Recent advances in the construction of functional nucleic acids with isothermal amplification for heavy metal ions sensor

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成果类型：

期刊论文

作者：

Liu, Chen;Li, Yujie;Liu, Jinquan*;Liao, Lifu;Zhou, Renlong;...

通讯作者：

Liu, Jinquan;Li, Qiangxiang;Xiao, Xilin

作者机构：

[Li, Qian; Yu, Wenzhan; Liu, JQ; Li, QX; Xiao, XL; Liu, Chen; Xiao, Xilin; Liao, Lifu; Li, Yujie] Univ South China, Sch Chem & Chem Engn, Hunan Key Lab Design & Applicat Actinide Complexe, Sch Pharmaceut Sci,Sch Resource & Environm & Safe, Hengyang 421001, Hunan, Peoples R China.

[Liu, Jinquan; He, Liqiong; Zhou, Renlong; Xiao, Xilin] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Xilin] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Li, Qiangxiang] Clin Res Ctr Geriatr Dis, Yinchuan 750001, Ningxia, Peoples R China.

通讯机构：

[Liu, JQ; Li, QX; Xiao, XL] U

Univ South China, Sch Chem & Chem Engn, Hunan Key Lab Design & Applicat Actinide Complexe, Sch Pharmaceut Sci,Sch Resource & Environm & Safe, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Functional nucleic acids;Biosensors;Isothermal amplification strategies;Heavy metal ions;Ultrasensitive detection

期刊：

Microchemical Journal

ISSN：

0026-265X

年：

2022

卷：

175

页码：

107077

DOI：

10.1016/j.microc.2021.107077

基金类别：

National Natural Science Foun-dation of ChinaNational Natural Science Foundation of China (NSFC) [11475079]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ5471, 2020JJ8012, 2019JJ40244]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [19B481]; Novel coronavirus pneumonia prevention and control foundation of Hengyang science and technology project [202010031546]; Ningxia Hui Autonomous Region Key Research and Development Project [2020BEG03051]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

公共卫生学院

摘要：

Heavy metal ions are a class of pollutant with serious threat to ecosystem and human health. To recognize effectively heavy metal ions, some functional nucleic acids (FNAs) are fabricated to serve as recognition element in biosensors. However, there are some challenges that limit the sensitivity of FNAs-based biosensors for the detection of heavy metal ions, such as extremely low abundance and wide concentration range. Nucleic acid amplification is an effective signal amplification technique. Among these methods, alternative to polymerase chain reaction (PCR) acting as gold standard, isotherma...

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Recent advances in the construction of functional nucleic acids with isothermal amplification for heavy metal ions sensor

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