The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zongchao Li;Aonan Dai;Xiaoxiang Fang;Kexing Tang;Kun Chen;...

通讯作者：

Li, LJ;Deng, ZH

作者机构：

[Peng Gao; Kun Chen; Aonan Dai; Liangjun Li; Li, Liangjun; Zongchao Li; Kexing Tang; Xiaoxiang Fang] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Orthopaed, Changsha 410004, Hunan, Peoples R China.

[Jingyue Su; Shengwu Yang; Xin Chen; Zhenhan Deng; Deng, Zhenhan] Wenzhou Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Wenzhou 325000, Zhejiang, Peoples R China.

[Jingyue Su; Shengwu Yang; Xin Chen; Zhenhan Deng; Deng, Zhenhan] Wenzhou Med Univ, Affiliated Hosp 1, Geriatr Ctr, Wenzhou 325000, Zhejiang, Peoples R China.

通讯机构：

[Li, LJ ] U

[Deng, ZH ] W

Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Orthopaed, Changsha 410004, Hunan, Peoples R China.

Wenzhou Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Wenzhou 325000, Zhejiang, Peoples R China.

Wenzhou Med Univ, Affiliated Hosp 1, Geriatr Ctr, Wenzhou 325000, Zhejiang, Peoples R China.

语种：

英文

关键词：

chondrocyte;miR-6779;osteoarthritis;senescence;X-linked inhibitor of apoptosis protein

期刊：

动物模型与实验医学(英文)

ISSN：

2096-5451

年：

2025

DOI：

10.1002/ame2.12529

基金类别：

Natural Science Foundation of Hunan Province#&#&#2020JJ8043 National Natural Science Foundation of China#&#&#82472495

机构署名：

本校为第一且通讯机构

摘要：

BACKGROUND: Osteoarthritis (OA) is a long-term degenerative joint disease worsening over time. Aging and chondrocyte senescence contribute to OA progression. MicroRNAs have been confirmed to regulate different cellular processes. They contribute to OA pathology and may help to identify novel biomarkers and therapies for OA. METHODS: This study used bioinformatics and experimental investigations to analyze and validate differentially expressed miRNAs in OA that might affect chondrocyte apoptosis and senescence. RESULTS: miR-6779 was found to be ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问