MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway

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成果类型：

期刊论文

作者：

Chu, Hanyu;Du, Can;Yang, Yue;Feng, Xiangling;Zhu, Lemei;...

通讯作者：

Jihua Chen<&wdkj&>Fei Yang

作者机构：

[Chu, Hanyu; Yang, Fei] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.

[Chen, Jihua; Du, Can; Feng, Xiangling; Yang, Fei; Yang, Yue] Cent South Univ, Xiangya Sch Publ Hlth, Changsha 410078, Peoples R China.

[Zhu, Lemei] Changsha Med Univ, Sch Publ Hlth, Changsha 410219, Peoples R China.

[Yang, Fei] Univ South China, Sch Basic Med Sci, Key Lab Ecol Environm & Crit Human Dis Prevent Hun, Dept Educ,Hengyang Med Sch, Hengyang 421001, Peoples R China.

通讯机构：

[Jihua Chen; Fei Yang] A

Authors to whom correspondence should be addressed.<&wdkj&>Xiangya School of Public Health, Central South University, Changsha 410078, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province, Department of Education, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Xiangya School of Public Health, Central South University, Changsha 410078, China<&wdkj&>Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China

语种：

英文

关键词：

MC-LR;aggravates;liver;lipid metabolism;obese mice

期刊：

TOXINS

ISSN：

2072-6651

年：

2022

卷：

期：

页码：

833-

DOI：

10.3390/toxins14120833

基金类别：

Conceptualization, H.C., C.D., X.F., J.C. and F.Y.; methodology, H.C., C.D., Y.Y., X.F., L.Z. and J.C.; animal experiments, H.C., C.D., Y.Y., X.F. and J.C.; data analysis, H.C. and C.D.; writing—original draft, H.C. and C.D.; writing—review and editing, F.Y.; funding acquisition, L.Z. and F.Y. All authors have read and agreed to the published version of the manuscript. The work was supported by the Hunan Province Excellent Youth Fund (2020JJ3053); the National Natural Science Foundation of China (81773393); and the Key Research and Development Projects in Hunan Province (2022SK2089, 2019SK2041).

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

Obesity, a metabolic disease caused by excessive fat accumulation in the body, has attracted worldwide attention. Microcystin-LR (MC-LR) is a hepatotoxic cyanotoxin which has been reportedly to cause lipid metabolism disorder. In this study, C57BL/6J mice were fed a high-fat diet (HFD) for eight weeks to build obese an animal model, and subsequently, the obese mice were fed MC-LR for another eight weeks, and we aimed to determine how MC-LR exposure affects the liver lipid metabolism in high-fat-diet-induced obese mice. The results show that MC-LR increased the obese mice serum aspartate aminot...

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MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway

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