MoS_2 nanosheets and bulk materials altered lipid profiles in 3D Caco-2 spheroids

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成果类型：

期刊论文

作者：

Xie, Min;Huang, Chaobo;Liang, Yongqi;Li, Shuang;Sheng, Liping*;...

通讯作者：

Sheng, Liping;Cao, Yi

作者机构：

[Xie, Min; Sheng, Liping] Hunan Normal Univ, Coll Chem & Chem Engn, Natl Local Joint Engn Lab New Petro Chem Mat & Fi, Changsha 410081, Peoples R China.

[Xie, Min; Huang, Chaobo] Nanjing Forestry Univ NFU, Coll Chem Engn, Nanjing 210037, Peoples R China.

[Xie, Min; Liang, Yongqi; Li, Shuang] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Lab Biochem,Minist Educ, Xiangtan 411105, Peoples R China.

[Cao, Yi] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haz, Hengyang 421001, Peoples R China.

通讯机构：

[Sheng, Liping] H

[Cao, Yi] U

Hunan Normal Univ, Coll Chem & Chem Engn, Natl Local Joint Engn Lab New Petro Chem Mat & Fi, Changsha 410081, Peoples R China.

Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haz, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

3D Caco-2 spheroids;Fat digestion and absorption (map04975);Lipidomics;MoS2 nanosheets (NSs);Transcriptomics

期刊：

中国化学快报：英文版

ISSN：

1001-8417

年：

2022

卷：

期：

页码：

293-297

DOI：

10.1016/j.cclet.2021.06.049

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51803055]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ50372]; Hunan Provincial Key Research and Development Program [2018GK2062]

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

MoS2 nanosheets (NSs) are novel 2D nanomaterials (NMs) with potential uses in many areas, and therefore oral exposure route to MoS2 NSs is plausible. Currently, MoS2 NSs are considered as biocompatible NMs, but there is lacking of systemic investigations to study the interactions of MoS2 NSs with intestinal cells. In this study, we exposed the 3D Caco-2 spheroids to MoS2 NSs or MoS2 powders (denoted as MoS2-bulk), and investigated the potential adverse effects of MoS2-materials based on transcriptomics and lipidomics analysis. As expected, both...

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MoS_2 nanosheets and bulk materials altered lipid profiles in 3D Caco-2 spheroids

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