the temperature. Our results further promote the practical integration application of tunable and multi-dimensional elastic wave devices.
Manipulation of elastic waves to achieve rainbow trapping effect has attracted wide attention. However, most of the current researches achieve rainbow trapping effect by changing the structural parameters, which means that the structure and mechanical properties are always fixed. Realizing the actively tunable working frequency range in elastic topological systems and obtain multi-dimensional rainbow trapping is still a challenge. In this paper, we design a topologically protected second-order thermostatic phononic crystal (PC) plate by using ferroelectric ceramic materials. By adjusting the rotation angle of the T-shaped scatterer, we can realize the multi-dimensional topological phase transition between the bulk and edge bands of elastic wave. Then, a “trivial-nontrivial-trivial” (TNT) heterostructure is constructed to obtain the coupled topological edge states of elastic wave, and the influence of intermediate coupling layer number on the edge states is investigated, which exhibits a multi-mode interference effect. Furthermore, the tunable topological edge states and corner states of elastic wave are obtained based on the temperature control of the ferroelectric materials. In addition, by employing the active tunability of the coupled edge states and corner states, the multi-dimensional topological rainbow trapping of elastic wave in ferroelectric PC plates is demonstrated. The edge and corner states of different frequencies are well separated and captured in different spatial positions, and the working frequency range of the PC plate can be easily tuned by controlling the temperature. Our results further promote the practical integration application of tunable and multi-dimensional elastic wave devices.
作者机构：
[Ouyang, Yanquan; Xie, Xiangmin; He, Jiakun; He, Bo] Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China;[Tang, Xian] Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China. Electronic address: xiantang@usc.edu.cn
通讯机构：
[Tang, Xian] K;Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China. Electronic address:
关键词：
Black phosphorene;Electrochemical sensing;Nucleophilic substitution;Oligonucleotide;Uranyl ion
摘要：
The development of efficient, sensitive and rapid uranyl ion (UO 2 2+ ) detection technology plays a critical role in promoting the utilization of uranium resources and protecting the environment. In this study, a novel composite of BP-mPEG-Olig was synthesized by immobilizing oligonucleotides (Oligs) on black phosphorene (BP), using maleimide-polyethylene glycol (mPEG) as both the linker and passivator. BP-mPEG-Olig utilizes the excellent electrical conductivity and high specific surface area of BP and the high affinity and molecular recognition capability of Oligs for electrochemical UO 2 2+ sensing. Multiple material characterizations, including small-angle X-ray scattering, revealed the morphology and microstructures of BP-mPEG-Olig. The high electrochemical activity of BP-mPEG-Olig was achieved by abundant active reactions sites and rational charge transport. By systematically optimizing the detection conditions of differential pulse voltammetry, including electrode modification density, pH, temperature, and enrichment time, the developed electrochemical UO 2 2+ sensor based on the BP-mPEG-Olig modified glassy carbon electrode demonstrated a linear detection range of 7.4 × 10 −8 ‒6.66 × 10 −7 M and a detection limit of 2.36 × 10 −10 M. The sensor showed good reproducibility and stability for real-world samples. The results indicate that post-graphene two-dimensional materials, represented by BP, have important prospects for the detection of trace uranium and other low-level radioactive elements where chemical sensors are applicable.
The development of efficient, sensitive and rapid uranyl ion (UO 2 2+ ) detection technology plays a critical role in promoting the utilization of uranium resources and protecting the environment. In this study, a novel composite of BP-mPEG-Olig was synthesized by immobilizing oligonucleotides (Oligs) on black phosphorene (BP), using maleimide-polyethylene glycol (mPEG) as both the linker and passivator. BP-mPEG-Olig utilizes the excellent electrical conductivity and high specific surface area of BP and the high affinity and molecular recognition capability of Oligs for electrochemical UO 2 2+ sensing. Multiple material characterizations, including small-angle X-ray scattering, revealed the morphology and microstructures of BP-mPEG-Olig. The high electrochemical activity of BP-mPEG-Olig was achieved by abundant active reactions sites and rational charge transport. By systematically optimizing the detection conditions of differential pulse voltammetry, including electrode modification density, pH, temperature, and enrichment time, the developed electrochemical UO 2 2+ sensor based on the BP-mPEG-Olig modified glassy carbon electrode demonstrated a linear detection range of 7.4 × 10 −8 ‒6.66 × 10 −7 M and a detection limit of 2.36 × 10 −10 M. The sensor showed good reproducibility and stability for real-world samples. The results indicate that post-graphene two-dimensional materials, represented by BP, have important prospects for the detection of trace uranium and other low-level radioactive elements where chemical sensors are applicable.
期刊：
Materials Science and Engineering B-Advanced Functional Solid-State Materials,2026年323:118719 ISSN：0921-5107
通讯作者：
Yueyuan Gu
作者机构：
[Zhouxi Yin; Zhaolin Liu] School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, China;School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;[Yueyuan Gu] School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
通讯机构：
[Yueyuan Gu] S;School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
摘要：
The conventional Pr 0.5 Sr 0.5 ScO 3 proton conductor is modified through Fe-doping, aiming to introduce enhanced electronic conductivity and catalytic activity into the proton-conducting oxide matrix, thereby rendering it suitable for application as a cathode for proton-conducting solid oxide fuel cells (H-SOFCs). A low Fe-doping concentration inadequately develops electronic conduction pathways within the material, diminishing its power output. Conversely, employing an oxide with excessively high Fe concentration similarly fails to yield optimal performance. Optimal cathode functionality is achieved by establishing a proper compositional equilibrium between Sc and Fe. Specifically, the Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 cathode demonstrates superior performance, delivering a peak power density of 1730 mW cm −2 and a minimal area-specific polarization resistance of 0.0304 Ω cm 2 at 700 °C. Furthermore, Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 exhibits excellent chemical compatibility and robust phase stability. These attributes enable sustained fuel cell operation under working conditions for over 100 h, demonstrating significant promise for practical fuel cell implementations.
The conventional Pr 0.5 Sr 0.5 ScO 3 proton conductor is modified through Fe-doping, aiming to introduce enhanced electronic conductivity and catalytic activity into the proton-conducting oxide matrix, thereby rendering it suitable for application as a cathode for proton-conducting solid oxide fuel cells (H-SOFCs). A low Fe-doping concentration inadequately develops electronic conduction pathways within the material, diminishing its power output. Conversely, employing an oxide with excessively high Fe concentration similarly fails to yield optimal performance. Optimal cathode functionality is achieved by establishing a proper compositional equilibrium between Sc and Fe. Specifically, the Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 cathode demonstrates superior performance, delivering a peak power density of 1730 mW cm −2 and a minimal area-specific polarization resistance of 0.0304 Ω cm 2 at 700 °C. Furthermore, Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 exhibits excellent chemical compatibility and robust phase stability. These attributes enable sustained fuel cell operation under working conditions for over 100 h, demonstrating significant promise for practical fuel cell implementations.
期刊：
Annals of Nuclear Energy,2026年226:111846 ISSN：0306-4549
通讯作者：
Meng Li
作者机构：
[Yin Zhao; Ke Zhang] School of Computing, University of South China, Hengyang, 421001, China;Hunan Engineering Research Center of Software Evaluation and Testing for Intellectual Equipment, Hengyang, 421001, China;CNNC Key Laboratory on High Trusted Computing, Hengyang, 421001, China;[Meng Li; Xiaohua Yang; Jie Liu; Shiyu Yan] School of Computing, University of South China, Hengyang, 421001, China<&wdkj&>Hunan Engineering Research Center of Software Evaluation and Testing for Intellectual Equipment, Hengyang, 421001, China<&wdkj&>CNNC Key Laboratory on High Trusted Computing, Hengyang, 421001, China
通讯机构：
[Meng Li] S;School of Computing, University of South China, Hengyang, 421001, China<&wdkj&>Hunan Engineering Research Center of Software Evaluation and Testing for Intellectual Equipment, Hengyang, 421001, China<&wdkj&>CNNC Key Laboratory on High Trusted Computing, Hengyang, 421001, China
摘要：
The multi-scale coupling program for high temperature gas-cooled reactors encompasses complex physical phenomena across the microscopic, mesoscopic, and macroscopic level. Owing to the significant development expenses and the complexity of forming precise analytical solutions, making traditional testing methods invalid, verifying multi-scale codes is hindered by the oracle problem. Metamorphic testing is an effective technique to alleviate the oracle problem. This study uses a two-stage verification method grounded in metamorphic relations, following the introduction of code verification in the nuclear domain. Upon identifying 13 metamorphic relations and 1 property based on fundamental physical characteristics, 87 test case pairs successfully revealed two deeply hidden faults undetected by traditional testing methods. The experimental findings indicate that metamorphic testing serves both as a mechanism to evaluate the code correctness and as a technique to increase the number of verification cases. Furthermore, it presents great potential for applications in the verification of nuclear software.
The multi-scale coupling program for high temperature gas-cooled reactors encompasses complex physical phenomena across the microscopic, mesoscopic, and macroscopic level. Owing to the significant development expenses and the complexity of forming precise analytical solutions, making traditional testing methods invalid, verifying multi-scale codes is hindered by the oracle problem. Metamorphic testing is an effective technique to alleviate the oracle problem. This study uses a two-stage verification method grounded in metamorphic relations, following the introduction of code verification in the nuclear domain. Upon identifying 13 metamorphic relations and 1 property based on fundamental physical characteristics, 87 test case pairs successfully revealed two deeply hidden faults undetected by traditional testing methods. The experimental findings indicate that metamorphic testing serves both as a mechanism to evaluate the code correctness and as a technique to increase the number of verification cases. Furthermore, it presents great potential for applications in the verification of nuclear software.
作者：
Da Hu*;Xuejuan Xiang;Junjie Huang;Kai Qi;Yongsuo Li;...
期刊：
Journal of Pipeline Systems Engineering and Practice,2025年16(3):03125001 ISSN：1949-1190
通讯作者：
Da Hu
作者机构：
[Yongsuo Li] Professor, Hunan Engineering Research Center of Structural Safety and Disaster Prevention for Urban Underground Infrastructure, Hunan City Univ., No. 518, Yingbin East Rd., Yiyang 413000, China;[Xian Yang; Xiaoqiang Liang] Associate Professor, Hunan Engineering Research Center of Structural Safety and Disaster Prevention for Urban Underground Infrastructure, Hunan City Univ., No. 518, Yingbin East Rd., Yiyang 413000, China;[Kai Qi] Master’s Student, School of Civil Engineering, Univ. of South China, No. 28, Changsheng West Rd., Hengyang 421001, China;Hunan Engineering Research Center of Structural Safety and Disaster Prevention for Urban Underground Infrastructure, Hunan City Univ., No. 518, Yingbin East Rd., Yiyang 413000, China;[Xuejuan Xiang; Junjie Huang] Master’s Student, School of Civil Engineering, Hunan City Univ., No. 518, Yingbin East Rd., Yiyang 413000, China
通讯机构：
[Da Hu] P;Professor, Hunan Engineering Research Center of Structural Safety and Disaster Prevention for Urban Underground Infrastructure, Hunan City Univ., No. 518, Yingbin East Rd., Yiyang 413000, China
关键词：
Rectangular top pipe tunnel;Experimental analysis method;Empirical formula method;Numerical simulation method;Theoretical analysis method
摘要：
The jacking force in the construction process of rectangular pipe jacking tunnels is characterized by its intermittent, discontinuous, and unstable nature. This force not only determines the speed of tunneling but also controls the rate at which soil stress is released, leading to deformation of the formation and land subsidence, thereby impacting the surrounding environment. To accurately calculate and predict the jacking force of rectangular pipe jacking tunnels, this study conducts a comprehensive investigation and analysis of relevant literature on the calculation methods employed both domestically and internationally. The calculation methods are categorized into four types: experimental analysis methods, numerical simulation methods, theoretical formula methods, and empirical formula methods. The research content of each of these methods is analyzed and organized, and the existing research is summarized in terms of its problems and shortcomings. Furthermore, suggestions for future research on the calculation method of the jacking force are proposed, aiming to provide a technical reference for the theoretical research and engineering practice of calculating and predicting the jacking force of rectangular pipe jacking tunnels.
作者机构：
[Lin, Ya; Zhang, Xiaoxiao; Zuo, Ziyi] Wenzhou Med Univ, Affiliated Hosp 1, Div Pulm Med, Wenzhou 325000, Zhejiang, Peoples R China.;[Xiao, Yijia] Univ South China, Affiliated Changsha Cent Hosp, Dept Pulm & Crit Care Med, Changsha 410004, Hunan, Peoples R China.
通讯机构：
[Xiao, YJ ] U;Univ South China, Affiliated Changsha Cent Hosp, Dept Pulm & Crit Care Med, Changsha 410004, Hunan, Peoples R China.
关键词：
Gut microbiota;Mendelian randomization analysis;Genome-wide association study;Chronic lung diseases;Insilico in-situ microbiota resequencing
摘要：
Evidence from observational studies and clinical trials has reported that gut microbiota (GM) was associated with chronic lung diseases (CLDs). However, the causal relationships between GM and CLDs have yet to be fully ascertained. The Mendelian randomization (MR) based causal analysis was performed using the genome-wide association study (GWAS) summary statistics from the MiBioGen and FinnGen consortium. GM served as exposure, and CLDs were taken for outcomes. Inverse variance weighted, MR-Egger, and weighted median methods were utilized to examine the causal association between GM and CLDs. The sensitivity analyses were then conducted to validate the robustness of the results. Further, the reverse MR analysis was performed to evaluate the possibility of reverse causation. Finally, the in-silico in-situ microbiota resequencing (ISSMR) of high-throughput sequencing data was utilized as a supplement to dissect the role of microbiota spatial distribution disturbance on the onset of idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). This study revealed that GM had causal associations with CLDs. Conversely, reverse MR analysis suggested that the presence of COPD and IPF may causally influence the abundance of specific GM. And ISSMR further provided clues to the interaction of intra-tissue as well as gut microbe disturbance in IPF and COPD from synergistic or independent perspectives. In short, the MR analysis revealed a causal relationship between GM and CLDs from a host genetic perspective, and ISSMR extended the host-microbe regulatory modality from a microbe genetic perspective, thus together providing novel insights into the gut microbiota-mediated development mechanism of CLDs.
作者：
Jiuzhen Zeng;Laurence T. Yang;Chao Wang;Lei Zhang
期刊：
ACM Transactions on Autonomous and Adaptive Systems,2025年 ISSN：1556-4665
作者机构：
[Jiuzhen Zeng] Huazhong University of Science and Technology, China;[Lei Zhang] Hexi University, China;[Laurence T. Yang] Huazhong University of Science and Technology, China, Zhengzhou University, China, St. Francis Xavier University, Canada;[Chao Wang] University of South China, China
摘要：
Given the vulnerability of vehicular networks to security attacks and the criticality
of secure AI-powered autonomous driving, this paper emphasizes the security issue
concerning vehicular networks in AI-powered autonomous vehicles. The novel ...
摘要：
Seismic events and wave action can induce volumetric strain ( ε v ) accumulation in saturated sandy soils, leading to damage to the ground surface and structures. A quantifiable relationship exists between the generation of ε v in sandy soils under drained conditions and the development of pore water pressures under undrained conditions. In this study, the impact of relative density ( D r ), cyclic stress path, and stress level on the characteristics of volumetric strain ( ε v ) generation in saturated coral sands (SCS) was evaluated through drained tests employing various cyclic stress paths. The test findings demonstrate that the rate of ε v accumulation in SCS is notably affected by the cyclic stress path. The rise in peak volumetric strain ( ε vp ) in SCS, as a function of the number of cycles, conforms to the arctangent function model. The unit cyclic stress ratio (USR) was employed as an indicator of complex cyclic loading levels. It was determined that coefficient ( ε vp ) u is positively correlated with USR at a specific D r . At the same D r , coefficient C N 1 exhibits a positive correlation with USR, while coefficient C N 2 displays a negative correlation with USR, following a power-law relationship. Irrespective of cyclic loading conditions, ε vp rises with an increase in generalized shear strain amplitude ( γ ga ). A power function model was established to represent the relationship between ε vp and γ ga . The coefficient ζ 1 decreases as D r increases. Comparisons were drawn between ε vp and γ ga for Ottawa sand and SCS. The results indicate that, as D r of Ottawa sand increases from 30 % to 70 %, the coefficient ζ 1 decreases from 1.54 to 0.73, representing a reduction of approximately 53 %. In contrast, under identical conditions, the coefficient ζ 1 of SCS exhibits a less pronounced decrease, from 1.16 to 0.79, corresponding to a reduction of roughly 32 %. These observations suggest that variations in D r have a more substantial impact on generating ε vp in Ottawa sand compared to SCS.
Seismic events and wave action can induce volumetric strain ( ε v ) accumulation in saturated sandy soils, leading to damage to the ground surface and structures. A quantifiable relationship exists between the generation of ε v in sandy soils under drained conditions and the development of pore water pressures under undrained conditions. In this study, the impact of relative density ( D r ), cyclic stress path, and stress level on the characteristics of volumetric strain ( ε v ) generation in saturated coral sands (SCS) was evaluated through drained tests employing various cyclic stress paths. The test findings demonstrate that the rate of ε v accumulation in SCS is notably affected by the cyclic stress path. The rise in peak volumetric strain ( ε vp ) in SCS, as a function of the number of cycles, conforms to the arctangent function model. The unit cyclic stress ratio (USR) was employed as an indicator of complex cyclic loading levels. It was determined that coefficient ( ε vp ) u is positively correlated with USR at a specific D r . At the same D r , coefficient C N 1 exhibits a positive correlation with USR, while coefficient C N 2 displays a negative correlation with USR, following a power-law relationship. Irrespective of cyclic loading conditions, ε vp rises with an increase in generalized shear strain amplitude ( γ ga ). A power function model was established to represent the relationship between ε vp and γ ga . The coefficient ζ 1 decreases as D r increases. Comparisons were drawn between ε vp and γ ga for Ottawa sand and SCS. The results indicate that, as D r of Ottawa sand increases from 30 % to 70 %, the coefficient ζ 1 decreases from 1.54 to 0.73, representing a reduction of approximately 53 %. In contrast, under identical conditions, the coefficient ζ 1 of SCS exhibits a less pronounced decrease, from 1.16 to 0.79, corresponding to a reduction of roughly 32 %. These observations suggest that variations in D r have a more substantial impact on generating ε vp in Ottawa sand compared to SCS.
通讯机构：
[Tao, GQ ] U;Univ South China, Sch Resource & Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China.
关键词：
Cut-off grade drawing method;Insert drawing technique;Loss and dilution;Sublevel caving
摘要：
Sublevel caving (SLC) is widely used in underground mines for its low cost and high production rate, but it faces challenges such as high ore loss and dilution. The previous research has focused on shape of draw bodies, stope structural parameters of SLC and drawing management. However, the flow of waste rocks, ore-rock contact and its control in the drawing process are not deeply studied. This study analyzed the main causes of these issues and the formation mechanism of waste rock funnels, proposing the insert drawing method (IDM) to reduce ore loss and dilution. This technique involves actively controlling the contact, movement direction, and path of ore-rock near the drawpoints using an insert device. By manipulating insert device, the technique effectively enhances ore flow velocity and area, resulting in enhanced ore recovery. By managing the movement of waste rock funnel, the technique can delay dilution entry in the drawpoints, effectively reducing ore dilution. Further, to validate IDM's effectiveness, comparative experiments were conducted between IDM and traditional cut-off grade drawing method (COGDM). The experimental results indicate that IDM outperforms COGDM in terms of ore recovery rate. For the mining of massive orebodies with SLC, IDM achieves a 10.96% higher ore recovery rate compared to COGDM; for steeply inclined medium-thick orebodies, IDM's ore recovery rate surpasses COGDM by 15.68-30.88%. The research demonstrates that IDM effectively reduces ore loss and dilution in SLC, making it suitable for widespread application in other SLC mines.
摘要：
Aims/Background Silver-containing dressings are commonly utilized in burns treatment by virtue of their excellent antibacterial properties. Further research is needed to determine the type of silver-containing dressing that is more effective and safer for burns treatment. Pyperbranched polyamide-Ag dressing (HBPs-Ag dressing) is a modified polyamide dressing with a uniform coating of the Amino-terminated hyperbranched polymer (HBP-NH(2))/Ag(+) compound on its surface. This study aimed to evaluate the efficacy and safety of a silver ion-containing dressing (HBPs-Ag) for wound contact layer in the treatment of deep partial-thickness burns versus a silver-impregnated tulle dressing (Atrauman Ag). Methods This study was conducted between October 2019 to January 2021 at six sites in China. A total of 132 patients with deep partial-thickness burns (aged 18-65 years, injury occurring within 72 hours, burns <30% total burn surface area) were randomized 1:1 to HBPs-Ag group (study group) or Atrauman Ag group (control group). Data were obtained and analyzed, including total efficacy, wound healing rate, wound healing time, rate of negative bacterial culture from wound secretions, systemic response, skin or tissue irritation, local skin color changes, wound swelling, wound pain and adverse events. Results For partial thickness burns, the HBPs-Ag dressing was not inferior to Atrauman Ag dressing because the total efficiency of HBPs-Ag group (98.3%) was comparable to that of Atrauman Ag group (94.7%) (p > 0.05). There were no significant differences in efficacy, wound healing rate, wound healing time, and rate of negative bacterial culture from wound secretions between the two groups (p > 0.05). There were no statistical differences in all safety indicators tested between the two groups (p > 0.05). Silver was detected in the blood or urine of only 5 patients (3.79%). Conclusion The HBPs-Ag dressing was not inferior to Atrauman Ag dressing in deep partial-thickness burns treatment, with both of them showcasing comparable efficacy and safety. Clinical Trial Registration Chinese Clinical Trial Registry (ChiCTR2100049814).
摘要：
This study systematically investigated the antioxidant activities and phytochemical profiles of petroleum ether (PE), ethyl acetate (EtOAc), n-butanol (n-BuOH) and aqueous fractions of edible (tubers) and non-edible portions (peels) of Pachyrhizus erosus. The results showed that both the tubers and peels from P. erosus were rich in polyphenols and flavonoids, whereas the EtOAc fraction of peels had the highest polyphenol content, and the PE fraction of peels had the highest total flavonoid content. ABTS, DPPH, and FRAP assays revealed that both the EtOAc fraction of tubers and peels from P. erosus showed significant antioxidant activity, whereas the EtOAc fraction of peels possessed better antioxidant activity than that of tubers. UPLC-Orbitrap-MS/MS analysis indicated that thirty compounds were identified from the EtOAc fractions of peels and tubers, including twenty-one flavonoids, six phenolics, two coumarins, and one lignan, some of which have previously been revealed to display significant antioxidant and anti-inflammatory effects via the Nrf2-Keap1 and NF-kappa B signaling pathways. These findings provide robust scientific evidence for the health-promoting properties and pharmaceutical potential of P. erosus, and its non-edible portion (peels) has great potential for use as a natural antioxidant in the food, cosmetic, and pharmaceutical industries.
期刊：
Journal of Alloys and Compounds,2025年1021:179708 ISSN：0925-8388
通讯作者：
Chen, W;Lin, YC
作者机构：
[Chen, Wei; Gan, Lang; Chen, Kang; Xu, Xinru; Li, Cong; Chen, W; Qiu, Wei; Chen, Jian] Changsha Univ Sci & Technol, Sch Energy & Power Engn, Changsha 410114, Hunan, Peoples R China.;[Jiang, Peipei] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China.;[Lin, Yongcheng; He, Daoguang] Cent South Univ, Sch Mech & Elect Engn, Changsha 410083, Hunan, Peoples R China.
通讯机构：
[Chen, W ; Lin, YC ] C;Changsha Univ Sci & Technol, Sch Energy & Power Engn, Changsha 410114, Hunan, Peoples R China.;Cent South Univ, Sch Mech & Elect Engn, Changsha 410083, Hunan, Peoples R China.
关键词：
Al-Si-Mg alloy;Rare earth oxide;Mechanical properties;Corrosion resistance;Al 7 Fe 6 La phase
摘要：
This study examines the impact of the rare earth oxide La 2 O 3 on the microstructure, mechanical and corrosion resistance properties of as-cast Al-Si-Mg (A356) alloys, with a specific focus on the A356 alloy. By incorporating varying amounts of La 2 O 3 (0 wt%, 0.2 wt%, 0.3 wt%, and 0.4 wt%) into the A356 alloy, four samples (AL0, AL2, AL3, and AL4) were produced. The findings demonstrate that an optimal addition of La 2 O 3 (0.3 wt%) can effectively reduce the secondary dendrite arm spacing (SDAS), refine the eutectic Si phase, and modify the morphology of Fe-rich phases, thereby significantly enhancing the overall performance of the alloy. The transformation in the morphology of the Fe-rich phases is accompanied by changes in their elemental composition, including the transition from elongated rod-like AlFeSi phases to shorter rod-like Al 7 Fe 6 La phases. Specifically, the AL3 sample displays the best mechanical properties, with increases in hardness, yield strength (YS), ultimate tensile strength (UTS) and elongation (EL) of 11.11 %, 71.43 %, 36.45 % and 233.46 %, respectively. Moreover, AL3 exhibits superior corrosion resistance, characterized by the highest corrosion potential (-0.88 V) and the lowest corrosion current density (3.6 ×10 −7 A/cm 2 ). The addition of La 2 O 3 promotes grain refinement, reduces the size of secondary phase particles, and the formation of Al 7 Fe 6 La phase collectively contributing to the enhanced performance of the A356 alloy. The present study provides theoretical support for utilizing rare earth oxides as a viable alternative to pure rare earth metals in Al alloys, presenting a cost-efficient strategy tailored for industrial implementations.
This study examines the impact of the rare earth oxide La 2 O 3 on the microstructure, mechanical and corrosion resistance properties of as-cast Al-Si-Mg (A356) alloys, with a specific focus on the A356 alloy. By incorporating varying amounts of La 2 O 3 (0 wt%, 0.2 wt%, 0.3 wt%, and 0.4 wt%) into the A356 alloy, four samples (AL0, AL2, AL3, and AL4) were produced. The findings demonstrate that an optimal addition of La 2 O 3 (0.3 wt%) can effectively reduce the secondary dendrite arm spacing (SDAS), refine the eutectic Si phase, and modify the morphology of Fe-rich phases, thereby significantly enhancing the overall performance of the alloy. The transformation in the morphology of the Fe-rich phases is accompanied by changes in their elemental composition, including the transition from elongated rod-like AlFeSi phases to shorter rod-like Al 7 Fe 6 La phases. Specifically, the AL3 sample displays the best mechanical properties, with increases in hardness, yield strength (YS), ultimate tensile strength (UTS) and elongation (EL) of 11.11 %, 71.43 %, 36.45 % and 233.46 %, respectively. Moreover, AL3 exhibits superior corrosion resistance, characterized by the highest corrosion potential (-0.88 V) and the lowest corrosion current density (3.6 ×10 −7 A/cm 2 ). The addition of La 2 O 3 promotes grain refinement, reduces the size of secondary phase particles, and the formation of Al 7 Fe 6 La phase collectively contributing to the enhanced performance of the A356 alloy. The present study provides theoretical support for utilizing rare earth oxides as a viable alternative to pure rare earth metals in Al alloys, presenting a cost-efficient strategy tailored for industrial implementations.
期刊：
JOURNAL OF SPINAL CORD MEDICINE,2025年:1-10 ISSN：1079-0268
通讯作者：
Yin, H
作者机构：
[Lv, JinYe; Yin, H; Yin, Heng; Chen, Yilin; Li, Xiaolong] Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu Prov, Peoples R China.;[Lv, JinYe; Yin, H; Yin, Heng; Chen, Yilin; Li, Xiaolong] Nanjing Univ Chinese Med, Wuxi Affiliated Hosp, Wuxi 214071, Jiangsu Prov, Peoples R China.;[Yuan, Yuan] Univ South China, Hengyang Med Coll, Hengyang, Hunan Prov, Peoples R China.;[Lian, Yihao] Capital Med Univ, Affiliated Beijing Tongren Hosp, Beijing, Peoples R China.
通讯机构：
[Yin, H ] N;Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu Prov, Peoples R China.;Nanjing Univ Chinese Med, Wuxi Affiliated Hosp, Wuxi 214071, Jiangsu Prov, Peoples R China.
关键词：
Early surgical decompression;Meta-analysis;Time-dependent efficacy;Total motor score;Traumatic spinal cord injury
摘要：
OBJECTIVE: Numerous studies have demonstrated that early surgical intervention in patients with traumatic spinal cord injury leads to superior recovery of various indicators, including neurological function, compared to late surgical intervention. However, some relevant clinical randomized controlled trials have indicated that the motor function recovery of patients undergoing early surgical decompression does not show a significant advantage during initial follow-up periods. The benefits of early surgical decompression become more apparent as the follow-up duration extends. Therefore, this study aims to evaluate the prognosis of early versus late surgical intervention on traumatic spinal cord injury and to analyze whether the prognostic benefits of early surgical decompression in traumatic spinal cord injury patients are time-dependent. METHODS: We performed a systematic review and meta-analysis by searching the PubMed, Embase, and Cochrane Library databases for randomized controlled trials and quasi-randomized controlled trials that addressed the timing of surgical intervention for traumatic spinal cord injury. The data extracted from all included studies were processed and analyzed utilizing the RevMan 5.4 software. RESULTS: Eight studies involving 702 patients were included in this analysis, with 345 patients in the early surgery group and 357 patients in the late surgery group. The results showed that the early surgery group had a significantly higher rate of improvement in AIS grade (OR = 1.50; 95% CI: 1.05-2.15; p = 0.03) and a shorter hospital stay (MD = -4.76; 95% CI: -9.19 - -0.32; p = 0.04) compared to the late surgery group. Although there was no significant difference in total motor scores between the two groups in the early postoperative period, the pooled data still favored the early surgery group (MD = 4.43; 95% CI: 1.23-7.63; p = 0.007). There was no significant difference in postoperative complications between the two groups (RR = 0.61; 95% CI: 0.30-1.22; p = 0.16). CONCLUSION: Early surgical decompression leads to better prognosis in patients with traumatic spinal cord injury and shows a trend of more obvious advantages in motor function recovery with longer follow-up time than late surgical intervention.
