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Intravenous Tenecteplase before Thrombectomy in Stroke.

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成果类型:
期刊论文
作者:
Qiu, Zhongming;Li, Fengli;Sang, Hongfei;Yuan, Guangxiong;Xie, Dongjing;...
作者机构:
[You, Feng; Zi, Wenjie; Li, Maohua; Li, Linyu; Tian, Yan; Xie, Dongjing; Long, Xingmin; Qiu, Zhongming; Tao, Jian; Jiang, Ling; Meng, Zhaoyou; Zhou, Kai; Li, Fengli] Department of Neurology, Second Affiliated Hospital of Army Medical University (Xinqiao Hospital), Chongqing, China
[Feng, Xinggang; Wu, Yuelu; Cai, Lingyu; Li, Qi; Qiu, Zhongming; Jiang, Bingwu] Department of Neurology, No. 903 Hospital of the People's Liberation Army (PLA) Joint Logistics Support Force, Hangzhou, China
[Yin, Congguo; Sang, Hongfei] Department of Neurology, Hangzhou First People's Hospital and School of Medicine of Westlake University, Hangzhou, China
[Wu, Junxiong; Long, Chen; Wu, Derong; Yuan, Guangxiong] Emergency Department, Xiangtan Central Hospital (Affiliated Hospital of Hunan University), Xiangtan, China
[Yang, Bo; Kong, Zhenyu] Department of Neurology, First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People's Hospital), Jiaozuo, China
语种:
英文
期刊:
NEW ENGLAND JOURNAL OF MEDICINE
ISSN:
0028-4793
年:
2025
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
BACKGROUND: The safety and efficacy of treatment with intravenous tenecteplase before endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion remain uncertain. METHODS: In this open-label trial conducted in China, we randomly assigned patients with acute ischemic stroke due to large-vessel occlusion who had presented within 4.5 hours after onset and were eligible for thrombolysis to receive either intravenous tenecteplase followed by endovascular thrombectomy or endovascular thrombectomy alone. The primary...

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