期刊：
FRONTIERS IN CARDIOVASCULAR MEDICINE,2025年12:1555544 ISSN：2297-055X
作者机构：
[Yu, Hang; Li, Guoliang; Chen, Tao; Lei, Xinjun] Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, Shaanxi, China;[Zhang, Xiaowei] Department of Neonatology, First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China;[Dang, Shaonong] Global Health Institute, School of Medicine, Xian Jiaotong University, Xi'an, Shaanxi, China;[Ma, Xiaofeng] Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital, Xining, Qinghai Province, China;[Zhang, Wei] Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
关键词：
Acute Coronary Syndrome;Percutaneous coronary interventions;Digital health management;cardiovascular events;post-PCI outpatient care
摘要：
Coronary heart disease prevalence is rising in developing nations, with acute coronary syndrome (ACS) posing significant global health burdens. Limited access to cardiac rehabilitation and preventive care necessitates scalable, cost-effective solutions. While smartphone-based interventions show promise in modifying risk factors and behaviors, existing evidence lacks robust multicenter randomized controlled trials (RCTs) and comprehensive evaluations of clinical endpoints, quality of life, and psychological outcomes. This study aims to evaluate a smartphone-enabled digital management model integrated with standard post-PCI care for ACS patients, compared to conventional follow-up alone.We conducted a single-blind, multicenter RCT involving 1366 ACS patients post-PCI, with 12-month follow-up. Participants were randomized into two groups: the experimental group received standard postoperative follow-up plus a digital platform providing personalized rehabilitation guidance, medication reminders, risk factor monitoring, and psychological support; the control group received standard follow-up alone. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCEs), including cardiac death, myocardial infarction, stroke, or unplanned revascularization. Secondary endpoints encompassed cardiac function metrics (e.g., LVEF, NT-proBNP), Seattle Angina Questionnaire scores, Hospital Anxiety and Depression Scale (HADS) assessments, and medication adherence rates.Results will determine whether the digital intervention reduces MACCE incidence and improves multidimensional recovery outcomes. If effective, this model could address global cardiac rehabilitation gaps by offering an accessible, low-cost solution—particularly impactful in rural and resource-limited settings. Clinically, it may enhance secondary prevention through real-time monitoring and behavioral reinforcement. Public health systems could leverage this approach to mitigate workforce shortages and geographic barriers to care.Ethical approval was obtained from the First Affiliated Hospital of Xi'an Jiaotong University (XJTU1AF2024LSYY-134). Trial registration: ChiCTR2400086452. Findings will be disseminated via peer-reviewed publications and conference presentations.This trial provides pivotal evidence for digital health integration into post-PCI care, potentially reshaping rehabilitation paradigms through technology-driven, patient-centered strategies. The scalable design emphasizes applicability across diverse healthcare systems, offering a framework to improve long-term outcomes in ACS management.
摘要：
Intelligent fault diagnosis (IFD) plays a crucial role in reducing maintenance costs and enhancing the reliability of safety-critical energy systems (SCESs). In recent years, deep learning-based IFD methods have achieved high fault diagnosis accuracy extracting implicit higher-order correlations between features. However, the excessive long training time of deep learning models conflicts with the requirements of real-time analysis for IFD, hindering their further application in practical industrial environments. To address the aforementioned challenge, this paper proposes an innovative IFD method for SCES that combines the particle swarm optimization (PSO) algorithm and the ensemble broad learning system (EBLS). Specifically, the broad learning system (BLS), known for its low time complexity and high classification accuracy, is adopted as an alternative to deep learning for fault diagnosis in SCES. Furthermore, EBLS is designed to enhance model stability and classification accuracy with high-dimensional small samples by incorporating the random forest (RF) algorithm and an ensemble strategy into the traditional BLS framework. In order to reduce the computational cost of the EBLS, which is constrained by the selection of its hyperparameters, the PSO algorithm is employed to optimize the hyperparameters of the EBLS. Finally, the model is validated through simulated data from a complex nuclear power plant (NPP). Numerical experiments reveal that the proposed method significantly improved the diagnostic efficiency while maintaining high accuracy. In summary, the proposed approach shows great promise for boosting the capabilities of the IFD models for SCES.
摘要：
Aims/Background Silver-containing dressings are commonly utilized in burns treatment by virtue of their excellent antibacterial properties. Further research is needed to determine the type of silver-containing dressing that is more effective and safer for burns treatment. Pyperbranched polyamide-Ag dressing (HBPs-Ag dressing) is a modified polyamide dressing with a uniform coating of the Amino-terminated hyperbranched polymer (HBP-NH(2))/Ag(+) compound on its surface. This study aimed to evaluate the efficacy and safety of a silver ion-containing dressing (HBPs-Ag) for wound contact layer in the treatment of deep partial-thickness burns versus a silver-impregnated tulle dressing (Atrauman Ag). Methods This study was conducted between October 2019 to January 2021 at six sites in China. A total of 132 patients with deep partial-thickness burns (aged 18-65 years, injury occurring within 72 hours, burns <30% total burn surface area) were randomized 1:1 to HBPs-Ag group (study group) or Atrauman Ag group (control group). Data were obtained and analyzed, including total efficacy, wound healing rate, wound healing time, rate of negative bacterial culture from wound secretions, systemic response, skin or tissue irritation, local skin color changes, wound swelling, wound pain and adverse events. Results For partial thickness burns, the HBPs-Ag dressing was not inferior to Atrauman Ag dressing because the total efficiency of HBPs-Ag group (98.3%) was comparable to that of Atrauman Ag group (94.7%) (p > 0.05). There were no significant differences in efficacy, wound healing rate, wound healing time, and rate of negative bacterial culture from wound secretions between the two groups (p > 0.05). There were no statistical differences in all safety indicators tested between the two groups (p > 0.05). Silver was detected in the blood or urine of only 5 patients (3.79%). Conclusion The HBPs-Ag dressing was not inferior to Atrauman Ag dressing in deep partial-thickness burns treatment, with both of them showcasing comparable efficacy and safety. Clinical Trial Registration Chinese Clinical Trial Registry (ChiCTR2100049814).
通讯机构：
[Tan, XF; Yang, QL ; Wu, GL] U;Univ South China, Affiliated Hosp 1, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, NHC Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.;Univ South China, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.
关键词：
NIR-II;Phototheranostics;Endoplasmic reticulum;Triple-negative breast cancer;Intermolecular π–π stacking interaction
摘要：
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as a promising strategy for the treatment of TNBC. This approach works by selectively destroying tumor cells, releasing tumor-associated antigens, activating the immune system, and effectively inhibiting tumor proliferation and metastasis. However, the majority of current phototheranostic approaches are hindered by limited tissue penetration in the first near-infrared (NIR-I) and ultraviolet-visible (UV-Vis) regions. Additionally, due to the lack of specific subcellular targets, it may be difficult to effectively treat deep-seated lesions with ambiguous and extensive boundaries caused by TNBC metastases. Consequently, the development of effective, deep-penetrating, organelle-targeted phototheranostics is essential for enhancing treatment outcomes in TNBC. This work proposes a novel molecular design strategy of NIR-II phototheranostics to realize planar rigid conjugation and alkyl chain functionalization. The di-hexaalkyl chains in a vertical configuration on the donor (4H-cyclopenta[2,1-b:3,4-b'] dithiophene) and shielding units (fluorene) are introduced to construct a S-D-A-D-S type NIR-II phototheranostics (IR-FCD). The planar and rigid structure of IR-FCD exhibits a robust intramolecular charge transfer capability, a lower band gap, enhanced photon absorption properties, and significant steric hindrance from vertically arranged alkyl chains to minimize non-radiative energy loss. By incorporating N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide at the terminus of an elongated alkyl chain, followed by self-assembly into DSPE-S-S-PEG2000, NIR-II excitable phototheranostics (IR-FCD-Ts NPs) with endoplasmic reticulum (ER) targeting capability were successfully synthesized for imaging-guided photoimmunotherapy of TNBC. The IR-FCD-Ts NPs demonstrate exceptional optical characteristics, with maximum absorption at 1068nm (extending to 1300nm) and emission at 1273nm (extending to 1700nm), along with a high molar absorption coefficient of 2.76*10(4)L/mol·c at 1064nm in aqueous solution. Under exposure to 1064nm laser irradiation, IR-FCD-Ts NPs exhibit superior photothermal properties and have the potential for photodynamic therapy. By targeting ER, thereby inducing ER stress and significantly enhancing immunogenic cell death (ICD) in tumor cells, it triggers a strong antitumor immune response and inhibits the proliferation and metastasis of TNBC.
摘要：
The rapid and selective identification of microorganisms is of great significance for clinical therapy applications. To develop high performance probes for microbe determination, we systemically constructed series aggregation-induced emission (AIE) luminogens by modulating the structural planarity, the basicity of functional group, the length of linker moiety and the hydrophobicity based on our previous work. The detail structure-property relationship study based on experimental and theoretical observation revealed that: i) the planar skeleton is essential for probe insertion towards the cell wall via van n der Waals' force. ii) the basic function group enable the anchoring on the membrane by binding with acidic biomolecules. iii) the shortened alkyl chain is in favor of the efficient binding of basic groups with microbes and endows the desirable hydrophobicity. Based on the developed probes, the successful detection of the pathogens in clinic samples was achieved in highly sensitive and simple way. This work provides a reliable strategy for designing intelligent luminogens for microorganism discrimination and identification in efficient and sensitive way for in vitro diagnosis applications, especially point-of-care testing (POCT).
The rapid and selective identification of microorganisms is of great significance for clinical therapy applications. To develop high performance probes for microbe determination, we systemically constructed series aggregation-induced emission (AIE) luminogens by modulating the structural planarity, the basicity of functional group, the length of linker moiety and the hydrophobicity based on our previous work. The detail structure-property relationship study based on experimental and theoretical observation revealed that: i) the planar skeleton is essential for probe insertion towards the cell wall via van n der Waals' force. ii) the basic function group enable the anchoring on the membrane by binding with acidic biomolecules. iii) the shortened alkyl chain is in favor of the efficient binding of basic groups with microbes and endows the desirable hydrophobicity. Based on the developed probes, the successful detection of the pathogens in clinic samples was achieved in highly sensitive and simple way. This work provides a reliable strategy for designing intelligent luminogens for microorganism discrimination and identification in efficient and sensitive way for in vitro diagnosis applications, especially point-of-care testing (POCT).
作者机构：
[Zhang, Shijie; Zou, Pinyu; Liu, Yizhi; Chen, Zhenfu; Liu, YZ; Tao, Qiuwang; Chen, ZF; Wu, Dan] Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.;[Zhang, Shijie; Liu, Yizhi; Chen, Zhenfu; Liu, YZ; Tao, Qiuwang; Chen, ZF; Wu, Dan] Univ South China, China Nucl Ind Key Lab High Performance Concrete, Hengyang 421001, Peoples R China.;[Zhang, Shijie; Liu, Yizhi; Chen, Zhenfu; Liu, YZ; Tao, Qiuwang; Chen, ZF; Wu, Dan] Univ South China, Hunan Prov Key Lab High Performance Special Concre, Hengyang 421001, Peoples R China.
通讯机构：
[Liu, YZ ; Chen, ZF] U;Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.;Univ South China, China Nucl Ind Key Lab High Performance Concrete, Hengyang 421001, Peoples R China.;Univ South China, Hunan Prov Key Lab High Performance Special Concre, Hengyang 421001, Peoples R China.
摘要：
Steel-concrete-steel (SCS) composite slabs are widely used in critical infrastructures such as nuclear power plants, where systematic performance evaluation through multiple criteria is crucial due to their safety functions. During their use, fires may occur due to fuel or gas leaks, leading to explosions. This article uses ABAQUS 2020 finite element software and combines the different advantages of the implicit heat transfer algorithm and explosion display algorithm to establish a numerical simulation method for dynamic analysis of SCS slab under explosion after fire. Based on different fire conditions and the propagation laws of explosion shock waves, some key dynamic indicators and failure modes of the slab were studied. The results reveal progressive damage mechanisms with increasing fire duration, characterized by expanding damage areas, significant stress fluctuations, and increasing displacement rates. Additionally, the fire surface shows greater vulnerability than the back fire surface. The results provide multiple evaluation criteria for assessing structural performance, including temperature distribution, stress evolution, and damage patterns, which can support engineering decision-making in structural safety management.
作者机构：
[Chen, YD; Chen, Yidian] Hangzhou Normal Univ, Sch Phys, Hangzhou 311121, Peoples R China.;[Chen, Xun] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Chen, Xun] Cent China Normal Univ, Key Lab Quark & Lepton Phys MOE, Wuhan 430079, Peoples R China.;[Li, Danning] Jinan Univ, Dept Phys, Guangzhou 510632, Peoples R China.;[Li, Danning] Jinan Univ, Siyuan Lab, Guangzhou 510632, Peoples R China.
通讯机构：
[Chen, YD ] H;Hangzhou Normal Univ, Sch Phys, Hangzhou 311121, Peoples R China.
摘要：
We investigate the effects of rotation on deconfinement and chiral phase transitions in the framework of the dynamical holographic QCD model. Instead of transforming to the rotating system by Lorentz boost, we construct an anisotropic gravitational background by incorporating the rotating boundary current. We first investigate the pure gluon system under rotation to extract deconfinement phase transition from the Polyakov loop then add two-flavor probe for chiral restoration phase transition from the chiral condensate. It is observed that at low chemical potentials, the deconfinement phase transition of pure gluon system is of first order and the chiral phase transition of a two-flavor system is of crossover. Both the critical temperatures of deconfinement and chiral phase transitions decrease/increase with imaginary/real angular velocity (Omega(I)/Omega) as T/T-c similar to 1 - C-2 Omega(2)(I) and T/T-c similar to 1 + C-2 Omega(2), which is consistent with lattice QCD results. In the temperature-chemical potential T - mu phase diagram, the critical end point moves toward regions of higher temperature and chemical potential with real angular velocity.
作者机构：
[Huang, Bingsheng; Wu, Hui; Wang, Junli] Department of Obstetrics and Gynecology, Affiliated Hospital of Youjiang Medical University for Nationalities, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Baise S33000, Guangxi, China;[Huang, Bingsheng; Wang, Junli] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Reproductive Medicine, Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China;[Lei, Xiaocan; Zhang, Yu; She, Wendian; Peng, Qingwen; Zhu, Yueze; Zhou, Ziyu] Clinical Anatomy and Reproductive Medicine Application Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China;[Dong, Mingyou] Department of Reproductive Medicine, Affliated Hospital of Youjiang Medical University for Nationalities, Baise, S33000, China Guangxi
摘要：
Natural uranium is a ubiquitous element in the environment, and human exposure to low levels of uranium is unavoidable. Several concerns have recently been raised about the reproductive effects of chronic exposure to low levels of uranium. Therefore, the aim of this study was to investigate the protective effect of Nicotinamide mononucleotide（NMN） on uranium exposure-induced testicular sperm function in mice. To this end, a research model was established in which testicular damage and spermatogenic dysfunction were induced in adult male mice by intraperitoneal injection of two different doses of uranyl nitrate. Following a week of intraperitoneal injection, the mice were given oral doses of 500 mg/kg of NMN, a dose that was validated in an in vitro cellular model. The results demonstrated a decline in testicular weight and epididymis weight, along with a reduction in sperm count, in comparison to the control group. Subsequent observation of testicular morphology revealed the presence of disorganized seminiferous tubules, characterized by reduced area and diameter. Concurrently, a downregulation of the anti-apoptotic factor (Bcl-2) and an upregulation of the apoptotic factor (Bax) were observed in the testis. Furthermore, an analysis of testicular genetic expression levels of Sertoli cell (SCs) markers (WT-1, Sox9, PCNA, and Vimentin) revealed a substantial exacerbation of pathological changes, including an augmentation in the severity of tubular degeneration. NMN treatment resulted in a significant enhancement of testicular function, as evidenced by an increase in epididymal and testicular weights, as well as sperm counts, when compared to saline-treated uranium-exposed mice.
摘要：
This study conducts the numerical implementation and solver development of four sub-models based on the Eulerian method with OpenFOAM software, which have been used in prior numerical simulations of wind-induced snow drifting. Verification studies are conducted on the sub-models to assess their applicability and limitations in the field of snow protection engineering. Wind tunnel experiments conducted on a snow fence in Hokkaido serve as a benchmark for these evaluations. A comparative analysis indicates that the mixture multiphase flow model, incorporating two-way coupling between phases, adeptly reproduces snow distribution around snow fences. In contrast, scalar transport models, which consider one-way coupling, are suitable only for studying snowdrifts in the early stage of protection engineering with relatively low snow concentrations. Efforts to integrate phase coupling effects by introducing source terms into the turbulence model are found to be unsatisfactory. By employing a mixture multiphase flow model, this study explores the effects of six typical collector fences on wind-induced snow drifting in road cuttings. Comparative analyses are performed on several aspects, including the morphology of the cutting flow field, snow distribution, snow concentration, and the protective efficacy of the fences, with the aim to evaluate the effectiveness and applicability of snow fences. The results show that collector fences exhibit effective snow protection capabilities for road cuttings. The snow fence in Hokkaido, wind fence, and the snow fence in Wyoming demonstrate the highest protection efficiency among the analyzed collector fences, indicating superior snowdrift control effectiveness within the cuttings. The protective mechanism of collector fences is to decrease the snow transport rate within the saltation layer at the entrance of the protected area, leading to a notable decrease in snow concentration within the saltation layer in the cuttings. This study offers valuable insights and suggestions for snow protection engineering in road cuttings.
This study conducts the numerical implementation and solver development of four sub-models based on the Eulerian method with OpenFOAM software, which have been used in prior numerical simulations of wind-induced snow drifting. Verification studies are conducted on the sub-models to assess their applicability and limitations in the field of snow protection engineering. Wind tunnel experiments conducted on a snow fence in Hokkaido serve as a benchmark for these evaluations. A comparative analysis indicates that the mixture multiphase flow model, incorporating two-way coupling between phases, adeptly reproduces snow distribution around snow fences. In contrast, scalar transport models, which consider one-way coupling, are suitable only for studying snowdrifts in the early stage of protection engineering with relatively low snow concentrations. Efforts to integrate phase coupling effects by introducing source terms into the turbulence model are found to be unsatisfactory. By employing a mixture multiphase flow model, this study explores the effects of six typical collector fences on wind-induced snow drifting in road cuttings. Comparative analyses are performed on several aspects, including the morphology of the cutting flow field, snow distribution, snow concentration, and the protective efficacy of the fences, with the aim to evaluate the effectiveness and applicability of snow fences. The results show that collector fences exhibit effective snow protection capabilities for road cuttings. The snow fence in Hokkaido, wind fence, and the snow fence in Wyoming demonstrate the highest protection efficiency among the analyzed collector fences, indicating superior snowdrift control effectiveness within the cuttings. The protective mechanism of collector fences is to decrease the snow transport rate within the saltation layer at the entrance of the protected area, leading to a notable decrease in snow concentration within the saltation layer in the cuttings. This study offers valuable insights and suggestions for snow protection engineering in road cuttings.
期刊：
FRONTIERS IN ONCOLOGY,2025年15:1515502 ISSN：2234-943X
通讯作者：
Yan, YY
作者机构：
[Mo, Wenjuan; Li, Mengnan] Univ South China, Sch Nursing, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.;[Yan, YY; Yan, Yuanyuan; Fu, Guang] Univ South China, Affiliated Hosp 1, Dept Gastrointestinal Surg, Hengyang, Peoples R China.
通讯机构：
[Yan, YY ] U;Univ South China, Affiliated Hosp 1, Dept Gastrointestinal Surg, Hengyang, Peoples R China.
关键词：
best evidence;gastric cancer;intervention strategies;prevention;pulmonary complications
摘要：
BACKGROUND: Postoperative pulmonary complications in gastric cancer surgery significantly impact patient recovery and prognosis. These complications, including infections, can increase hospital stays and costs, and even lead to death. Numerous risk factors are involved, such as age, smoking history, and lung function. Although preventive measures exist, a unified and effective strategy is lacking. Therefore, researching and implementing effective prevention measures is crucial for improving patients' postoperative quality of life and survival rates. AIM: To collate and summarize the best available evidence for the prevention of pulmonary complications in patients undergoing gastric cancer surgery, thereby providing a reference for the clinical development of relevant intervention strategies. METHODS: A literature search was conducted in databases including BMJ Best Practice, UpToDate, JBI, Cochrane Library, PubMed, Embase, the Ontario Nurses Registration Network, the U.S. National Clinical Practice Guidelines, and MedLine, for documents related to the prevention of pulmonary complications in gastric cancer surgery patients. The search period extended from the inception of these databases to July 25, 2024. The quality of the literature was evaluated according to the standards of the Joanna Briggs Institute (JBI) Evidence-Based Health Care Center, and evidence was extracted from the included documents. RESULTS: A total of 27 documents were ultimately included. The extracted content encompassed three areas: preoperative assessment, risk prevention and intervention measures, totaling 31 best evidences across five categories. The findings of our study underscore the significance of comprehensive preoperative assessments, such as the ARISCAT index for pulmonary risk evaluation, and stress the importance of preoperative interventions like inspiratory muscle training, smoking cessation, and oral care in mitigating postoperative pulmonary complications (PPCs) following gastric cancer surgery. We also advocate for the adoption of protective lung ventilation strategies during surgery and continuous pulse oximetry monitoring postoperatively, along with targeted treatments for specific complications. CONCLUSION: The best evidence extracted for the prevention of complications in gastric cancer surgery patients serves as a basis for evidence-based practice for the prevention of pulmonary complications in this patient group. Further research topics on pulmonary complications of gastric cancer, we recommend further optimization of preoperative assessment tools, investigation into the efficacy of smoking cessation programs, comparative studies on intraoperative ventilation strategies, development of postoperative rehabilitation programs, and research into culturally and resource-sensitive interventions to broaden the global applicability of these practices.
作者：
Jiuzhen Zeng;Laurence T. Yang;Chao Wang;Lei Zhang
期刊：
ACM Transactions on Autonomous and Adaptive Systems,2025年 ISSN：1556-4665
作者机构：
[Jiuzhen Zeng] Huazhong University of Science and Technology, China;[Lei Zhang] Hexi University, China;[Laurence T. Yang] Huazhong University of Science and Technology, China, Zhengzhou University, China, St. Francis Xavier University, Canada;[Chao Wang] University of South China, China
摘要：
Given the vulnerability of vehicular networks to security attacks and the criticality
of secure AI-powered autonomous driving, this paper emphasizes the security issue
concerning vehicular networks in AI-powered autonomous vehicles. The novel ...
摘要：
BACKGROUND: Delayed diagnosis of inflammatory bowel disease (IBD) is common in Europe and North America, with limited research in Asia. We aimed to investigate factors influencing delayed diagnosis of IBD in Chinese children and the impact of delayed diagnosis on growth. METHODS: This was a retrospective study. Clinical data on children with IBD were collected through electronic medical records. The diagnostic interval includes the time from symptom onset to hospital admission and admission to diagnosis. Diagnostic delay was defined as the upper quartile of the time interval from the first symptom to the diagnosis of IBD. For the effect on growth indicators, the length of follow-up was at least 3 months from diagnosis. RESULTS: This study included 222 children with IBD, predominantly with Crohn's disease (86.0%). Approximately one-quarter of children require more than 366 days to be diagnosed with IBD, primarily due to the extended interval between the onset of initial symptoms and hospital admission. Multivariate logistic regression models showed that fever was associated with a prolonged time interval from first symptom onset to admission and the odds ratio (OR) was 0.45 [95% confidence interval (CI) 0.22-0.94]. Age and bloody stools were associated with prolonged intervals from admission to diagnosis, with ORs of 0.84 (95% CI 0.77-0.92) and 0.36 (95% CI 0.14-0.94), respectively. Delayed diagnosis was associated with height at first admission and follow-up. Children with a delayed diagnosis had a 5.87-fold higher chance of growth retardation upon initial admission compared to children without a delayed diagnosis (95% CI 1.59-24.05). After 15.7 months of follow-up, this elevated risk remained (OR 3.28, 95% CI 1.00-10.50). CONCLUSION: Delayed diagnosis is common in Chinese children with IBD and is associated with persistent height impairment.
作者：
Pu Jiao;Zi-Rui Hao;Qian-Kun Sun;Long-Xiang Liu;Hang-Hua Xu;...
期刊：
核技术(英文版),2025年36(6):1-1 ISSN：1001-8042
通讯作者：
Gong-Tao Fan<&wdkj&>Chun-Wang Ma
作者机构：
[Yu-Ting Wang; Hui-Ling Wei] School of Physics, Centre for Theoretical Physics, Henan Normal University, Xinxiang, China;[Zi-Rui Hao; Long-Xiang Liu; Hang-Hua Xu; Yue Zhang] Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China;[Yao Fu] Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China;University of Chinese Academy of Science, Beijing, China;College of Physics, Centre for Theoretical Physics, Henan Normal University, Xinxiang, China
通讯机构：
[Gong-Tao Fan; Chun-Wang Ma] S;Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China<&wdkj&>Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China<&wdkj&>University of Chinese Academy of Science, Beijing, China<&wdkj&>School of Physics, Centre for Theoretical Physics, Henan Normal University, Xinxiang, China<&wdkj&>Institute of Nuclear Science and Technology, Henan Academy of Sciences, Zhengzhou, China
通讯机构：
[Dai, ZR ] U;[Han, S ] H;Hebei Univ Engn, Coll Mat Sci & Engn, Handan Key Lab Novel Nanobiomat, Handan 056000, Peoples R China.;Univ South China, Key Discipline Lab Natl Def Biotechnol Uranium Min, Hengyang 421001, Peoples R China.
摘要：
Photocatalytic removal of uranium is an efficient method for uranium removal. In this paper, a novel g-C 3 N 4 @C-PAN nanofiber membrane has been prepared by electrospinning and thermal polymerization from carbonized dicyandiamide and polyacrylonitrile fiber film, and it has been used for photocatalytic removal of U( VI ) under LED illumination. The experimental results show that the removal rate of U( VI ) by g-C 3 N 4 @C-PAN was nearly 100% in a wide concentration range of U( VI ) with great anti-interference performance. After 5 cycles, the removal rate of g-C 3 N 4 @C-PAN for uranium remains above 90%, showing excellent reusable performance. The mechanism studies show that the e − and ˙O 2 − play an important role in the photocatalytic removal of U( VI ), and they can react with U( VI ) to form (UO 2 )O 2 ·2H 2 O, thus realizing the fixation and removal of U( VI ). This work shows that the nanofiber membrane prepared by electrospinning technology has considerable application prospects for the photocatalytic treatment of uranium-containing wastewater.
摘要：
The multiple nuclides identification algorithm with low consumption and strong robustness is crucial for rapid radioactive source searching. This study investigates the design of a low-consumption multiple nuclides identification algorithm for portable gamma spectrometers. First, the gamma spectra of 12 target nuclides (including the background case) were measured to create training datasets. The characteristic energies, obtained through energy calibration and full-energy peak addresses, are utilized as input features for a neural network. A large number of single- and multiple-nuclide training datasets are generated using random combinations and small-range drifting. Subsequently, a multi-label classification neural network based on a binary cross-entropy loss function is applied to export the existence probability of certain nuclides. The designed algorithm effectively reduces the computation time and storage space required by the neural network and has been successfully implemented in a portable gamma spectrometer with a running time of
$$t_\text {r}<{2\,\textrm{s}}$$
. Results show that, in both validation and actual tests, the identification accuracy of the designed algorithm reaches 94.8%, for gamma spectra with a dose rate of
$$d\approx {0.5\,\mathrm{\upmu Sv/h}}$$
and a measurement time
$$t_\text {m}={60\,\textrm{s}}$$
. This improves the ability to perform rapid on-site nuclide identification at important sites.
摘要：
In recent years, the development of new types of nuclear reactors, such as transportable, marine, and space reactors, has presented new challenges for the optimization of reactor radiation-shielding design. Shielding structures typically need to be lightweight, miniaturized, and radiation-protected, which is a multi-parameter and multi-objective optimization problem. The conventional multi-objective (two or three objectives) optimization method for radiation-shielding design exhibits limitations for a number of optimization objectives and variable parameters, as well as a deficiency in achieving a global optimal solution, thereby failing to meet the requirements of shielding optimization for newly developed reactors. In this study, genetic and artificial bee-colony algorithms are combined with a reference-point-selection strategy and applied to the many-objective (having four or more objectives) optimal design of reactor radiation shielding. To validate the reliability of the methods, an optimization simulation is conducted on three-dimensional shielding structures and another complicated shielding-optimization problem. The numerical results demonstrate that the proposed algorithms outperform conventional shielding-design methods in terms of optimization performance, and they exhibit their reliability in practical engineering problems. The many-objective optimization algorithms developed in this study are proven to efficiently and consistently search for Pareto-front shielding schemes. Therefore, the algorithms proposed in this study offer novel insights into improving the shielding-design performance and shielding quality of new reactor types.
