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Nicotinamide mononucleotide ameliorates impaired testicular spermatogenesis in uranium-exposed mice by modulating glycolytic pathways.

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成果类型:
期刊论文
作者:
Wu, Hui;Huang, Bingsheng;Zhou, Ziyu;Lei, Xiaocan;Zhang, Yu;...
作者机构:
[Huang, Bingsheng; Wu, Hui; Wang, Junli] Department of Obstetrics and Gynecology, Affiliated Hospital of Youjiang Medical University for Nationalities, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Baise S33000, Guangxi, China
[Huang, Bingsheng; Wang, Junli] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Reproductive Medicine, Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
[Lei, Xiaocan; Zhang, Yu; She, Wendian; Peng, Qingwen; Zhu, Yueze; Zhou, Ziyu] Clinical Anatomy and Reproductive Medicine Application Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China
[Dong, Mingyou] Department of Reproductive Medicine, Affliated Hospital of Youjiang Medical University for Nationalities, Baise, S33000, China Guangxi
语种:
英文
关键词:
Uranium;apoptosis;glycolysis;spermatogenic disorders;testicular damage
期刊:
Toxicological Sciences
ISSN:
1096-6080
年:
2025
机构署名:
本校为其他机构
摘要:
Natural uranium is a ubiquitous element in the environment, and human exposure to low levels of uranium is unavoidable. Several concerns have recently been raised about the reproductive effects of chronic exposure to low levels of uranium. Therefore, the aim of this study was to investigate the protective effect of Nicotinamide mononucleotide(NMN) on uranium exposure-induced testicular sperm function in mice. To this end, a research model was established in which testicular damage and spermatogenic dysfunction were induced in adult male mice ...

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