摘要：
Quinic acid (QA) and its derivatives have good lipid-lowering and hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on atherogenesis in Apoe−/− mice induced by HFD. HE staining and oil red O staining were used to observe the pathology. The PCSK9, Mac-3 and SM22a expressions were detected by IHC. Cholesterol, HMGB1, TIMP-1 and CXCL13 levels were measured by biochemical and ELISA. Lipid metabolism and the HMGB1-SREBP2-SR-BI pathway were detected by PCR and WB. 16 S and metabolomics were used to detect gut microbiota and serum metabolites. QA or low-frequency ABX inhibited weight gain and aortic tissue atherogenesis in HFD-induced Apoe−/− mice. QA inhibited the increase of cholesterol, TMA, TMAO, CXCL13, TIMP-1 and HMGB1 levels in peripheral blood of Apoe−/− mice induced by HFD. Meanwhile, QA or low-frequency ABX treatment inhibited the expression of CAV-1, ABCA1, Mac-3 and SM22α, and promoted the expression of SREBP-1 and LXR in the vascular tissues of HFD-induced Apoe−/− mice. QA reduced Streptococcus_danieliae abundance, and promoted Lactobacillus_intestinalis and Ileibacterium_valens abundance in HFD-induced Apoe−/− mice. QA altered serum galactose metabolism, promoted SREBP-2 and LDLR, inhibited IDOL, FMO3 and PCSK9 expression in liver of HFD-induced Apoe−/− mice. The combined treatment of QA and low-frequency ABX regulated microbe-related Glycoursodeoxycholic acid and GLYCOCHENODEOXYCHOLATE metabolism in HFD-induced Apoe−/− mice. QA inhibited TMAO or LDL-induced HCAECs damage and HMGB1/SREBP2 axis dysfunction, which was reversed by HMGB1 overexpression. QA regulated the gut-liver lipid metabolism and chronic vascular inflammation of TMA/TMAO through gut microbiota to inhibit the atherogenesis in Apoe−/− mice, and the mechanism may be related to the HMGB1/SREBP2 pathway.
摘要：
The concentration of metallic elements is closely associated with overall health. However, the discharge of untreated industrial wastewater can lead to metal -containing pollutants entering the human body through the food chain, disrupting the organism's homeostasis and posing a risk to human health. Covalent organic framework materials (COFs) have emerged as a novel porous material for detecting or adsorbing metal ions due to their unique pore structure, topological structure and flexible design. This paper summarizes the role, toxicity, and sources of metal ions related to human health, as well as the design, synthesis and performance of COFs fluorescent materials for detecting these elements. The interaction mechanism of different fluorescent COFs and metal ions are discussed. Additionally, the remaining challenges and prospects of COFs fluorescence sensors are provided. We believe this review will be useful in directing the development of fluorescent COFs towards metal ions. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
期刊：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,2024年38(1):e23608- ISSN：1095-6670
通讯作者：
Zhenjie Wang<&wdkj&>Zhenjie Wang Zhenjie Wang Zhenjie Wang
作者机构：
Department of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China;Institute of Emergency and Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China;[Shugen Xu; Shugen Xu Shugen Xu Shugen Xu] Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China;[Zhenjie Wang; Zhaolei Qiu; Chuanming Zheng; Feng Cheng; Lei Li; Zhipeng Xu; Qi Song; Fulong Zhang; Zhenjie Wang Zhenjie Wang Zhenjie Wang; Zhaolei Qiu Zhaolei Qiu Zhaolei Qiu; Chuanming Zheng Chuanming Zheng Chuanming Zheng; Feng Cheng Feng Cheng Feng Cheng; Lei Li Lei Li Lei Li; Zhipeng Xu Zhipeng Xu Zhipeng Xu; Qi Song Qi Song Qi Song; Fulong Zhang Fulong Zhang Fulong Zhang] Department of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China<&wdkj&>Institute of Emergency and Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
通讯机构：
[Zhenjie Wang; Zhenjie Wang Zhenjie Wang Zhenjie Wang] D;Department of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China<&wdkj&>Institute of Emergency and Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
摘要：
<jats:title>Abstract</jats:title><jats:p>This study aimed to explore the impact of different pH values of resuscitation fluid on traumatic hemorrhagic shock (THS),focusing on their effects on glycocalyx and inflammation. A rat model of THS was induced by hemorrhage from a left femur fracture, while an oxygen‐glucose deprivation/reoxygenation (OGD/R)‐induced HULEC‐5acell model was considered as an in vitro THSmodel. The lung tissue pathology and glycocalyx structure were assessed through hematoxylin–eosin (H&E) staining and transmission electron microscope examination. The levels of glycocalyx‐related factors and inflammation‐related factors were determined by enzyme‐linked immunosorbent assay (ELISA).The expression of glycocalyx‐related proteins, cell junction‐related proteins, and proteins involved in the PI3K/Akt/NF‐κB signaling pathway was analyzed by western blot. The results showed that both sodium bicarbonate Ringer's solution (BRS)and lactate Ringer's solution (LRS)were effective in restoring mean arterial pressure and heart rate in THS rats. However, LRS has a stronger impact on promoting inflammation and damaging the glycocalyx compared withBRS. In OGD/R‐induced HULEC‐5a cells, a pH of 7.4 and 6.5 increased inflammation and disrupted the glycocalyx, while a pH of 8.1 had no significant effect on inflammation or glycocalyx. Furthermore, the PI3K/Akt/NF‐κBsignaling pathway was activated by fluid resuscitation and different pH values. However, the activating effect of BRS and pH 8.1 on the PI3K/Akt/NF‐κBsignaling pathway was milder compared withLRS and pH6.5. In conclusion, an alkaline recovery environment was more beneficial for the treatment of THS.</jats:p>
摘要：
We investigate the hydrostatic equilibrium configurations of strange stars within the framework of Rastall-Rainbow theory of gravity. These stars are primarily composed of strange quark matter, with its distribution governed by the color-flavor-locked phase of quark matter equation of state (EoS). Using this EoS, we numerically solve the modified Tolman-Oppenheimer-Volkoff equation to obtain different quark star models. We find that the parameters from this modified gravity have specific contributions to the structure of quark stars and introduce new descriptions for massive celestial bodies. Also, the mass-radius relation strongly depends on the parameters from the considered EoS. Furthermore, we analyze the impact of these parameters on the gravitational redshift and compactness of quark stars.
摘要：
We study wave equations with various spins on the background of a general spherically symmetric spacetime. We obtain the unified expression of the Teukolsky-like master equations and the corresponding radial equations with the general spins. We also discuss the gauge dependence in the gravitational-wave equations, which have appeared in previous studies.
期刊：
JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS,2024年2024(02):046 ISSN：1475-7516
作者机构：
[Nakajima, Hiroaki] School of Mathematics and Physics, University of South China, Hengyang, 421001, China;School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, 610031, China;[Guo, Ya; Lin, Wenbin] School of Mathematics and Physics, University of South China, Hengyang, 421001, China<&wdkj&>School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, 610031, China
摘要：
<jats:title>Abstract</jats:title>
<jats:p>We study an axisymmetric metric satisfying the Petrov type D property with some additional
ansatze, but without assuming the vacuum condition. We find that our metric in turn becomes
conformal to the Kerr metric deformed by one function of the radial coordinate. We then study the
gravitational-wave equations on this background metric in the case that the conformal factor is
unity. We find that under an appropriate gauge condition, the homogeneous wave equations admit the
separation of the variables, which is also helpful for solving the nonhomogeneous equations. The
resultant ordinary differential equation for the radial coordinate gives a natural extension of
the Teukolskyequation.</jats:p>
摘要：
Evaporative cooling (EC) technology can effectively improve the energy efficiency of the mechanical vapor compression (MVC) system by enhancing the heat exchange capacity of its condenser. However, the current evaporative-cooling condenser system is usually only equipped with a single-stage evaporative cooler as the precooling unit, and these designs are mainly suitable for hot-dry conditions. In this study, three hybrid air-conditioning systems with different two-stage evaporative-cooling condenser configurations were proposed, one is single-condenser type and the other two are dual-condenser type, which are used to improve the exergy performance and adaptability of the evaporative condenser system under hot-humid climates. Then, the all systems were modeled via the distributed parametric method and analyzed comparatively based on the exergy method. A suitable exergy reference temperature at air saturation was discussed. Finally, the effect of four key parameters (ambient temperature and relative humidity, outdoor airflow rate and room heat load) was studied. The results showed that under the high temperature, relative humidity or room heat load conditions, the hybrid systems have a low exergy efficiency ratio (EXR) and high exergy efficiency (eta x,OEC). x , OEC ). Among them, the newly countercurrent dual-condenser configuration (MVC-TSEC(C)) exhibits the best exergy performance under most hot-humid conditions. Compared to the conventional MVC system, the EXR and eta x , OEC of MVC-TSEC(C) increased by at most 35.0 % and 78.2 %, respectively. Moreover, its components like compressor, condenser and expansion valve have the maximum reduction rates of exergy destruction of 43.5 %, 17.2 % and 55.3 %, respectively.
作者机构：
[Chen, Zhenfu; Tao, Qiuwang; Jin, Dan; Chen, ZF; Wang, Minghui; Wu, Dan; Luo, Lincheng] Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.;[Chen, Zhenfu; Tao, Qiuwang; Chen, ZF; Wang, Minghui; Wu, Dan; Luo, Lincheng] Univ South China, China Nucl Ind Key Lab High Performance Concrete, Hengyang 421001, Peoples R China.;[Chen, Zhenfu; Tao, Qiuwang; Jin, Dan; Chen, ZF; Wang, Minghui; Wu, Dan; Luo, Lincheng] Univ South China, Hunan Prov Key Lab High Performance Special Concre, Hengyang 421001, Peoples R China.;[Yang, Yan'e] Lanzhou Univ Technol, Sch Civil Engn, Lanzhou 730050, Peoples R China.;[Xie, Liping] China Nucl Ind 22ND Construct Co Ltd, Yichang 443101, Peoples R China.
通讯机构：
[Chen, ZF ] U;Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.;Univ South China, China Nucl Ind Key Lab High Performance Concrete, Hengyang 421001, Peoples R China.;Univ South China, Hunan Prov Key Lab High Performance Special Concre, Hengyang 421001, Peoples R China.
关键词：
high temperature;lead–zinc tailings;radiation shielding concrete;mechanical strength;gamma ray shielding;ultrasonic pulse velocity
摘要：
<jats:p>Due to the high prices, the popularity of radiation shielding concrete (RSC) has been greatly limited. To solve this, this research reused the lead–zinc tailings (LZT) as a fine aggregate replacement ranging from 0% to 60% for the RSC. The results revealed that the RSC containing 30% LZT presented better workability and achieved 95.84% of the compressive strength and 98.49% of the linear attenuation coefficient of the RSC, and reached the highest splitting tensile strength values, which increased by 4.43%. Meanwhile, after the heat treatments, there were favorable correlations between the relative velocity and relative strength, as well as between the damage index and the relative linear attenuation coefficient, which could accurately reflect the degradation of not only the mechanical but also the shielding properties. Considering the temperature and shielding thickness, the reuse of LZT can bring considerable economic and environmental benefits.</jats:p>
通讯机构：
[Deng, Y ] H;Hunan Univ Technol, Hunan Key Lab Biomed Nanomat & Devices, Zhuzhou 412007, Hunan, Peoples R China.
关键词：
Aptamer;Aptamer screening;Aptasensor;Virus
摘要：
Virus-induced infectious diseases have a detrimental effect on public health and exert significant influence on the global economy. Therefore, the rapid and accurate detection of viruses is crucial for effectively preventing and diagnosing infections. Aptamer-based detection technologies have attracted researchers' attention as promising solutions. Aptamers, small single-stranded DNA or RNA screened via systematic evolution of ligands by exponential enrichment (SELEX), possess a high affinity towards their target molecules. Numerous aptamers targeting viral marker proteins or virions have been developed and widely employed in aptamer-based biosensors (aptasensor) for virus detection. This review introduces SELEX schemes for screening aptamers and discusses distinctive SELEX strategies designed explicitly for viral targets. Furthermore, recent advances in aptamer-based biosensing methods for detecting common viruses using different virus-specific aptamers are summarized. Finally, limitations and prospects associated with developing of aptamer-based biosensors are discussed.
作者：
Wang, Miaomiao;Jin, Lian;Leung, Polly Hang-Mei;Chow, Franklin Wang-Ngai;Zhao, Xiaoni;...
期刊：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2024年12:1393789 ISSN：2296-4185
通讯作者：
Li, S;Liu, Hongna
作者机构：
[Jin, Lian; Li, Song; Wang, Miaomiao; Li, S; Chen, Hui] Hunan Univ Technol, Hunan Key Lab Biomed Nanomat & Devices, Zhuzhou, Peoples R China.;[Leung, Polly Hang-Mei; Chow, Franklin Wang-Ngai] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong, Peoples R China.;[Zhao, Xiaoni] Guangzhou Wanfu Biotechnol Co, Guangzhou, Peoples R China.;[Li, Song; Li, S; Liu, Hongna; Pan, Wenjing] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.;[Li, Song; Li, S] Hunan Prov Maternal & Child Healthcare Hosp, Natl Hlth Commiss Key Lab Birth Defect Res & Preve, Changsha, Peoples R China.
通讯机构：
[Li, S ] H;[Liu, HN] U;Hunan Univ Technol, Hunan Key Lab Biomed Nanomat & Devices, Zhuzhou, Peoples R China.;Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.;Hunan Prov Maternal & Child Healthcare Hosp, Natl Hlth Commiss Key Lab Birth Defect Res & Preve, Changsha, Peoples R China.
关键词：
magnetic nanoparticles;POCT;Biosensors;Biological detection;SEPARATION
摘要：
The significance of point-of-care testing (POCT) in early clinical diagnosis and personalized patient care is increasingly recognized as a crucial tool in reducing disease outbreaks and improving patient survival rates. Within the realm of POCT, biosensors utilizing magnetic nanoparticles (MNPs) have emerged as a subject of substantial interest. This review aims to provide a comprehensive evaluation of the current landscape of POCT, emphasizing its growing significance within clinical practice. Subsequently, the current status of the combination of MNPs in the Biological detection has been presented. Furthermore, it delves into the specific domain of MNP-based biosensors, assessing their potential impact on POCT. By combining existing research and spotlighting pivotal discoveries, this review enhances our comprehension of the advancements and promising prospects offered by MNP-based biosensors in the context of POCT. It seeks to facilitate informed decision-making among healthcare professionals and researchers while also promoting further exploration in this promising field of study.
作者机构：
[Qin, Qin; Zhong, Li-Yuan; Zeng, Xi; Weng, Xin; Cao, De-Liang; Xie, Li-Hua; Ge, Wen-Jun] Univ South China, Canc Res Inst, Hunan Engn Res Ctr Early Diag & Treatment Liver Ca, Hengyang Med Sch,Hunan Prov Key Lab Tumor Cellular, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.;[Zeng, Wei-Hong] Hunan Normal Univ, Coll Life Sci, Lab Mol & Stat Genet, Changsha 410081, Hunan, Peoples R China.;[Lai, Zhen] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.;[Liu, Peng] Hunan Normal Univ, Affiliated Hosp 1, Peoples Hosp, Dept Gastroenterol, Changsha 410005, Hunan, Peoples R China.
通讯机构：
[Zeng, X ] U;Univ South China, Canc Res Inst, Hunan Engn Res Ctr Early Diag & Treatment Liver Ca, Hengyang Med Sch,Hunan Prov Key Lab Tumor Cellular, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
摘要：
Chemotherapy remains a prevalent treatment for a wide range of tumors; however, the majority of patients undergoing conventional chemotherapy experience varying levels of chemoresistance, ultimately leading to suboptimal outcomes. The present article provided an in‑depth review of chemotherapy resistance in tumors, emphasizing the underlying factors contributing to this resistance in tumor cells. It also explored recent advancements in the identification of key molecules and molecular mechanisms within the primary chemoresistant pathways.
作者：
Fujita, Mitsutoshi;He, Song;Sun, Yuan;Zhang, Jun
期刊：
Journal of High Energy Physics,2024年2024(1) ISSN：1029-8479
通讯作者：
Fujita, M
作者机构：
[Fujita, M; Fujita, Mitsutoshi] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[He, Song] Jilin Univ, Coll Phys, Ctr Theoret Phys, Changchun 130012, Peoples R China.;[He, Song] Albert Einstein Inst, Max Planck Inst Grav Phys, Muhlenberg 1, D-14476 Golm, Germany.;[Sun, Yuan] Cent South Univ, Sch Phys & Elect, Changsha 418003, Peoples R China.;[Zhang, Jun] Univ Alabama, Dept Phys & Astron, 514 Univ Blvd, Tuscaloosa, AL 35487 USA.
通讯机构：
[Fujita, M ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
Gauge-Gravity Correspondence;Holography and Condensed Matter Physics (AdS/CMT);Confinement
摘要：
<jats:title>A<jats:sc>bstract</jats:sc>
</jats:title><jats:p>We compute holographic entanglement entropy (EE) and the renormalized EE in AdS solitons with gauge potential for various dimensions. The renormalized EE is a cutoff-independent universal component of EE. Via Kaluza-Klein compactification of <jats:italic>S</jats:italic><jats:sup>1</jats:sup> and considering the low-energy regime, we deduce the (<jats:italic>d</jats:italic> − 1)-dimensional renormalized EE from the odd-dimensional counterpart. This corresponds to the shrinking circle of AdS solitons, probed at large <jats:italic>l</jats:italic>. The minimal surface transitions from disk to cylinder dominance as <jats:italic>l</jats:italic> increases. The quantum phase transition occurs at a critical subregion size, with renormalized EE showing non-monotonic behavior around this size. Across dimensions, massive modes decouple at lower energy, while degrees of freedom with Wilson lines contribute at smaller energy scales.</jats:p>
期刊：
Journal of Radioanalytical and Nuclear Chemistry,2024年333(5):2263-2271 ISSN：0236-5731
通讯作者：
Liu, L
作者机构：
[Yu, Shiwei; Liu, Lie; Ling, Ke; Liu, L] Univ South China, Sch Elect Engn, Hengyang 421000, Peoples R China.;[Liu, Lie; Zhang, Junze; Han, Lianghua; Liu, L] Univ South China, Sch Mech Engn, Hengyang 421000, Peoples R China.
通讯机构：
[Liu, L ] U;Univ South China, Sch Elect Engn, Hengyang 421000, Peoples R China.;Univ South China, Sch Mech Engn, Hengyang 421000, Peoples R China.
摘要：
It is essential to treat high-level liquid waste (HLLW) in a secure and effective manner. As a result, we first propose rapid vitrification of simulated HLLW using an ultra-high power laser. First, a cured body with a mass of 24.4 kg was obtained by using ultra-high power laser sintering. Subsequently, four different locations of the curing body were tested and the measured performance indicators were all in accordance with the regulations. This demonstrates the potential of ultra-high power lasers in HLLW glass curing processes.
摘要：
BACKGROUND: Under normal circumstances, high-density lipoprotein (HDL) is considered to have cardiovascular protective effects, but the impact of oxidized HDL (ox-HDL) on vascular endothelial function remains poorly understood. Mitochondrial function is closely related to endothelial function, and hydrogen sulfide (H₂S) is a gas with endothelial protective properties. The novel hydrogen sulfide donor AP39 can target mitochondria to release H₂S, but the combined effects of ox-HDL and AP39 on vascular endothelium are not well studied. METHODS: We established a cell model of ox-HDL-induced endothelial cell damage and mitochondrial dysfunction using human umbilical vein endothelial cells (HUVECs) and conducted AP39 pretreatment. The experiments confirmed the functional damage and mitochondrial dysfunction in HUVECs caused by ox-HDL. Additionally, to further explore the role of SIRT1 in AS, we analyzed SIRT1 expression in AS carotid artery tissue. This included the analysis of differentially expressed genes from AS-related datasets, presented through volcano plots and heatmaps, with enrichment analysis of downregulated genes in KEGG pathways and GO functions. Furthermore, we evaluated the differences in SIRT1 expression in coronary arteries with varying degrees of stenosis and in early and late-stage AS carotid artery tissues, and analyzed data from SIRT1 knockout mouse models. RESULTS: The experimental results indicate that AP39 effectively alleviated ox-HDL-induced endothelial cell damage and mitochondrial dysfunction by upregulating SIRT1 expression. MTT and CCK-8 assays showed that ox-HDL treatment led to decreased cell viability and proliferation in HUVECs, reduced eNOS expression, and significantly increased levels of ICAM-1, IL-6, and TNF-α, along with enhanced monocyte adhesion. These findings reveal the damaging effects of ox-HDL on HUVECs. Transcriptomic data indicated that while SIRT1 expression did not significantly differ in coronary arteries with varying degrees of stenosis, it was notably downregulated in AS carotid artery tissues, especially in late-stage AS tissues. KEGG pathway enrichment analysis revealed that SIRT1 downregulated genes were associated with processes such as vascular smooth muscle contraction, while GO analysis showed that these downregulated genes were involved in muscle system processes and muscle contraction functions, further confirming SIRT1's critical role in AS pathology. In transcriptomic data from the SIRT1 knockout mouse model, elevated levels of inflammation-related proteins IL-6 and TNF-α were observed after SIRT1 knockout, along with decreased expression of the chaperone protein PGC-1α. The expression of mitochondrial-related functional proteins Nrf2 and PGC-1α was positively correlated with SIRT1 expression, while inflammation-related proteins ICAM-1, IL-6, IL-20, and TNF-α were negatively correlated with SIRT1 expression. We further discovered that ox-HDL triggered mitochondrial dysfunction, as evidenced by reduced expression of Mfn2, Nrf2, PGC1-α, UCP-1, and SIRT1, corroborating the results from the previous database analysis. Additionally, mitochondrial dysfunction was characterized by decreased mitochondrial membrane potential (MMP), increased mitochondrial ROS levels, and reduced ATP content, further impacting cellular energy metabolism and respiratory function. Subsequent experimental results showed that the addition of AP39 mitigated these adverse effects, as evidenced by decreased levels of ICAM-1, IL-6, and TNF-α, increased eNOS expression, reduced monocyte adhesion, increased mitochondrial H₂S content, and upregulated expression of SIRT1 protein associated with mitochondrial function, reduced ROS levels, and increased ATP content. Furthermore, validation experiments using the SIRT1 inhibitor EX527 confirmed that AP39 alleviated ox-HDL-induced endothelial cell damage and mitochondrial dysfunction by upregulating SIRT1 expression. CONCLUSION: Ox-HDL can induce damage and mitochondrial dysfunction in HUVECs, while AP39 inhibits ox-HDL-induced endothelial cell damage and mitochondrial dysfunction by upregulating SIRT1.
通讯机构：
[Chen, GD; Wu, DC ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg,Lab Struct Immuno, Hengyang 421001, Hunan, Peoples R China.
关键词：
Combination therapy;Therapeutic cancer vaccine;Tumor antigen
摘要：
Therapeutic cancer vaccines have shown promising efficacy in helping immunotherapy for cancer patients, but the systematic characterization of the clinical application and the method for improving efficacy is lacking. Here, we mainly summarize the classification of therapeutic cancer vaccines, including protein vaccines, nucleic acid vaccines, cellular vaccines and anti-idiotypic antibody vaccines, and subdivide the above vaccines according to different types and delivery forms. Additionally, we outline the clinical efficacy and safety of vaccines, as well as the combination strategies of therapeutic cancer vaccines with other therapies. This review will provide a detailed overview and rationale for the future clinical application and development of therapeutic cancer vaccines.
