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Diallyl disulfide downregulating RhoGDI2 induces differentiation and inhibit invasion via the Rac1/Pak1/LIMK1 pathway in human leukemia HL-60 cells

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成果类型:
期刊论文
作者:
Tan, Hui;Jiang, Yiling;Chen, Guangqun;Liu, Ran;Ling, Hui;...
通讯作者:
Su, Qi(suqi1945@163.com)
作者机构:
[Chen, Guangqun; He, Jie; Jiang, Yiling; Yi, Lan; Tan, Hui; Liu, Ran; Ling, Hui; Qi, Su] Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang, Peoples R China.
[Jiang, Yiling; Qi, Su] Univ South China, Affiliated Hosp 1, Dept Oncol, Hengyang, Peoples R China.
[Chen, Guangqun] Loudi Cent Hosp, Dept Oncol, Loudi, Peoples R China.
[Liu, Ran] First Hosp Changsha, Dept Pathol, Changsha, Peoples R China.
[Qi, Su] Univ South China, Canc Res Inst, Coll Hunan Prov, Key Lab Tumor Cellular & Mol Pathol,Hengyang Med C, 28 Changsheng Xi Rd, Hengyang 421001, Peoples R China.
通讯机构:
[Qi Su] H
Hunan Province Key Laboratory of Cancer Cellular and Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, China<&wdkj&>Department of Oncology, First Affiliated Hospital, University of South China, Hengyang, China
语种:
英文
关键词:
diallyl disulfide;HL-60 cells;LIMK1;Pak1;Rac1;RhoGDI2
期刊:
ENVIRONMENTAL TOXICOLOGY
ISSN:
1520-4081
年:
2023
卷:
38
期:
5
页码:
1063-1077
基金类别:
National Natural Science Foundation of China, Grant/Award Numbers: 81400117, 31201027, 81100375; Patent Fund of Hunan University Innovation Platform, Grant/Award Number: 11K057; Natural Science Foundation of Hunan Province, Grant/Award Numbers: 2022JJ30508, 2015JJ4042 Funding information
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Leukemia is a type of disease in which hematopoietic stem cells proliferate clonally at the genetic level. We discovered previously by high-resolution mass spectrometry that diallyl disulfide (DADS), which is one of the effective ingredients of garlic, reduces the performance of RhoGDI2 from APL HL-60 cells. Although RhoGDI2 is oversubscribed in several cancer categories, the effect of RhoGDI2 in HL-60 cells has remained unexplained. We aimed to investigate the influence of RhoGDI2 on DADS-induced differentiation of HL-60 cells to elucidate the...

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