Integrated Analysis of Proteome and Transcriptome Profiling Reveals Pan-Cancer-Associated Pathways and Molecular Biomarkers

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成果类型：

期刊论文

作者：

Hu, Guo-sheng;Zheng, Zao-zao;He, Yao-hui;Wang, Du-chuang;Nie, Rui-chao;...

通讯作者：

Liu, W

作者机构：

[Hu, Guo-sheng] Fujian Normal Univ, Coll Life Sci, Biomed Res Ctr South China, Fuzhou, Peoples R China.

[Hu, Guo-sheng; Zheng, Zao-zao; He, Yao-hui; Wang, Du-chuang; Nie, Rui-chao; Liu, Wen] Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Hengyang, Hunan, Peoples R China.

[Hu, Guo-sheng; Zheng, Zao-zao; He, Yao-hui; Wang, Du-chuang; Nie, Rui-chao; Liu, Wen] Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Hengyang, Hunan, Peoples R China.

[Hu, Guo-sheng; Zheng, Zao-zao; He, Yao-hui; Wang, Du-chuang; Nie, Rui-chao; Liu, Wen] Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Xiang An Biomed Lab, Hengyang, Hunan, Peoples R China.

[He, Yao-hui] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang, Hunan, Peoples R China.

通讯机构：

[Liu, W ] U

Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Hengyang, Hunan, Peoples R China.

Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Hengyang, Hunan, Peoples R China.

Univ South China, Fac Med & Life Sci, Sch Pharmaceut Sci, Xiang An Biomed Lab, Hengyang, Hunan, Peoples R China.

Xiamen Univ, Natl Inst Data Sci Hlth & Med, Xiamen, Fujian, Peoples R China.

语种：

英文

关键词：

Diagnostic marker;Drug targets;Pan-cancer;Prognostic marker;Proteomics;Transcriptomics

期刊：

Molecular & Cellular Proteomics

ISSN：

1535-9476

年：

2025

卷：

期：

页码：

100919

DOI：

10.1016/j.mcpro.2025.100919

基金类别：

China Postdoctoral Science Foundation#&#&#2022M712661 National Natural Science Foundation of China#&#&#82203476#&#&#82125028#&#&#91953114#&#&#82303108#&#&#U22A20320#&#&#31871319 Key Technologies Research and Development Program#&#&#2020YFA0803600#&#&#2020YFA0112300 National Key Research and Development Program of China Science, Technology and Innovation Commission of Shenzhen Municipality Shenzhen Science and Technology Innovation Program#&#&#JCYJ20230807091159001

机构署名：

本校为通讯机构

摘要：

Understanding dysregulated genes and pathways in cancer is critical for precision oncology. Integrating mass spectrometry–based proteomic data with transcriptomic data presents unique opportunities for systematic analyses of dysregulated genes and pathways in pan-cancer. Here, we compiled a comprehensive set of datasets, encompassing proteomic data from 2404 samples and transcriptomic data from 7752 samples across 13 cancer types. Comparisons between normal or adjacent normal tissues and tumor tissues identified several dysregulated pathways i...

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Integrated Analysis of Proteome and Transcriptome Profiling Reveals Pan-Cancer-Associated Pathways and Molecular Biomarkers

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