期刊论文

Ma, Q;Wang, FD

英文

Journal of Cachexia, Sarcopenia and Muscle

2190-5991

2022

13

3

1717-1730

10.1002/jcsm.12953

This work was supported by the following funding sources: the National Natural Science Foundation of China (81772133 and 82072100 to Q.M.), the Guangdong Natural Science Fund (2020A1515011367 to Q.M.), the National Key Research and Development Program of China (2018YFA0507802 to F.W.), the National Natural Science Foundation of China (31930057 to F.W.). The authors thank Professor Jin-qiang Guo (Department of Heat Environmental Medicine, Southern Medical University) for his assistance in the use of the artificial climate chamber. The authors of this manuscript certify that they comply with the ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle.38

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Background: Rhabdomyolysis (RM) is a common complication of exertional heat stroke (EHS) and constitutes a direct cause of death. However, the mechanism underlying RM following EHS remains unclear. Methods: The murine EHS model was prepared by our previous protocol. RNA sequencing is applied to identify the pathological pathways that contribute to RM following EHS. Inhibition of the acyl-CoA synthetase long-chain family member 4 (ACSL4) was achieved by RNA silencing in vitro prior to ionomycin plus heat stress exposure or pharmacological inhibi...