作者机构:
[Huang, Yun; Huang, Weiguo; Xiao, Shengjun] Guilin Med Univ, Guangxi Key Lab Tumor Immun & Microenvironm Regula, Guilin 541199, Peoples R China.;[Cheng, Ailan; Huang, Yun; Huang, Weiguo] Univ South China, Canc Res Inst, Hengyang Med Coll, Hengyang 421001, Peoples R China.;[Wei, Dengshuai; Tang, Dongsheng; Wang, Bin] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China.;[Yu, Yingjie] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China.
通讯机构:
[Yingjie Yu] S;[Weiguo Huang] G;State Key Laboratory of Organic-Inorganic Composites;Beijing Laboratory of Biomedical Materials;Beijing University of Chemical Technology, Beijing 100029, China<&wdkj&>Guangxi Key Laboratory of Tumor Immunity and Microenvironment Regulation, Guilin Medical University, Guilin 541199, China<&wdkj&>Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang 421001, China
关键词:
DNA damage;Immunogenic cell death;Immunotherapy;Mild hyperthermia;Oxaliplatin
作者机构:
[Peng, Jie; Jiang, Yuyang; Gao, Dan; Chen, Yulin] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Guangdong Prov Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China.;[Zhu, Qingyun] Univ South China, Affiliated Hosp 1, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.;[Chu, Bizhu] Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China.;[Wang, Jian] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Thorac Surg, Shenzhen 518020, Guangdong, Peoples R China.;[Wang, Jian; Liu, Liping] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China.
通讯机构:
[Dan Gao] S;State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China
作者机构:
[Li, Ao; He, Longwei; Liu, Yalan; Chen, Zhe; Li, Songjiao; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharm, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microen, Hengyang 421001, Peoples R China.;[Zhong, Rongbin; Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang 421002, Peoples R China.
通讯机构:
[Linxi Chen; Longwei He] S;School of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, PR China
通讯机构:
[Li Tang; Qinglai Yang] C;[Shoujun Zhu] S;Center for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China<&wdkj&>State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China<&wdkj&>Center for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China
作者机构:
[Chen, Guangqun; He, Jie; Jiang, Yiling; Yi, Lan; Tan, Hui; Liu, Ran; Ling, Hui; Qi, Su] Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang, Peoples R China.;[Jiang, Yiling; Qi, Su] Univ South China, Affiliated Hosp 1, Dept Oncol, Hengyang, Peoples R China.;[Chen, Guangqun] Loudi Cent Hosp, Dept Oncol, Loudi, Peoples R China.;[Liu, Ran] First Hosp Changsha, Dept Pathol, Changsha, Peoples R China.;[Qi, Su] Univ South China, Canc Res Inst, Coll Hunan Prov, Key Lab Tumor Cellular & Mol Pathol,Hengyang Med C, 28 Changsheng Xi Rd, Hengyang 421001, Peoples R China.
通讯机构:
[Qi Su; Qi Su Qi Su Qi Su] H;Hunan Province Key Laboratory of Cancer Cellular and Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, China<&wdkj&>Department of Oncology, First Affiliated Hospital, University of South China, Hengyang, China
作者机构:
[Liu, Ying; Yang, Ke; He, Longwei; Wang, Peipei; Li, Songjiao] Univ South China, Hengyang Med Sch, Canc Res Inst, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.;[Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Clin Res Inst, Hengyang, Peoples R China.
通讯机构:
[Dan Cheng] C;[Longwei He] H;Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Cancer Research Institute, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, 421001, PR China
作者机构:
[Ding, Yiteng; Zhong, Rongbin; Yang, Xuefeng; Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang 421002, Hunan, Peoples R China.;[He, Longwei; Jiang, Renfeng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang 421002, Hunan, Peoples R China.;[Yuan, Lin; He, Longwei; Cheng, Dan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.
通讯机构:
[Longwei He; Dan Cheng] H;Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease, Clinical Research Institute, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
关键词:
acute kidney injury;fluorescent probe;near-infrared;peroxynitrite and glutathione;reversible imaging
作者机构:
[Liu, Ying; Yang, Ke; He, Longwei; Wang, Peipei; Li, Songjiao] Univ South China, Canc Res Inst, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microenv, Hengyang 421001, Peoples R China.;[Zhong, Rongbin; Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.
通讯机构:
[Dan Cheng] C;[Longwei He] H;Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China<&wdkj&>Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Cancer Research Institute, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, 421001, PR China
作者机构:
[Li, Chen; Zhao, Qiang; Zhang, Zhiwei; Liu, Lu] Univ South China, Dept Pathol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Xiao, Juan] Univ South China, Dept Otorhinolaryngol, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.;[Wu, Shihua] Second Hosp Shaoyang Coll, Dept Pathol, Hunan, Shaoyang 422000, Hunan, Peoples R China.;[Zhang, Zhiwei; Zeng, Xuemei] Univ South China, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.;[Zhao, Qiang] Univ South China, Dept Pathol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Qiang Zhao; Zhiwei Zhang] D;Department of Pathology, The First Affiliated Hospital of University of South China, Hunan, Hengyang, 421001, Hunan Province, China<&wdkj&>Cancer Research Institute of Hengyang Medical College, University of South China, Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Hunan, Hengyang, 421001, China<&wdkj&>Department of Pathology, The First Affiliated Hospital of University of South China, Hunan, Hengyang, 421001, Hunan Province, China
作者机构:
[Zeng, Jiayu; Yuan, Lin; Zhong, Rongbin; He, Longwei; Yang, Xuefeng; Cheng, Dan; Jiang, Renfeng] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst,Hengyang Med Sch, Hunan Prov Clin Res Ctr Metab Assoc Fatty Liver Di, Hengyang 421002, Hunan, Peoples R China.;[Yuan, Lin; Gong, Xiangyang; Cheng, Dan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemomet, Changsha 410082, Peoples R China.
通讯机构:
[He, L.; Cheng, D.] H;Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease, Hunan, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan, China
作者机构:
[He, LW; Zeng, Jiayu; Yang, Ke; He, Longwei; Li, Songjiao] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Sch, Canc Res Inst,Dept Pharm & Pharmacol, Hengyang, Peoples R China.;[Cheng, Dan; Xia, Yuqing] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Clin Res Inst, Hengyang, Peoples R China.;[Cheng, Dan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha, Peoples R China.
通讯机构:
[He, LW ; Cheng, D ] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Sch, Canc Res Inst,Dept Pharm & Pharmacol, Hengyang, Peoples R China.;Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Clin Res Inst, Hengyang, Peoples R China.;Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha, Peoples R China.
摘要:
Carbon monoxide (CO) is regarded as one of the most important gaseous transmitters, playing a vital role in biological systems; meanwhile, abnormal levels of CO can be correlated with conditions such as lung disease, Alzheimer's disease, and cardiovascular disease. CO-releasing molecules (CORMs) are chemical agents used to release CO as an endogenous, biologically active molecule in order to treat diseases. CO-releasing molecule-3 (CORM-3), as a convenient and safe CO donor and therapeutic drug molecule, has been widely used to release exogenous CO in living cells to study the physiological and pathological roles of CO in living systems. Herein, we designed a NIR-emitting probe (NIR-CORM-3) with a large Stokes shift based on a 4-(dimethylamino)cinnamaldehyde lepidine derived fluorophore. A 4-nitrobenzyl group was selected as the CORM-3 recognizing moiety, and the probe is able to selectively and sensitively respond to CORM-3 (within only 15 min). Upon encountering CORM-3, NIR-CORM-3 releases a fluorophore with a response at 670 nm, and it shows a remarkable Stokes shift (up to 250 nm). In addition, NIR-CORM-3 has low cytotoxicity and exhibits outstanding NIR imaging abilities in living cells and mice.
期刊:
Applied Microbiology and Biotechnology,2022年106(19-20):6657-6669 ISSN:0175-7598
通讯作者:
Zeng, Yanhua(zengyihua21cn@usc.edu.cn)
作者机构:
[Liao, Yating; Liu, Peng; Ye, Youyuan; Peng, Kailan; Zeng, Yanhua; Li, Xia] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang City 421001, Hunan, Peoples R China.;[Liao, Yating] Univ South China, Ctr Med Lab, Peoples Hosp 1, Chenzhou 423000, Peoples R China.
通讯机构:
[Yanhua Zeng] I;Institute of Pathogenic Biology, Hengyang Medical School, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang City, People’s Republic of China
作者机构:
[Zhu, Yanli] Hunan Univ Technol & Business, Sch Resources & Environm, Changsha 410205, Peoples R China.;[Zhou, Jiecan; Xie, Haitao; Fu, Chengxiao] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab,Hengyang Clin Pharmacol Res Ctr, Hengyang 421001, Peoples R China.;[Liu, Hailing] Wuhan Univ, Dept Respirator y & Crit Care Med, Renmin Hosp, Wuhan 430060, Peoples R China.;[Wang, Jikai; Sun, Yiyang; Zeng, Pengfei] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Inst Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Jikai Wang] H;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P. R. China
作者机构:
[Wang, Weiguo; Wu, Jingjun; Yang, Lin; He, Jian; Cao, Qianqian; He, Dongxiu; Li, Sang] Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.;[Wang, Weiguo; Wu, Jingjun; Yang, Lin; He, Jian; Cao, Qianqian; He, Dongxiu; Li, Sang] Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang, Hunan, Peoples R China.;[Wang, Weiguo; Wu, Jingjun; Yang, Lin; He, Jian; Cao, Qianqian; He, Dongxiu; Li, Sang] Hunan Xinhexin Biol Med Co Ltd, Pharm Grad Educ Innovat Base, Hengyang, Hunan, Peoples R China.;[Li, Ranhui] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hengyang 421000, Hunan, Peoples R China.;[Wu, Xian; Duan, Yunfeng] Hunan Prov Directly Affiliated TCM Hosp, Affiliated Hosp 1, Hunan Coll Tradit Chinese Med, Zhuzhou, Peoples R China.
通讯机构:
[Dongxiu He; Weiguo Wang] I;Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, Hunan, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, China<&wdkj&>Hunan Xinhexin Biological Medicine Co., Ltd., Pharmacy Graduate Education Innovation Base, Hengyang, Hunan, China
通讯机构:
[Xiaofeng Tan; Qinglai Yang] C;Center for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan421001, China