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Ferroptosis and metabolic dysfunction-associated fatty liver disease: Is there a link?

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成果类型:
期刊论文
作者:
Feng, Gong;Byrne, Christopher D.;Targher, Giovanni;Wang, Fudi*;Zheng, Ming-Hua*
通讯作者:
Zheng, Ming-Hua;Wang, Fudi
作者机构:
[Feng, Gong] Xian Med Univ, Xian, Peoples R China.
[Byrne, Christopher D.] Univ Hosp Southampton, Southampton Gen Hosp, Southampton Natl Inst Hlth Res Biomed Res Ctr, Southampton, Hants, England.
[Targher, Giovanni] Univ Verona, Dept Med, Sect Endocrinol Diabet & Metab, Verona, Italy.
[Targher, Giovanni] Azienda Osped Univ Integrata Verona, Verona, Italy.
[Wang, Fudi] Zhejiang Univ, Affiliated Hosp 4, Sch Publ Hlth, Sch Med, Hangzhou, Peoples R China.
通讯机构:
[Zheng, Ming-Hua] W
[Wang, Fudi] Z
Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, NAFLD Res Ctr, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.
Zhejiang Univ, Sch Med, Affiliated Hosp 1, Sch Publ Hlth,Inst Translat Med, Hangzhou 310058, Peoples R China.
语种:
英文
关键词:
ferroptosis;MAFLD;metabolic syndrome;pathogenesis;type 2 diabetes
期刊:
LIVER INTERNATIONAL
ISSN:
1478-3223
年:
2022
卷:
42
期:
7
页码:
1496-1502
基金类别:
Luca Valenti This work was supported by grants from the National Natural Science Foundation of China (82070588), National Key Research and Development Program of China (2018YFA0507802 to F.W.), High Level Creative Talents from Department of Public Health in Zhejiang Province (S2032102600032), Science and Technology project of Shaanxi Province (2021ZDLSF02-09) and Project of New Century 551 Talent Nurturing in Wenzhou. GT is supported in part by grants from the University School of Medicine of Verona, Verona, Italy. CDB is supported in part by the Southampton NIHR Biomedical Research Centre (IS-BRC-20004), UK.
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
Non-alcoholic fatty liver disease (NAFLD), recently re-defined and re-classified as metabolic dysfunction-associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD/MAFLD. As a newly discovered form of iron-dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that l...

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