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The adhesion protein of Mycoplasma genitalium inhibits urethral epithelial cell apoptosis through CypA-CD147 activating PI3K/ Akt/NF-κB pathway

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成果类型:
期刊论文
作者:
Liao, Yating;Peng, Kailan;Li, Xia;Ye, Youyuan;Liu, Peng;...
通讯作者:
Zeng, Yanhua(zengyihua21cn@usc.edu.cn)
作者机构:
[Liao, Yating; Liu, Peng; Ye, Youyuan; Peng, Kailan; Zeng, Yanhua; Li, Xia] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang City 421001, Hunan, Peoples R China.
[Liao, Yating] Univ South China, Ctr Med Lab, Peoples Hosp 1, Chenzhou 423000, Peoples R China.
通讯机构:
[Yanhua Zeng] I
Y. Zeng
Institute of Pathogenic Biology, Hengyang Medical School, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang City, Hunan Province, 421001, China
email: zengyihua21cn@usc.edu.cn
语种:
英文
关键词:
Animals;Annexin A5;Apoptosis;bcl-2-Associated X Protein;Carrier Proteins;Caspase 3;Cyclophilin A;Cytokines;Epithelial Cells;Humans;Mice;Mice, Inbred C57BL;Mycoplasma genitalium;NF-kappa B;Phosphatidylinositol 3-Kinases;Proto-Oncogene Proteins c-akt;Abstracting;Adhesion;Bacteria;Mammals;Proteins;caspase 3;CD147 antigen;cell adhesion molecule;cyclophilin A;immunoglobulin enhancer binding protein;lipocortin 5;membrane receptor;phosphatidylinositol 3 kinase;protein Bax;protein kinase B;carrier protein;cyclophilin A;cytokine;immunoglobulin enhancer binding protein;lipocortin 5;phosphatidylinositol 3 kinase;protein Bax;protein kinase B;Cell apoptosis;Cyclophilin A;Cyclophilin A-knockout mouse;Epithelial cells;Knockout mice;Mycoplasma genitalium;PI3K/Akt;PI3K/akt/NF-κb;SV-HUC-1;apoptosis;bacterium;cell component;flow cytometry;membrane;animal cell;animal experiment;apoptosis;Article;C57BL mouse;cell viability;controlled study;enzyme activity;epithelium cell;flow cytometry;host cell;knockout gene;knockout mouse;male;mouse;Mycoplasma genitalium;NF kB signaling;nonhuman;protein expression;signal transduction;SV-HUC-1 cell line;Western blotting;animal;apoptosis;epithelium cell;genetics;human;metabolism;Cell death
期刊:
Applied Microbiology and Biotechnology
ISSN:
0175-7598
年:
2022
卷:
106
期:
19-20
页码:
6657-6669
基金类别:
This study was made possible by the financial support from the National Natural Science Foundation of China (NO: 81871256).
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Abstract: By interacting with the receptor on the host cells membrane, Mycoplasma genitalium, a prokaryotic bacterium primarily transmitted through sexual contact, can adhere to and even enter cells. The adhesion protein of M. genitalium (MgPa) plays a critical function in the adhering and subsequent invasion into host cells. Our prior studies verified that cyclophilin A (CypA) was the receptor of MgPa on human urethral epithelial cells (SV-HUC-1) membrane and could induce pro-inflammatory cytokines production through the CypA-CD147-ERK-NF-κB ...

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