作者机构：
School of Hydraulic and Ocean Engineering, Changsha University of Science & Technology, Changsha 410114, China;Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province, Changsha 410114, China;[Yanxiao Wei] RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan;[Jianhong Jiang; Qingchang Tang] China Machinery International Engineering Design & Research Institute Co., Ltd., Changsha 410007, China;[Xinying Kong] School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China
通讯机构：
[Hong Chen] S;School of Hydraulic and Ocean Engineering, Changsha University of Science & Technology, Changsha 410114, China<&wdkj&>Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province, Changsha 410114, China
摘要：
To explore the adaptive mechanisms of the partial nitritation-anammox (PNA) process under high salinity stress during kitchen wastewater treatment, focusing on their physiological and molecular responses through metagenomic analysis. An airlift inner-circulation partition bioreactor (AIPBR) was developed, featuring an inner cylinder and a flow guide tube to create distinct oxygen gradients, facilitating the study of microbial adaptation under varying salt conditions. The AIPBR was operated with synthetic wastewater containing ammonium concentrations of 1800 ± 100 mg/L and salinity gradients ranging from 1 to 10 g/L, followed by a fixed salinity period at 6 g/L, with ammonium concentrations approximately 850 mg/L. High-throughput metagenomic analysis revealed shifts in functional genes and metabolic pathways in response to salinity stress. Anammox bacteria adapted by enriching genes involved in the synthesis of osmoprotective compounds and activating energy-producing pathways like the tricarboxylic acid cycle (TCA). These adaptations, along with modifications in membrane composition, were essential for sustaining system stability under elevated salinity. Under prolonged high salinity stress, anaerobic ammonium oxidizing (AnAOB) exhibited improved salt tolerance, maintaining a total nitrogen removal efficiency above 85 % and stabilizing after an adaptation phase. The metagenomic data revealed a marked enrichment of genes associated with ion transport, stress response mechanisms, and DNA repair pathways. Changes in microbial community composition favored salt-tolerant species, supporting system stability. These findings highlight the applicability of the developed bioreactor for scaling up the PNA process to handle high-salinity wastewater, providing a promising avenue for sustainable nitrogen removal in challenging environments.
To explore the adaptive mechanisms of the partial nitritation-anammox (PNA) process under high salinity stress during kitchen wastewater treatment, focusing on their physiological and molecular responses through metagenomic analysis. An airlift inner-circulation partition bioreactor (AIPBR) was developed, featuring an inner cylinder and a flow guide tube to create distinct oxygen gradients, facilitating the study of microbial adaptation under varying salt conditions. The AIPBR was operated with synthetic wastewater containing ammonium concentrations of 1800 ± 100 mg/L and salinity gradients ranging from 1 to 10 g/L, followed by a fixed salinity period at 6 g/L, with ammonium concentrations approximately 850 mg/L. High-throughput metagenomic analysis revealed shifts in functional genes and metabolic pathways in response to salinity stress. Anammox bacteria adapted by enriching genes involved in the synthesis of osmoprotective compounds and activating energy-producing pathways like the tricarboxylic acid cycle (TCA). These adaptations, along with modifications in membrane composition, were essential for sustaining system stability under elevated salinity. Under prolonged high salinity stress, anaerobic ammonium oxidizing (AnAOB) exhibited improved salt tolerance, maintaining a total nitrogen removal efficiency above 85 % and stabilizing after an adaptation phase. The metagenomic data revealed a marked enrichment of genes associated with ion transport, stress response mechanisms, and DNA repair pathways. Changes in microbial community composition favored salt-tolerant species, supporting system stability. These findings highlight the applicability of the developed bioreactor for scaling up the PNA process to handle high-salinity wastewater, providing a promising avenue for sustainable nitrogen removal in challenging environments.
作者：
Hongjuan Liu;Chang Zhao;Shuibo Xie;Huaming Yang
期刊：
Chemical Engineering Science,2026年320:122625 ISSN：0009-2509
通讯作者：
Hongjuan Liu<&wdkj&>Huaming Yang
作者机构：
[Hongjuan Liu; Chang Zhao] School of Nuclear Science and Technology, University of South China, Hengyang 421001, China;[Huaming Yang] Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan 430074, China;[Shuibo Xie] Hunan Province Key Laboratory of Pollution Control and Resources Reuse Technology, University of South China, Hengyang 421001, China
通讯机构：
[Hongjuan Liu] S;[Huaming Yang] E;Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan 430074, China<&wdkj&>School of Nuclear Science and Technology, University of South China, Hengyang 421001, China
摘要：
The development of nuclear science and technology has generated plentiful radioactive waste, which has posed serious threat to human beings and the environment due to radioactivity and toxicity of radionuclides. Therefore, the reduction and elimination of radioactive contaminants is an urgent task. Clay mineral used for the treatment of radionuclides pollution have attracted widespread interest due to its rich reserves, low cost, and excellent cation exchange capacity, etc. In this review, the structure characteristics of clay mineral were introduced. Modification strategies such as acid- or alkaline-activation, heat treatment, pillaring, exfoliation, surface modification for enhancing adsorption performance of clay mineral were presented. These modification strategies can increase their pore size, pore volume and specific surface area, expose more adsorption sites, turn natural clay mineral into nano-clay mineral, or introduce functional groups, thereby improving the adsorption ability for radionuclides. Moreover, various clay minerals including kaolinite, halloysite, palygorskite, illite, sepiolite, montmorillonite and bentonite as adsorbents for application in radioactive waste treatment were discussed. The interaction mechanisms between clay minerals and radionuclides were elaborated. The challenges and prospects of clay mineral-based materials in the treatment of radioactive pollution were pointed out. This review provides valuable inspiration for designing novel and high-performance clay mineral-based adsorbents for the application of nuclear waste treatment.
The development of nuclear science and technology has generated plentiful radioactive waste, which has posed serious threat to human beings and the environment due to radioactivity and toxicity of radionuclides. Therefore, the reduction and elimination of radioactive contaminants is an urgent task. Clay mineral used for the treatment of radionuclides pollution have attracted widespread interest due to its rich reserves, low cost, and excellent cation exchange capacity, etc. In this review, the structure characteristics of clay mineral were introduced. Modification strategies such as acid- or alkaline-activation, heat treatment, pillaring, exfoliation, surface modification for enhancing adsorption performance of clay mineral were presented. These modification strategies can increase their pore size, pore volume and specific surface area, expose more adsorption sites, turn natural clay mineral into nano-clay mineral, or introduce functional groups, thereby improving the adsorption ability for radionuclides. Moreover, various clay minerals including kaolinite, halloysite, palygorskite, illite, sepiolite, montmorillonite and bentonite as adsorbents for application in radioactive waste treatment were discussed. The interaction mechanisms between clay minerals and radionuclides were elaborated. The challenges and prospects of clay mineral-based materials in the treatment of radioactive pollution were pointed out. This review provides valuable inspiration for designing novel and high-performance clay mineral-based adsorbents for the application of nuclear waste treatment.
摘要：
High-concentration erbium-doped WSe 2 monolayer (7.2 at%) is synthesized via in-situ CVD, enabling electric-field-tunable photoluminescence (PL) with enhanced quantum efficiency. Structural characterization results verify the homogeneous incorporation of Er 3+ into the host WSe 2 , while gate-controlled devices reveal bidirectional modulation of up/down-conversion PL. The material exhibits broadband emission from UV to visible and near-infrared under 980 nm excitation, and a distinct 780 nm visible peak under 532 nm excitation. Vertical electric fields suppress PL under positive bias but boost up-conversion efficiency under negative bias. Through first-principles calculations, this is attributed to field-induced bandgap narrowing and enhanced electron-hole symmetry. These factors together promote radiative recombination. Power-dependent PL confirms stable exciton/trion emission, supporting high-power applications. This synergy of rare-earth doping and field engineering advances tunable optoelectronics, including adaptive photodetectors, bioimaging, and energy-efficient cooling systems.
High-concentration erbium-doped WSe 2 monolayer (7.2 at%) is synthesized via in-situ CVD, enabling electric-field-tunable photoluminescence (PL) with enhanced quantum efficiency. Structural characterization results verify the homogeneous incorporation of Er 3+ into the host WSe 2 , while gate-controlled devices reveal bidirectional modulation of up/down-conversion PL. The material exhibits broadband emission from UV to visible and near-infrared under 980 nm excitation, and a distinct 780 nm visible peak under 532 nm excitation. Vertical electric fields suppress PL under positive bias but boost up-conversion efficiency under negative bias. Through first-principles calculations, this is attributed to field-induced bandgap narrowing and enhanced electron-hole symmetry. These factors together promote radiative recombination. Power-dependent PL confirms stable exciton/trion emission, supporting high-power applications. This synergy of rare-earth doping and field engineering advances tunable optoelectronics, including adaptive photodetectors, bioimaging, and energy-efficient cooling systems.
作者机构：
[Liu, Ming-Xuan] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: mingxuanliu@ntu.edu.cn;[Zhou, Meng-Zhu; Tao, Yi-Tong; Wu, Wei; Zhang, Su-Yun; Zhu, Ya-Qi; Yang, Yue] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China;[Liu, Yong-Hong] School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225001, Jiangsu, PR China;[Yang, Yuan] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address: 2023010013@usc.edu.cn;[Zhang, Xiao-Ling] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: Zhangxiaoling@ntu.edu.cn
通讯机构：
[Yang, Yuan] D;[Zhang, Xiao-Ling; Liu, Ming-Xuan] S;School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address:;Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address:
摘要：
Hepatic fibrosis impacts millions of patients globally suffering from various liver diseases. Therefore, development of novel therapeutic strategies is urgently required. Since macrophage recruitment increases during liver fibrosis progression, macrophage membrane-coated biomimetic complexes can be designed for targeted anti-liver fibrosis therapy. In this study, a biomimetic “gas-gene” strategy was proposed to enhance anti-liver fibrosis efficacy. A macrophage membrane-coated carbon nitride-based biomimetic delivery platform loaded with DNA nanoparticles (M-PEISeCCNs@DNA) was developed. The macrophage membrane coating facilitated the delivery of M-PEISeCCNs@SBP1 to the liver fibrosis site and reversed the positive charge of the carriers to avoid cation-induced cytotoxicity. Under near-infrared (NIR) irradiation, M-PEISeCCNs@SBP1 could trigger water splitting to produce O 2 , thereby mitigating hypoxia and alleviating liver fibrosis. The light-responsive release of the SBP1-DNA plasmid was also achieved through carrier photolysis. The delivered SBP1-DNA and the Se element within the vectors synergistically upregulated the expression of selenium-binding protein-1 (SBP1). Additionally, we demonstrated for the first time that SBP1 is an effective therapeutic target for liver fibrosis, and its overexpression inhibits epithelial-mesenchymal transition (EMT) and attenuates CCl 4 -induced liver fibrosis in mice. In this experiment, M-PEISeCCNs@SBP1 effectively treated liver fibrosis in mice through the SBP1-mediated NOTCH2/Wnt pathway.
Hepatic fibrosis impacts millions of patients globally suffering from various liver diseases. Therefore, development of novel therapeutic strategies is urgently required. Since macrophage recruitment increases during liver fibrosis progression, macrophage membrane-coated biomimetic complexes can be designed for targeted anti-liver fibrosis therapy. In this study, a biomimetic “gas-gene” strategy was proposed to enhance anti-liver fibrosis efficacy. A macrophage membrane-coated carbon nitride-based biomimetic delivery platform loaded with DNA nanoparticles (M-PEISeCCNs@DNA) was developed. The macrophage membrane coating facilitated the delivery of M-PEISeCCNs@SBP1 to the liver fibrosis site and reversed the positive charge of the carriers to avoid cation-induced cytotoxicity. Under near-infrared (NIR) irradiation, M-PEISeCCNs@SBP1 could trigger water splitting to produce O 2 , thereby mitigating hypoxia and alleviating liver fibrosis. The light-responsive release of the SBP1-DNA plasmid was also achieved through carrier photolysis. The delivered SBP1-DNA and the Se element within the vectors synergistically upregulated the expression of selenium-binding protein-1 (SBP1). Additionally, we demonstrated for the first time that SBP1 is an effective therapeutic target for liver fibrosis, and its overexpression inhibits epithelial-mesenchymal transition (EMT) and attenuates CCl 4 -induced liver fibrosis in mice. In this experiment, M-PEISeCCNs@SBP1 effectively treated liver fibrosis in mice through the SBP1-mediated NOTCH2/Wnt pathway.
期刊：
Progress in Nuclear Energy,2026年191:106098 ISSN：0149-1970
通讯作者：
Tao Yu<&wdkj&>Zhenping Chen
作者机构：
School of Nuclear Science and Technology, University of South China, Hengyang, Hunan, 421001, China;Key Lab of Advanced Nuclear Energy Design and Safety, Ministry of Education, University of South China, Hengyang, Hunan, 421000, China;[Hongyue Zhang] Science and Technology on Reactor System Design Technology Laboratory, Nuclear Power Institute of China, Chengdu, 610200, China;[Chengwei Liu; Aikou Sun; Chao Yang; Tao Yu; Zhenping Chen] School of Nuclear Science and Technology, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Lab of Advanced Nuclear Energy Design and Safety, Ministry of Education, University of South China, Hengyang, Hunan, 421000, China
通讯机构：
[Tao Yu; Zhenping Chen] S;School of Nuclear Science and Technology, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Lab of Advanced Nuclear Energy Design and Safety, Ministry of Education, University of South China, Hengyang, Hunan, 421000, China
摘要：
Small Modular Reactors (SMRs) are widely used to supply energy in special scenarios such as remote mountainous areas, oceanic scientific expeditions, and space exploration due to their flexible installation characteristics. A critical challenge to address is designing a miniaturized, lightweight radiation shielding system that ensures dual-stage radiation safety during both reactor operation and shutdown, allowing nuclear devices to adapt to a variety of complex environments. To address these challenges, this paper proposes a dual-stage radiation-shielding optimization design (DROD) method. DROD integrates evolutionary algorithms with the Monte Carlo method under massive parallelism to optimize radiation-shielding designs for both reactor operation and shutdown stage. Additionally, a multi-objective evolutionary algorithm based on hypervolume guidance and reference-point association (HV-RP-MOEA) is proposed as a solution to the expensive constrained multi-objective optimization problem in radiation shielding. The performance of HV-RP-MOEA was verified through multi-objective test problems, demonstrating its fast convergence and multi-objective optimization capabilities. Furthermore, DROD was applied to optimize the radiation-shielding design of the small pressurized water reactor KLT-40. The results indicate that DROD can efficiently explore a wide range of shielding solutions, outperforming conventional multi-objective radiation-shielding optimization methods in terms of both depth and breadth of optimization. This work provides new insights into the optimization design of radiation-shielding.
Small Modular Reactors (SMRs) are widely used to supply energy in special scenarios such as remote mountainous areas, oceanic scientific expeditions, and space exploration due to their flexible installation characteristics. A critical challenge to address is designing a miniaturized, lightweight radiation shielding system that ensures dual-stage radiation safety during both reactor operation and shutdown, allowing nuclear devices to adapt to a variety of complex environments. To address these challenges, this paper proposes a dual-stage radiation-shielding optimization design (DROD) method. DROD integrates evolutionary algorithms with the Monte Carlo method under massive parallelism to optimize radiation-shielding designs for both reactor operation and shutdown stage. Additionally, a multi-objective evolutionary algorithm based on hypervolume guidance and reference-point association (HV-RP-MOEA) is proposed as a solution to the expensive constrained multi-objective optimization problem in radiation shielding. The performance of HV-RP-MOEA was verified through multi-objective test problems, demonstrating its fast convergence and multi-objective optimization capabilities. Furthermore, DROD was applied to optimize the radiation-shielding design of the small pressurized water reactor KLT-40. The results indicate that DROD can efficiently explore a wide range of shielding solutions, outperforming conventional multi-objective radiation-shielding optimization methods in terms of both depth and breadth of optimization. This work provides new insights into the optimization design of radiation-shielding.
作者机构：
[Yuan Yi] University of South China, School of Resource Environment and Safety Engineering, 28 Changsheng West Road, Hengyang, Hunan, 421001, PR China;[Akira Nakayama] Faculty of Engineering, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu, 432-8561, Japan
通讯机构：
[Akira Nakayama] F;Faculty of Engineering, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu, 432-8561, Japan
摘要：
A three-energy-equation model for individual phases in porous media was developed to analyze forced convective heat transfer in a solar volumetric receiver composed of dual-structured porous media. The model comprises three energy equations: one for air and two for heat conduction in the small- and large-scale solid structures. These equations were fully coupled to derive exact analytical solutions for the axial temperature distributions within the volumetric receiver. The model was used to investigate the influence of key parameters, such as the volume fraction of the filler (small rods), the diameter ratio of small to large rods, and the thermal conductivity ratio of solids for dual-structured porous media consisting of large and small rod bundles. Results showed that increasing the filler fraction or decreasing the diameter ratio (e.g., from 1.0 to 0.25) significantly reduced the thermal entrance length, promoting faster thermal equilibrium among the phases. The thermal conductivity ratio primarily influenced the temperature of the small rods, with minimal effect on entrance length. While receiver efficiency was found to be relatively insensitive to geometric parameters, it was highly dependent on mass flux, especially in the low range. A practical approximate formula was developed to estimate the threshold mass flux, providing a guideline for optimizing the receiver's operational performance.
A three-energy-equation model for individual phases in porous media was developed to analyze forced convective heat transfer in a solar volumetric receiver composed of dual-structured porous media. The model comprises three energy equations: one for air and two for heat conduction in the small- and large-scale solid structures. These equations were fully coupled to derive exact analytical solutions for the axial temperature distributions within the volumetric receiver. The model was used to investigate the influence of key parameters, such as the volume fraction of the filler (small rods), the diameter ratio of small to large rods, and the thermal conductivity ratio of solids for dual-structured porous media consisting of large and small rod bundles. Results showed that increasing the filler fraction or decreasing the diameter ratio (e.g., from 1.0 to 0.25) significantly reduced the thermal entrance length, promoting faster thermal equilibrium among the phases. The thermal conductivity ratio primarily influenced the temperature of the small rods, with minimal effect on entrance length. While receiver efficiency was found to be relatively insensitive to geometric parameters, it was highly dependent on mass flux, especially in the low range. A practical approximate formula was developed to estimate the threshold mass flux, providing a guideline for optimizing the receiver's operational performance.
作者机构：
[Wei, Yanhong] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address: 2514138998@qq.com;[Huang, Qiumei] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address: 17877325360@163.com;[Fu, Zhenhui] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address: fuzhenhui10@163.com;[Wang, Rutong] Institute of Clinical Anatomy & Reproductive Medicine Department of Histology and Embryology Hengyang Medical School University of South China Hengyang, Hunan 421001, China. Electronic address: 18754723679@163.com;[Zhou, Runtang] Institute of Clinical Anatomy & Reproductive Medicine Department of Histology and Embryology Hengyang Medical School University of South China Hengyang, Hunan 421001, China. Electronic address: 2662580138@qq.com
通讯机构：
[Huang, Qiumei; Hu, Linlin; Fu, Zhenhui; Wei, Yanhong] K;[Wang, Rutong; Lei, Xiaocan; Zhou, Runtang] I;[Le, Jianghua] D;Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address:;Institute of Clinical Anatomy & Reproductive Medicine Department of Histology and Embryology Hengyang Medical School University of South China Hengyang, Hunan 421001, China. Electronic address:
关键词：
Gut microbiome;Male infertility;Metabolomics;Network pharmacology;Obesity;Pyrroloquinoline quinone
摘要：
This study employed an obese mouse model to investigate the effects of pyrroloquinoline quinone (PQQ) intervention on reproductive physiology and glycolytic pathways. Our findings demonstrate that PQQ markedly enhanced glycolytic activity in obese mice, promoting glucose breakdown and metabolism to improve energy supply efficiency. These metabolic improvements correlated with significant support for reproductive system functionality. Mechanistic analyses revealed PQQ's potential to augment mitochondrial respiration, ameliorate mitochondrial dysfunction, and counteract obesity-associated inflammation, thereby preserving the balance between fatty acid degradation and integrated glycolysis-cholesterol metabolism. Collectively, this work provides novel insights into PQQ's molecular mechanisms for promoting glycolysis and ameliorating infertility in obese males.
This study employed an obese mouse model to investigate the effects of pyrroloquinoline quinone (PQQ) intervention on reproductive physiology and glycolytic pathways. Our findings demonstrate that PQQ markedly enhanced glycolytic activity in obese mice, promoting glucose breakdown and metabolism to improve energy supply efficiency. These metabolic improvements correlated with significant support for reproductive system functionality. Mechanistic analyses revealed PQQ's potential to augment mitochondrial respiration, ameliorate mitochondrial dysfunction, and counteract obesity-associated inflammation, thereby preserving the balance between fatty acid degradation and integrated glycolysis-cholesterol metabolism. Collectively, this work provides novel insights into PQQ's molecular mechanisms for promoting glycolysis and ameliorating infertility in obese males.
作者机构：
[Zhang, Yu; Han, Peigang; Shi, Tingshu; Liu, Zhixin; Wang, Junyu; Tang, Zeguo; Zheng, Xiaojian; Xu, Guoqiang; Khan, Danish; Lu, Di; Tang, Jun] Shenzhen Technol Univ, Coll New Mat & New Energies, Lantian Rd 3002, Shenzhen 518118, Peoples R China.;[Yan, Lei; Wang, Xingzhu; Zheng, Xiaojian; Xu, Guoqiang] Univ South China, Engn & Res Ctr Integrated New Energy Photovolta &, Hengyang 421001, Peoples R China.;[Yan, Lei; Wang, Xingzhu; Zheng, Xiaojian; Xu, Guoqiang] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.;[Ahmed, Shehzad] Shanghai Jiao Tong Univ, China UK Low Carbon Coll, Shanghai 201306, Peoples R China.;[Chen, Wei] Shenzhen Technol Univ, Coll Engn Phys, Shenzhen 518118, Guangdong, Peoples R China.
通讯机构：
[Liu, ZX; Khan, D; Tang, ZG ] S;[Wang, XZ ] U;Shenzhen Technol Univ, Coll New Mat & New Energies, Lantian Rd 3002, Shenzhen 518118, Peoples R China.;Univ South China, Engn & Res Ctr Integrated New Energy Photovolta &, Hengyang 421001, Peoples R China.;Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.
关键词：
3D/2D perovskite films;Benzamidine;Amorphous passivation;2D passivation;Inverted perovskite solar cells
摘要：
The introduction of two-dimensional (2D) perovskite layers on top of three-dimensional (3D) perovskite films enhances the performance and stability of perovskite solar cells (PSCs). However, the electronic effect of the spacer cation and the quality of the 2D capping layer are critical factors in achieving the required results. In this study, we compared two fluorinated salts: 4-(trifluoromethyl) benzamidine hydrochloride (4TF-BA<middle dot>HCl) and 4-fluorobenzamidine hydrochloride (4F-BA<middle dot>HCl) to engineer the 3D/2D perovskite films. Surprisingly, 4F-BA formed a high-performance 3D/2D heterojunction, while 4TF-BA produced an amorphous layer on the perovskite films. Our findings indicate that the balanced intramolecular charge polarization, which leads to effective hydrogen bonding, is more favorable in 4F-BA than in 4TF-BA, promoting the formation of a crystalline 2D perovskite. Nevertheless, 4TF-BA managed to improve efficiency to 24%, surpassing the control device, primarily due to the natural passivation capabilities of benzamidine. Interestingly, the devices based on 4F-BA demonstrated an efficiency exceeding 25% with greater longevity under various storage conditions compared to 4TF-BA-based and the control devices.
摘要：
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
摘要：
Objective This study aimed to integrate network pharmacology, bioinformatics analysis, molecular docking, and experimental validation to construct a “component–target–pathway” multidimensional network model, systematically elucidate the potential mechanisms underlying the therapeutic effects of the extract of Potentilla freyniana Bornm. (PFB) on hepatocellular carcinoma (HCC), and thereby clarify its pharmacological basis.
This study aimed to integrate network pharmacology, bioinformatics analysis, molecular docking, and experimental validation to construct a “component–target–pathway” multidimensional network model, systematically elucidate the potential mechanisms underlying the therapeutic effects of the extract of Potentilla freyniana Bornm. (PFB) on hepatocellular carcinoma (HCC), and thereby clarify its pharmacological basis.
Methods HCC datasets were retrieved from GEO and TCGA databases, and the DEGs were screened. The active components of the n-butanol extract of PFB were obtained by UHPLC-MS/MS, and the candidate target genes were predicted by the SwissTargetPrediction, Similarity Ensemble Approach, and SuperPred databases. The overlapping target genes were selected by GO and KEGG enrichment analysis, and the key target genes were screened by the SVM and RF algorithms. The verification of differentially expressed target genes and ROC analysis of key target genes were performed. Molecular docking was performed using CB-Dock2. We investigated the parameters of proliferation, migration, invasion, and apoptosis in the n-butanol extract of PFB treated HCC, and we verified the expressions of key proteins in HCC by Western blot.
HCC datasets were retrieved from GEO and TCGA databases, and the DEGs were screened. The active components of the n-butanol extract of PFB were obtained by UHPLC-MS/MS, and the candidate target genes were predicted by the SwissTargetPrediction, Similarity Ensemble Approach, and SuperPred databases. The overlapping target genes were selected by GO and KEGG enrichment analysis, and the key target genes were screened by the SVM and RF algorithms. The verification of differentially expressed target genes and ROC analysis of key target genes were performed. Molecular docking was performed using CB-Dock2. We investigated the parameters of proliferation, migration, invasion, and apoptosis in the n-butanol extract of PFB treated HCC, and we verified the expressions of key proteins in HCC by Western blot.
Results Toxicity experiments showed that the n-butanol extract of PFB did not cause significant toxic damage to the mice heart, liver, and kidney. CCK8 assays detected that the n-butanol extract of PFB had inhibitory effects on HCC. Through network pharmacology, we obtained a total of 17 overlapping genes and finally screened out 6 key target genes by SVM and RF algorithm analyses. Molecular docking and molecular dynamics results showed that the active components of PFB, such as ellagic acid, luteolin, berberrubine, procyanidin B1, and adenosine, had better affinity with these key target genes. By qPCR and Western blot assays, we verified that the expressions of CDK1 and EZH2 and the key factors of the MPAK signaling pathway were significantly down-regulated in HCC.
Toxicity experiments showed that the n-butanol extract of PFB did not cause significant toxic damage to the mice heart, liver, and kidney. CCK8 assays detected that the n-butanol extract of PFB had inhibitory effects on HCC. Through network pharmacology, we obtained a total of 17 overlapping genes and finally screened out 6 key target genes by SVM and RF algorithm analyses. Molecular docking and molecular dynamics results showed that the active components of PFB, such as ellagic acid, luteolin, berberrubine, procyanidin B1, and adenosine, had better affinity with these key target genes. By qPCR and Western blot assays, we verified that the expressions of CDK1 and EZH2 and the key factors of the MPAK signaling pathway were significantly down-regulated in HCC.
Conclusion This study demonstrated that the n-butanol extract of PFB exhibits a strong inhibitory effect on the proliferation of HepG2 cells and clarifies the underlying molecular mechanisms involved. By precisely modulating the expression levels of critical signaling molecules - including CDK1, PDGFRB, AKT1, FGFR1, MAPK1, and EZH2 - the n-butanol extract of PFB robustly disrupts cancer cell cycle progression and perturbs the activity of associated signaling pathways, thereby significantly curtailing the aberrant proliferation of tumor cells. This study not only elucidated the effects of the n-butanol extract of PFB on the aforementioned targets but also established a theoretical and experimental basis for further investigating their application in the treatment of HCC. Furthermore, it offers novel insights and research directions for the development of innovative therapeutic strategies derived from natural products, particularly those centered on multi-target synergistic approaches for liver cancer treatment.
This study demonstrated that the n-butanol extract of PFB exhibits a strong inhibitory effect on the proliferation of HepG2 cells and clarifies the underlying molecular mechanisms involved. By precisely modulating the expression levels of critical signaling molecules - including CDK1, PDGFRB, AKT1, FGFR1, MAPK1, and EZH2 - the n-butanol extract of PFB robustly disrupts cancer cell cycle progression and perturbs the activity of associated signaling pathways, thereby significantly curtailing the aberrant proliferation of tumor cells. This study not only elucidated the effects of the n-butanol extract of PFB on the aforementioned targets but also established a theoretical and experimental basis for further investigating their application in the treatment of HCC. Furthermore, it offers novel insights and research directions for the development of innovative therapeutic strategies derived from natural products, particularly those centered on multi-target synergistic approaches for liver cancer treatment.
作者机构：
[Qingqing Yang; Haiyi Gong; Qingyan Zhang; Shuaishuai Guo; Qingyi Zeng] School of Resources & Environment and Safety Engineering, University of South China, Hengyang 421001, China;[Yi-Lin Liu] School of Mechanical Engineering, University of South China, Hengyang 421001, China
通讯机构：
[Yi-Lin Liu; Qingyi Zeng] S;School of Resources & Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>School of Mechanical Engineering, University of South China, Hengyang 421001, China
摘要：
Simultaneous uranium recovery, organic pollutant degradation, and electricity generation were achieved by employing a self-driven photoelectrochemical (PEC) system equipped with a modified carbon felt (MCF) cathode for the treatment of complex radioactive wastewater. The MCF cathode was synthesized via a facile hydrothermal method, which modified the surface functional groups on carbon felt (CF) with enhanced active site availability and facilitated interfacial charge transfer, thus improving its UO 2 2+ adsorption and reduction capacities. The self-driven PEC system with the MCF cathode demonstrated remarkable removal efficiencies and rate constants ( k ) for UO 2 2+ (98.8 % and 0.111 min −1 ) and chlortetracycline hydrochloride (CTC) (92.9 % and 0.028 min −1 ) within 40 min and 90 min, respectively, coupled with an excellent power output of 1.41 mW/cm 2 . Additionally, the system with the MCF cathode exhibited superior removal performance for UO 2 2+ and CTC in treating model complex wastewater under wide conditions. Even under natural sunlight, the system achieved over 80 % removal efficiency for both UO 2 2+ and CTC. Moreover, the uranium immobilized on the MCF cathode was mainly reduced to U(IV) species (90.51 %), and performance remained robust over ten operational cycles. The cathode surface modification strategy and its application in the system provide a cost-effective, multi-functional and high-efficiency approach to controlling nuclides and organic pollutants in complex radioactive wastewater.
Simultaneous uranium recovery, organic pollutant degradation, and electricity generation were achieved by employing a self-driven photoelectrochemical (PEC) system equipped with a modified carbon felt (MCF) cathode for the treatment of complex radioactive wastewater. The MCF cathode was synthesized via a facile hydrothermal method, which modified the surface functional groups on carbon felt (CF) with enhanced active site availability and facilitated interfacial charge transfer, thus improving its UO 2 2+ adsorption and reduction capacities. The self-driven PEC system with the MCF cathode demonstrated remarkable removal efficiencies and rate constants ( k ) for UO 2 2+ (98.8 % and 0.111 min −1 ) and chlortetracycline hydrochloride (CTC) (92.9 % and 0.028 min −1 ) within 40 min and 90 min, respectively, coupled with an excellent power output of 1.41 mW/cm 2 . Additionally, the system with the MCF cathode exhibited superior removal performance for UO 2 2+ and CTC in treating model complex wastewater under wide conditions. Even under natural sunlight, the system achieved over 80 % removal efficiency for both UO 2 2+ and CTC. Moreover, the uranium immobilized on the MCF cathode was mainly reduced to U(IV) species (90.51 %), and performance remained robust over ten operational cycles. The cathode surface modification strategy and its application in the system provide a cost-effective, multi-functional and high-efficiency approach to controlling nuclides and organic pollutants in complex radioactive wastewater.
期刊：
European Journal of Mechanics - A/Solids,2026年115:105822 ISSN：0997-7538
通讯作者：
Jiu-Jiu Chen
作者机构：
[Shao-Yong Huo; Qiu-Shuang Yang; Zhi-Peng Jin; Shu-xin Zhang; Chun-Ming Fu] College of Mechanical Engineering, University of South China, Hengyang, 421001, China;[Jiu-Jiu Chen] State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China;[Rong-hua Chen] School of Aeronautics and Mechanical Engineering, Jiangsu College Key Laboratory of Non-Traditional Machining, Changzhou Institute of Technology, Changzhou, Jiangsu, 213032, China
通讯机构：
[Jiu-Jiu Chen] S;State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China
摘要：
Manipulation of elastic waves to achieve rainbow trapping effect has attracted wide attention. However, most of the current researches achieve rainbow trapping effect by changing the structural parameters, which means that the structure and mechanical properties are always fixed. Realizing the actively tunable working frequency range in elastic topological systems and obtain multi-dimensional rainbow trapping is still a challenge. In this paper, we design a topologically protected second-order thermostatic phononic crystal (PC) plate by using ferroelectric ceramic materials. By adjusting the rotation angle of the T-shaped scatterer, we can realize the multi-dimensional topological phase transition between the bulk and edge bands of elastic wave. Then, a “trivial-nontrivial-trivial” (TNT) heterostructure is constructed to obtain the coupled topological edge states of elastic wave, and the influence of intermediate coupling layer number on the edge states is investigated, which exhibits a multi-mode interference effect. Furthermore, the tunable topological edge states and corner states of elastic wave are obtained based on the temperature control of the ferroelectric materials. In addition, by employing the active tunability of the coupled edge states and corner states, the multi-dimensional topological rainbow trapping of elastic wave in ferroelectric PC plates is demonstrated. The edge and corner states of different frequencies are well separated and captured in different spatial positions, and the working frequency range of the PC plate can be easily tuned by controlling the temperature. Our results further promote the practical integration application of tunable and multi-dimensional elastic wave devices.
Manipulation of elastic waves to achieve rainbow trapping effect has attracted wide attention. However, most of the current researches achieve rainbow trapping effect by changing the structural parameters, which means that the structure and mechanical properties are always fixed. Realizing the actively tunable working frequency range in elastic topological systems and obtain multi-dimensional rainbow trapping is still a challenge. In this paper, we design a topologically protected second-order thermostatic phononic crystal (PC) plate by using ferroelectric ceramic materials. By adjusting the rotation angle of the T-shaped scatterer, we can realize the multi-dimensional topological phase transition between the bulk and edge bands of elastic wave. Then, a “trivial-nontrivial-trivial” (TNT) heterostructure is constructed to obtain the coupled topological edge states of elastic wave, and the influence of intermediate coupling layer number on the edge states is investigated, which exhibits a multi-mode interference effect. Furthermore, the tunable topological edge states and corner states of elastic wave are obtained based on the temperature control of the ferroelectric materials. In addition, by employing the active tunability of the coupled edge states and corner states, the multi-dimensional topological rainbow trapping of elastic wave in ferroelectric PC plates is demonstrated. The edge and corner states of different frequencies are well separated and captured in different spatial positions, and the working frequency range of the PC plate can be easily tuned by controlling the temperature. Our results further promote the practical integration application of tunable and multi-dimensional elastic wave devices.
通讯作者：
Jun Li<&wdkj&>Zhen Wang<&wdkj&>Jong Seung Kim
作者机构：
[Linsheng Zhuo; Xi Zhang; Yan Peng; Hongyun Zou; Zhen Wang] School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China;[Goeun Kim; Hoyeon Jang; Jun Li; Jong Seung Kim] Department of Chemistry, Korea University, Seoul 02841, Republic of Korea;Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China;Pharmaceutical Research Institute, Yichang Humanwell Pharmaceutical Co., Ltd, Yichang, Hubei 443000, China;[Hao Xiong] Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China<&wdkj&>Pharmaceutical Research Institute, Yichang Humanwell Pharmaceutical Co., Ltd, Yichang, Hubei 443000, China
通讯机构：
[Jun Li; Jong Seung Kim] D;[Zhen Wang] S;Department of Chemistry, Korea University, Seoul 02841, Republic of Korea<&wdkj&>School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
摘要：
Privileged scaffolds, as functional building blocks in approved drugs and drug candidates, have been instrumental in accelerating the discovery of new molecular entities due to their ability to enhance the drug potency as well as overcome drug resistance. Among these scaffolds, o -aminobenzamide distinguishes itself as a novel scaffold with considerable potential, although it has been rarely explored in previous studies. This review mainly focuses on o -aminobenzamide motif for the first time, emphasizing its medicinal versatility in drug discovery. Herein, we provide a comprehensive summary of the structure-activity relationship and the structural basis for target recognition of such analogs. Owing to their wide-ranging applications in antiviral, anti-inflammatory, and particularly antitumor therapies, o -aminobenzamide derivatives are poised to gain increasing attention from medicinal chemists. This review could serve as a valuable reference for diverse drug discovery initiatives in the future.
Privileged scaffolds, as functional building blocks in approved drugs and drug candidates, have been instrumental in accelerating the discovery of new molecular entities due to their ability to enhance the drug potency as well as overcome drug resistance. Among these scaffolds, o -aminobenzamide distinguishes itself as a novel scaffold with considerable potential, although it has been rarely explored in previous studies. This review mainly focuses on o -aminobenzamide motif for the first time, emphasizing its medicinal versatility in drug discovery. Herein, we provide a comprehensive summary of the structure-activity relationship and the structural basis for target recognition of such analogs. Owing to their wide-ranging applications in antiviral, anti-inflammatory, and particularly antitumor therapies, o -aminobenzamide derivatives are poised to gain increasing attention from medicinal chemists. This review could serve as a valuable reference for diverse drug discovery initiatives in the future.
作者机构：
[Liqun Liu; Li Dan; Jingsong Wang; Gaoshang Ouyang] School of Civil Engineering, University of South China, Hengyang 421200, China;[Ming Jiang; Kuixiang Guo] Shanghai Urban Construction Design & Research Institute Groups Co., Ltd., Shanghai 200125, China
通讯机构：
[Jingsong Wang] S;School of Civil Engineering, University of South China, Hengyang 421200, China
摘要：
The high-temperature behavior of ternary geopolymers reinforced with polyimide fibers (PIF) remain insufficiently understood. This work systematically evaluates the composite properties of PIF doping metakaolin–fly ash–coal gangue geopolymers (MFCG) via mechanical property, shrinkage, and high-temperature (200 °C, 400 °C, 600 °C, 800 °C, 1000 °C) resistance tests. The results showed that the optimal PIF content was 0.8 %, when the compressive and flexural strengths were increased by 24.8 % and 19.0 %, respectively, and the early shrinkage was reduced by 10.8 %. Besides, at 400 °C, the residual compressive strength of PIF-MFCG was still 24.0 % higher than that of MFCG. The combination of TG-DTG, MIP and SEM analysis indicates the high thermal stability and strong interfacial adhesion of PIF to MFCG leads to enhanced mechanical and high-temperature resistance properties. This work provides guidance for designing high-performance PIF-MFCG composites for high-temperature services.
The high-temperature behavior of ternary geopolymers reinforced with polyimide fibers (PIF) remain insufficiently understood. This work systematically evaluates the composite properties of PIF doping metakaolin–fly ash–coal gangue geopolymers (MFCG) via mechanical property, shrinkage, and high-temperature (200 °C, 400 °C, 600 °C, 800 °C, 1000 °C) resistance tests. The results showed that the optimal PIF content was 0.8 %, when the compressive and flexural strengths were increased by 24.8 % and 19.0 %, respectively, and the early shrinkage was reduced by 10.8 %. Besides, at 400 °C, the residual compressive strength of PIF-MFCG was still 24.0 % higher than that of MFCG. The combination of TG-DTG, MIP and SEM analysis indicates the high thermal stability and strong interfacial adhesion of PIF to MFCG leads to enhanced mechanical and high-temperature resistance properties. This work provides guidance for designing high-performance PIF-MFCG composites for high-temperature services.
期刊：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2026年344(Pt 1):126623 ISSN：1386-1425
通讯作者：
Longwei He<&wdkj&>Songjiao Li
作者机构：
[Deng, Min; Ai, Siwei; Liu, Ying; Zhang, Hailin; Zhai, Zibo; Li, Songjiao] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang 421002, China;Department of Gastroenterology, Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, PR China;School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, PR China;[Cheng, Dan] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>Department of Gastroenterology, Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, PR China;[He, Longwei] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, PR China
通讯机构：
[Longwei He; Songjiao Li] H;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, PR China
摘要：
In osteoarthritis , hypochlorous acid (HClO)—a critical biomarker of inflammation—and neutrophil elastase (NE)—a key mediator of inflammatory responses—undergo significant changes. Fluorescent probes , which offer high sensitivity and real-time visualization, have been widely employed for osteoarthritis imaging. However, most existing probes are designed to detect only a single biomarker, which can lead to false-positive signals in complex biological environments. In contrast, dual-locked fluorescent probes, which require activation by two distinct biomarkers, offer improved specificity and reliability. These probes are particularly advantageous for multiplexed detection in arthritis-related imaging. To date, no dual-responsive fluorescent probe targeting both HClO and NE has been reported. In this study, we introduce Cou-HN, a dual-locked fluorescent probe that exhibits a significant fluorescence enhancement at 470 nm only when both HClO and NE are present simultaneously. Neither HClO nor NE alone is sufficient to trigger a notable fluorescence response. This dual-activation strategy provides Cou-HN with superior imaging accuracy compared to single-locked probes. Both in vitro and in vivo experiments confirm its excellent performance, highlighting its promise for more precise diagnosis and monitoring of osteoarthritis.
In osteoarthritis , hypochlorous acid (HClO)—a critical biomarker of inflammation—and neutrophil elastase (NE)—a key mediator of inflammatory responses—undergo significant changes. Fluorescent probes , which offer high sensitivity and real-time visualization, have been widely employed for osteoarthritis imaging. However, most existing probes are designed to detect only a single biomarker, which can lead to false-positive signals in complex biological environments. In contrast, dual-locked fluorescent probes, which require activation by two distinct biomarkers, offer improved specificity and reliability. These probes are particularly advantageous for multiplexed detection in arthritis-related imaging. To date, no dual-responsive fluorescent probe targeting both HClO and NE has been reported. In this study, we introduce Cou-HN, a dual-locked fluorescent probe that exhibits a significant fluorescence enhancement at 470 nm only when both HClO and NE are present simultaneously. Neither HClO nor NE alone is sufficient to trigger a notable fluorescence response. This dual-activation strategy provides Cou-HN with superior imaging accuracy compared to single-locked probes. Both in vitro and in vivo experiments confirm its excellent performance, highlighting its promise for more precise diagnosis and monitoring of osteoarthritis.
作者机构：
[Zhiting Zhan; Jiazuo Zhou] College of Marine Science and Technology, China University of Geosciences, Wuhan, China;CNOOC Research Institute Company Limited, Beijing, China;State Key Laboratory of Natural Gas Hydrates, Beijing, China;[Pan Chen] State Key Laboratory of Geomechanics and Geotechnical Engineering Safety, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan, China;[Changfu Wei] School of Resources Environment and Safety Engineering, University of South China, Hengyang, China
通讯机构：
[Jiazuo Zhou] C;College of Marine Science and Technology, China University of Geosciences, Wuhan, China
关键词：
Hydrate-bearing sediments;Discrete element method;Direct shear test;Shear strength;Shear band
摘要：
To investigate the macroscopic mechanical response and microscale failure mechanisms of hydrate-bearing sediments (HBS), numerical simulations for direct shear and multi-reversal direct shear tests were carried out based on two-dimensional discrete element modeling under various hydrate saturations and normal stress conditions. By validating against laboratory tests, the simulation results successfully reproduce the stress-strain behavior and shear band development, and reveal the microscale origins of dilation, strain-softening, and particle wear. The results indicate that the increasing hydrate saturation significantly enhances the shear strength of HBS, while also intensifying strain-softening and dilation effects. Higher normal stress increases both the peak and residual shear strength of HBS and promotes the formation of flatter shear bands, but it also suppresses dilation. During multi-reversal shearing, HBS samples exhibit marked dilation and strength reduction during the initial forward shear, whereas dilation weakens in subsequent cycles due to particle rearrangement and wear. In addition, the cementation effect of hydrate can effectively inhibits the detachment of sediment particles, while the increasing normal stress exacerbates sample wear. This study elucidates the microscale mechanisms of HBS shearing and failure behavior at the particle level, providing theoretical support for geomechanical analysis in hydrate exploitation and carbon dioxide sequestration processes.
To investigate the macroscopic mechanical response and microscale failure mechanisms of hydrate-bearing sediments (HBS), numerical simulations for direct shear and multi-reversal direct shear tests were carried out based on two-dimensional discrete element modeling under various hydrate saturations and normal stress conditions. By validating against laboratory tests, the simulation results successfully reproduce the stress-strain behavior and shear band development, and reveal the microscale origins of dilation, strain-softening, and particle wear. The results indicate that the increasing hydrate saturation significantly enhances the shear strength of HBS, while also intensifying strain-softening and dilation effects. Higher normal stress increases both the peak and residual shear strength of HBS and promotes the formation of flatter shear bands, but it also suppresses dilation. During multi-reversal shearing, HBS samples exhibit marked dilation and strength reduction during the initial forward shear, whereas dilation weakens in subsequent cycles due to particle rearrangement and wear. In addition, the cementation effect of hydrate can effectively inhibits the detachment of sediment particles, while the increasing normal stress exacerbates sample wear. This study elucidates the microscale mechanisms of HBS shearing and failure behavior at the particle level, providing theoretical support for geomechanical analysis in hydrate exploitation and carbon dioxide sequestration processes.
期刊：
Journal of Retailing and Consumer Services,2026年88:104499 ISSN：0969-6989
通讯作者：
Yuan Feng
作者机构：
[Yongxi Yi; Yuan Feng; Yuqiong Li; Chao Li] School of Economics Management and Law, University of South China, Hengyang, 421001, China
通讯机构：
[Yuan Feng] S;School of Economics Management and Law, University of South China, Hengyang, 421001, China
摘要：
This study examines how the adoption of blockchain influences the selection of sales models (reselling vs. consignment) in e-commerce supply chains in which consumers have reference-quality effects. Using a dynamic game-theoretic model between a supplier and a platform, analyse four scenarios that combine blockchain adoption with different sales models. We find that: (1) A high correlation between consumer quality effects and brand goodwill suppresses quality improvement and platform reputation, hurting supplier profits but exhibiting a U-shaped effect on platform profits. (2) Blockchain, despite its upfront costs, proves to be a viable long-term investment, boosting both product quality and platform goodwill. (3) The consignment model favours suppliers under low commission rates, while reselling dominates at higher rates, with platform profits peaking at intermediate commission levels. These insights guide platforms in aligning blockchain adoption with sales strategies to mitigate reference-quality challenges.
This study examines how the adoption of blockchain influences the selection of sales models (reselling vs. consignment) in e-commerce supply chains in which consumers have reference-quality effects. Using a dynamic game-theoretic model between a supplier and a platform, analyse four scenarios that combine blockchain adoption with different sales models. We find that: (1) A high correlation between consumer quality effects and brand goodwill suppresses quality improvement and platform reputation, hurting supplier profits but exhibiting a U-shaped effect on platform profits. (2) Blockchain, despite its upfront costs, proves to be a viable long-term investment, boosting both product quality and platform goodwill. (3) The consignment model favours suppliers under low commission rates, while reselling dominates at higher rates, with platform profits peaking at intermediate commission levels. These insights guide platforms in aligning blockchain adoption with sales strategies to mitigate reference-quality challenges.
作者机构：
[Yu, Mengyao; Zhang, Yifang] Department of Pathophysiology, Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China;[Chen, Yan] Department of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, China;[Huang, Ji] Department of Pathophysiology, Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China. Electronic address: huangjicpu@hotmail.com
通讯机构：
[Huang, Ji] D;Department of Pathophysiology, Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China. Electronic address:
摘要：
High-density lipoprotein (HDL) plays a key role in reverse cholesterol transport (RCT), traditionally associated with cardiovascular protection. However, while low HDL-cholesterol (HDL-C) levels correlate with increased cardiovascular risk, therapeutic interventions raising HDL-C (e.g., niacin, fibrates) have failed to reduce cardiovascular events. Recent evidence reveals a U-shaped relationship between HDL-C and mortality, with both excessively high and low levels conferring risk—indicating functional impairment as the critical determinant. Consequently, focus has shifted from HDL-C quantification to functional assessment: (1) Cholesterol efflux capacity (CEC) exhibits a stronger inverse correlation with cardiovascular risk than HDL-C; (2) HDL particle number (HDL-P) outperforms HDL-C in predicting cardiovascular events; (3) HDL subclass heterogeneity (e.g., HDL2, HDL3), where composition and distribution determine the protective functions of HDL particles. This review synthesizes evidence demonstrating that comprehensively assessing HDL functionality—including quality metrics, particle concentration, and subclass distribution—provides superior cardiovascular risk assessment. Future research must prioritize restoring or enhancing HDL function rather than merely increasing its concentration.
High-density lipoprotein (HDL) plays a key role in reverse cholesterol transport (RCT), traditionally associated with cardiovascular protection. However, while low HDL-cholesterol (HDL-C) levels correlate with increased cardiovascular risk, therapeutic interventions raising HDL-C (e.g., niacin, fibrates) have failed to reduce cardiovascular events. Recent evidence reveals a U-shaped relationship between HDL-C and mortality, with both excessively high and low levels conferring risk—indicating functional impairment as the critical determinant. Consequently, focus has shifted from HDL-C quantification to functional assessment: (1) Cholesterol efflux capacity (CEC) exhibits a stronger inverse correlation with cardiovascular risk than HDL-C; (2) HDL particle number (HDL-P) outperforms HDL-C in predicting cardiovascular events; (3) HDL subclass heterogeneity (e.g., HDL2, HDL3), where composition and distribution determine the protective functions of HDL particles. This review synthesizes evidence demonstrating that comprehensively assessing HDL functionality—including quality metrics, particle concentration, and subclass distribution—provides superior cardiovascular risk assessment. Future research must prioritize restoring or enhancing HDL function rather than merely increasing its concentration.
作者机构：
[Ruiyun Li] School of Materials & Energy, Lanzhou University, Lanzhou 730000, PR China;[Xing Yang; Yongfu Wang; Junyan Zhang] State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China;[Chengtao Yue] School of Nuclear Science and Technology, University of South China, Hengyang 421001, China;[Huiting Liang] School of Materials & Energy, Lanzhou University, Lanzhou 730000, PR China<&wdkj&>State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China
通讯机构：
[Ruiyun Li; Junyan Zhang] S;State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China<&wdkj&>School of Materials & Energy, Lanzhou University, Lanzhou 730000, PR China
摘要：
As the increased use of radiation-emitting devices in medical diagnostics and treatments, more individuals are exposed to radioactivity environments. Here, the friction behaviors of diamond-like carbon (DLC) and MoS 2 /DLC under low irradiation (50–300 Gy) were investigated. The γ-irradiation induces slight carbon transformation into fullerene-like structures in both DLC and MoS 2 /DLC, bestowing their higher hardness. Under combined action of friction process, the lower irradiated doses induce higher graphitization process, exhibiting lower COF (0.05) and wear rate (0.38 ×10 −8 mm 3 N −1 m −1 ), which is further enhanced by MoS 2 . The HRTEM observations show the graphene/MoS 2 heterostructures formation at irradiated and wear-induced MoS 2 /DLC surfaces, with higher graphitization than irradiated DLC. The results indicate that MoS 2 /DLC composite is easy to achieve low friction under low γ-irradiation doses.
As the increased use of radiation-emitting devices in medical diagnostics and treatments, more individuals are exposed to radioactivity environments. Here, the friction behaviors of diamond-like carbon (DLC) and MoS 2 /DLC under low irradiation (50–300 Gy) were investigated. The γ-irradiation induces slight carbon transformation into fullerene-like structures in both DLC and MoS 2 /DLC, bestowing their higher hardness. Under combined action of friction process, the lower irradiated doses induce higher graphitization process, exhibiting lower COF (0.05) and wear rate (0.38 ×10 −8 mm 3 N −1 m −1 ), which is further enhanced by MoS 2 . The HRTEM observations show the graphene/MoS 2 heterostructures formation at irradiated and wear-induced MoS 2 /DLC surfaces, with higher graphitization than irradiated DLC. The results indicate that MoS 2 /DLC composite is easy to achieve low friction under low γ-irradiation doses.
期刊：
Dyes and Pigments,2026年245:113195 ISSN：0143-7208
通讯作者：
Yuli Yin
作者机构：
[Chao Fu; Wei Zhao; Hongmian Yu; Xiruo Li; Jiayi Li; Guoqi Chen; Yuli Yin; Rong Hu] School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, PR China
通讯机构：
[Yuli Yin] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, PR China
摘要：
The construction of organic photosensitizers with near infrared (NIR) emission has shown great promise for precise therapeutic applications. However, fluorescence imaging and phototherapy efficacy are dependent on competitive photophysical processes, so it is still a great challenge to engineer photosensitizer with appreciable light emission especially in the NIR light region, and highly efficient energy conversion into valuable reactive oxygen species. In this paper, we report series of simple perylene diimide (PDI)-based NIR photosensitizers by regulating the position of a phenyl moiety in the donor-acceptor-donor conjugated backbone, a packing balance between the twisted molecular structure and effective π-conjugation is actualized. Photodynamic property observation reveals that the developed fluorophores present desirable photosensitizing ability with the production of both type I and II reactive oxygen species (ROS) under light irradiation, and the eradication of tumor cells is realized based on ferroptosis mechanism. Moreover, the bright emission in NIR region allows for the sensitive detection of pulmonary metastasis in vivo . These results provide an illuminating NIR photosensitizers design strategy for image-guided tumor photodynamic therapy applications.
The construction of organic photosensitizers with near infrared (NIR) emission has shown great promise for precise therapeutic applications. However, fluorescence imaging and phototherapy efficacy are dependent on competitive photophysical processes, so it is still a great challenge to engineer photosensitizer with appreciable light emission especially in the NIR light region, and highly efficient energy conversion into valuable reactive oxygen species. In this paper, we report series of simple perylene diimide (PDI)-based NIR photosensitizers by regulating the position of a phenyl moiety in the donor-acceptor-donor conjugated backbone, a packing balance between the twisted molecular structure and effective π-conjugation is actualized. Photodynamic property observation reveals that the developed fluorophores present desirable photosensitizing ability with the production of both type I and II reactive oxygen species (ROS) under light irradiation, and the eradication of tumor cells is realized based on ferroptosis mechanism. Moreover, the bright emission in NIR region allows for the sensitive detection of pulmonary metastasis in vivo . These results provide an illuminating NIR photosensitizers design strategy for image-guided tumor photodynamic therapy applications.
