Dexmedetomidine for cancer pain: mechanisms and opioid-sparing effects

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liao, Wei;Li, Shuzhai;Chen, Qisheng;Li, Wenjie;Peng, Shixuan;...

通讯作者：

Zhang, ZM

作者机构：

[Zhang, Zhiming; Li, Shuzhai; Liao, Wei; Ouyang, Huidan; Tan, Lingli; Li, Wenjie; Zhu, Xiaoling; Chen, Qisheng] Univ South China, Peoples Hosp Chenzhou 1, Dept Anesthesiol, Affiliated ChenZhou Hosp,Hengyang Med Sch, Chenzhou 423000, Hunan, Peoples R China.

[Chen, Qisheng] Hunan Univ, Xiangtan Cent Hosp, Affiliated Hosp, Dept Pharmacol, Xiangtan, Hunan, Peoples R China.

[Peng, Shixuan] Peking Univ Canc Hosp & Inst, Gastrointestinal Canc Ctr, Dept Oncol, State Key Lab Holist Integrat Management Gastroint, Beijing, Peoples R China.

通讯机构：

[Zhang, ZM ] U

Univ South China, Peoples Hosp Chenzhou 1, Dept Anesthesiol, Affiliated ChenZhou Hosp,Hengyang Med Sch, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

cancer pain;dexmedetomidine;opioid-sparing;opioids;α-2 adrenergic receptors

期刊：

International Journal of Surgery

ISSN：

1743-9191

年：

2025

卷：

111

期：

页码：

4694-4703

DOI：

10.1097/JS9.0000000000002536

基金类别：

General Program of the Medical and Health Science and Technology Development Research Center, National Health Commission [WKZX2024CX301203]; Health Appropriate Technology Promotion Project of Hunan Provincial Health Commission [202319019440]; Hunan Provincial Natural Science Foundation [2024JJ7030]; Science and Technology Development Program of Chenzhou Science and Technology Bureau [ZDYF2020051]; Scientific Research Project of the First People's Hospital of Chenzhou [CZYY202213]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND AND OBJECTIVE: Cancer pain treatment faces challenges such as ineffective pain management, high-dose opioid use, and insufficient analgesia. Dexmedetomidine (DEX), a novel α2 receptor agonist, is a potential adjuvant analgesic. Its analgesic mechanism involves central coeruleus cell hyperpolarization, activation of peripheral, spinal cord, and spinal α2 receptors, and regulation of cellular signaling pathways and inflammatory factors. DEX reduces harmful neurotransmitter production and pain signal transmission and enhances opioid a...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Dexmedetomidine for cancer pain: mechanisms and opioid-sparing effects

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问