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Development of a Golgi-targeted superoxide anion fluorescent probe for elucidating protein GOLPH3 function in myocardial ischemia-reperfusion injury

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成果类型:
期刊论文
作者:
Li, Ao;Liu, Yalan;Chen, Zhe;Li, Songjiao;Zhong, Rongbin;...
通讯作者:
He, Longwei(helongwei0110@163.com);Chen, Linxi(1995001765@usc.edu.cn)
作者机构:
[Li, Ao; He, Longwei; Liu, Yalan; Chen, Zhe; Li, Songjiao; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharm, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microen, Hengyang 421001, Peoples R China.
[Zhong, Rongbin; Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang 421002, Peoples R China.
通讯机构:
[Linxi Chen; Longwei He] S
School of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, PR China
语种:
英文
关键词:
Apoptosis;Fluorescent probe;GOLPH3;Golgi apparatus;Myocardial ischemia-reperfusion injury;Superoxide anion
期刊:
Analytica Chimica Acta
ISSN:
0003-2670
年:
2023
卷:
1255
页码:
341100
基金类别:
This work was financially supported by The National Natural Science Foundation of China ( 81973326 ), The Natural Science Foundation of Hunan Province, China (No. 2022JJ30484 ), The Start-up funds of University of South China (No. 201RGC012 ), and The Open Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics (No. 2021013 ).
机构署名:
本校为第一机构
院系归属:
医学院
药学与生物科学学院
摘要:
Superoxide anion (O2•-) is an important reactive oxygen species (ROS) and participates in various physiological and pathological processes in the organism. The O2•- burst induced by ischemia-reperfusion (I/R) is associated with cardiovascular disease and promotes the cell apoptosis. In this work, a turn-on type Golgi-targeting fluorescent probe Gol-Cou-O2•- was rationally designed for sensitive and selective detection of O2•-. The minimum detection limit concentration for O2•- was about 3.9 × 10−7 M in aqueous solution. Gol-Cou-O2•- sho...

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