Cardiovascular protective effects of GLP-1: a focus on the MAPK signaling pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Yu-Yan;Chen, Lin-Hui;Huang, Liang;Li, Yong-Zhen;Yang, Chen;...

通讯作者：

Zhang, C

作者机构：

[Yang, Chen; Li, Yong-Zhen; Qu, Shun-Lin; Zhang, Chi; Zhao, Yu-Yan; Chen, Lin-Hui] Univ South China, Hengyang Med Coll, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Huang, Liang] Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Hunan, Peoples R China.

[Zhu, Ying] Univ South China, Coll Publ Hlth, Dept Hlth Inspect & Quarantine, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhang, C ] U

Univ South China, Hengyang Med Coll, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

glucagon-like peptide 1;type 2 diabetes;mitogen-activated protein kinase pathway;cardiovascular disease;peptide GLP-1;diabète de type2;voie de la MAPK;maladies cardiovasculaires

期刊：

BIOCHEMISTRY AND CELL BIOLOGY

ISSN：

0829-8211

年：

2022

卷：

100

期：

页码：

9-16

DOI：

10.1139/bcb-2021-0365

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100106, 81670424]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2021JJ30602]; International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province [2018WK4031]; Outstanding Youth Project by Scientific Research Fund of Hunan Provincial Education Department [19B478]; Scientific Research Foundation for Doctor of University of South China [2012XQD37, 2017XQD04]; Scientific Research Foundation for the Returned Overseas Scholars of University of South ChinaScientific Research Foundation for the Returned Overseas Chinese Scholars [2017XQD29]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Cardiovascular and related metabolic diseases are significant global health challenges. Glucagon-like peptide 1 (GLP-1) is a brain-gut peptide secreted by the ileal endocrine system and is now an established drug target in type 2 diabetes (T2DM). GLP-1 targeting agents have been shown not only to treat T2DM, but also to exert cardiovascular protective effects by regulating multiple signaling pathways. The mitogen-activated protein kinase (MAPK) pathway, a common signal transduction pathway for transmitting extracellular signals to downstream ef...

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Cardiovascular protective effects of GLP-1: a focus on the MAPK signaling pathway

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