The addition of alpha-ketoglutarate to NT-proBNP improves the prediction of long-term all-cause mortality in acute heart failure patients

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成果类型：

期刊论文

作者：

Xu, Tianyu;Zhang, Hao;Peng, Zhengliang;Huang, Yuli;Zhan, Qiong;...

通讯作者：

Xu, DL;Dong, YG

作者机构：

[Xu, Tianyu; Liu, Chen; Dong, Yugang] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, NHC Key Lab Assisted Circulat & Vasc Dis, Guangzhou, Peoples R China.

[Zeng, Xianghui; Zhan, Qiong; Xu, Dingli; Zeng, Qingchun; Zhang, Hao; Ma, Zhuang] Southern Med Univ, Nanfang Hosp, Dept Cardiol, State Key Lab Organ Failure Res, Guangzhou, Peoples R China.

[Zhang, Hao; Huang, Yuli] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Dept Cardiol, Foshan, Peoples R China.

[Peng, Zhengliang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Emergency, Hengyang, Peoples R China.

[Xu, DL] Southern Med Univ, Nanfang Hosp, Dept Cardiol, 1838 Northern Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.

通讯机构：

[Xu, DL ; Dong, YG ] S

Southern Med Univ, Nanfang Hosp, Dept Cardiol, 1838 Northern Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.

Sun Yat sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou 510080, Guangdong, Peoples R China.

Sun Yat sen Univ, NHC Key Lab Assisted Circulat & Vasc Dis, Guangzhou 510080, Guangdong, Peoples R China.

语种：

英文

关键词：

Alpha-ketoglutarate;NT-proBNP;prognosis;long-term all-cause mortality;heart failure

期刊：

Annals of Medicine

ISSN：

0785-3890

年：

2025

卷：

期：

页码：

2477827

DOI：

10.1080/07853890.2025.2477827

基金类别：

Science and Technology Planning Project of Guangzhou [201707020012]; National Key Research and Development Program of China [2017YFC1308304]; National Natural Science Foundation of China [81970336]

机构署名：

本校为其他机构

摘要：

BACKGROUND AND OBJECTIVE: Alpha-ketoglutarate (AKG), is a major intermediate metabolite of the tricarboxylic acid cycle, and is closely associated with cardiometabolic disease prognosis. Previous studies indicated that AKG is related to myocardial energy expenditure levels and reflects adverse short-term outcomes in heart failure (HF) patients. In this prospective cohort study, we examined the long-term prognostic value of AKG levels in acute HF (AHF) patients. METHODS: Plasma AKG levels were assessed in patients hospitalized with AHF. Hazard r...

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The addition of alpha-ketoglutarate to NT-proBNP improves the prediction of long-term all-cause mortality in acute heart failure patients

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