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Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder

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成果类型:
期刊论文
作者:
Du, Can;Zheng, Shuilin;Yang, Yue;Feng, Xiangling;Chen, Jihua;...
通讯作者:
Yang, Fei
作者机构:
[Yang, Fei] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410078, Peoples R China.
[Wang, Hui; Yang, Fei] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
[Yang, Fei] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing 210009, Peoples R China.
[Yang, Fei] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Crit Human Dis Prevent Hunan Prov Dept Educ, Hengyang 421001, Peoples R China.
通讯机构:
[Fei Yang] H
Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, China<&wdkj&>Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, China<&wdkj&>Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China<&wdkj&>The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China
语种:
英文
关键词:
Microcystin-LR;Chronic oral exposure;Liver;Lipid metabolism;Inflammation
期刊:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
年:
2022
卷:
239
页码:
113649
基金类别:
The work was supported by the Hunan Province Excellent Youth Fund ( 2020JJ3053 ); National Natural Science Foundation of China ( 81773393 ); the Key Research and Development Projects in Hunan Province ( 2022SK2089 , 2019SK2041 ).
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
Microcystin-LR (MC-LR), a potent hepatotoxin can cause liver damages. However, research on hepatic lipid metabolism caused by long-term exposure to environmental concentrations MC-LR is limited. In the current study, mice were exposed to various low concentrations of MC-LR (0, 1, 30, 60, 90, 120 μg/L in the drinking water) for 9 months. The general parameters, serum and liver lipids, liver tissue pathology, lipid metabolism-related genes and proteins of liver were investigated. The results show that chronic MC-LR exposure had increased the lev...

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