Protein tyrosine nitration in atherosclerotic endothelial dysfunction

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成果类型：

期刊论文

作者：

Jiang, Miao;Zhao, Xiao-Mei;Jiang, Zhi-Sheng*;Wang, Gui-Xue*;Zhang, Da-wei

通讯作者：

Jiang, Zhi-Sheng;Wang, Gui-Xue

作者机构：

[Jiang, Miao; Jiang, Zhi-Sheng] Univ South China, Inst Cardiovasc Dis, Dept Pathophysiol,Postdoctoral Res Stn Basic Med, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, Hengyang 421001, Peoples R China.

[Jiang, Miao; Wang, Gui-Xue] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Bioengn Coll, Chongqing 400030, Peoples R China.

[Zhao, Xiao-Mei] Univ South China, Coll Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Da-wei] Univ Alberta, Fac Med & Dent, Dept Pediat, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

通讯机构：

[Jiang, Zhi-Sheng] I

[Wang, Gui-Xue] K

Institute of Cardiovascular Disease, Department of Pathophysiology, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic disease, Postdoctoral Research Station of Basic Medicine, University of South China, Hengyang, 421001, China. Electronic address:

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering Collage of Chongqing University, Chongqing, 400030, China. Electronic address:

语种：

英文

关键词：

Atherosclerosis;Cardiovascular disease;Endothelial dysfunction;Protein tyrosine nitration;ROS/RNS

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2022

卷：

529

页码：

34-41

DOI：

10.1016/j.cca.2022.02.004

基金类别：

This work was supported by National Natural Science Foundation of China (No. 81670429, 91839103 to ZS Jiang, No. 32101018 to Miao Jiang), Hunan Provincial Natural Science Foundation of China (No. 2018JJ3430 to Miao Jiang), China Postdoctoral Science Foundation (No. 2018M632974 to Miao Jiang) and Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education foundation (No. QKLBST-2018-015 to Miao Jiang), Doctoral start-up fund in University of South China to Miao Jiang, and China Scholarship Council funding (201808430244 to Miao Jiang).

机构署名：

本校为第一机构

院系归属：

医学院

公共卫生学院

摘要：

Accumulation of reactive oxygen species (ROS) can induce both protein tyrosine nitration and endothelial dysfunction in atherosclerosis. Endothelial dysfunction refers to impaired endothelium-dependent vasorelaxation that can be triggered by an imbalance in nitric oxide (NO) production and consumption. ROS reacts with NO to generate peroxynitrite, decreasing NO bioavailability. Peroxynitrite also promotes protein tyrosine nitration in vivo that can affect protein structure and function and further damage endothelial function. In this review, we...

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Protein tyrosine nitration in atherosclerotic endothelial dysfunction

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