A mitochondrial-targeted near-infrared fluorescent probe for visualizing the fluctuation of hypochlorite acid in idiopathic pulmonary fibrosis mice

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成果类型：

期刊论文

作者：

Li, Songjiao;Wang, Peipei;Liu, Ying;Yang, Ke;Zhong, Rongbin;...

通讯作者：

He, Longwei(helongwei0110@163.com);Cheng, Dan(flychand0110@163.com)

作者机构：

[Liu, Ying; Yang, Ke; He, Longwei; Wang, Peipei; Li, Songjiao] Univ South China, Canc Res Inst, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microenv, Hengyang 421001, Peoples R China.

[Zhong, Rongbin; Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.

通讯机构：

[Dan Cheng] C

[Longwei He] H

Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China<&wdkj&>Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Cancer Research Institute, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, 421001, PR China

语种：

英文

关键词：

Fluorescent probe;Hypochlorous acid;Idiopathic pulmonary fibrosis;Near-infrared

期刊：

Analytica Chimica Acta

ISSN：

0003-2670

年：

2023

卷：

1239

页码：

340731

DOI：

10.1016/j.aca.2022.340731

基金类别：

CRediT authorship contribution statement Songjiao Li: Methodology, Investigation, Data curation, Writing – original draft, acquisition. Peipei Wang: Investigation, Synthesis, Spectral analysis, Formal analysis, Software. Ying Liu: Formal analysis, Software. Ke Yang: Formal analysis, Spectral analysis, Software. Rongbin Zhong: Software. Dan Cheng: acquisition, Validation, Writing – review & editing, Resources. Longwei He: Project administration, Supervision, Validation, acquisition, Writing – review & editing,

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Idiopathic pulmonary fibrosis (IPF) is a chronic inflammatory disease destroying lungs irreversibly with high mortality rates. There are challenges in diagnosing IPF and treating it at an early stage. Mounting evidence suggests that hypochlorous acid (HClO) can help in diagnosing inflammation and relevant conditions. Pulmonary fibrosis is linked to the mitochondrial oxidative stress where excessive HClO production is a key molecular mechanism. Measuring mitochondrial HClO levels assists in the investigations of how the mitochondrial oxidative s...

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A mitochondrial-targeted near-infrared fluorescent probe for visualizing the fluctuation of hypochlorite acid in idiopathic pulmonary fibrosis mice

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