Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Li, Songjiao;Wang, Peipei;Yang, Ke;Liu, Ying;Cheng, Dan;...

通讯作者：

He, Longwei(helongwei0110@163.com);Cheng, Dan(flychand0110@163.com)

作者机构：

[Liu, Ying; Yang, Ke; He, Longwei; Wang, Peipei; Li, Songjiao] Univ South China, Hengyang Med Sch, Canc Res Inst, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

[Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Clin Res Inst, Hengyang, Peoples R China.

通讯机构：

[Dan Cheng] C

[Longwei He] H

Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Cancer Research Institute, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, 421001, PR China

语种：

英文

关键词：

Fluorescent probe;Hepatocellular carcinoma;Hypochlorous acid;Near-infrared

期刊：

Analytica Chimica Acta

ISSN：

0003-2670

年：

2023

卷：

1252

页码：

341009

DOI：

10.1016/j.aca.2023.341009

基金类别：

CRediT authorship contribution statement Songjiao Li: Methodology, Investigation, Data curation, Writing – original draft, acquisition. Peipei Wang: Investigation, Formal analysis, Software. Ke Yang: Formal analysis, Software. Ying Liu: Formal analysis, Software. Dan Cheng: acquisition, Validation, Writing – review & editing. Longwei He: Project administration, Supervision, Validation, acquisition, Writing – review & editing, Resources.

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Hepatocellular carcinoma (HCC) is one of the most common malignancies in the liver with poor prognosis. In order to improve the prognosis and overall survival of patients with HCC, it is important to identify it at early stage and resect it precisely. Cell microenvironment, active compounds, and enzymes may change during the cancerization of hepatocytes. Hypochlorous acid (HClO), one of the most significant signal molecules in the cellular signaling pathway, plays an important role in many cellular processes. To detect and treat liver cancers, ...

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Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma

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