作者机构：
[Zeng, Li; Song, Shenghua; Jia, Chiyu; Zeng, L; Jia, CY; Liao, Wanxing; Wang, Yiping; Chen, Nian; Wang, Yihao] Univ South China, Affiliated Hosp 1, Ctr Burn & Plast & Wound Healing Surg, Hengyang Med Sch, Hengyang, Peoples R China.;[Shen, Xu] First Peoples Hosp, Med Cosmetol Dept, Changde, Peoples R China.;[Song, Shenghua] Dongguan Tungwah Hosp, Burns & Plast Surg Dept, Dongguan, Peoples R China.
通讯机构：
[Zeng, L ; Jia, CY] U;Univ South China, Affiliated Hosp 1, Ctr Burn & Plast & Wound Healing Surg, Hengyang Med Sch, Hengyang, Peoples R China.
关键词：
ADSCs;exosomes;GSH;photoaging;ROS
摘要：
OBJECTIVE: Exosomes (Exos) from adipose derived stem cells (ADSCs) can delay skin photoaging, but their effects on reactive oxygen species (ROS) remains unclear. This study aimed to investigate the relationship between adipose derived stem cell exosomes (ADSCs-Exos) in anti-photoaging of skin and glutathione (GSH)/ ROS expression in human fibroblasts. METHODS: A skin photoaging model was established by irradiating human fibroblasts with ultraviolet B (UVB) light invitro. Next, exosomes from ADSCs were isolated for treating the photoaged fibroblasts. Afterwards, the alterations in photoaged fibroblasts were analyzed by a series of assays including senescence-associated β-galactosidase (SA-β-Gal) staining, p16 expression, ROS staining, and GSH content. RESULTS: After a human fibroblast photoaging model was subjected to ADSCs-Exos treatment, we found that the high concentration exosome group had the highest GSH content. Cellular staining showed that levels of SA-β-Gal, p16, and ROS of the high concentration-treated group were lower than other groups. CONCLUSIONS: ADSCs-Exos can protect skin fibroblasts from photoaging via increasing the ratio of GSH/ROS.
作者机构：
[He, Yueqi; Yang, Yufan; Xiao, Zhenghui; Lu, Xiulan; Huang, Jiaotian; Xiao, ZH] Univ South China, Hunan Childrens Hosp, Hengyang Med Sch, Sch Pediat,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.;[Yang, Yufan; Xiao, Zhenghui; Lu, Xiulan; Huang, Jiaotian; Xiao, ZH] Cent South Univ, Hunan Childrens Hosp, Affiliated Childrens Hosp, Xiangya Sch Med,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Xiao, ZH ] U;Univ South China, Hunan Childrens Hosp, Hengyang Med Sch, Sch Pediat,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.;Cent South Univ, Hunan Childrens Hosp, Affiliated Childrens Hosp, Xiangya Sch Med,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.
摘要：
Sepsis is a systemic syndrome characterized by widespread inflammatory responses induced by pathogenic microorganism invasion into the body, with increased susceptibility to major organs. Sepsis-induced cardiomyopathy is characterized by reversible myocardial depression or injury, primarily presenting as acute heart failure and/or arrhythmias triggered by sepsis. The mortality rate substantially increases when septic patients develop sepsis-induced cardiomyopathy. The cholinergic anti-inflammatory pathway (CAP) regulates inflammatory responses through the release of acetylcholine (ACh) via the vagus nerve and acts upon cx 7 nicotinic acetylcholine receptors (cx7nAChR) on immune cells to suppress pro-inflammatory sytokines synthesis. In this review, we provide a concise overview of the current understanding of the cx 7nAChR- mediated CAP in sepsis-induced cardiac injury, with a primary focus on cx 7nAChR involvement in immune regulation.
作者：
Yan, Yin;Derong, Tan;Qin, Tong;Zhi, Xu;Xia, Liu
期刊：
European Journal of Oncology Nursing,2025年76:102884 ISSN：1462-3889
通讯作者：
Yan, Y
作者机构：
[Yan, Yin; Xia, Liu; Qin, Tong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol Breast Lymphoma Subspecialty, Hengyang, Hunan, Peoples R China.;[Derong, Tan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol Abdominal Tumor Subspecialty, Hengyang, Hunan, Peoples R China.;[Zhi, Xu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol Head & Neck Pelv Tumor Subspecialty, Hengyang, Hunan, Peoples R China.;[Yan, Y] 69 Chuanshan Rd, Hengyang City, Hunan Province, Peoples R China.
通讯机构：
[Yan, Y ] 6;69 Chuanshan Rd, Hengyang City, Hunan Province, Peoples R China.
摘要：
Purpose The study aims to explore the factors influencing advance care planning among cancer patients, recognizing the importance of understanding these factors to enhance patient outcomes and ensure that patients' preferences are honored.
The study aims to explore the factors influencing advance care planning among cancer patients, recognizing the importance of understanding these factors to enhance patient outcomes and ensure that patients' preferences are honored.
Methods Conducted from May to November 2023, this qualitative descriptive study employed a phenomenological research approach. In-depth face-to-face interviews and observations were utilized to gather insights into the factors influencing participation in advance care planning, guided by a semi-structured interview outline based on social ecosystem theory. Content analysis and thematic analysis were applied to identify and interpret key themes from the data.
Conducted from May to November 2023, this qualitative descriptive study employed a phenomenological research approach. In-depth face-to-face interviews and observations were utilized to gather insights into the factors influencing participation in advance care planning, guided by a semi-structured interview outline based on social ecosystem theory. Content analysis and thematic analysis were applied to identify and interpret key themes from the data.
Results A total of 17 cancer patients participated in the interviews. The analysis revealed four main themes. Facilitating factors included optimistic health views and positive attitudes toward advance care planning, which encouraged engagement. Conversely, barriers such as a lack of understanding of advance care planning, misconceptions, and negative attitudes hindered participation. Family dynamics played a significant role; trust in family decisions facilitated discussions, while family pressure created challenges. Economic burdens and cultural taboos surrounding death, along with reliance on healthcare providers, impeded open conversations. These findings highlight the necessity for targeted strategies to enhance patient involvement in advance care planning.
A total of 17 cancer patients participated in the interviews. The analysis revealed four main themes. Facilitating factors included optimistic health views and positive attitudes toward advance care planning, which encouraged engagement. Conversely, barriers such as a lack of understanding of advance care planning, misconceptions, and negative attitudes hindered participation. Family dynamics played a significant role; trust in family decisions facilitated discussions, while family pressure created challenges. Economic burdens and cultural taboos surrounding death, along with reliance on healthcare providers, impeded open conversations. These findings highlight the necessity for targeted strategies to enhance patient involvement in advance care planning.
Conclusion Cancer patients' advance care planning is influenced by positive factors like optimistic health views and supportive family dynamics, as well as obstacles such as misconceptions, cultural taboos, and economic burdens. Targeted interventions are needed to empower patients and better align care with their values.
Cancer patients' advance care planning is influenced by positive factors like optimistic health views and supportive family dynamics, as well as obstacles such as misconceptions, cultural taboos, and economic burdens. Targeted interventions are needed to empower patients and better align care with their values.
摘要：
利用宇宙线缪子对物体成像需要确定缪子的径迹，而对缪子的击中点进行精确定位是缪子径迹重建的关键。当前主流的缪子径迹探测系统需要搭配多路电子学通道才能对缪子的击中点进行精确定位，此类探测系统的构造复杂且成本高昂。为实现简便、低成本且高精度的缪子径迹探测系统设计，本研究基于Geant4软件，对无切割式的方形和圆形塑料闪烁体耦合硅光电倍增器（Silicon Photonmultipliers，SiPMs）的探测器进行模拟研究，使用SiPM收集的光子数和触发SiPM响应的时间作为特征参数，采用人工智能回归算法作为缪子定位的方法。模拟结果表明：以光子数作为特征参数的回归算法中，长短时间记忆（Long Short Term Memory，LSTM）算法在三种回归算法中的精度最高；在LSTM算法下，探测器上表面耦合12个SiPM的位置分辨率可达到厘米级别；当使用光子数和触发时间作为特征参数时，在探测器侧边仅耦合6个SiPM的位置分辨率同样能达到厘米级别，且与大面积塑料闪烁体四角耦合光电倍增管（Photomultiplier Tube，PMT）的探测器在实验中对缪子定位得到的结果吻合。本研究使用LSTM回归算法作为缪子定位算法，提出的在塑料闪烁体侧边耦合6个SiPM的探测器系统结构简便、制造成本低且定位精度达到厘米级别。 您的浏览器不支持 audio 元素。 AI语音播报 Background Facilitating object imaging through the utilization of cosmic-ray muons mandates the precise delineation of muon trajectories, where the pinpoint localization of muon impact points assumes paramount importance for effective muon track reconstruction. Existing muon track detection systems necessitate the integration of multifaceted electronic channels to attain meticulous positioning of muon impact points. The construction of such detection systems is distinguished by its intricacy and entails substantial associated costs. Purpose This study aims to achieve a design for a muon track detection system that is characterized by simplicity, low cost, and high precision. Methods The Geant4 software was applied to the simulation of detectors comprising square and circular plastic scintillators coupled with silicon photon multipliers (SiPMs) without segmentation. The SiPMs was used to collect the number of photons and the time triggering SiPM responsed as characteristic parameters in the simulation, and a uncut square and circular plastic scintillator detector with an area of 200 mm × 200 mm was constructed, with a thickness of 10 mm. The surface was coated with a TiO 2 reflective coating with a thickness of 0.11 mm and a reflectivity of 95%. Then, three types of artificial intelligence regression algorithms, i.e., extreme gradient boosting (XGBoost), multilayer perceptron (MLP) and long short-term memory (LSTM), were employed as the method for muon localization. Results The simulation results demonstrate that LSTM algorithm achieves the highest accuracy among the three regression algorithms when photon number is considered as the characteristic parameter. Specifically, under the LSTM algorithm, the position resolution of a configuration comprising 12 SiPMs coupled to the upper surface of the detector can attain a resolution at the centimeter level. Furthermore, by employing photon number and trigger time as characteristic parameters, the position resolution of a setup involving only 6 SiPMs coupled to the side of the detector also reaches the centimeter level. Remarkably, these results align with the experimental findings obtained from a detector equipped with a photomultiplier tube (PMT) coupled to a large-area plastic scintillator. Conclusions This study employs the LSTM regression algorithm as the muon localization method, proposing a detector system structure for plastic scintillators with 6 SiPMs coupled to the side. The proposed structure is characterized by simplicity, low manufacturing cost, and achieves a positioning accuracy at the centimeter level.
摘要：
We present new data on the
$$^{63}$$
Cu(
$$\gamma$$
, n) cross-section studied using a quasi-monochromatic and energy-tunable
$$\gamma$$
beam produced at the Shanghai Laser Electron Gamma Source to resolve the long-standing discrepancy between existing measurements and evaluations of this cross-section. Using an unfolding iteration method,
$$^{63}$$
Cu(
$$\gamma$$
, n) data were obtained with an uncertainty of less than 4%, and the inconsistencies between the available experimental data were discussed. The
$$\gamma$$
-ray strength function of
$$^{63}$$
Cu(
$$\gamma$$
, n) was successfully extracted as an experimental constraint. We further calculated the cross-section of the radiative neutron capture reaction
$$^{62}$$
Cu(n,
$$\gamma$$
) using the TALYS code. Our calculation method enables the extraction of (n,
$$\gamma$$
) cross-sections for unstable nuclides.
期刊：
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,2025年37(6):683-690 ISSN：0954-691X
作者机构：
[Pan, Linghui; Yan, Fangran] Department of Anesthesiology, Guangxi Medical University Cancer Hospital;[Yan, Fangran; Du, Xueke] Department of Anesthesiology;[Zhou, Zenghua] Departments of Pain, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region;[He, Sheng] Department of Anesthesiology, The First Affiliated Hospital of Southern China University, Hengyang, Hunan Province;[Pan, Linghui] Guangxi Clinical Research Center for Anesthesiology
摘要：
Acute kidney injury (AKI) is associated with poor prognosis. New biomarkers, like neutrophil gelatinase-associated lipocalin (NGAL), are helpful for early warning of AKI. This study aims to investigate the accuracy of NGAL in evaluating the perioperative AKI of liver transplantation. The four databases, PubMed, Web of Science, Embase, and Cochrane Library, were searched for relevant studies published from database inception to August 2023. Results were pooled using random-effects models, and heterogeneity was examined. A total of 16 case-control studies with 1271 patients were included. The results showed that both preoperative [standardized mean difference (SMD) = 0.53; 95% confidence interval (CI): 0.15, 0.91; P < 0.001] and postoperative NGAL levels (SMD = 0.63; 95% CI: 0.24, 1.03; P < 0.001) were higher in the AKI group compared with the non-AKI group. Subgroup analysis by continents showed higher preoperative NGAL levels in AKI patients in the European population (SMD = 1.63; 95% CI: 0.55, 0.27; P = 0.003), but no differences in Asian, African, North American, and South American. Subgroup analysis by continents revealed higher postoperative NGAL levels in the European (SMD = 1.63; 95% CI: 0.55, 0.27; P = 0.002) and Asian populations (SMD = 0.42; 95% CI: 0.04, 0.81; P = 0.039). Higher postoperative NGAL levels in plasma and urine were observed in AKI patients compared with non-AKI patients [plasma (SMD = 1.29; 95% CI: 0.21, 2.38; P = 0.011), urine (SMD = 0.88; 95% CI: 0.18, 1.59; P = 0.035)], while there was no difference in African, North American, South American, and serum NGAL. NGAL level may be an important biomarker for early detection of AKI in the perioperative period of liver transplantation.
作者机构：
[Yan, Haipeng; Luo, Lan; Zeng, Xiaohui] Cent South Univ, Xiangya Sch Med, Hunan Childrens Hosp, Internat Inpatient Ward,Affiliated Childrens Hosp, Changsha, Peoples R China.;[Yan, Haipeng; Yang, Yufan; Lu, Xiulan; Luo, Lan; Xiao, Zhenghui; Zeng, Xiaohui; Li, Xiao] Cent South Univ, Xiangya Sch Med, Hunan Childrens Hosp, Hunan Prov Key Lab Emergency Med Children,Affiliat, Changsha, Peoples R China.;[Li, Xun; Wang, Xiangyu; Luo, Ting; Xie, Longlong] Cent South Univ, Affiliated Childrens Hosp Xiangya, Hunan Childrens Hosp, Pediat Res Inst Hunan Prov,Sch Med, Changsha, Peoples R China.;[Li, Xun; Wang, Xiangyu; Luo, Ting; Xie, Longlong] Cent South Univ, Affiliated Childrens Hosp Xiangya, Hunan Childrens Hosp, Pediat Intens Care Unit,Sch Med, Changsha, Peoples R China.;[Li, Xun; Wang, Xiangyu; Luo, Ting; Xie, Longlong] Cent South Univ, Affiliated Childrens Hosp Xiangya, Hunan Childrens Hosp, Hunan Prov Key Lab Emergency Med Children,Sch Med, Changsha, Peoples R China.
通讯机构：
[Lu, XL; Xiao, ZH ] C;Cent South Univ, Xiangya Sch Med, Hunan Childrens Hosp, Hunan Prov Key Lab Emergency Med Children,Affiliat, Changsha, Peoples R China.;Cent South Univ, Affiliated Childrens Hosp, Hunan Childrens Hosp, Pediat Intens Care Unit,Xiangya Sch Med, Changsha, Peoples R China.
关键词：
Epstein-Barr virus;Immune response;Immune dysregulation;Epstein-Barr virus DNA load
摘要：
BACKGROUND: This study investigated active Epstein-Barr virus (EBV) infection in children and examined the associations among EBV deoxyribonucleic acid (DNA) load, infection types, disease severity, and immune characteristics. METHODS: A total of 35,956 pediatric patients who underwent EBV DNA load testing were included. Patients were categorized based on their EBV DNA levels and infection status. RESULTS: Spearman's rank correlation analysis revealed a positive association between EBV DNA levels and the mortality rate, as well as the incidence rates of acute kidney injury (AKI), respiratory failure, cardiovascular complications, coagulation abnormalities, and liver injury. Mortality risk significantly increased when EBV DNA exceeded 1 × 10(5) copies/mL (adjusted odds ratio: 10.53, 95% confidence interval: 2.38-46.59, P < 0.05). As EBV DNA levels increase, the rise in mortality rate during activation- immunoglobulin G (IgG(+)) was more pronounced than that observed during primary infections. Gaussian mixture model clustering identified two immune clusters. Cluster 0 exhibited elevated pro-inflammatory indicators (IFN-γ, IL-6) and anti-inflammatory indicator (IL-10) levels, along with reduced immune cell counts. This cluster showed higher activation-IgG(+) and mortality rates compared with Cluster 1. CONCLUSIONS: An elevated EBV DNA load (> 1 × 10(5) copies/mL) in children is associated with increased mortality risk. High pro-inflammatory and anti-inflammatory states, coupled with low immune cell numbers, indicate critical condition. Simultaneous examinations of EBV DNA, antibodies, and immune status are recommended, especially for children with EBV DNA > 1 × 10(5) copies/mL, emphasizing the need for caution in those with activation-IgG(+) and immune dysregulation.
通讯机构：
[Zhang, S ; Chen, LW] A;[Chen, LW ] C;[Li, XX ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;Adv Energy Sci & Technol Guangdong Lab, Huizhou 516000, Peoples R China.
关键词：
Classical trajectory Monte Carlo;Heavy ion-water molecule collision;Inelastic cross sections
摘要：
Inelastic collisions are the dominant cause of energy loss in radiotherapy. In the energy range around the Bragg peak, single ionization (SI) and single-electron capture (SC) are the primary inelastic collisions that lead to energy loss. This study employs the classical trajectory Monte Carlo method to study the SI and SC processes of H
$$_{2}$$
O molecules using He
$$^{2+}$$
and C
$$^{6+}$$
projectiles in the energy range of 10 keV/u to 10 MeV/u. The total cross sections, single differential cross sections, impact parameter dependence of SI and SC, and fragmentation cross sections were investigated. Results illustrate that the cross section for SI is the highest when the projectile energy is close to the Bragg peak energy. When the projectile energy is below the Bragg peak energy, the ionized electrons in the forward direction dominate, and the removal of electrons can be associated with large impact parameters. As the projectile energy increases, the emission angle of the electrons gradually transitions from small angles (
$$0^{\circ} \sim 30^{\circ}$$
) to large angles (
$$60^{\circ} \sim 120^{\circ}$$
), and the removal of electrons is associated with small impact parameters. The energy distributions of the ionized electron are similar when the projectile energy is equal to, below or above the Bragg peak energy. The fragmentation cross sections after SI and SC in the energy range around the Bragg peak were also estimated.
作者机构：
[Guo, Yuan; Liu, Zhi; Chen, Zhu; Chen, Yajie; Guo, Y] Univ South China, Grad Collaborat Training Base Zhuzhou Cent Hosp, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[He, Yi; Guo, Yuan; Liu, Zhi; Chen, Yajie; Guo, Y] Cent South Univ, Xiangya Sch Med, Dept Cardiovasc Med, Zhuzhou Hosp, 116 South Changjiang Rd, Zhuzhou 412007, Hunan, Peoples R China.;[Wang, Li; Bai, Zhuojun; Wang, L; Chen, Xiang] Cent South Univ, Xiangya Sch Med, Dept Lab, Zhuzhou Hosp, 116 South Changjiang Rd, Zhuzhou 412007, Hunan, Peoples R China.
通讯机构：
[Wang, L ; He, Y] C;[Guo, Y ] U;Univ South China, Grad Collaborat Training Base Zhuzhou Cent Hosp, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Cent South Univ, Xiangya Sch Med, Dept Cardiovasc Med, Zhuzhou Hosp, 116 South Changjiang Rd, Zhuzhou 412007, Hunan, Peoples R China.;Cent South Univ, Xiangya Sch Med, Dept Lab, Zhuzhou Hosp, 116 South Changjiang Rd, Zhuzhou 412007, Hunan, Peoples R China.
摘要：
Pulmonary hypertension (PH) is a serious disease characterized by elevated pulmonary artery pressure, with its prevalence and incidence continuously increasing, posing a threat to the lives of many patients worldwide. Due to the complex etiology of PH and the lack of specificity in clinical manifestations, there is currently a lack of effective and specific methods for early diagnosis in clinical practice. Biosensors hold significant promise for the early detection, therapeutic monitoring, prognostic evaluation, and personalized treatment of PH, owing to their rapid, sensitive, and highly selective characteristics. The rapid development of various types of biosensors, such as electrochemical biosensors, optical biosensors, microfluidic biosensors, and wireless biosensors, combined with the use of nanomaterials, makes the rapid and accurate detection of PH-related biomarkers possible. Despite the broad application prospects of biosensors in the field of PH, challenges remain in terms of sensitivity, selectivity, stability, and regulation. This article reviews the main pathophysiological mechanisms and commonly used biomarkers of PH, the types and principles of biosensors, and summarizes the progress of biosensors in PH research as well as the current challenges, in order to promote further in-depth research and the development of biosensor technology, thereby improving the diagnosis and treatment effects of PH.
Clinical trial number: Not applicable.
摘要：
硼中子俘获治疗(Boron Neutron Capture Therapy,BNCT)是一种新兴的放射治疗技术，而呼吸运动是BNCT治疗肺癌影响剂量准确度的关键问题。为了量化呼吸运动对BNCT治疗肺癌的剂量学影响，采用蒙特卡罗模拟方法构建肺癌治疗中肿瘤及器官随呼吸运动时空变化的动态模型，并开展BNCT蒙特卡罗剂量计算。本文基于多功能数智化蒙特卡罗程序平台(Multi-function and Generalized Intelligent Code-bench based on Monte Carlo method, MagicMC)，结合描述呼吸运动的高阶余弦函数，建立动态剂量计算模型，采用MagicMC计算呼吸运动三维空间不同运动方向造成的肿瘤及器官剂量误差。结果表明：在一个呼吸周期中，三个运动方向上肿瘤均在50%时相剂量百分差异最大，左右方向(Lateral,LR)为0.310%，前后方向(Anterior-posterior,AP)为5.830%，头脚方向(Superior-inferior,SI)为-2.852%。健康组织器官距照射野距离越近，器官受照剂量率越高，LR方向心脏剂量百分差异最大为2.070%,AP、SI方向右肺剂量百分差异最大分别为4.128%、-11.962%。在BNCT治疗照射时间下，器官AP方向运动对肿瘤剂量影响最大，剂量误差为1.644%。对于健康组织器官，三个运动方向造成的剂量误差均不超过±4%。研究表明，BNCT治疗肺癌时器官呼吸运动会对肿瘤及健康器官所受剂量产生影响，计算结果可为BNCT治疗肺癌剂量精准计算与临床照射剂量修正提供参考。
作者机构：
[Hu, Guo-sheng] Fujian Normal Univ, Coll Life Sci, Biomed Res Ctr South China, Fuzhou, Peoples R China.;[Hu, Guo-sheng; Zheng, Zao-zao; He, Yao-hui; Wang, Du-chuang; Nie, Rui-chao; Liu, Wen] Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Hengyang, Hunan, Peoples R China.;[Hu, Guo-sheng; Zheng, Zao-zao; He, Yao-hui; Wang, Du-chuang; Nie, Rui-chao; Liu, Wen] Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Hengyang, Hunan, Peoples R China.;[Hu, Guo-sheng; Zheng, Zao-zao; He, Yao-hui; Wang, Du-chuang; Nie, Rui-chao; Liu, Wen] Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Xiang An Biomed Lab, Hengyang, Hunan, Peoples R China.;[He, Yao-hui] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang, Hunan, Peoples R China.
通讯机构：
[Liu, W ] U;Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Hengyang, Hunan, Peoples R China.;Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Hengyang, Hunan, Peoples R China.;Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Xiang An Biomed Lab, Hengyang, Hunan, Peoples R China.;Xiamen Univ, Natl Inst Data Sci Hlth & Med, Xiamen, Fujian, Peoples R China.
摘要：
Understanding dysregulated genes and pathways in cancer is critical for precision oncology. Integrating mass spectrometry–based proteomic data with transcriptomic data presents unique opportunities for systematic analyses of dysregulated genes and pathways in pan-cancer. Here, we compiled a comprehensive set of datasets, encompassing proteomic data from 2404 samples and transcriptomic data from 7752 samples across 13 cancer types. Comparisons between normal or adjacent normal tissues and tumor tissues identified several dysregulated pathways including mRNA splicing, interferon pathway, fatty acid metabolism, and complement coagulation cascade in pan-cancer. Additionally, pan-cancer upregulated and downregulated genes (PCUGs and PCDGs) were also identified. Notably, RRM2 and ADH1B, two genes which belong to PCUGs and PCDGs, respectively, were identified as robust pan-cancer diagnostic biomarkers. TNM stage-based comparisons revealed dysregulated genes and biological pathways involved in cancer progression, among which the dysregulation of complement coagulation cascade and epithelial-mesenchymal transition are frequent in multiple types of cancers. A group of pan-cancer continuously upregulated and downregulated proteins in different tumor stages (PCCUPs and PCCDPs) were identified. We further constructed prognostic risk stratification models for corresponding cancer types based on dysregulated genes, which effectively predict the prognosis for patients with these cancers. Drug prediction based on PCUGs and PCDGs as well as PCCUPs and PCCDPs revealed that small molecule inhibitors targeting CDK, HDAC, MEK, JAK, PI3K, and others might be effective treatments for pan-cancer, thereby supporting drug repurposing. We also developed web tools for cancer diagnosis, pathologic stage assessment, and risk evaluation. Overall, this study highlights the power of combining proteomic and transcriptomic data to identify valuable diagnostic and prognostic markers as well as drug targets and treatments for cancer.
Understanding dysregulated genes and pathways in cancer is critical for precision oncology. Integrating mass spectrometry–based proteomic data with transcriptomic data presents unique opportunities for systematic analyses of dysregulated genes and pathways in pan-cancer. Here, we compiled a comprehensive set of datasets, encompassing proteomic data from 2404 samples and transcriptomic data from 7752 samples across 13 cancer types. Comparisons between normal or adjacent normal tissues and tumor tissues identified several dysregulated pathways including mRNA splicing, interferon pathway, fatty acid metabolism, and complement coagulation cascade in pan-cancer. Additionally, pan-cancer upregulated and downregulated genes (PCUGs and PCDGs) were also identified. Notably, RRM2 and ADH1B, two genes which belong to PCUGs and PCDGs, respectively, were identified as robust pan-cancer diagnostic biomarkers. TNM stage-based comparisons revealed dysregulated genes and biological pathways involved in cancer progression, among which the dysregulation of complement coagulation cascade and epithelial-mesenchymal transition are frequent in multiple types of cancers. A group of pan-cancer continuously upregulated and downregulated proteins in different tumor stages (PCCUPs and PCCDPs) were identified. We further constructed prognostic risk stratification models for corresponding cancer types based on dysregulated genes, which effectively predict the prognosis for patients with these cancers. Drug prediction based on PCUGs and PCDGs as well as PCCUPs and PCCDPs revealed that small molecule inhibitors targeting CDK, HDAC, MEK, JAK, PI3K, and others might be effective treatments for pan-cancer, thereby supporting drug repurposing. We also developed web tools for cancer diagnosis, pathologic stage assessment, and risk evaluation. Overall, this study highlights the power of combining proteomic and transcriptomic data to identify valuable diagnostic and prognostic markers as well as drug targets and treatments for cancer.
摘要：
In this paper, we give six classes of permutation polynomials of the form $ (x^{2^m}+x+\delta)^s+ax $ over $ \mathbb{F}_{2^{2m}} $ and six classes of permutation polynomials of the form $ (x^{p^m}-x+\delta)^s+ax^{p^m}+a^{p^m}x $ over $ \mathbb{F}_{p^{2m}} $ ($ p $ being an odd prime), respectively. In addition, we also investigate permutation polynomials obtained from piecewise functions. Consequently, we find some complete permutation polynomials.
通讯机构：
[Li, LJ ] U;[Deng, ZH ] W;Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Orthopaed, Changsha 410004, Hunan, Peoples R China.;Wenzhou Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Wenzhou 325000, Zhejiang, Peoples R China.;Wenzhou Med Univ, Affiliated Hosp 1, Geriatr Ctr, Wenzhou 325000, Zhejiang, Peoples R China.
关键词：
chondrocyte;miR-6779;osteoarthritis;senescence;X-linked inhibitor of apoptosis protein
摘要：
BACKGROUND: Osteoarthritis (OA) is a long-term degenerative joint disease worsening over time. Aging and chondrocyte senescence contribute to OA progression. MicroRNAs have been confirmed to regulate different cellular processes. They contribute to OA pathology and may help to identify novel biomarkers and therapies for OA. METHODS: This study used bioinformatics and experimental investigations to analyze and validate differentially expressed miRNAs in OA that might affect chondrocyte apoptosis and senescence. RESULTS: miR-6779 was found to be significantly down-regulated in OA. Seventy-six of the predicted and miR-6779 targeted genes and the OA-associated disease genes overlapped, and these were enriched in cell proliferation, cell apoptosis, and cell cycle. miR-6779 overexpression remarkably attenuated IL-1β effects on chondrocytes by reducing MMP3 and MMP13 levels, promoting cell apoptosis, suppressing cell senescence, and increasing caspase-3, caspase-9 and reducing P16 and P21 levels. miR-6779 targeted inhibition of X-linked inhibitor of apoptosis protein (XIAP) expression. XIAP knockdown partially improved IL-1β-induced chondrocyte senescence and dysfunction. Lastly, when co-transfected with a miR-6779 agomir, the XIAP overexpression vector partially attenuated the effects of miR-6779 overexpression on chondrocytes; miR-6779 improved IL-1β-induced senescence and dysfunction in chondrocytes through targeting XIAP. CONCLUSION: miR-6779 is down-regulated, and XIAP is up-regulated in OA cartilage and IL-1β-treated chondrocytes. miR-6779 inhibits XIAP expression, thereby promoting senescent chondrocyte cell apoptosis and reducing chondrocyte senescence and ECM loss through XIAP.
作者机构：
[Dai, Miao; Yan, Jialong; Xu, Si; Xi, Hanqing; Ou, Guifang; Li, Xiaoxue; Xue, Wen; Chen, Guang; Tang, Yonghong; Wang, Jiwu; Liu, Xuelian] Clinical Research Institute, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China;[Dai, Miao; Xu, Si; Xi, Hanqing; Ou, Guifang; Tang, Yonghong] Department of Neurology, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China;[Li, Xiaoxue] Institute of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421002, China;[Luo, Si; Wei, Ping] Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
摘要：
This work delves into the mechanism enabling pH interference resistance in iron-based bimetallic oxides within the peroxymonosulfate (PMS) system. We employed MnFe₂O₄ spinel oxides as a catalyst for an in-depth comparison with monometallic analogs. We discovered that Fe(III) sites within the bimetallic oxide serve as sacrificial sites for hydroxyl ions as pH rises, stabilizing the cycling of active Mn sites. Elevated pH promotes the formation of surface hydroxyl groups, which enhance PMS and phenol adsorption via hydrogen bonding, thereby facilitating PMS activation by adjacent Mn sites and accelerating phenol degradation on the catalyst's surface. The cooperative effects of Fe(III) sacrifice and enhanced hydrogen bonding contribute significantly to the expanded pH tolerance of the iron-based bimetallic system, achieving nearly a 4.9-fold increase in kinetic efficiency at pH 6.2 relative to pH 3.2. This study deepens our understanding of sustainable Fenton-like systems and highlights their promising role in the degradation of pollutants.
This work delves into the mechanism enabling pH interference resistance in iron-based bimetallic oxides within the peroxymonosulfate (PMS) system. We employed MnFe₂O₄ spinel oxides as a catalyst for an in-depth comparison with monometallic analogs. We discovered that Fe(III) sites within the bimetallic oxide serve as sacrificial sites for hydroxyl ions as pH rises, stabilizing the cycling of active Mn sites. Elevated pH promotes the formation of surface hydroxyl groups, which enhance PMS and phenol adsorption via hydrogen bonding, thereby facilitating PMS activation by adjacent Mn sites and accelerating phenol degradation on the catalyst's surface. The cooperative effects of Fe(III) sacrifice and enhanced hydrogen bonding contribute significantly to the expanded pH tolerance of the iron-based bimetallic system, achieving nearly a 4.9-fold increase in kinetic efficiency at pH 6.2 relative to pH 3.2. This study deepens our understanding of sustainable Fenton-like systems and highlights their promising role in the degradation of pollutants.
作者机构：
[Lin, Wenbin; Jiang, Chunhua; Yang, Bo; Lin, WB] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Yang, Bo] Chinese Acad Sci, Purple Mt Observ, Nanjing 210023, Peoples R China.
通讯机构：
[Lin, WB ] U;Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.
关键词：
Black holes;Regular Simpson-Visser black-bounce spacetime;Periastron advance
摘要：
In this paper, we present the second post-Newtonian solution for the quasi-Keplerian motion of a test particle in the regular Simpson-Visser black-bounce spacetime which has a bounce parameter $a$. The obtained solution is formulated in terms of the orbital energy, angular momentum, and the bounce parameter of the black hole. We explicitly analyze the leading effects of the bounce parameter, which has dimensions of length, on the test particle's orbit, including the periastron advance and orbital period. Then, we apply this model to the precessing motion of OJ 287 and determine the upper limits of the dimensionless bounce parameter as $a/m =3.45\pm 0.01$, where $m$ is the mass of the regular black hole. Compared with the bound given by the periastron advance of star S2, our bound on $a/m$ is reduced by one order of magnitude, although our upper limit of $a$ still needs further improvement.
摘要：
Objective This systematic review and meta-analysis aimed to identify the main factors influencing the public’s willingness to participate in out-of-hospital emergency care.
This systematic review and meta-analysis aimed to identify the main factors influencing the public’s willingness to participate in out-of-hospital emergency care.
Methods Studies were searched in online databases, including PubMed, Embase, Web of Science, and the Cochrane Library. The articles included in this review were published from inception to July 31, 2024. The Iain Crombie assessment tool was used to assess study quality. Meta-analysis was performed using RevMan (version 5.4) software. The review protocol has been registered with PROSPERO (CRD42024570491).
Studies were searched in online databases, including PubMed, Embase, Web of Science, and the Cochrane Library. The articles included in this review were published from inception to July 31, 2024. The Iain Crombie assessment tool was used to assess study quality. Meta-analysis was performed using RevMan (version 5.4) software. The review protocol has been registered with PROSPERO (CRD42024570491).
Results A total of 1,434 research articles were initially identified, among which 18 were incorporated into this study, and all of the included studies were cross-sectional. Meta-analysis results demonstrated that gender (male; OR = 1.37, 95% CI : 1.28–1.47), profession (healthcare provider; OR = 0.17, 95% CI: 0.06–0.47), knowledge and skill level ( OR = 1.63, 95% CI: 1.25–2.11), willingness to undergo training ( OR = 2.68, 95% CI: 1.89–3.79), interest in first aid ( OR = 2.08, 95% CI: 1.60–2.69), previous training ( OR = 2.14, 95% CI: 1.49–3.08), and previous first-aid experience ( OR = 1.70, 95% CI: 1.37–2.11) were the principal influencing factors of the public’s willingness to engage in out-of-hospital cardiopulmonary resuscitation.
A total of 1,434 research articles were initially identified, among which 18 were incorporated into this study, and all of the included studies were cross-sectional. Meta-analysis results demonstrated that gender (male; OR = 1.37, 95% CI : 1.28–1.47), profession (healthcare provider; OR = 0.17, 95% CI: 0.06–0.47), knowledge and skill level ( OR = 1.63, 95% CI: 1.25–2.11), willingness to undergo training ( OR = 2.68, 95% CI: 1.89–3.79), interest in first aid ( OR = 2.08, 95% CI: 1.60–2.69), previous training ( OR = 2.14, 95% CI: 1.49–3.08), and previous first-aid experience ( OR = 1.70, 95% CI: 1.37–2.11) were the principal influencing factors of the public’s willingness to engage in out-of-hospital cardiopulmonary resuscitation.
Conclusion Demographic factors, knowledge, belief, and behavior are crucial in influencing public emergency decision-making. Medical personnel could create specialized training programs based on relevant factors to enhance the public's willingness to engage in out-of-hospital CPR.
Demographic factors, knowledge, belief, and behavior are crucial in influencing public emergency decision-making. Medical personnel could create specialized training programs based on relevant factors to enhance the public's willingness to engage in out-of-hospital CPR.
摘要：
Background The important effects of variability of some physiological/biological characteristics (such as LDL cholesterol, blood pressure) on cardiovascular outcomes have been elucidated, while the role of insulin variability is undefined.
The important effects of variability of some physiological/biological characteristics (such as LDL cholesterol, blood pressure) on cardiovascular outcomes have been elucidated, while the role of insulin variability is undefined.
Objectives To investigate the associations of long-term fasting insulin variability during young adulthood before the onset of diabetes with subsequent cardiovascular outcomes in middle age.
To investigate the associations of long-term fasting insulin variability during young adulthood before the onset of diabetes with subsequent cardiovascular outcomes in middle age.
Methods We included 3,983 CARDIA (Coronary Artery Risk Development Study in Young Adults) participants aged 18 to 30 years with at least three fasting insulin measurements. Intra-individual fasting insulin variability was defined by the average real variability (ARV) of insulin and standard deviation (SD) of insulin during 30-year follow-up. The presence and the degree of coronary artery calcification (CAC) were assessed by computed tomography at year 25. Incident cardiovascular disease (CVD) and all-cause mortality were adjudicated.
We included 3,983 CARDIA (Coronary Artery Risk Development Study in Young Adults) participants aged 18 to 30 years with at least three fasting insulin measurements. Intra-individual fasting insulin variability was defined by the average real variability (ARV) of insulin and standard deviation (SD) of insulin during 30-year follow-up. The presence and the degree of coronary artery calcification (CAC) were assessed by computed tomography at year 25. Incident cardiovascular disease (CVD) and all-cause mortality were adjudicated.
Results After multivariable adjustment, comparing high versus low tertile of insulin ARV, the hazard of CVD increased by 65 % (HR, 1.65; 95 % CI, 1.13–2.39) and all-cause mortality by 97 % (HR, 1.97; 95 % CI, 1.38–2.82). Higher tertile of insulin ARV was associated with significantly worse degree of CAC (β =0.1; 95 % CI, 0.03–0.18) but not with the presence of CAC ( P = 0.197). Similar results were also observed in insulin SD.
After multivariable adjustment, comparing high versus low tertile of insulin ARV, the hazard of CVD increased by 65 % (HR, 1.65; 95 % CI, 1.13–2.39) and all-cause mortality by 97 % (HR, 1.97; 95 % CI, 1.38–2.82). Higher tertile of insulin ARV was associated with significantly worse degree of CAC (β =0.1; 95 % CI, 0.03–0.18) but not with the presence of CAC ( P = 0.197). Similar results were also observed in insulin SD.
Conclusion High long-term insulin variability in young adulthood before the onset of diabetes was associated with an increased risk of CVD and all-cause mortality in later life, independent of average FG, HOMA-IR and other established cardiovascular risk factors. Long-term insulin variability was associated with the degree but not the presence of CAC.
High long-term insulin variability in young adulthood before the onset of diabetes was associated with an increased risk of CVD and all-cause mortality in later life, independent of average FG, HOMA-IR and other established cardiovascular risk factors. Long-term insulin variability was associated with the degree but not the presence of CAC.
作者机构：
[Lin, Wenbin; Lin, WB] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Lin, Wenbin; Lin, WB] Southwest Jiaotong Univ, Sch Phys Sci & Technol, Chengdu 610031, Peoples R China.
通讯机构：
[Lin, WB ] U;Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;Southwest Jiaotong Univ, Sch Phys Sci & Technol, Chengdu 610031, Peoples R China.
关键词：
post-Newtonian approximation;gravitomagnetic field;second gravitational potential;spherically-symmetric system
摘要：
We prove that the post-Newtonian time-dependent metric of the self-gravitating and collapsing infinitely-thin spherical shell does satisfy Einstein field equations to the corresponding order. Meanwhile, the leading-order components of the thin spherical shell's energy-momentum tensor are recovered.
