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Inhibition of VSMC Ferroptosis Mitigates Pathological Vascular Remodeling: A Novel Therapeutic Strategy for Abdominal Aortic Aneurysm.

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成果类型:
期刊论文
作者:
Yating Zhou;Yanyu Chen;Yuting Cui;Ni Gan;Qiong Xiang;...
通讯作者:
Dai, Xiaoyan;Peng, Juan;Tang, Zhihan
作者机构:
[Ni Gan; Yanyu Chen; Qiong Xiang; Yuting Cui; Man Li; Yating Zhou] Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China
[Wen Zeng] Shaoyang Branch of Key Laboratory for Arteriosclerology of Hunan Province, The Central Hospital of Shaoyang, Shaoyang, 421001, China
[Xi-Long Zheng] Departments of Biochemistry & Molecular Biology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
[Xiaoyan Dai] Clinical Research Center, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421002, China. xdai@usc.edu.cn
[Xiaoyan Dai] Hunan Provincial Key Laboratory of Basic and Clinical Pharmacological Research of Gastrointestinal Cancer, Hengyang, 421002, China. xdai@usc.edu.cn
通讯机构:
[Peng, Juan; Tang, Zhihan] I
[Dai, Xiaoyan] C
Clinical Research Center, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421002, China.
Hunan Provincial Key Laboratory of Basic and Clinical Pharmacological Research of Gastrointestinal Cancer, Hengyang, 421002, China.
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.
语种:
英文
关键词:
Abdominal aortic aneurysm;Ferroptosis;Ferrostatin-1;Pathological vascular remodeling;Vascular smooth muscle cell
期刊:
Journal of Cardiovascular Translational Research
ISSN:
1937-5387
年:
2025
页码:
1-15
基金类别:
This work was supported by the Hunan Provincial Health High-Level Talent Scientific Research Project (grant number R2023046); the Natural Science Foundation of Hunan Province (grant number 2025JJ90128); and the Guidance Program of Health Commission of Hunan Province (grant number 20201905).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Ferroptosis plays a key role in abdominal aortic aneurysm (AAA) development. This study explores whether and how ferroptosis regulates AAA progression. Ferroptosis was confirmed in human AAA tissue. In vitro experiments with primary mouse vascular smooth muscle cells (VSMCs) and abdominal aortic rings revealed that angiotensin II (Ang II) triggered ferroptosis in VSMCs. Ferrostatin-1 (Fer-1), a potent ferroptosis inhibitor, effectively suppressed this effect. Additionally, the ferroptosis inducer erastin and Ang II can both promoted pathological remodeling of abdominal aortic rings, but Fer-1 ...

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