Association of long-term insulin variability before the onset of diabetes with cardiovascular outcomes in later life: Findings from the coronary artery risk development in young adults (CARDIA) study

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成果类型：

期刊论文

作者：

Zhang, Kun;Huang, Chunlan;Li, Junping;Mai, Peibiao;Xu, Shuwan;...

通讯作者：

Zhang, Huanji;Liu, Yang;Feng, WJ

作者机构：

[Zhang, Kun] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Cardiol, 628 Zhenyuan Rd, Shenzhen 518107, Peoples R China.

[Huang, Chunlan] Univ South China, Affiliated Hosp 2, Dept Neurol, 30 Jiefang Rd, Hengyang 421001, Peoples R China.

[Li, Junping] Guangdong Second Prov Gen Hosp, Dept Urol, 466 Xingang Middle Rd, Guangzhou 510317, Peoples R China.

[Mai, Peibiao] Chinese Acad Med Sci, Fuwai Hosp, Shenzhen Sun Yat sen Cardiovasc Hosp, Dept Cardiol, Shenzhen, Peoples R China.

[Xu, Shuwan] Peking Univ Third Hosp, Dept Cardiol, 49 Huayuan North Rd, Beijing 100191, Peoples R China.

通讯机构：

[Liu, Y; Zhang, HJ; Feng, WJ ] S

Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Cardiac Funct & Microcircul, State Key Lab Organ Failure Res,Dept Cardiol,Sch C, 1838 Guangzhou North Rd, Guangzhou 510515, Peoples R China.

语种：

英文

关键词：

Insulin variability;Insulin resistance;Coronary artery calcification;Cardiovascular diseases;All-cause mortality

期刊：

American Journal of Preventive Cardiology

ISSN：

2666-6677

年：

2025

卷：

页码：

100952

DOI：

10.1016/j.ajpc.2025.100952

基金类别：

NIA; NHLBI [AG0005]; National Natural Science Foundation of China [81600351, 82200900]; Guangdong Basic and Applied Basic Research Foundation [2023A1515010474, 2024A1515011270]; China Post-doctoral Science Foundation [2022M721495, 2023T160292]; President Foundation of Nanfang Hospital Southern Medical University [2021B001]; Natural Science Foundation of Hunan Province [2019JJ50532]; Scientific Research Project of Hunan Provincial Health Commission [B202303078230]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Background The important effects of variability of some physiological/biological characteristics (such as LDL cholesterol, blood pressure) on cardiovascular outcomes have been elucidated, while the role of insulin variability is undefined. The important effects of variability of some physiological/biological characteristics (such as LDL cholesterol, blood pressure) on cardiovascular outcomes have been elucidated, while the role of insulin variability is undefined. Objectives To investigate the associations of long-term fasting insulin variabili...

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Association of long-term insulin variability before the onset of diabetes with cardiovascular outcomes in later life: Findings from the coronary artery risk development in young adults (CARDIA) study

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