Intravenous Tenecteplase before Thrombectomy in Stroke

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成果类型：

期刊论文

作者：

Qiu, Zhongming*;Li, Fengli;Sang, Hongfei;Yuan, Guangxiong;Xie, Dongjing;...

通讯作者：

Qiu, Zhongming;Zi, Wenjie;Yang, QW

作者机构：

[You, Feng; Zi, Wenjie; Li, Maohua; Li, Linyu; Tian, Yan; Xie, Dongjing; Yang, Qingwu; Long, Xingmin; Qiu, Zhongming; Tao, Jian; Zi, WJ; Jiang, Ling; Qiu, ZM; Meng, Zhaoyou; Zhou, Kai; Li, Fengli] Army Med Univ, Affiliated Hosp 2, Dept Neurol, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.

[Feng, Xinggang; Wu, Yuelu; Cai, Lingyu; Li, Qi; Qiu, Zhongming; Jiang, Bingwu] Zhejiang Hosp, Dept Neurol, Hangzhou, Peoples R China.

[Yin, Congguo; Sang, Hongfei] Westlake Univ, Hangzhou Peoples Hosp 1, Sch Med, Dept Hematol, Hangzhou, Peoples R China.

[Wu, Junxiong; Long, Chen; Wu, Derong; Yuan, Guangxiong] Hunan Univ, Xiangtan Cent Hosp, Affiliated Hosp, Dept Cardiol, Xiangtan, Peoples R China.

[Yang, Bo; Kong, Zhenyu] Henan Polytech Univ, Jiaozuo Peoples Hosp 2, Affiliated Hosp 1, Dept Neurol, Jiaozuo, Peoples R China.

通讯机构：

[Zi, WJ; Yang, QW ; Qiu, ZM] A

Army Med Univ, Affiliated Hosp 2, Dept Neurol, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.

语种：

英文

期刊：

NEW ENGLAND JOURNAL OF MEDICINE

ISSN：

0028-4793

年：

2025

卷：

393

期：

页码：

139-150

DOI：

10.1056/NEJMoa2503867

基金类别：

Chongqing Science and Health Joint Medical Research Project [2023GGXM007]; National Natural Science Foundation of China [82090040, 82371342]; Second Affiliated Hospital of Army Medical University (key project of clinical new technology) [2021JSLC0001]; China Shijiazhuang Pharmaceutical Company Recomgen Pharmaceutical (Guangzhou)

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

BACKGROUND The safety and efficacy of treatment with intravenous tenecteplase before endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion remain uncertain. METHODS In this open-label trial conducted in China, we randomly assigned patients with acute ischemic stroke due to large-vessel occlusion who had presented within 4.5 hours after onset and were eligible for thrombolysis to receive either intravenous tenecteplase followed by endovascular thrombectomy or endovascular thrombectomy alone. The primary outcome was functional independence (a score of 0 t...

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Intravenous Tenecteplase before Thrombectomy in Stroke

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