摘要：
Atherosclerosis is a chronic inflammatory disease of the arterial wall caused by an imbalance of lipid metabolism and a maladaptive inflammatory response. A variety of harmful cellular changes associated with atherosclerosis include endothelial dysfunction, the migration of circulating inflammatory cells to the arterial wall, the production of proinflammatory cytokines, lipid buildup in the intima, local inflammatory responses in blood vessels, atherosclerosis-associated apoptosis, and autophagy. PTEN inhibits the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT)/mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity. Previous studies have shown that PTEN is closely related to atherosclerosis. This article reviews the role of PTEN in atherosclerosis from the perspectives of autophagy, apoptosis, inflammation, proliferation, and angiogenesis.
摘要：
Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from cognitive impairments by attenuating neuronal ferroptosis in the hippocampal CA1 region. STZ-induced T2DM mice were treated with artemisinin (40 mg/kg, i.p.), or cotreated with artemisinin and Nrf2 inhibitor MEL385 or ferroptosis inducer erastin for 4 weeks. Cognitive performance was determined by the Morris water maze and Y maze tests. Hippocampal ROS, MDA, GSH, and Fe2+ contents were detected by assay kits. Nrf2, p-Nrf2, HO-1, and GPX4 proteins in hippocampal CA1 were assessed by Western blotting. Hippocampal neuron injury and mitochondrial morphology were observed using H&E staining and a transmission electron microscope, respectively. Artemisinin reversed diabetic cognitive impairments, decreased the concentrations of ROS, MDA and Fe2+, and increased the levels of p-Nr2, HO-1, GPX4 and GSH. Moreover, artemisinin alleviated neuronal loss and ferroptosis in the hippocampal CA1 region. However, these neuroprotective effects of artemisinin were abolished by Nrf2 inhibitor ML385 and ferroptosis inducer erastin. Artemisinin effectively ameliorates neuropathological changes and learning and memory decline in T2DM mice; the underlying mechanism involves the activation of Nrf2 to inhibit neuronal ferroptosis in the hippocampus.
作者机构：
[Yang, Q; Fang, J; Xu, Y; Yang, Y] Department of Neonatology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, China;[Yan, X H] Department of Blood Transfusion, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, China
摘要：
To explore the application value of SAA (serum amyloid A), CRP (C reactive protein), PCT (procalcitonin), WBC (white blood cell) and N% (neutrophil %) in the diagnosis of neonatal septicemia. This study was a retrospective study. 173 children with clinically diagnosed septicemia and 66 children with definitely diagnosed septicemia admitted to the Department of Neonatology, the Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China,from January 2022 to January 2024 were selected as the case group, and 148 children with neonatal jaundice who were hospitalized during the same period were selected as the control group. Fasting venous blood was collected within 24 hours after the children's admission to detect the levels of serum WBC, N%, SAA, CRP and PCT. One-way analysis of variance and Kruskal-Wallis H test were used to compare the general data and inflammatory index levels of the three groups of children. The correlation analysis between SAA and other inflammatory indicators was conducted using Spearman correlation analysis. The receiver operating characteristic (ROC) curve was used to determine the diagnostic efficacy of different inflammatory indicators for patients with definitely diagnosed septicemia and those with clinically diagnosed septicemia, and for those with clinically diagnosed septicemia and those without infection. The results showed that the levels of WBC [(16.88±5.64)×10(9)/L], N% [70.00 (63.00, 75.00)], PCT [2.22 (1.20, 5.55) mg/L], CRP [3.00 (0.50, 10.30) mg/L], SAA [19.70 (10.82, 49.90) mg/L] in the clinically diagnosed septicemia group and WBC [(16.10±7.48)×10(9)/L], N% [73.50 (61.50, 80.93)], PCT [5.35 (0.69, 20.07) mg/L], CRP [15.52 (4.98, 30.50) mg/L], SAA [43.95 (14.00, 175.98) mg/L] in the definitely diagnosed septicemia group were all higher than those in the control group (11.17±3.38)×10(9)/L, 49.81 (36.93, 62.75), 0.20 (0.07, 0.99) mg/L, 0.54 (0.20, 1.40) mg/L, 5.15 (3.60, 8.68) mg/L, and the differences were all statistically significant (all P<0.05). Spearman correlation analysis showed that the level of SAA was positively correlated with WBC, N%, PCT and CRP (r(s)=0.453, 0.540, 0.343, 0.550, all P<0.05). ROC curve analysis showed that the area under ROC curve(AUC) of SAA for the definitely diagnosed septicemia group and the clinically diagnosed septicemia group was higher than that of other inflammatory indicators, among them, the AUC of SAA for diagnosing the definitely diagnosed neonatal septicemia group was 0.933 (95%CI: 0.809-1.000, P<0.05), with a sensitivity of 92.90% and a specificity of 99.30%. The AUC of SAA for diagnosing the clinically diagnosed septicemia group was 0.861 (95%CI: 0.818-0.904, P<0.05), with a sensitivity of 83.20% and a specificity of 81.80%. In conclusion, compared with CRP, PCT, WBC and N%, SAA has higher sensitivity and specificity for distinguishing neonatal septicemia (including definitely diagnosed septicemia and clinically diagnosed septicemia), and has certain auxiliary diagnostic value for neonatal septicemia.
摘要：
BACKGROUND: Social isolation not only increases the risk of mortality in later life but also causes depressive symptoms, cognitive and physical disabilities. Although RNA m6A modifications are suggested to play key roles in brain development, neuronal signaling and neurological disorders, both the roles of m6A and the enzymes that regulate RNA m6A modification in social isolation induced abnormal behavior is unknown. The present study aims to explore the possible epitranscriptomic role of RNA m6A modifications and its enzymes in social isolation induced impaired behavior. METHODS: 3-4weeks mice experiencing 8weeks social isolation stress (SI) were used in the present study. We quantified m6A levels in brain regions related to mood and cognitive behavior. And the expression of hippocampal m6A enzymes was also determined. The role of hippocampal m6A and its enzymes in SI induced abnormal behavior was further verified by the virus tool. RESULTS: SI led to not only depressive and anxiety-like behaviors but also cognitive impairment, with corresponding decreases in hippocampal m6A and METTL14. Hippocampal over-expression METTL14 with lentivirus not only rescued these behaviors but also enhanced the hippocampal m6A level. Hippocampal over-expression METTL14 resulted in increased synaptic related genes. CONCLUSIONS: We provide the first evidence that post-weaning social isolation reduces hippocampal m6A level and causes altered expression of m6A enzyme in mice. Importantly, hippocampal METTL14 over-expression alleviated the SI-induced depression/anxiety-like and impaired cognitive behaviors and enhanced m6A level and synaptic related genes expression.
期刊：
Journal of the European Academy of Dermatology and Venereology,2024年38(8):1478-1490 ISSN：0926-9959
通讯作者：
Zhao, FJ;Liu, SQ
作者机构：
[Xiong, Shun; Zhao, Feijun; Liu, Shuangquan; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Yao, Jiangchen; Zhang, Xiaohong; Xu, Man] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang, Peoples R China.;[Xiong, Shun; Zhao, Feijun; Liu, Shuangquan; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Yao, Jiangchen; Zhang, Xiaohong; Xu, Man] Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang, Peoples R China.;[Xiong, Shun; Zhao, Feijun; Liu, Shuangquan; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Yao, Jiangchen; Zhang, Xiaohong; Xu, Man] Univ South China, Affiliated Hosp 1, Hengyang Med Coll, Dept Clin Lab Med, Hengyang, Peoples R China.;[Zhao, Feijun; Zhao, FJ] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang 421001, Peoples R China.;[Zhao, Feijun; Zhao, FJ] Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang 421001, Peoples R China.
通讯机构：
[Zhao, FJ ; Liu, SQ ] U;Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang 421001, Peoples R China.;Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang 421001, Peoples R China.;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Inst Microbiol & Infect Dis,Dept Clin Lab Med, Hengyang 421001, Peoples R China.
摘要：
<jats:title>Abstract</jats:title><jats:p><jats:italic>Treponema pallidum</jats:italic> is the causative factor of syphilis, a sexually transmitted disease (STD) characterized by perivascular infiltration of inflammatory cells, vascular leakage, swelling and proliferation of endothelial cells (ECs). The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of <jats:italic>T. pallidum</jats:italic>. In this review, we focus on how <jats:italic>T. pallidum</jats:italic> establish intimate interactions with ECs, triggering endothelial dysfunction such as endothelial inflammation, abnormal repairment and damage of ECs. In addition, we summarize that migration and invasion of <jats:italic>T. pallidum</jats:italic> across vascular ECs may occur through two pathways. These two mechanisms of transendothelial migration are paracellular and cholesterol‐dependent, respectively. Herein, clarifying the relationship between <jats:italic>T. pallidum</jats:italic> and endothelial dysfunction is of great significance to provide novel strategies for diagnosis and prevention of syphilis, and has a great potential prospect of clinical application.</jats:p>
摘要：
The green and circular economy are two significant themes intertwined in sustainable development, which requires that they be dealt with integral rather than fragmented, as in most previous cases. Therefore, this paper models a closed-loop supply chain consisting of a manufacturer, an e-commerce platform, and a recycler. Among them, the manufacturer with CSR, the game leader, is responsible for green technology innovation, product manufacturing, and remanufacturing. The e-commerce platform and recycler follow online sales and recycling for used products. To solve this Stackelberg game model, we distinguish three scenarios, i.e., the recycler with sufficient funds, financially constrained recycler financing from the manufacturer, or the e-commerce platform. The results show that the recycling rate, the level of green innovation, the profit of each party, and total social welfare are the highest, second, and lowest in those three scenarios, respectively, if borrowing rates are the same in the latter two cases. The interest rate decreases to a certain extent under both financing models, contributing to improving supply chain performance. The manufacturer assumes CSR contributes to the profit of all other parties, the increase in the recycling rate, and the level of green innovation. However, the manufacturer's profit decreases instead of rising, which reveals that the manufacturer should be actively assuming CSR to a certain extent.
作者：
Guan, T. Y.;Zhang, Y. P.;Wang, B.;Guo, C.;Liu, J. C.;...
期刊：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT,2024年1063:169244 ISSN：0168-9002
通讯作者：
Guo, C;Tang, Q
作者机构：
[Li, C.; Tang, Q.; Wang, B.; Guan, T. Y.] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Guo, C.; Zhang, Y. P.; Liu, J. C.; Yang, C. G.] Chinese Acad Sci, Expt Phys Div, Inst High Energy Phys, Beijing 100049, Peoples R China.;[Guo, C.; Zhang, Y. P.; Liu, J. C.; Yang, C. G.] Univ Chinese Acad Sci, Sch Phys, Beijing 100049, Peoples R China.;[Guo, C.; Zhang, Y. P.; Liu, J. C.; Yang, C. G.] State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;[Guo, C; Guo, C.] 19B YuQuan Rd, Beijing, Peoples R China.
通讯机构：
[Guo, C ] 1;[Tang, Q ] 2;19B YuQuan Rd, Beijing, Peoples R China.;28 Changsheng West Rd, Beijing, Hunan, Peoples R China.
关键词：
Atomic physics;Degassing;Neutrons;Observatories;Particle detectors;Photomultipliers;Radioactivity;Trace elements;Degassing membrane;Liquid scintillator;Micro-bubble generators;Neutrino physics;Physics experiments;Radon concentrations;South China;State of the art;Ultra-pure water;Water Cherenkov detectors;Radon
作者机构：
[Xie, Shujing; Wang, Minghua; Zhu, Ziyan; Wang, Yan] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, Y ] U;Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.
关键词：
geographic routing;link detection and repair;node collaborative scheduling;energy optimization
摘要：
Energy efficiency and data reliability are important indicators to measure network performance in wireless sensor networks. In existing research schemes of routing protocols, the impact of node coverage on the network is often ignored, and the possibility that multiple sensor nodes may sense the same spatial point is not taken into account, which results in a waste of network resources, especially in large-scale networks. Apart from that, the blindness of geographic routing in data transmission has been troubling researchers, which means that the nodes are unable to determine the validity of data transmission. In order to solve the above problems, this paper innovatively combines the routing protocol with the coverage control technique and proposes the node collaborative scheduling algorithm, which fully considers the correlation characteristics between sensor nodes to reduce the number of active working nodes and the number of packets generated, to further reduce energy consumption and network delay and improve packet delivery rate. In order to solve the problem of unreliability of geographic routing, a highly reliable link detection and repair scheme is proposed to check the communication link status and repair the invalid link, which can greatly improve the packet delivery rate and throughput of the network, and has good robustness. A large number of experiments demonstrate the effectiveness and superiority of our proposed scheme and algorithm.
摘要：
The conversion of triacylglycerols in edible oils into diacylglycerols (DAGs) is of great significance for obtaining products with health benefits. Camellia seed oil (C-oil), which is rich in oleic acid and linoleic acid, is an excellent raw material for the production of DAGs. In this study, single factor optimization experiments were carried out for hydrolysis and esterification respectively. Using Lipozyme (R) RM IM as catalyst, the maximum percent of C-oil hydrolysis reached 87.14% at the reaction temperature of 60 degrees C, reaction time of 24 h, water content of 30% and enzyme addition amount of 4%. The maximum content of camellia seed oil diacylglycerol (C-DAG) reached 62.49% under the conditions of Lipozyme (R) RM IM as catalyst, vacuum system, 3% enzyme addition, 2% water addition, reaction temperature of 50 degrees C and substrate molar ratio of free fatty acid to glycerol of 1:1. The high content of DAG was obtained by a coupled method, which eliminated the purification steps and reduced production costs. C-oil and C-DAG have been characterized by GC, TG, DSC, and GC-IMS. Our results showed that the enzymatic coupling method did not affect the structural of the substances, but did affect the crystallization and melting properties of the oils. Moreover, the taste of C-DAG was more delicate than C-oil. Finally, the reaction mechanism was analyzed using FTIR spectroscopy, revealing that C-oil was primarily hydrolyzed into free fatty acids. C-DAG exhibited ester C-O stretching vibrations in the range 1280-1030 cm-1, indicating successful esterification reaction between camellia seed oil free fatty acids (C-FFAs) and glycerol catalyzed by lipases.
