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Tectorigenin attenuates myocardial damage by doxorubicin-induced ferroptosis by activating the p62-Keap1-Nrf2/HO-1/GPX4 axis

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成果类型:
期刊论文
作者:
Like Xie;Sujun Xiao;Qinyi Zhou;Wang Chen;Zhihao Hu;...
通讯作者:
Yuan Li
作者机构:
[Like Xie; Sujun Xiao; Qinyi Zhou; Wang Chen; Zhihao Hu; Yizhou Liu; Xiaofeng Ma] Department of Cardiology, Nanhua Hospital affiliated to Nanhua University, Hengyang 421001, Hunan Province, China
[Yunhui Li] Zhuzhou Central Hospital, General Medicine,Zhuzhou 412001, Hunan Province, China
[Yuan Li] Nanhua Hospital Affiliated to Nanhua University, Hengyang 421001, Hunan Province, China
通讯机构:
[Yuan Li] N
Nanhua Hospital Affiliated to Nanhua University, Hengyang 421001, Hunan Province, China
语种:
英文
关键词:
HO-1;Keap1;Nrf2;Oxidative stress;ROS
期刊:
Journal of Traditional and Complementary Medicine
ISSN:
2225-4110
年:
2025
机构署名:
本校为第一且通讯机构
摘要:
Background Anticancer agent doxorubicin is essential for cancer treatment but often causes cardiotoxicity. Tectorigenin has shown potential cardioprotective effects, but underlying mechanisms remain unclear. We aimed to investigate whether Tectorigenin attenuates doxorubicin-induced myocardial injury. Anticancer agent doxorubicin is essential for cancer treatment but often causes cardiotoxicity. Tectorigenin has shown potential cardioprotective effects, but underlying mechanisms remain unclear. We aimed to investigate whether Tectorigenin atten...

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