Double Signal Amplification Strategy for Dual-Analyte Fluorescent Aptasensors for Visualizing Cancer Biomarker Proteins

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成果类型：

期刊论文

作者：

Zhu, Yanli;Wang, Jikai;Xie, Haitao;Fu, Chengxiao;Zhou, Jiecan;...

通讯作者：

Wang, Jikai(jkwang@hnu.edu.cn)

作者机构：

[Zhu, Yanli] Hunan Univ Technol & Business, Sch Resources & Environm, Changsha 410205, Peoples R China.

[Zhou, Jiecan; Xie, Haitao; Fu, Chengxiao] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab,Hengyang Clin Pharmacol Res Ctr, Hengyang 421001, Peoples R China.

[Liu, Hailing] Wuhan Univ, Dept Respirator y & Crit Care Med, Renmin Hosp, Wuhan 430060, Peoples R China.

[Wang, Jikai; Sun, Yiyang; Zeng, Pengfei] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Inst Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Jikai Wang] H

J. Wang

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China

email: jkwang@hnu.edu.cn

语种：

英文

关键词：

Alkalinity;Amplification;Color;Colorimetry;Diseases;Fluorescence;Image enhancement;Infrared devices;Sulfur compounds;Alkaline earth sulfides;Amplification strategy;Analytes;Aptasensors;Cancer biomarkers;Cancer diagnosis;Fluorescence assay;Nanodots;Ratiometric fluorescence;Signal amplifications;Biomarkers

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2022

卷：

期：

页码：

10451-10461

DOI：

10.1021/acs.analchem.2c01649

基金类别：

Doctoral Scientific Research Foundation of University of South China, (200XQD042) Scientific Research Project of Hunan Provincial Department of Education, (21C0474) Scientific Research Project of Hunan Provincial Health Commission, (202112062218) Natural Science Foundation ofHunan Province, (2019JJ80035, 2021JJ40452, 2021JJ80072) Natural Science Foundation ofHunan Province

机构署名：

本校为其他机构

院系归属：

医学院

药学与生物科学学院

摘要：

The simultaneous analysis of diversified biomarkers with high sensitivity and in a point-of-care (POC) manner is of great significance for facile and early cancer diagnosis. Herein, we develop a target amplification-assisted ratiometric fluorescence assay (TARFA) platform integrating the dual-amplification strategy and colorimetric readout technology for sensitive and specific detection of two malignancy-associated biomarkers. Meanwhile, the NIR-excited alkaline-earth sulfide nanodots (ASNDs) with an ultrasmall (

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Double Signal Amplification Strategy for Dual-Analyte Fluorescent Aptasensors for Visualizing Cancer Biomarker Proteins

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