Development of a Golgi-targeted superoxide anion fluorescent probe for elucidating protein GOLPH3 function in myocardial ischemia-reperfusion injury

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成果类型：

期刊论文

作者：

Li, Ao;Liu, Yalan;Chen, Zhe;Li, Songjiao;Zhong, Rongbin;...

通讯作者：

He, Longwei(helongwei0110@163.com);Chen, Linxi(1995001765@usc.edu.cn)

作者机构：

[Li, Ao; He, Longwei; Liu, Yalan; Chen, Zhe; Li, Songjiao; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharm, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microen, Hengyang 421001, Peoples R China.

[Zhong, Rongbin; Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang 421002, Peoples R China.

通讯机构：

[Linxi Chen; Longwei He] S

L. He

School of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, China

email: helongwei0110@163.com

L. Chen

语种：

英文

关键词：

Animals;Fluorescent Dyes;Golgi Apparatus;Myocardial Reperfusion Injury;Oxygen;Reactive Oxygen Species;Superoxides;Zebrafish;Diagnosis;Fluorescence imaging;Fluorescence spectroscopy;Ions;Probes;Proteins;fluorescent dye;golgi phosphoprotein 3;phosphoprotein;reactive oxygen metabolite;superoxide;unclassified drug;fluorescent dye;oxygen;reactive oxygen metabolite;Cell apoptosis;Fluorescent probes;Golgi apparatus;Golgi phosphoprotein 3;Ischaemia-reperfusion;Myocardial ischemia-reperfusion injuries;Pathological process;Physiological process;Reactive oxygen species;Superoxide anions;animal cell;animal experiment;apoptosis;Article;biocompatibility;cardiac stem cell;cardiovascular disease;cell survival;column chromatography;confocal microscopy;controlled study;cytotoxicity;development;down regulation;flow cytometry;fluorescence imaging;fluorescence intensity;fluorescence microscopy;gene;gene silencing;genetic transfection;golph3 gene;H9c2(2-1) cell line;Hep-G2 cell line;high performance liquid chromatography;human;human cell;imaging;immunoblotting;limit of detection;liquid chromatography-mass spectrometry;mass spectrometry;MTT assay;myocardial ischemia reperfusion injury;nonhuman;nuclear magnetic resonance;oxidative stress;physiological stress;protein expression;upregulation;animal;diagnostic imaging;Golgi complex;metabolism;pathology;zebra fish;Cell death

期刊：

Analytica Chimica Acta

ISSN：

0003-2670

年：

2023

卷：

1255

页码：

341100

DOI：

10.1016/j.aca.2023.341100

基金类别：

National Natural Science Foundation of China, NSFC, (81973326) National Natural Science Foundation of China, NSFC Natural Science Foundation ofHunan Province, (2022JJ30484) Natural Science Foundation ofHunan Province University of South China, USC, (201RGC012) University of South China, USC State Key Laboratory of Chemo/Biosensing and Chemometrics, (2021013) State Key Laboratory of Chemo/Biosensing and Chemometrics

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Superoxide anion (O2•-) is an important reactive oxygen species (ROS) and participates in various physiological and pathological processes in the organism. The O2•- burst induced by ischemia-reperfusion (I/R) is associated with cardiovascular disease and promotes the cell apoptosis. In this work, a turn-on type Golgi-targeting fluorescent probe Gol-Cou-O2•- was rationally designed for sensitive and selective detection of O2•-. The minimum detection limit concentration for O2•- was about 3.9 × 10−7 M in aqueous solution. Gol-Cou-O2•- sho...

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Development of a Golgi-targeted superoxide anion fluorescent probe for elucidating protein GOLPH3 function in myocardial ischemia-reperfusion injury

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