期刊论文

He, Longwei(helongwei0110@163.com);Cheng, Dan(flychand0110@163.com)

英文

Analytical Chemistry

0003-2700

2023

95

4

2428-2435

10.1021/acs.analchem.2c04587

This work was supported by the National Natural Science Foundation of China (21904035), the Science and Technology Project of Hunan Province (2021RC3108), the Hunan Provincial Natural Science Foundation of China (2022JJ10042 and 2022JJ30484), the Special Funding for the Construction of Innovative Provinces in Hunan (2021SK4031), and the China Postdoctoral Science Foundation (2020T130184).

本校为第一机构

Selective fluorescence imaging of analytes is a challenge for monitoring diseases as homologues interfere with the imaging agents. Leucine aminopeptidase (LAP), a kind of protease, is related to tumor pathogenesis. The known LAP fluorescent probes based on leucine recognition have limited selectivity. Herein, a selective t-butyl-alanine recognition unit for LAP through the ligand regulation strategy is prepared as a new near-infrared (NIR) fluorescent probe (DCM-LAP) having a large Stokes shift of 214 nm and a high sensitivity with a detection ...