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The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

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成果类型:
期刊论文
作者:
Fang, Xuexian;Ardehali, Hossein;Min, Junxia;Wang, Fudi
通讯作者:
Min, J.;Wang, F.
作者机构:
[Fang, Xuexian] Hangzhou Normal Univ, Sch Publ Hlth, Dept Nutr & Toxicol, State Key Lab Expt Hematol, Hangzhou, Peoples R China.
[Min, Junxia; Wang, Fudi; Fang, Xuexian] Zhejiang Univ, Affiliated Hosp 4, Affiliated Hosp 1,State Key Lab Expt Hematol, Canc Ctr,Sch Med,Inst Translat Med,Sch Publ Hlth, Hangzhou, Peoples R China.
[Wang, Fudi; Fang, Xuexian] Univ South China, Affiliated Hosp 1, Affiliated Hosp 2, Sch Publ Hlth,Basic Med Sci,Hengyang Med Sch, Hengyang, Peoples R China.
[Ardehali, Hossein] Northwestern Univ, Feinberg Cardiovasc & Renal Res Inst, Chicago, IL 60611 USA.
通讯机构:
[Junxia Min; Fudi Wang] T
The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, China<&wdkj&>The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, China<&wdkj&>The First Affiliated Hospital, The Second Affiliated Hospital, Basic Medical Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China
语种:
英文
期刊:
Nature Reviews Cardiology
ISSN:
1759-5002
年:
2022
卷:
20
期:
1
页码:
7-23
基金类别:
The authors receive support from the National Natural Science Foundation of China (82170644 and 31900835 to X.F., 31970689 to J.M. and 31930057 to F.W.), the National Key R&D Program (2018YFA0507801 to J.M. and 2018YFA0507802 to F.W.), the Zhejiang Provincial Natural Science Foundation of China (Y22C115257 to X.F.), the NIH (grants NHLBI HL127646, HL140973, R01 HL140927 and HL138982 to H.A.) and the Leducq Foundation (to H.A.). The authors thank L. Luo (Guangdong Medical University, China) for helping to draft the figures before submission. The authors thank X. Bi, X. Yang and Y. Yu (Zhejiang University School of Medicine, China) for their contribution to the discussion of this Review and apologize to their colleagues whose valuable contributions are not cited in this manuscript owing to space limitations.
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemia–reperfusion injury, sepsis-induced cardiomy...

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