α 7nAChR-mediated cholinergic anti-inflammatory pathway of immune cells in sepsis induced cardiac injury

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成果类型：

期刊论文

作者：

Yang, Yufan;He, Yueqi;Huang, Jiaotian;Lu, Xiulan;Xiao, Zhenghui

通讯作者：

Xiao, ZH

作者机构：

[He, Yueqi; Yang, Yufan; Xiao, Zhenghui; Lu, Xiulan; Huang, Jiaotian; Xiao, ZH] Univ South China, Hunan Childrens Hosp, Hengyang Med Sch, Sch Pediat,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.

[Yang, Yufan; Xiao, Zhenghui; Lu, Xiulan; Huang, Jiaotian; Xiao, ZH] Cent South Univ, Hunan Childrens Hosp, Affiliated Childrens Hosp, Xiangya Sch Med,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Xiao, ZH ] U

Univ South China, Hunan Childrens Hosp, Hengyang Med Sch, Sch Pediat,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.

Cent South Univ, Hunan Childrens Hosp, Affiliated Childrens Hosp, Xiangya Sch Med,Dept Intens Care Unit, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

cx 7nAChR;Mediated cholinergic anti-inflammatory pathway;Immune cells;Sepsis;Cardiac injury

期刊：

SIGNA VITAE

ISSN：

1334-5605

年：

2025

卷：

期：

页码：

21-24

DOI：

10.22514/sv.2025.003

基金类别：

National Natural Science Foundation of China [82302428]; Hunan Provincial Science and Technology Department Project [2022JJ40205, 2020SK2114, 2020SK1014-3]

机构署名：

本校为第一且通讯机构

摘要：

Sepsis is a systemic syndrome characterized by widespread inflammatory responses induced by pathogenic microorganism invasion into the body, with increased susceptibility to major organs. Sepsis-induced cardiomyopathy is characterized by reversible myocardial depression or injury, primarily presenting as acute heart failure and/or arrhythmias triggered by sepsis. The mortality rate substantially increases when septic patients develop sepsis-induced cardiomyopathy. The cholinergic anti-inflammatory pathway (CAP) regulates inflammatory responses through the release of acetylcholine (ACh) via the...

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α 7nAChR-mediated cholinergic anti-inflammatory pathway of immune cells in sepsis induced cardiac injury

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