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NIR-II light evokes DNA cross-linking for chemotherapy and immunogenic cell death

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成果类型:
期刊论文
作者:
Huang, Yun;Wei, Dengshuai;Wang, Bin;Tang, Dongsheng;Cheng, Ailan;...
通讯作者:
Yu, Yingjie(yuyingjie@mail.buct.edu.cn)
作者机构:
[Huang, Yun; Huang, Weiguo; Xiao, Shengjun] Guilin Med Univ, Guangxi Key Lab Tumor Immun & Microenvironm Regula, Guilin 541199, Peoples R China.
[Cheng, Ailan; Huang, Yun; Huang, Weiguo] Univ South China, Canc Res Inst, Hengyang Med Coll, Hengyang 421001, Peoples R China.
[Wei, Dengshuai; Tang, Dongsheng; Wang, Bin] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China.
[Yu, Yingjie] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China.
通讯机构:
[Yingjie Yu] S
[Weiguo Huang] G
State Key Laboratory of Organic-Inorganic Composites
Beijing Laboratory of Biomedical Materials
Beijing University of Chemical Technology, Beijing 100029, China<&wdkj&>Guangxi Key Laboratory of Tumor Immunity and Microenvironment Regulation, Guilin Medical University, Guilin 541199, China<&wdkj&>Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang 421001, China
语种:
英文
关键词:
DNA damage;Immunogenic cell death;Immunotherapy;Mild hyperthermia;Oxaliplatin
期刊:
Acta Biomaterialia
ISSN:
1742-7061
年:
2023
卷:
160
页码:
198-210
基金类别:
Author contributions Author contributions are defined based on the CRediT (Contributor Roles Taxonomy) and listed alphabetically. Conceptualization: Y. H., Y.Y.; D. W.; formal analysis: Y. H., B.W., D.T.; funding acquisition: W. H., Y. Y.; investigation: Y. Y., Y. H., W. H.; methodology: D. W., Y. H., B.W., D.T., A.C., S. X.; project administration: Y. Y., W.H.; resources: Y. Y.; W. H.; software: Y. H., B.W.; supervision: W. H.; validation: Y. H.; visualization: B.W., Y. H., D. W.; writing – original draft: Y. H., Acknowledgements and This work was supported by National Natural Science Foundation of China (81172210, 82060500), Special Topic of Basic Application Research of Hengyang (2019YJ010631).
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
As a DNA damaging agent, oxaliplatin (OXA) can induce immunogenic cell death (ICD) in tumors to activate the immune system. However, the DNA damage induced by OXA is limited and the ICD effect is not strong enough to enhance anti-tumor efficacy. Here, we propose a strategy to maximize the ICD effect of OXA through the mild hyperthermia generated by nanoparticles with a platinum (IV) prodrug of OXA (Pt(IV)-C16) and a near-infrared-II (NIR-II) photothermal agent IR1061 upon the irradiation of NIR-II light. The mild hyperthermia (43 °C) holds adv...

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