Halcinonide activates smoothened to ameliorate ischemic stroke injury

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成果类型：

期刊论文

作者：

Liu, Jingjing;Zhao, Wenyang;Kang, Jia;Li, Xiangxiang;Han, Liang;...

通讯作者：

Liu, Xiaohua;Chen, XP;Gu, YQ

作者机构：

[Gao, Xiaoshan; Li, Xiangxiang; Hu, Zhuozhou; Zhang, Yixuan; Meng, Xinrui; Chen, Xinping; Han, Liang; Liu, Jingjing; Zhao, Wenyang; Kang, Jia; Zhou, Jing; Liu, Xiaohua; Liu, XH] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.

[Liu, Jingjing] Univ South China, Sch Basic Med Sci, Hengyang 421001, Hunan, Peoples R China.

[Chen, Xinping] Lanzhou Univ, Coll Vet Med, State Key Lab Vet Etiol Biol, Lanzhou 730000, Peoples R China.

[Chen, Xinping] Lanzhou Univ, Southeast Res Inst, Lanzhou 730000, Peoples R China.

[Gu, Youquan; Gu, YQ] Lanzhou Univ, Hosp 1, Dept Neurol, Lanzhou 730000, Peoples R China.

通讯机构：

[Liu, XH; Gu, YQ ; Chen, XP ] L

Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.

Lanzhou Univ, Coll Vet Med, State Key Lab Vet Etiol Biol, Lanzhou 730000, Peoples R China.

Lanzhou Univ, Hosp 1, Dept Neurol, Lanzhou 730000, Peoples R China.

语种：

英文

关键词：

Adeno-associated virus;Halcinonide;Ischemic stroke;Smoothened;Sonic hedgehog pathway

期刊：

Life Sciences

ISSN：

0024-3205

年：

2025

卷：

361

页码：

123324

DOI：

10.1016/j.lfs.2024.123324

基金类别：

This study was financially supported the “Double First-Class” University project funding from Lanzhou University ( 561119201 , granted to XPC), Fundamental Research Funds for the Central Universities ( lzujbky-2021-kb05 , granted to XPC) and Natural Science Foundation of Fujian Province for Southeast Research Institute, Lanzhou University ( 2022 J01526 , granted to XPC).

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本校为其他机构

摘要：

Objectives The Shh pathway may shed new light on developing new cell death inhibitors for the therapy of ischemic stroke. We aimed to examine whether the Shh co-reporter SMO or its agonist halcinonide can upregulate Bcl-2 to suppress neuronal cell death, ultimately improving behavioral deficits and reducing cerebral infarction in an ischemic stroke model. The Shh pathway may shed new light on developing new cell death inhibitors for the therapy of ischemic stroke. We aimed to examine whether the Shh co-reporter SMO or its agonist halcinonide ca...

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Halcinonide activates smoothened to ameliorate ischemic stroke injury

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