作者机构：
[Liu, Ming-Xuan] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: mingxuanliu@ntu.edu.cn;[Zhou, Meng-Zhu; Tao, Yi-Tong; Wu, Wei; Zhang, Su-Yun; Zhu, Ya-Qi; Yang, Yue] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China;[Liu, Yong-Hong] School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225001, Jiangsu, PR China;[Yang, Yuan] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address: 2023010013@usc.edu.cn;[Zhang, Xiao-Ling] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: Zhangxiaoling@ntu.edu.cn
通讯机构：
[Yang, Yuan] D;[Zhang, Xiao-Ling; Liu, Ming-Xuan] S;School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address:;Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address:
摘要：
Hepatic fibrosis impacts millions of patients globally suffering from various liver diseases. Therefore, development of novel therapeutic strategies is urgently required. Since macrophage recruitment increases during liver fibrosis progression, macrophage membrane-coated biomimetic complexes can be designed for targeted anti-liver fibrosis therapy. In this study, a biomimetic “gas-gene” strategy was proposed to enhance anti-liver fibrosis efficacy. A macrophage membrane-coated carbon nitride-based biomimetic delivery platform loaded with DNA nanoparticles (M-PEISeCCNs@DNA) was developed. The macrophage membrane coating facilitated the delivery of M-PEISeCCNs@SBP1 to the liver fibrosis site and reversed the positive charge of the carriers to avoid cation-induced cytotoxicity. Under near-infrared (NIR) irradiation, M-PEISeCCNs@SBP1 could trigger water splitting to produce O 2 , thereby mitigating hypoxia and alleviating liver fibrosis. The light-responsive release of the SBP1-DNA plasmid was also achieved through carrier photolysis. The delivered SBP1-DNA and the Se element within the vectors synergistically upregulated the expression of selenium-binding protein-1 (SBP1). Additionally, we demonstrated for the first time that SBP1 is an effective therapeutic target for liver fibrosis, and its overexpression inhibits epithelial-mesenchymal transition (EMT) and attenuates CCl 4 -induced liver fibrosis in mice. In this experiment, M-PEISeCCNs@SBP1 effectively treated liver fibrosis in mice through the SBP1-mediated NOTCH2/Wnt pathway.
Hepatic fibrosis impacts millions of patients globally suffering from various liver diseases. Therefore, development of novel therapeutic strategies is urgently required. Since macrophage recruitment increases during liver fibrosis progression, macrophage membrane-coated biomimetic complexes can be designed for targeted anti-liver fibrosis therapy. In this study, a biomimetic “gas-gene” strategy was proposed to enhance anti-liver fibrosis efficacy. A macrophage membrane-coated carbon nitride-based biomimetic delivery platform loaded with DNA nanoparticles (M-PEISeCCNs@DNA) was developed. The macrophage membrane coating facilitated the delivery of M-PEISeCCNs@SBP1 to the liver fibrosis site and reversed the positive charge of the carriers to avoid cation-induced cytotoxicity. Under near-infrared (NIR) irradiation, M-PEISeCCNs@SBP1 could trigger water splitting to produce O 2 , thereby mitigating hypoxia and alleviating liver fibrosis. The light-responsive release of the SBP1-DNA plasmid was also achieved through carrier photolysis. The delivered SBP1-DNA and the Se element within the vectors synergistically upregulated the expression of selenium-binding protein-1 (SBP1). Additionally, we demonstrated for the first time that SBP1 is an effective therapeutic target for liver fibrosis, and its overexpression inhibits epithelial-mesenchymal transition (EMT) and attenuates CCl 4 -induced liver fibrosis in mice. In this experiment, M-PEISeCCNs@SBP1 effectively treated liver fibrosis in mice through the SBP1-mediated NOTCH2/Wnt pathway.
摘要：
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
作者机构：
[Xiaoyuan Ye; Xiangjiu Guan; Liejin Guo] International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China;School of Civil Engineering, University of South China, Hengyang 421001, China;School of Electrical Engineering, Xi'an University of Technology, Xi'an 710054, China;[Wengao Zeng] International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China<&wdkj&>School of Civil Engineering, University of South China, Hengyang 421001, China;[Tuo Zhang] International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China<&wdkj&>School of Electrical Engineering, Xi'an University of Technology, Xi'an 710054, China
通讯机构：
[Xiangjiu Guan; Liejin Guo] I;International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi'an 710049, China
摘要：
Biomass represents a complex yet abundant resource. The reforming of biomass promises a potentially ideal low-carbon technology route to produce fuels and high-value chemicals. Thermo-photo catalysis, as an emerging technology, demonstrates the capacity to simultaneously harness light and heat energy for efficient biomass conversion. This approach integrates the individual advantages of photocatalysis and thermal catalysis, concurrently reducing the energy consumption of thermal catalysis and enhancing the efficiency of photocatalysis. This review introduces the primary types and pretreatment of biomass, together with advancements in the photoreforming of typical biomass and derivatives. By categorizing thermo-photo catalysis into three types, i.e., thermo-assisted photocatalysis, photo-promoted thermal catalysis, and thermo-photo cocatalysis, the roles of light energy and heat energy within the reaction system and the thermo-photo synergistic mechanisms are analyzed, with the applications in biomass reforming detailedly discussed. Key challenges including design of catalyst, investigation of mechanism, development of reactor, and thermal measurement at nanoscale are highlighted, emphasizing potential research directions in thermo-photo catalytic biomass reforming. This review aims to guide research and suggest innovations in materials and sustainable energy systems for the production of green fuels and high-value chemicals with potential practical adoption at an industrial scale.
Biomass represents a complex yet abundant resource. The reforming of biomass promises a potentially ideal low-carbon technology route to produce fuels and high-value chemicals. Thermo-photo catalysis, as an emerging technology, demonstrates the capacity to simultaneously harness light and heat energy for efficient biomass conversion. This approach integrates the individual advantages of photocatalysis and thermal catalysis, concurrently reducing the energy consumption of thermal catalysis and enhancing the efficiency of photocatalysis. This review introduces the primary types and pretreatment of biomass, together with advancements in the photoreforming of typical biomass and derivatives. By categorizing thermo-photo catalysis into three types, i.e., thermo-assisted photocatalysis, photo-promoted thermal catalysis, and thermo-photo cocatalysis, the roles of light energy and heat energy within the reaction system and the thermo-photo synergistic mechanisms are analyzed, with the applications in biomass reforming detailedly discussed. Key challenges including design of catalyst, investigation of mechanism, development of reactor, and thermal measurement at nanoscale are highlighted, emphasizing potential research directions in thermo-photo catalytic biomass reforming. This review aims to guide research and suggest innovations in materials and sustainable energy systems for the production of green fuels and high-value chemicals with potential practical adoption at an industrial scale.
期刊：
European Journal of Mechanics - A/Solids,2026年115:105822 ISSN：0997-7538
通讯作者：
Jiu-Jiu Chen
作者机构：
[Shao-Yong Huo; Qiu-Shuang Yang; Zhi-Peng Jin; Shu-xin Zhang; Chun-Ming Fu] College of Mechanical Engineering, University of South China, Hengyang, 421001, China;[Jiu-Jiu Chen] State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China;[Rong-hua Chen] School of Aeronautics and Mechanical Engineering, Jiangsu College Key Laboratory of Non-Traditional Machining, Changzhou Institute of Technology, Changzhou, Jiangsu, 213032, China
通讯机构：
[Jiu-Jiu Chen] S;State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China
摘要：
Manipulation of elastic waves to achieve rainbow trapping effect has attracted wide attention. However, most of the current researches achieve rainbow trapping effect by changing the structural parameters, which means that the structure and mechanical properties are always fixed. Realizing the actively tunable working frequency range in elastic topological systems and obtain multi-dimensional rainbow trapping is still a challenge. In this paper, we design a topologically protected second-order thermostatic phononic crystal (PC) plate by using ferroelectric ceramic materials. By adjusting the rotation angle of the T-shaped scatterer, we can realize the multi-dimensional topological phase transition between the bulk and edge bands of elastic wave. Then, a “trivial-nontrivial-trivial” (TNT) heterostructure is constructed to obtain the coupled topological edge states of elastic wave, and the influence of intermediate coupling layer number on the edge states is investigated, which exhibits a multi-mode interference effect. Furthermore, the tunable topological edge states and corner states of elastic wave are obtained based on the temperature control of the ferroelectric materials. In addition, by employing the active tunability of the coupled edge states and corner states, the multi-dimensional topological rainbow trapping of elastic wave in ferroelectric PC plates is demonstrated. The edge and corner states of different frequencies are well separated and captured in different spatial positions, and the working frequency range of the PC plate can be easily tuned by controlling the temperature. Our results further promote the practical integration application of tunable and multi-dimensional elastic wave devices.
Manipulation of elastic waves to achieve rainbow trapping effect has attracted wide attention. However, most of the current researches achieve rainbow trapping effect by changing the structural parameters, which means that the structure and mechanical properties are always fixed. Realizing the actively tunable working frequency range in elastic topological systems and obtain multi-dimensional rainbow trapping is still a challenge. In this paper, we design a topologically protected second-order thermostatic phononic crystal (PC) plate by using ferroelectric ceramic materials. By adjusting the rotation angle of the T-shaped scatterer, we can realize the multi-dimensional topological phase transition between the bulk and edge bands of elastic wave. Then, a “trivial-nontrivial-trivial” (TNT) heterostructure is constructed to obtain the coupled topological edge states of elastic wave, and the influence of intermediate coupling layer number on the edge states is investigated, which exhibits a multi-mode interference effect. Furthermore, the tunable topological edge states and corner states of elastic wave are obtained based on the temperature control of the ferroelectric materials. In addition, by employing the active tunability of the coupled edge states and corner states, the multi-dimensional topological rainbow trapping of elastic wave in ferroelectric PC plates is demonstrated. The edge and corner states of different frequencies are well separated and captured in different spatial positions, and the working frequency range of the PC plate can be easily tuned by controlling the temperature. Our results further promote the practical integration application of tunable and multi-dimensional elastic wave devices.
作者机构：
[Ouyang, Yanquan; Xie, Xiangmin; He, Jiakun; He, Bo] Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China;[Tang, Xian] Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China. Electronic address: xiantang@usc.edu.cn
通讯机构：
[Tang, Xian] K;Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China. Electronic address:
关键词：
Black phosphorene;Electrochemical sensing;Nucleophilic substitution;Oligonucleotide;Uranyl ion
摘要：
The development of efficient, sensitive and rapid uranyl ion (UO 2 2+ ) detection technology plays a critical role in promoting the utilization of uranium resources and protecting the environment. In this study, a novel composite of BP-mPEG-Olig was synthesized by immobilizing oligonucleotides (Oligs) on black phosphorene (BP), using maleimide-polyethylene glycol (mPEG) as both the linker and passivator. BP-mPEG-Olig utilizes the excellent electrical conductivity and high specific surface area of BP and the high affinity and molecular recognition capability of Oligs for electrochemical UO 2 2+ sensing. Multiple material characterizations, including small-angle X-ray scattering, revealed the morphology and microstructures of BP-mPEG-Olig. The high electrochemical activity of BP-mPEG-Olig was achieved by abundant active reactions sites and rational charge transport. By systematically optimizing the detection conditions of differential pulse voltammetry, including electrode modification density, pH, temperature, and enrichment time, the developed electrochemical UO 2 2+ sensor based on the BP-mPEG-Olig modified glassy carbon electrode demonstrated a linear detection range of 7.4 × 10 −8 ‒6.66 × 10 −7 M and a detection limit of 2.36 × 10 −10 M. The sensor showed good reproducibility and stability for real-world samples. The results indicate that post-graphene two-dimensional materials, represented by BP, have important prospects for the detection of trace uranium and other low-level radioactive elements where chemical sensors are applicable.
The development of efficient, sensitive and rapid uranyl ion (UO 2 2+ ) detection technology plays a critical role in promoting the utilization of uranium resources and protecting the environment. In this study, a novel composite of BP-mPEG-Olig was synthesized by immobilizing oligonucleotides (Oligs) on black phosphorene (BP), using maleimide-polyethylene glycol (mPEG) as both the linker and passivator. BP-mPEG-Olig utilizes the excellent electrical conductivity and high specific surface area of BP and the high affinity and molecular recognition capability of Oligs for electrochemical UO 2 2+ sensing. Multiple material characterizations, including small-angle X-ray scattering, revealed the morphology and microstructures of BP-mPEG-Olig. The high electrochemical activity of BP-mPEG-Olig was achieved by abundant active reactions sites and rational charge transport. By systematically optimizing the detection conditions of differential pulse voltammetry, including electrode modification density, pH, temperature, and enrichment time, the developed electrochemical UO 2 2+ sensor based on the BP-mPEG-Olig modified glassy carbon electrode demonstrated a linear detection range of 7.4 × 10 −8 ‒6.66 × 10 −7 M and a detection limit of 2.36 × 10 −10 M. The sensor showed good reproducibility and stability for real-world samples. The results indicate that post-graphene two-dimensional materials, represented by BP, have important prospects for the detection of trace uranium and other low-level radioactive elements where chemical sensors are applicable.
期刊：
Materials Science and Engineering B-Advanced Functional Solid-State Materials,2026年323:118719 ISSN：0921-5107
通讯作者：
Yueyuan Gu
作者机构：
[Zhouxi Yin; Zhaolin Liu] School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, China;School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;[Yueyuan Gu] School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
通讯机构：
[Yueyuan Gu] S;School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
摘要：
The conventional Pr 0.5 Sr 0.5 ScO 3 proton conductor is modified through Fe-doping, aiming to introduce enhanced electronic conductivity and catalytic activity into the proton-conducting oxide matrix, thereby rendering it suitable for application as a cathode for proton-conducting solid oxide fuel cells (H-SOFCs). A low Fe-doping concentration inadequately develops electronic conduction pathways within the material, diminishing its power output. Conversely, employing an oxide with excessively high Fe concentration similarly fails to yield optimal performance. Optimal cathode functionality is achieved by establishing a proper compositional equilibrium between Sc and Fe. Specifically, the Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 cathode demonstrates superior performance, delivering a peak power density of 1730 mW cm −2 and a minimal area-specific polarization resistance of 0.0304 Ω cm 2 at 700 °C. Furthermore, Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 exhibits excellent chemical compatibility and robust phase stability. These attributes enable sustained fuel cell operation under working conditions for over 100 h, demonstrating significant promise for practical fuel cell implementations.
The conventional Pr 0.5 Sr 0.5 ScO 3 proton conductor is modified through Fe-doping, aiming to introduce enhanced electronic conductivity and catalytic activity into the proton-conducting oxide matrix, thereby rendering it suitable for application as a cathode for proton-conducting solid oxide fuel cells (H-SOFCs). A low Fe-doping concentration inadequately develops electronic conduction pathways within the material, diminishing its power output. Conversely, employing an oxide with excessively high Fe concentration similarly fails to yield optimal performance. Optimal cathode functionality is achieved by establishing a proper compositional equilibrium between Sc and Fe. Specifically, the Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 cathode demonstrates superior performance, delivering a peak power density of 1730 mW cm −2 and a minimal area-specific polarization resistance of 0.0304 Ω cm 2 at 700 °C. Furthermore, Pr 0.5 Sr 0.5 Sc 0.25 Fe 0.75 O 3 exhibits excellent chemical compatibility and robust phase stability. These attributes enable sustained fuel cell operation under working conditions for over 100 h, demonstrating significant promise for practical fuel cell implementations.
期刊：
Annals of Nuclear Energy,2026年226:111846 ISSN：0306-4549
通讯作者：
Meng Li
作者机构：
[Yin Zhao; Ke Zhang] School of Computing, University of South China, Hengyang, 421001, China;Hunan Engineering Research Center of Software Evaluation and Testing for Intellectual Equipment, Hengyang, 421001, China;CNNC Key Laboratory on High Trusted Computing, Hengyang, 421001, China;[Meng Li; Xiaohua Yang; Jie Liu; Shiyu Yan] School of Computing, University of South China, Hengyang, 421001, China<&wdkj&>Hunan Engineering Research Center of Software Evaluation and Testing for Intellectual Equipment, Hengyang, 421001, China<&wdkj&>CNNC Key Laboratory on High Trusted Computing, Hengyang, 421001, China
通讯机构：
[Meng Li] S;School of Computing, University of South China, Hengyang, 421001, China<&wdkj&>Hunan Engineering Research Center of Software Evaluation and Testing for Intellectual Equipment, Hengyang, 421001, China<&wdkj&>CNNC Key Laboratory on High Trusted Computing, Hengyang, 421001, China
摘要：
The multi-scale coupling program for high temperature gas-cooled reactors encompasses complex physical phenomena across the microscopic, mesoscopic, and macroscopic level. Owing to the significant development expenses and the complexity of forming precise analytical solutions, making traditional testing methods invalid, verifying multi-scale codes is hindered by the oracle problem. Metamorphic testing is an effective technique to alleviate the oracle problem. This study uses a two-stage verification method grounded in metamorphic relations, following the introduction of code verification in the nuclear domain. Upon identifying 13 metamorphic relations and 1 property based on fundamental physical characteristics, 87 test case pairs successfully revealed two deeply hidden faults undetected by traditional testing methods. The experimental findings indicate that metamorphic testing serves both as a mechanism to evaluate the code correctness and as a technique to increase the number of verification cases. Furthermore, it presents great potential for applications in the verification of nuclear software.
The multi-scale coupling program for high temperature gas-cooled reactors encompasses complex physical phenomena across the microscopic, mesoscopic, and macroscopic level. Owing to the significant development expenses and the complexity of forming precise analytical solutions, making traditional testing methods invalid, verifying multi-scale codes is hindered by the oracle problem. Metamorphic testing is an effective technique to alleviate the oracle problem. This study uses a two-stage verification method grounded in metamorphic relations, following the introduction of code verification in the nuclear domain. Upon identifying 13 metamorphic relations and 1 property based on fundamental physical characteristics, 87 test case pairs successfully revealed two deeply hidden faults undetected by traditional testing methods. The experimental findings indicate that metamorphic testing serves both as a mechanism to evaluate the code correctness and as a technique to increase the number of verification cases. Furthermore, it presents great potential for applications in the verification of nuclear software.
摘要：
The rapid and selective identification of microorganisms is of great significance for clinical therapy applications. To develop high performance probes for microbe determination, we systemically constructed series aggregation-induced emission (AIE) luminogens by modulating the structural planarity, the basicity of functional group, the length of linker moiety and the hydrophobicity based on our previous work. The detail structure-property relationship study based on experimental and theoretical observation revealed that: i) the planar skeleton is essential for probe insertion towards the cell wall via van n der Waals' force. ii) the basic function group enable the anchoring on the membrane by binding with acidic biomolecules. iii) the shortened alkyl chain is in favor of the efficient binding of basic groups with microbes and endows the desirable hydrophobicity. Based on the developed probes, the successful detection of the pathogens in clinic samples was achieved in highly sensitive and simple way. This work provides a reliable strategy for designing intelligent luminogens for microorganism discrimination and identification in efficient and sensitive way for in vitro diagnosis applications, especially point-of-care testing (POCT).
The rapid and selective identification of microorganisms is of great significance for clinical therapy applications. To develop high performance probes for microbe determination, we systemically constructed series aggregation-induced emission (AIE) luminogens by modulating the structural planarity, the basicity of functional group, the length of linker moiety and the hydrophobicity based on our previous work. The detail structure-property relationship study based on experimental and theoretical observation revealed that: i) the planar skeleton is essential for probe insertion towards the cell wall via van n der Waals' force. ii) the basic function group enable the anchoring on the membrane by binding with acidic biomolecules. iii) the shortened alkyl chain is in favor of the efficient binding of basic groups with microbes and endows the desirable hydrophobicity. Based on the developed probes, the successful detection of the pathogens in clinic samples was achieved in highly sensitive and simple way. This work provides a reliable strategy for designing intelligent luminogens for microorganism discrimination and identification in efficient and sensitive way for in vitro diagnosis applications, especially point-of-care testing (POCT).
期刊：
EXPERIMENTAL AND THERAPEUTIC MEDICINE,2025年29(3):56 ISSN：1792-0981
通讯作者：
Tang, J
作者机构：
[Cao, Chuangjie] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.;[Xie, Haitao] Univ South China, Affiliated Hosp 1, Inst Microbiol & Infect Dis, Dept Clin Lab Med,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Dou, Chengyun; Tang, Jian; Tang, J; Guo, Ruohan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Infect Dis, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Tang, J ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Infect Dis, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
coronavirus disease 2019;distinction;eosinophil;influenza A;neutrophil-to-lymphocyte ratio
摘要：
Coronavirus disease 2019 (COVID-19) and influenza A outbreaks have spread rapidly in China. It is difficult to accurately differentiate these two different respiratory tract infections on the basis of their similar early-stage symptoms and lymphocytopenia. In the present study, the age, sex and white blood cell, neutrophil, lymphocyte, monocyte and eosinophil counts, as well as the neutrophil-to-lymphocyte ratio (NLR) of 201 outpatients with confirmed COVID-19 and 246 outpatients with influenza A were investigated and compared. A receiver operating characteristic curve was drawn to determine the thresholds in distinguishing COVID-19 from influenza A Our study found that the monocyte count and NLR were significantly elevated, while the eosinophil count/percentage was higher in outpatients with COVID-19 than in those with influenza A (0.06±0.07 vs. 0.04±0.09, P=0.002; 0.95±1.12 vs. 0.56±0.95, P<0.001, respectively). Logit(P)=-1.11 + 1.29 x eosinophil percentage -12.07 x eosinophil count +1.10 x monocyte count, deduced from the eosinophil count/percentage and monocyte count, had the largest area under the curve at 0.67, with high specificity (80.1%) and a sensitivity of 47.3%. The present study demonstrated that a higher eosinophil count/percentage may be a potential biomarker to significantly differentiate early COVID-19 from influenza A.
摘要：
Laser cladding rapid solidification technique is an effective strategy for manufacturing ultra-high-strength martensitic stainless steels (UHS-MSS). Due to super-saturation solution strengthening of interstitial atoms (IAs), martensitic stainless steels containing IAs exhibit excellent ultra-high strength and toughness and have high tolerance for oxygen impurities. Hence, studying the specific speciation and structural characteristics of IAs is of great significance for guiding laser cladding of ultra-high-strength steels. Herein, we use density functional theory (DFT) computations to analyze the stable occupancies of IAs and their interactions in body-centered cubic iron (BCC Fe). The findings show that single IAs prefer to occupy octahedral sites over tetrahedral sites. Therefore, octahedral sites are selected as the optimal sites for the following double IAs study. For homo IAs, C-C and N-N configurations exhibit greater stability at long-range distances, whereas O-O demonstrate optimal stability at intermediate distances. Crucially, hetero IAs configurations are more stable compared to single IAs and homo IAs, exhibiting a synergistic effect. Especially, the C-O combination shows the highest stability and strongest bonding character. Meanwhile, the dissociation behavior of O indicates that C-O and N-O have higher dissociation temperatures than single O, further verifying the synergistic effect of hetero IAs. This provides a theoretical basis for understanding the interstitial solution strengthening of laser cladding UHS-MSS.
作者机构：
[Li, Xinyuan; Yang, Yuan; Jiang, Qilin; Ning, Xufeng; Cai, Fuchao; Huang, Fan] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China;[Zhou, Lingshan] Department of Geriatrics Ward 2, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China;[Zeng, Bin] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. zbss1229@163.com;[Zhou, Weiwei] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. 543906753@qq.com;[Hu, Guangsheng] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. 360680725@qq.com
摘要：
In this study, we determined whether gypenosides exert a therapeutic effect on colitis. We then explored the underlying mechanism of gypenosides in the treatment of ulcerative colitis (UC) via multiomics analyses. Dextran sulfate sodium (DSS) was used to establish a UC model in mice, and a subgroup of colitis model mice was subjected to gypenosides intervention. The inflammatory manifestations of the model and drug groups were determined via histological and molecular experiments. In addition, tissue and blood samples were collected for transcriptome and metabolomics analysis, respectively. Immunohistochemistry was used to detect the key proteins involved in UC pathogenesis and drug intervention. By combining transcriptomics and metabolomics assays, we explored one of the possible mechanisms by which gypenosides ameliorate UC in mice. Gypenosides treatment significantly alleviated clinical symptoms, prevented colon shortening, and decreased the disease activity index (DAI) in an 3% DSS-induced UC mouse model. Transcriptome sequencing revealed that the intestinal stem genes Ascl2 and Lgr5 ranked forefront in terms of differential expression before and after intervention with gypenosides. The metabolomics results suggest that the tricarboxylic acid cycle (TCA) and amino acid metabolism (AM) were the main metabolic pathways associated with UC and gypenosides treatment. Taken together, these results suggest that gypenosides may affect the biological activity of stem cells by regulating the tricarboxylic acid cycle and glutamine metabolism, promoting the repair of the damaged mucosa. In this study, we demonstrated that gypenosides alleviate colitis, likely by regulating the expression of genes associated with stemness and modulating the tricarboxylic acid cycle and amino acid metabolism, in a DSS-induced colitis mouse model.
摘要：
OBJECTIVE: Endothelial dysfunction is the altered pathological ability of endothelial cells to modulate the passage of cells and solutes across vessels, which underlies the development of inflammatory diseases. Betanin (betanidin-5-O-β-glucoside), a natural product rich in red beets, is a water-soluble nitrogen-containing pigment, and its potential protective effects on cardiovascular disease have been reported. In this study, we investigated the protective role of betanin in vascular endothelial dysfunction induced by TNFα and explored potential mechanisms. METHODS: We modelled endothelial dysfunction through TNFα stimulation in human umbilical vein endothelial cells (HUVECs) and examined the role of betanin and its possible mechanism of action by MTT assay, western blotting, and immunofluorescence staining. A systemic inflammation model of mice was built through LPS to investigate the protective roles of betanin. RESULTS: Betanin pre-treatment increased cell viability, inhibited the expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM- 1), and improved endothelial tight junction by upregulating the expression of occludin and zonula occludens-1 (ZO-1) after TNFα stimulation in HUVECs. In terms of endothelial-mesenchymal transition, betanin up-regulated the expression of endothelial phenotypes VE-cadherin and CD31, whereas it inhibited the expression of mesenchymal phenotype N-cadherin, indicating that betanin reduced endothelial-mesenchymal transition in TNFα-stimulated HUVECs. In addition, betanin increased the expression of LC3 and decreased the expression of p62, two central proteins in autophagy. Betanin also reversed the abnormal autophagic flux after TNFα exposure. However, the specific autophagy inhibitor, 3-methyladenine, blocked the protective effect of betanin. Finally, betanin was found to greatly decrease ICAM-1 and VCAM-1 expression, and upregulate occludin and ZO-1 levels in a systemic inflammation model of mice. CONCLUSIONS: The above results collectively suggested that betanin may improve endothelial dysfunction by promoting autophagy, thus exerting beneficial effects on cardiovascular health.
作者机构：
[Haoyu Huang; Yunyun Du; Junhe Xie; Zhenqun Guan] State Key Laboratory of Structure Analysis, Optimization and CAE Software for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China;[Fei Yu] HONG KONG QUANTUM AI LAB, Hong Kong Special Administrative Region;[Xiaoyu Jiang; Julin Shan; Haidong Zhang] Shanghai NineCube Microelectronic Co., Ltd, Shanghai, China;[Jie Cao] School of Mathematics and Physics, University of South China, Hengyang, China
通讯机构：
[Zhenqun Guan] S;State Key Laboratory of Structure Analysis, Optimization and CAE Software for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China
摘要：
Physical field simulations demand efficient mesh deformation and adaptive refinement methods. This paper proposes a systematical method tailored to the specific needs of simulations. Interpolation-based methods are preferred for large-scale mesh deformation due to computational efficiency. Improving the inverse distance weighted method by introducing auxiliary nodes using the sub-mesh. A node smoothing algorithm based on layered mesh is also devised to enhance mesh deformation ability. Optimizing the convergence criterion greatly reduces computation time. To improve element quality after deformation and meet the requirement for iterative refinement of mesh in simulation, a mesh refinement method is proposed. To address challenges in inserting nodes into narrow spaces, a novel algorithm is developed, which integrates the boundary constraints with the longest-edge propagation path. The co-optimization of surface and tetrahedral meshes is achieved through an algorithm based on size-field and an improved surface priority insertion strategy. A boundary edge priority algorithm is proposed to preserve the fitness between mesh and geometry. Flow field examples demonstrate the method’s effectiveness in mesh deformation and the optimization of poor-quality elements. Electromagnetic simulation results show that, compared to commercial software, the method significantly reduces the number of elements after refinement while maintaining solver accuracy.
Physical field simulations demand efficient mesh deformation and adaptive refinement methods. This paper proposes a systematical method tailored to the specific needs of simulations. Interpolation-based methods are preferred for large-scale mesh deformation due to computational efficiency. Improving the inverse distance weighted method by introducing auxiliary nodes using the sub-mesh. A node smoothing algorithm based on layered mesh is also devised to enhance mesh deformation ability. Optimizing the convergence criterion greatly reduces computation time.
To improve element quality after deformation and meet the requirement for iterative refinement of mesh in simulation, a mesh refinement method is proposed. To address challenges in inserting nodes into narrow spaces, a novel algorithm is developed, which integrates the boundary constraints with the longest-edge propagation path. The co-optimization of surface and tetrahedral meshes is achieved through an algorithm based on size-field and an improved surface priority insertion strategy. A boundary edge priority algorithm is proposed to preserve the fitness between mesh and geometry. Flow field examples demonstrate the method’s effectiveness in mesh deformation and the optimization of poor-quality elements. Electromagnetic simulation results show that, compared to commercial software, the method significantly reduces the number of elements after refinement while maintaining solver accuracy.
摘要：
Ruthenium removal from complex solutions (highly saline effluents, seawater) is a critical challenge. Herein, the sorption capacity of chitosan/SiO2 composite beads (Ch-Si) for ruthenium nitrosyl is increased three-fold after phosphoramidate grafting (DPA-Ch-Si, 1.6 mmol Ru g−1) at pH 5. Uptake kinetics and sorption isotherms are compared at pH0: 3, 5 and 10; playing with the mode of agitation (mechanical, MA, vs. ultrasonic treatment, UT). The sorbent maintains good sorption capacities at pH 3 and 10. Uptake kinetics modeled by pseudo-first order rate equation is boosted by functionalization. For Ch-Si, sorption isotherms are modeled by the Langmuir or Sips equations (depending on the pH), while for DPA-Ch-Si the best fits depend on pH, temperature and mode of agitation. Ruthenium sorption is spontaneous and endothermic for the two sorbents. For DPA-Ch-Si, the sorption capacity increases from 1.62 to 1.70 mmol Ru g−1 to 2.23–2.32 mmol Ru g−1 (T increasing from 21 to 50 °C). Nitric acid solution (0.3 M) reveals highly efficient for back extraction; ruthenium is completely released in <15 min. The functionalized sorbent can be reused for a minimum of 10 cycles, with limited loss in performance. Phosphoramidation improves sorption selectivity for the treatment of equimolar multicomponent solutions (Na, Ca, Mg, Fe, Al, U, and Nd). The effect of pH on sorption selectivity is evaluated in simple multi-metal solutions and complex environment. In seawater, the selective recovery of ruthenium is favored at pH close to 10. These tests confirm the promising perspectives offered for ruthenium removal from complex environments. Physicochemical characterizations of the sorbent (and their modes of interaction with ruthenium nitrosyl) included SEM, BET, TGA, FTIR, XPS, and elemental analyses.
Ruthenium removal from complex solutions (highly saline effluents, seawater) is a critical challenge. Herein, the sorption capacity of chitosan/SiO2 composite beads (Ch-Si) for ruthenium nitrosyl is increased three-fold after phosphoramidate grafting (DPA-Ch-Si, 1.6 mmol Ru g−1) at pH 5. Uptake kinetics and sorption isotherms are compared at pH0: 3, 5 and 10; playing with the mode of agitation (mechanical, MA, vs. ultrasonic treatment, UT). The sorbent maintains good sorption capacities at pH 3 and 10. Uptake kinetics modeled by pseudo-first order rate equation is boosted by functionalization. For Ch-Si, sorption isotherms are modeled by the Langmuir or Sips equations (depending on the pH), while for DPA-Ch-Si the best fits depend on pH, temperature and mode of agitation. Ruthenium sorption is spontaneous and endothermic for the two sorbents. For DPA-Ch-Si, the sorption capacity increases from 1.62 to 1.70 mmol Ru g−1 to 2.23–2.32 mmol Ru g−1 (T increasing from 21 to 50 °C). Nitric acid solution (0.3 M) reveals highly efficient for back extraction; ruthenium is completely released in <15 min. The functionalized sorbent can be reused for a minimum of 10 cycles, with limited loss in performance. Phosphoramidation improves sorption selectivity for the treatment of equimolar multicomponent solutions (Na, Ca, Mg, Fe, Al, U, and Nd). The effect of pH on sorption selectivity is evaluated in simple multi-metal solutions and complex environment. In seawater, the selective recovery of ruthenium is favored at pH close to 10. These tests confirm the promising perspectives offered for ruthenium removal from complex environments. Physicochemical characterizations of the sorbent (and their modes of interaction with ruthenium nitrosyl) included SEM, BET, TGA, FTIR, XPS, and elemental analyses.
作者机构：
[Pei, Yanfang; Zhou, Wei; Cao, Yan; Han, Xiaotong; Liu, Xin; Yan, Xiquan; Hu, Conglong] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Emergency Med, Changsha, Peoples R China.;[Cao, Yan] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Sepsis Res Ctr Hunan Prov Geriatr Inst, Changsha, Peoples R China.;[Hu, Bangqi] Hunan Normal Univ, Affiliated Hosp 1, Dept Emergency Med, Changsha, Peoples R China.;[Liu, Zhengyu] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Cardiol, Changsha, Peoples R China.;[Liu, Zhengyu] Hunan Normal Univ, Affiliated Hosp 1, Clin Med Res Ctr Heart Failure Hunan Prov, Hunan Prov Peoples Hosp, Changsha, Peoples R China.
通讯机构：
[Ding, N ; He, LD] U;Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Emergency Med, 161 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.
关键词：
E. coli sepsis;Serum magnesium;Mortality;MIMIC-IV database
摘要：
OBJECTIVE: Escherichia coli (E.coli) is the leading pathogen for deaths associated with antimicrobial resistance, making it the most problematic bacteria for human infections. This study aimed to investigate the association between serum magnesium levels and clinical outcomes in patients with E.coli sepsis. METHOD: Data of E.coli septic patients were collected from the MIMIC-IV database. Patients were divided into three groups based on tertiles of serum magnesium levels. Three models were utilized, including the raw model (unadjusted), Model I (adjusted for age and gender), and Model II (adjusted for all potential confounding factors). Linear model and two-segment nonlinear model were established to examine the relationship between serum magnesium and 30-day, 60-day, and 90-day mortality rates. Kaplan-Meier survival curve analysis was performed to assess cumulative hazard of mortalities at 30-day, 60-day, 90-day based on tertiles of serum magnesium levels. RESULTS: A total of 421 E.coli septic patients were included and classified into tertiles: Q1(< 1.6mg/dL), Q2 (1.6-1.9mg/dL), Q3(> 1.9mg/dL). In the Model adjusting for all potential confounders, for every 1mg/dL increase in serum magnesium, there was a significant increase in 30-day, 60-day, and 90-day mortality rates, with odds ratios of 4.01 (95% CI 1.22-13.19, P = 0.022), 4.81 (95% CI 1.59-14.53, P = 0.005), and 4.45 (95% CI 1.52-12.96, P = 0.006) respectively. And linear model is more suitable for describing the relationship between serum magnesium levels and clinical outcomes. Kaplan-Meier analysis revealed that the cumulative hazard of mortalities at 30-day, 60-day, 90-day increased with the prolongation of hospital stay, particularly in the group with the highest serum magnesium level. CONCLUSION: Increased level of serum magnesium is significantly associated with increased risk of 30-day, 60-day and 90-day mortality in a population of septic patients with E.coli infection.
摘要：
Brain tumor segmentation is crucial for diagnosing tumors and assessing clinical conditions. Diffusion models have become highly popular in medical image segmentation. However, current diffusion-based methods seldom fuse multi-modality images from a multi-scale perspective. Furthermore, removing the effect of noise in brain tumor images remains a significant challenge for brain tumor segmentation. In this paper, we propose a multi-scale diffusion model with an attention mechanism for brain tumor segmentation to address these challenges. Our method reduces the effects of noise and irrelevant background data in brain tumor images to enhance the capture of subtle differences and features across various tumor regions, improving segmentation performance. We incorporate an axial attention mechanism module (AAMM) into the denoising encoder to establish global long-range dependency, overcoming the limitations of convolutions and improving model’s interpretability. To use texture and contextual information from multi-scale features, we propose a multi-scale feature fusion module (MSFFM) in the decoder to adaptively fuse features from various scales and enhance the feature extraction ability of the model. We evaluate the proposed method on two public brain tumor segmentation datasets. The experimental results demonstrate that our method outperformed state-of-the-art brain tumor segmentation methods due to the effective denoising capability of the diffusion model.
Brain tumor segmentation is crucial for diagnosing tumors and assessing clinical conditions. Diffusion models have become highly popular in medical image segmentation. However, current diffusion-based methods seldom fuse multi-modality images from a multi-scale perspective. Furthermore, removing the effect of noise in brain tumor images remains a significant challenge for brain tumor segmentation. In this paper, we propose a multi-scale diffusion model with an attention mechanism for brain tumor segmentation to address these challenges. Our method reduces the effects of noise and irrelevant background data in brain tumor images to enhance the capture of subtle differences and features across various tumor regions, improving segmentation performance. We incorporate an axial attention mechanism module (AAMM) into the denoising encoder to establish global long-range dependency, overcoming the limitations of convolutions and improving model’s interpretability. To use texture and contextual information from multi-scale features, we propose a multi-scale feature fusion module (MSFFM) in the decoder to adaptively fuse features from various scales and enhance the feature extraction ability of the model. We evaluate the proposed method on two public brain tumor segmentation datasets. The experimental results demonstrate that our method outperformed state-of-the-art brain tumor segmentation methods due to the effective denoising capability of the diffusion model.
作者机构：
[Wei, Wenxuan; Kang, Xiaomei; Liu, Yujia; Guo, Qian; He, Qun; Bu, Weifeng; Bu, WF; Liu, Yilin] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat G, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.;[Wei, Wenxuan; Kang, Xiaomei; Liu, Yujia; Guo, Qian; He, Qun; Bu, Weifeng; Bu, WF; Liu, Yilin] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.;[Wei, Wenxuan; Zhou, Jin Yuan] Lanzhou Univ, Sch Phys Sci & Technol, Lanzhou 730000, Peoples R China.;[Zhu, Shoujun; Du, Yijing; Zhu, SJ] First Hosp Jilin Univ, Joint Lab Optofunct Theranost Med & Chem, Changchun 130021, Peoples R China.;[Zhu, Shoujun; Du, Yijing; Zhu, SJ] Jilin Univ, Coll Chem, Ctr Supramol Chem Biol, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China.
通讯机构：
[Bu, WF ] L;[Zhu, SJ ] F;[Wang, J ] U;Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat G, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.;Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.
关键词：
rhodium(I)-based nanoMOFs;NIR-II luminescence;Rh(I)Rh(I) interaction;vascular and tumorimaging
摘要：
Although luminescent metal-organic frameworks (MOFs) have been widely reported, rare examples were found to emit in the second near-infrared (NIR-II, 1000-1700 nm) window. In this work, two nanoscale rhodium(I)-based MOFs (Rh-1@SDS and Rh-1@DSPE-PEG) have been controllably constructed in the aqueous dispersions of sodium dodecyl sulfate (SDS) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol) (DSPE-PEG), wherein micelle- and vesicle-like aggregates form, respectively, with high colloidal stability. The vesicular dispersion of Rh-1@DSPE-PEG exhibits intense NIR-II luminescence at 1125 (1245, shoulder) nm. Consequently, this nanoMOF was used as an NIR-II luminescence probe, indicative of high-resolution systemic and local vascular imaging, where the postoperative recovery process of flap transplantation was clearly visualized. Meanwhile, it also demonstrates superior tumor targeting in the NIR-II window. To the best of our knowledge, this research represents the first example of nanoMOFs having intense NIR-II luminescence and excellent imaging capabilities.
摘要：
A multifunctional electrochemiluminescence (ECL) coreaction accelerator, AuAgPt nanoframes (NFs), is described for use in an ECL aptasensor for highly sensitive aflatoxin B1 (AFB1) detection. As a signal quencher, the broad UV-vis absorption spectrum of AuAgPt nanosheets (NSs) overlaps the ECL emission spectrum of g-C(3)N(4)@Au, triggering an ECL resonance energy transfer (ECL-RET). By the adjustment of the dosage of hydrogen peroxide (H(2)O(2)), the AuAgPt NSs are transformed into AuAgPt NFs because H(2)O(2) etches Ag in AuAgPt NSs into Ag(+), which disrupts the RET process. The as-formed AuAgPt NFs act as a coreaction accelerator to enhance the ECL response of the g-C(3)N(4)@Au/K(2)S(2)O(8) system. Without AFB1, the Ag-dependent DNAzyme is inactive, and a strong ECL signal is observed. After AFB1 is added, the AFB1 aptamer targets AFB1 and the DNAzyme active site is exposed. As-generated Ag(+) further activates DNAzyme to cut the substrate strand (S-DNA), which causes AuAgPt NFs to detach from the electrode surface and the ECL signal to significantly decrease. Under optimal conditions, the proposed ECL aptasensor exhibits high sensitivity with a limit of detection (LOD) of 0.11 fg/mL in the range of 1 fg/mL to 1 μg/mL for AFB1 detection.
