通讯机构：
[Tang, BS ; Qiu, J ; Qiu, J] C;Cent South Univ, Xiangya Hosp, Dept Neurol, Dept Geriatr, Changsha 410008, Peoples R China.;Cent South Univ, Xiangya Hosp, Hunan Key Lab Mol Precis Med, Changsha 41008, Peoples R China.
摘要：
OBJECTIVE: Despite substantial advancements in uncovering the genetic basis of Parkinson's disease (PD), a significant portion of cases characterized by familial PD remain genetically elusive. Here, we reported that biallelic variants in EPG5, a key autophagy gene responsible for Vici syndrome, are associated with PD. METHODS: Whole-exome sequencing (WES) was performed in the first cohort including 171 pedigrees with autosomal recessive PD (ARPD), 1,746 cases of sporadic early-onset PD (sEOPD, age at onset ≤ 50 years) and 1,652 healthy controls. Whole-genome sequencing (WGS) was performed in the second cohort consisting of 1,947 sporadic late-onset PD (sLOPD, age at onset >50 years) and 2,478 healthy controls. RESULTS: We identified 7 participants harboring compound heterozygous variants within the EPG5 gene across 1 family with ARPD (ARPD-F1), 4 sporadic EOPD cases, and 1 sporadic LOPD individual. A total of 10 novel variants in EPG5 were discovered in the 7 individuals, comprising 3 nonsense variants and 7 missense variants. The compound heterozygous variants in the EPG5 gene led to decreased expression of EPG5 protein, and impaired autophagy-lysosome function in cells derived from EPG5-PD individuals. We also revealed several key pathological features, including abnormal accumulation of autophagic vacuoles, aggregation of α-synuclein in skin tissue from EPG5-PD individuals. In mice, EPG5 deficiency led to progressive dopaminergic neurodegeneration in the substantia nigra of the midbrain. INTERPRETATION: Our results unveil a novel association between biallelic variants in EPG5 gene and PD, providing compelling initial evidence for the involvement of EPG5 and autophagy dysregulation in the development of PD. ANN NEUROL 2025.
期刊：
Separation and Purification Technology,2025年353:128486 ISSN：1383-5866
通讯作者：
Tao Li
作者机构：
[Yongchao Zhou; Yan Li; Ziyu Chen; Haibin Zeng; Wenhao Su; Zhao Zhao; Chengming Du; Chengzong Li; Tao Li] School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, PR China
通讯机构：
[Tao Li] S;School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, PR China
摘要：
Spent LiNi x Co y Mn z O 2 (NCM) recycling ensures the sustainable development of lithium-ion batteries (LIBs) industry by returning valuable metals back to the supply chain. However, traditional recovery techniques for extracting metals from spent NCM necessitate tedious separation and purification operations. Herein, a spray pyrolysis-based process has been proposed for spent NCM recycling, which achieves the preferential lithium (Li) extraction and ternary cathode precursor synthesis simultaneously. Specifically, after a process sequence of chlorination roasting, spray pyrolysis , water leaching, spent NCM cathode powder is transformed into a LiCl solution and ternary oxide, which can be directly used for the synthesis of battery-grade Li 2 CO 3 and NCM cathode, respectively. The pyrolysis behavior of different metal chloride solution is systematically examined and related thermodynamical mechanism is discussed. Besides, the residual Cl in the pyrolyzed powder is found to have a great influence on recovery efficiency and a corresponding Cl elimination method is proposed. Under the optimized conditions, >88 % of Li can be preferentially leached out and the regenerated single-crystal NCM811 retains 80 % capacity after 300 stable cycles at 1C. This work offers a short and robust process for obtaining high-value-added products from spent NCM cathode.
Spent LiNi x Co y Mn z O 2 (NCM) recycling ensures the sustainable development of lithium-ion batteries (LIBs) industry by returning valuable metals back to the supply chain. However, traditional recovery techniques for extracting metals from spent NCM necessitate tedious separation and purification operations. Herein, a spray pyrolysis-based process has been proposed for spent NCM recycling, which achieves the preferential lithium (Li) extraction and ternary cathode precursor synthesis simultaneously. Specifically, after a process sequence of chlorination roasting, spray pyrolysis , water leaching, spent NCM cathode powder is transformed into a LiCl solution and ternary oxide, which can be directly used for the synthesis of battery-grade Li 2 CO 3 and NCM cathode, respectively. The pyrolysis behavior of different metal chloride solution is systematically examined and related thermodynamical mechanism is discussed. Besides, the residual Cl in the pyrolyzed powder is found to have a great influence on recovery efficiency and a corresponding Cl elimination method is proposed. Under the optimized conditions, >88 % of Li can be preferentially leached out and the regenerated single-crystal NCM811 retains 80 % capacity after 300 stable cycles at 1C. This work offers a short and robust process for obtaining high-value-added products from spent NCM cathode.
摘要：
Peptides exhibit various biological activities, including biorecognition, cell targeting, and tumor penetration, and can stimulate immune cells to elicit immune responses for tumor immunotherapy. Peptide self-assemblies and peptide-functionalized nanocarriers can reduce the effect of various biological barriers and the degradation by peptidases, enhancing the efficiency of peptide delivery and improving antitumor immune responses. To date, the design and development of peptides with various functionalities have been extensively reviewed for enhanced chemotherapy; however, peptide-mediated tumor immunotherapy using peptides acting on different immune cells, to the knowledge, has not yet been summarized. Thus, this work provides a review of this emerging subject of research, focusing on immunomodulatory anticancer peptides. This review introduces the role of peptides in the immunomodulation of innate and adaptive immune cells, followed by a link between peptides in the innate and adaptive immune systems. The peptides are discussed in detail, following a classification according to their effects on different innate and adaptive immune cells, as well as immune checkpoints. Subsequently, two delivery strategies for peptides as drugs are presented: peptide self-assemblies and peptide-functionalized nanocarriers. The concluding remarks regarding the challenges and potential solutions of peptides for tumor immunotherapy are presented. This work introduces the role of peptides in immune regulation of innate and adaptive immune cells, as well as immune checkpoints. Then this work introduces two strategies for delivering polypeptides: peptide self-assemblies, and peptide-functionalized nanocarriers. Finally, the challenges and prospects of peptides in tumor immunotherapy are summarized. image
作者机构：
[Yuzhen Mai; Yupeng Xie; Pingping Huang; Keyou Shi; Yang Yang; Jie Chen; Yu Gao; Yanan Wan; Jiao Liu; Zihan Qin] School of Resource Environment and Safety Engineering, University of South China, 28 Changsheng West Road, Hengyang 421001, PR China;College of Physics and Optoelectronic Engineering, Shenzhen University, 3688 Nanhai avenue, Shenzhen 518000, PR China;[Yong Liu] School of Resource Environment and Safety Engineering, University of South China, 28 Changsheng West Road, Hengyang 421001, PR China<&wdkj&>College of Physics and Optoelectronic Engineering, Shenzhen University, 3688 Nanhai avenue, Shenzhen 518000, PR China
通讯机构：
[Yupeng Xie] S;School of Resource Environment and Safety Engineering, University of South China, 28 Changsheng West Road, Hengyang 421001, PR China
摘要：
A novel core-shell composite pellet waste form was developed to immobilize An 4+ radioactive waste via microwave heating, aiming to improve the solid solubility of radioactive waste. The simulated An 4+ radioactive waste (CeO 2 ) was successfully incorporated into a core-shell composite pellet at 1300 °C, in which CeO 2 was incorporated into monazite (CePO 4 ) to form the core layer, and encapsulated within a shell layer comprised of CaZrTi 2 O 7 glass ceramics (GCs). The phase evolution, microstructure, and densification of both the core and shell layers in the sintered matrix were systematically investigated. Furthermore, the chemical stability of the monolithic solidified waste forms was assessed using the ASTM C1220 protocol (MCC-1 method). The results indicated that the maximum solid solubility of CeO 2 was 27 wt .% at 1300 °C, which was substantially higher than previously reported research. Notably, such a CePO 4 @CaZrTi 2 O 7 GCs sintered pellet exhibited exceptional chemical stability. The normalized mass loss of Ce element (NL Ce ) was 3.43×10 -6 g·m -2 at 42 days. Consequently, the core-shell composite pellet waste form characterized by high waste loading and exceptional chemical stability, presents a promising solution for the immobilization of An 4+ nuclear waste.
A novel core-shell composite pellet waste form was developed to immobilize An 4+ radioactive waste via microwave heating, aiming to improve the solid solubility of radioactive waste. The simulated An 4+ radioactive waste (CeO 2 ) was successfully incorporated into a core-shell composite pellet at 1300 °C, in which CeO 2 was incorporated into monazite (CePO 4 ) to form the core layer, and encapsulated within a shell layer comprised of CaZrTi 2 O 7 glass ceramics (GCs). The phase evolution, microstructure, and densification of both the core and shell layers in the sintered matrix were systematically investigated. Furthermore, the chemical stability of the monolithic solidified waste forms was assessed using the ASTM C1220 protocol (MCC-1 method). The results indicated that the maximum solid solubility of CeO 2 was 27 wt .% at 1300 °C, which was substantially higher than previously reported research. Notably, such a CePO 4 @CaZrTi 2 O 7 GCs sintered pellet exhibited exceptional chemical stability. The normalized mass loss of Ce element (NL Ce ) was 3.43×10 -6 g·m -2 at 42 days. Consequently, the core-shell composite pellet waste form characterized by high waste loading and exceptional chemical stability, presents a promising solution for the immobilization of An 4+ nuclear waste.
作者：
Gao, Shuguang;Meng, Jiahao;Zeng, Chao;Monllau, Joan C;LaPrade, Robert F;...
期刊：
International Journal of Surgery,2025年 ISSN：1743-9191
作者机构：
[Zeng, Chao; Li, Yusheng; Lei, Guanghua; Xiong, Yilin; Meng, Jiahao; Xiao, Wenfeng; Gao, Shuguang; Liu, Pan] Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China;[Zeng, Chao; Lei, Guanghua; Gao, Shuguang] Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China;[Zeng, Chao; Lei, Guanghua; Gao, Shuguang] Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China;[Zeng, Chao; Lei, Guanghua; Gao, Shuguang] National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;[Monllau, Joan C] Department of Orthopaedic Surgery, Parc de Salut Mar, Hospital de la Esperanza, Universitat Autònoma de Barcelona, Barcelona, Spain
摘要：
BACKGROUND: Posterior cruciate ligament (PCL) injury is a relatively common musculoskeletal condition. However, there is currently a lack of consensus on decision-making, treatment and postoperative management for such injuries. OBJECTIVES: To use the modified Delphi method to reach expert consensus on the management of PCL injury. METHODS: A literature search of PubMed, Cochrane Library, Embase, and Web of Science for articles up to 17 October 2024, to support the development of recommendation statements. An Expert Panel of 90 experienced clinicians from orthopaedics and sports medicine participated in a two-round Delphi process. Each statement was evaluated in two parts: the first part assessed content appropriateness (score of 7-9 indicating appropriateness and 4-6 indicating possible appropriateness), while the second part assessed agreement (score of 5-9 indicating agreement). RESULTS: The panel members developed 11 statements using the Delphi process, addressing the following topics: (1) clinical decision-making, (2) treatment, and (3) postoperative management about PCL injuries. The final consensus was reached on 11 statements and we eventually translated these statements into a corresponding table of expert recommendations. CONCLUSION: Consensus was reached on 11 statements regarding three aspects of PCL injury management. These findings provide a foundation for developing evidence-based guidelines that can enhance clinical decision-making, improve treatment strategies, and optimize postoperative care for patients with PCL injuries.
摘要：
Microcystin-LR (MC-LR) is a toxin that causes hepatic steatosis. Our previous study found that exposure to 60 μg/L MC-LR for 9 months resulted in liver lipid accumulation, but the underlying mechanisms remain elusive. Herein, for the first time, fatty acid-targeted metabolome and RNA-seq were combined to probe the effect and mechanism of chronic (12-month) MC-LR treatment on mice lipid metabolism at environmental-related levels (1, 60, and 120 μg/L). It was found that MC-LR dose-dependently raised serum and liver lipid levels. The total cholesterol (TC) levels in the liver were significantly increased following treatment with 1 μg/L MC-LR (equivalent to 0.004 μ/L in human). Treatment with 60 and 120 μg/L MC-LR significantly elevated TC and triglyceride (TG) levels in both serum and liver. Serum fatty acid-targeted metabolome analysis demonstrated that exposure to 1, 60, and 120 μg/L MC-LR caused significant alterations in the fatty acid profile. Chronic 1, 60, and 120 μg/L MC-LR treatment significantly increased serum polyunsaturated fatty acids (PUFAs), including conjugated linoleic acid and eicosapentaenoic acid, which positively correlated with serum or liver TG levels. Chronic exposure to 120 μg/L MC-LR led to a significant decrease in the accumulation of saturated fatty acids, including citramalic acid, pentadecanoic acid, and docosanoic acid, which were negatively correlated with serum or liver lipid levels. These findings suggested that 1 μg/L MC-LR exposure caused mild lipid metabolism disruption, while 60 and 120 μg/L MC-LR treatment resulted in pronounced hepatic steatosis in mice. Transcriptome analysis revealed that chronic environmental MC-LR treatment regulated the expression of genes involved in the phosphatidylinositol 3-kinase (PI3K) complex and fatty acid metabolism. Western blotting and RT-qPCR confirmed that chronic environmental MC-LR exposure activated the PI3K/AKT/mTOR signaling pathway, the downstream of fads3 gene that participates in fatty acid desaturation was upregulated, fatty acid degradation-related genes, including acsl1, acsl4, and ehhadh were inhibited, and lipid transport-related genes, including slc27a4 and apol7a, were promoted. Thus, chronic environmental MC-LR exposure boosts hepatic steatosis. Our work indicated that the limit concentration of 1 μg/L MC-LR in human drinking water for safety needs to be discussed. The study provides the first evidence of the fatty acid profile and gene changes and gains new insights into the mechanisms of chronic environmental MC-LR treatment-induced hepatic steatosis.
通讯机构：
[Wang, F ] B;Beijing Inst Technol, Sch Phys, Beijing 100081, Peoples R China.
摘要：
We conducted a study on the electron stopping power of protons in aluminum at finite electron temperatures, utilizing time-dependent density functional theory nonadiabatically coupled with molecular dynamics. Our investigation focused on protons with initial velocities ranging from 0.1 to 1.0 a.u., providing a wealth of detailed information on the electronic states involved in the stopping process, with exceptional spatial and temporal resolution. Our results show that the electron temperature can significantly effect the electron stopping power. A quantum-blocking mechanism based on a physical picture of electronic transitions in energy levels has been proposed for explaining the phenomenon of electron stopping power decreasing with the increase of target electron temperature.
摘要：
Specifically exposed planes could play a crucial role in the chemical activity of nanomaterials. The morphology and structure of nano-structured WO3 particles with {020} exposure planes were successfully controlled via hydrothermal synthesis technology by adjusting the synthesis temperature and time. Additionally, the gas-sensing properties of sensors fabricated using these WO3 particles were investigated to detect different volatile gases. All the samples were found to be sensitive to alcohol gas, and the WO3 nanoparticles synthesized at 150 °C for 12 h exhibited excellent gas-sensing properties, which shows that these WO3 nanoparticles can act as an efficient gas-sensing material for the one-site selective detection of ethanol.
Specifically exposed planes could play a crucial role in the chemical activity of nanomaterials. The morphology and structure of nano-structured WO3 particles with {020} exposure planes were successfully controlled via hydrothermal synthesis technology by adjusting the synthesis temperature and time. Additionally, the gas-sensing properties of sensors fabricated using these WO3 particles were investigated to detect different volatile gases. All the samples were found to be sensitive to alcohol gas, and the WO3 nanoparticles synthesized at 150 °C for 12 h exhibited excellent gas-sensing properties, which shows that these WO3 nanoparticles can act as an efficient gas-sensing material for the one-site selective detection of ethanol.
摘要：
The rapid expansion of nuclear energy has led to increased uranium contamination in wastewater, necessitating the development of efficient, cost-effective, and recyclable materials for uranium removal. Hydroxyapatite (HAP) has emerged as a promising candidate due to its exceptional surface properties, structural tunability, and environmental compatibility. This review systematically evaluates recent progress in HAP-based materials for uranium remediation, focusing on advanced synthesis techniques and modification strategies that enhance adsorption capacity and ion selectivity. We analyze the underlying mechanisms, particularly the roles of material morphology and solution pH in optimizing uranium removal efficiency. Current limitations in practical applications are critically discussed, along with future research priorities for developing next-generation HAP composites. By establishing structure-performance relationships and addressing current challenges, this review provides fundamental insights to guide the design of high-performance radioactive wastewater treatment materials.
The rapid expansion of nuclear energy has led to increased uranium contamination in wastewater, necessitating the development of efficient, cost-effective, and recyclable materials for uranium removal. Hydroxyapatite (HAP) has emerged as a promising candidate due to its exceptional surface properties, structural tunability, and environmental compatibility. This review systematically evaluates recent progress in HAP-based materials for uranium remediation, focusing on advanced synthesis techniques and modification strategies that enhance adsorption capacity and ion selectivity. We analyze the underlying mechanisms, particularly the roles of material morphology and solution pH in optimizing uranium removal efficiency. Current limitations in practical applications are critically discussed, along with future research priorities for developing next-generation HAP composites. By establishing structure-performance relationships and addressing current challenges, this review provides fundamental insights to guide the design of high-performance radioactive wastewater treatment materials.
期刊：
Chemical Engineering Journal,2025年505:159469 ISSN：1385-8947
通讯作者：
Guibal, E;Hamza, MF
作者机构：
[Salih, Khalid A. M.; Zhou, Kanggen] Cent South Univ, Sch Met & Environm, Changsha 410083, Peoples R China.;[Guibal, Eric; Guibal, E] IMT Mines Ales, Polymers Compos & Hybrids PCH, Ales, France.;[Basiony, Ebtesam A.; Nassar, Lobna A.; Abdel-Rahman, Adel A. -H.] Menoufia Univ, Fac Sci, Chem Dept, Shibin Al Kawm 32511, Egypt.;[Ning, Shunyan; Wei, Yuezhou; Hamza, Mohammed F.; Hamza, MF] Univ South China, Sch Nucl Sci & Technol, Heng Yang 421001, Peoples R China.;[Wei, Yuezhou] Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, Shanghai, Peoples R China.
通讯机构：
[Hamza, MF ] U;[Guibal, E ] I;IMT Mines Ales, Polymers Compos & Hybrids PCH, Ales, France.;Univ South China, Sch Nucl Sci & Technol, Heng Yang 421001, Peoples R China.
关键词：
Carbamoylacetamide derivative grafted-chitosan;Enhancing U(VI) sorption by ion imprinting: improved uptake kinetics and selectivity;Comparative studies of ion-imprinting and non-imprinting sorbents;Remarkable stability after 10 cycles of sorption and desorption;Efficient uranium recovery from acidic ore leachate
摘要：
Uranium recovery from complex effluents requires the combination of different processes including metal sorption from low-concentration solutions containing several competitor metal ions. The design of efficient sorbents (BTC/CH(s), 2-(benzo[d]thiazol-2-yl)-N-carbamoyl acetamide grafted chitosan) that combine both high sorption capacity and high selectivity was achieved by adopting a dual strategy: (a) selecting efficient functional groups (amine, amide, thioester, and hydroxyl groups, in BTC/CH sorbents), and (b) adapting the arrangement of reactive groups appropriately to fit the specific shape of the complexes (ion-imprinting IP vs. non-ion-imprinted NIP materials). This dual strategy was applied to design a chitosan-based sorbent with high sorption capacity (≈1.5 mmol U g −1 ), fast uptake (equilibrium: 15–20 min), remarkable stability (limited loss of performances after 10 reuse cycles), and strong selectivity (tested on both equimolar multi-component solutions and pre-treated acid leachate), at moderately acidic pH (i.e., 4). Ion-templating strategy effectively improved selectivity by 5–10-folds. Uptake kinetics was fitted by the pseudo-first order rate equation, while the sorption isotherms were finely simulated by the Temkin equation. The sorption was exothermic, spontaneous, and the ion-templating allowed reaching more organized structure. The sorbent was highly selective against base metals, alkali and alkali-earth metals, but less efficient for the separation from thorium or rare-earth elements. The sorbent was successfully used for the recovery of residual uranyl from acidic leachates pre-treated with resins (Amberlite IRA-400 and DOWEX 50, for the recovery of U and rare-earth elements, respectively) and precipitation step (removal of Al(III)/Fe(III) at pH 4). The sorbents were characterized by elemental analysis, FTIR and XPS spectroscopy for analyzing the chemical structure of the materials and identifying their interactions with U(VI). Textural properties and pHpzc values were analyzed for supporting sorption behaviors.
Uranium recovery from complex effluents requires the combination of different processes including metal sorption from low-concentration solutions containing several competitor metal ions. The design of efficient sorbents (BTC/CH(s), 2-(benzo[d]thiazol-2-yl)-N-carbamoyl acetamide grafted chitosan) that combine both high sorption capacity and high selectivity was achieved by adopting a dual strategy: (a) selecting efficient functional groups (amine, amide, thioester, and hydroxyl groups, in BTC/CH sorbents), and (b) adapting the arrangement of reactive groups appropriately to fit the specific shape of the complexes (ion-imprinting IP vs. non-ion-imprinted NIP materials). This dual strategy was applied to design a chitosan-based sorbent with high sorption capacity (≈1.5 mmol U g −1 ), fast uptake (equilibrium: 15–20 min), remarkable stability (limited loss of performances after 10 reuse cycles), and strong selectivity (tested on both equimolar multi-component solutions and pre-treated acid leachate), at moderately acidic pH (i.e., 4). Ion-templating strategy effectively improved selectivity by 5–10-folds. Uptake kinetics was fitted by the pseudo-first order rate equation, while the sorption isotherms were finely simulated by the Temkin equation. The sorption was exothermic, spontaneous, and the ion-templating allowed reaching more organized structure. The sorbent was highly selective against base metals, alkali and alkali-earth metals, but less efficient for the separation from thorium or rare-earth elements. The sorbent was successfully used for the recovery of residual uranyl from acidic leachates pre-treated with resins (Amberlite IRA-400 and DOWEX 50, for the recovery of U and rare-earth elements, respectively) and precipitation step (removal of Al(III)/Fe(III) at pH 4). The sorbents were characterized by elemental analysis, FTIR and XPS spectroscopy for analyzing the chemical structure of the materials and identifying their interactions with U(VI). Textural properties and pHpzc values were analyzed for supporting sorption behaviors.
摘要：
Considering the issues of significant ammonia volatilization loss and toxic gas emission associated with the conventional ammonia leaching method used in the resource utilization of cobalt-rich alloy slag, a novel approach involving selective complexation leaching of cobalt in an alkaline histidine solution has been proposed. Under conditions of 35 degrees C temperature, a molar ratio of histidine to cobalt of 1.5, pH of 8, a leaching period of 12 h, and a stirring speed of 300 rpm, the cobalt leaching rate from cobalt-rich alloy slag exceeds 95%. In contrast, the leaching rates for impurity metals such as iron, lead, and copper remain below 3%, demonstrating outstanding leaching selectivity. Leaching kinetics calculations indicate that the rate-controlling step is chemical reaction control, with an apparent activation energy of 64.32 kJ/mol. Through the use of FTIR and XPS characterization techniques, it has been confirmed that histidine molecules form a stable complex with cobalt ions via the dual coordination of the carboxyl (COO-) and amino (-NH2) groups. This distinctive bifunctional synergistic coordination mechanism markedly enhances leaching selectivity and reaction efficiency.
摘要：
Multimodal medical image fusion aims to integrate complementary information from different modalities of medical images. Deep learning methods, especially recent vision Transformers, have effectively improved image fusion performance. However, there are limitations for Transformers in image fusion, such as lacks of local feature extraction and cross-modal feature interaction, resulting in insufficient multimodal feature extraction and integration. In addition, the computational cost of Transformers is higher. To address these challenges, in this work, we develop an adaptive cross-modal fusion strategy for unsupervised multimodal medical image fusion. Specifically, we propose a novel lightweight cross Transformer based on cross multi-axis attention mechanism. It includes cross-window attention and cross-grid attention to mine and integrate both local and global interactions of multimodal features. The cross Transformer is further guided by a spatial adaptation fusion module, which allows the model to focus on the most relevant information. Moreover, we design a special feature extraction module that combines multiple gradient residual dense convolutional and Transformer layers to obtain local features from coarse to fine and capture global features. The proposed strategy significantly boosts the fusion performance while minimizing computational costs. Extensive experiments, including clinical brain tumor image fusion, have shown that our model can achieve clearer texture details and better visual quality than other state-of-the-art fusion methods.
摘要：
External carbon sources have been recognized to affect the microbial-mediated remediation of microcystin (MC) in both natural and industrial polluted water bodies; however, the underlying molecular mechanisms remain unclear but would be worthy of further study. In this case, the MC-degrading bacterium, Sphingosinicella microcystinivorans Y2, was used to investigate the effect of exogenous glucose on MC biodegradation and its potential regulatory mechanisms. Our phenotypic results indicated that external glucose, within specific concentration ranges (125, 500, and 1000 mg/L), substantially accelerated the efficiency of MC degradation. Additionally, morphological observations suggested that glucose may positively impact the bacterial cells. A genome-oriented analysis of S . microcystinivorans Y2 was conducted to identify several Mlr-dependent MC-degrading genes, which were involved in the complete degradation of MC. Enrichment analysis of differentially expressed genes further indicated that glucose-promoted MC biodegradation may be associated with various biological processes. Furthermore, the gene-gene interaction network revealed the co-expression of genes mlrA and nadD , suggesting that increased levels of NAD + may positively stimulate various biochemical reactions to fuel the MC degradation of strain Y2. In short, our findings present that exogenous glucose might accelerate the bacterial-mediated MC biodegradation, and further reveal its underlying molecular mechanisms, which provides the theoretical basis for the application of external carbon in the microbial treatment of toxic MC.
External carbon sources have been recognized to affect the microbial-mediated remediation of microcystin (MC) in both natural and industrial polluted water bodies; however, the underlying molecular mechanisms remain unclear but would be worthy of further study. In this case, the MC-degrading bacterium, Sphingosinicella microcystinivorans Y2, was used to investigate the effect of exogenous glucose on MC biodegradation and its potential regulatory mechanisms. Our phenotypic results indicated that external glucose, within specific concentration ranges (125, 500, and 1000 mg/L), substantially accelerated the efficiency of MC degradation. Additionally, morphological observations suggested that glucose may positively impact the bacterial cells. A genome-oriented analysis of S . microcystinivorans Y2 was conducted to identify several Mlr-dependent MC-degrading genes, which were involved in the complete degradation of MC. Enrichment analysis of differentially expressed genes further indicated that glucose-promoted MC biodegradation may be associated with various biological processes. Furthermore, the gene-gene interaction network revealed the co-expression of genes mlrA and nadD , suggesting that increased levels of NAD + may positively stimulate various biochemical reactions to fuel the MC degradation of strain Y2. In short, our findings present that exogenous glucose might accelerate the bacterial-mediated MC biodegradation, and further reveal its underlying molecular mechanisms, which provides the theoretical basis for the application of external carbon in the microbial treatment of toxic MC.
期刊：
Journal of High Energy Physics,2025年2025(2):1-27 ISSN：1029-8479
通讯作者：
Chen, X
作者机构：
[Chen, Xun; Chen, X] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Chen, Xun; Chen, X] Cent China Normal Univ, Key Lab Quark & Lepton Phys MOE, Wuhan 430079, Peoples R China.;[Huang, Mei] Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 100049, Peoples R China.
通讯机构：
[Chen, X ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;Cent China Normal Univ, Key Lab Quark & Lepton Phys MOE, Wuhan 430079, Peoples R China.
关键词：
Gauge-Gravity Correspondence;Phase Diagram or Equation of State;Quark-Gluon Plasma
摘要：
QCD phase diagram in the T - mu plane and the equation of state for pure gluon, 2-flavor, 2+1-flavor systems, and 2+1+1-flavor systems have been investigated using the Einstein-Maxwell-Dilaton (EMD) framework at finite temperature and chemical potential. By inputting lattice QCD data for the equation of state and baryon number susceptibility at zero chemical potential into holographic model, all the parameters can be determined with the aid of machine learning algorithms. Our findings indicate that the deconfinement phase transition is of first order for the pure gluon system with critical temperature Tc = 0.265 GeV at vanishing chemical potential. The phase transition for the 2-flavor, 2+1-flavor systems, and 2+1+1-flavor systems are crossover at vanishing chemical potential and first-order at high chemical potential, and the critical endpoint (CEP) in the T - mu plane locates at (mu Bc\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\mu}_B<^>c $$\end{document} = 0.46 GeV, Tc= 0.147 GeV), (mu Bc\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\mu}_B<^>c $$\end{document} = 0.74 GeV, Tc = 0.094 GeV), and (mu Bc\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\mu}_B<^>c $$\end{document} = 0.87 GeV, Tc = 0.108 GeV), respectively. Additionally, the thermodynamic quantities of the system for different flavors at finite chemical potential are presented in this paper. It is observed that the difference between the 2+1-flavor and 2+1+1-flavor systems is invisible at vanishing chemical potential and low temperature. The location of CEP for 2+1+1-flavor system deviates explicitly from that of the 2+1-flavor system with the increase of chemical potential. Both 2+1-flavor and 2+1+1-flavor systems differ significantly from the 2-flavor system. Moreover, at zero temperature, the critical chemical potential is found to be mu B = 1.1 GeV, 1.6 GeV, 1.9 GeV for the 2-flavor, 2+1-flavor and 2+1+1-flavor systems, respectively.
作者机构：
[Zeng, Wengao] Natl & Local Joint Engn Res Ctr Airborne Pollutant, Hengyang 421001, Peoples R China.;[Zeng, Wengao] Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.;[Chen, Jie] Xi An Jiao Tong Univ, Sch Environm & Chem Engn, Xian 710049, Peoples R China.;[Zhang, Ziying; Ye, Xiaoyuan; Zhang, Tuo; Zeng, Wengao; Dong, Yuchen; Zhao, Yi; Zhang, Lei; Guan, Xiangjiu] Xian Jiaotong Univ XJTU, Int Res Ctr Renewable Energy IRCRE, State Key Lab Multiphase Flow Power Engn MFPE, 28 West Xianning Rd, Xian 710049, Peoples R China.
通讯机构：
[Guan, XJ ] X;Xian Jiaotong Univ XJTU, Int Res Ctr Renewable Energy IRCRE, State Key Lab Multiphase Flow Power Engn MFPE, 28 West Xianning Rd, Xian 710049, Peoples R China.
摘要：
Rationally modulating the adsorption of reaction intermediates on the surface sites of carbon nitride-based catalysts could facilitate the photocatalytic reduction of O2 to H2O2. Herein, theoretical calculations reveal that multiple sites of heteroatoms and defects can synergistically increase local proton coverage and lower the kinetic barrier for O2 protonation, thereby promoting the production of *OOH and the subsequent generation of H2O2. As a proof of concept, carbon nitride (BPMC-Vs) with multiheteroatoms (B and P) and multidefects (N defects, -C equivalent to N) was successfully synthesized, achieving optimized solar-to-chemical conversion efficiency and selectivity of 0.33% and 95.2%, respectively. In situ spectroscopic characterization combined with theoretical calculations confirms that P atoms and -C equivalent to N groups increase proton coverage, while B atoms and N defects effectively promote the protonation of O2 to *OOH, thereby significantly enhancing the generation of H2O2. This work provides insightful guidance for carbon nitride catalysis at the atomic scale for boosting photocatalytic H2O2 production.
期刊：
Separation and Purification Technology,2025年358:130299 ISSN：1383-5866
通讯作者：
Qingliang Wang<&wdkj&>Fang Hu
作者机构：
[Zhao, Xu] School of Nuclear Science and Technology, University of South China, Hengyang 421001, Hunan, China;[Lei, Zhiwu; Li, Haoshuai; Su, Yucheng; Ali, Khan Muhammad Yaruq; Hu, Eming; Wang, Hongqiang; Wang, Qingliang; Hu, Fang] School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, Hunan, China;[Hou, Hongshuai] State Key Laboratory of Powder Metallurgy, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;[Sun, Yige] College of Resources and Environment, Anhui Agricultural University, Hefei 230000, Anhui, China;Non–ferrous Heavy Metal Pollution Control Equipment Hunan Engineering Laboratory, Science Environmental Protection Co., Ltd., Changsha 410000, Hunan, China
通讯机构：
[Qingliang Wang; Fang Hu] S;School of Resource Environment and Safety Engineering, University of South China, Hengyang 421001, Hunan, China
摘要：
With the sensitization of carbon neutrality, the efficient removal of beryllium from beryllium-containing wastewater has gained increasing research interest in the environmental field. In this study, carbon dots (CDs)/phosphonated chitosan hydrogel (PCH@CDs) are prepared by cross-linking nanometer CDs with phosphoric acid, calcium hydroxide, and chitosan. The doping with CDs increases the number of adsorption active sites (AAS) on PCH@CDs, thereby improving the removal rates of small molecular pollutants. The adsorption isotherm results show that the maximum amount of Be(II) adsorbed by PCH@CDs in neutral water is approximately 59.84 mg/g. The excellent adsorption of Be(II) by PCH@CDs can be attributed to the homogeneous dispersion of CDs in PCH@CDs, which results in significant exposure of CDs binding sites to Be(II). In addition, the surface of PCH@CDs contains many phosphate groups, including N–H and O–H, which have strong synergistic adsorption capacity for Be(II). In simulated wastewater, the Be(II) distribution coefficient of PCH@CDs is 6.56 × 10 5 mL/g, which is significantly higher than that of other coexisting ions. Furthermore, PCH@CDs can reduce the Be(II) concentration to less than 5 µg/L when treating Be(II)-containing solutions with an initial Be(II) concentration of less than 5 mg/L.
With the sensitization of carbon neutrality, the efficient removal of beryllium from beryllium-containing wastewater has gained increasing research interest in the environmental field. In this study, carbon dots (CDs)/phosphonated chitosan hydrogel (PCH@CDs) are prepared by cross-linking nanometer CDs with phosphoric acid, calcium hydroxide, and chitosan. The doping with CDs increases the number of adsorption active sites (AAS) on PCH@CDs, thereby improving the removal rates of small molecular pollutants. The adsorption isotherm results show that the maximum amount of Be(II) adsorbed by PCH@CDs in neutral water is approximately 59.84 mg/g. The excellent adsorption of Be(II) by PCH@CDs can be attributed to the homogeneous dispersion of CDs in PCH@CDs, which results in significant exposure of CDs binding sites to Be(II). In addition, the surface of PCH@CDs contains many phosphate groups, including N–H and O–H, which have strong synergistic adsorption capacity for Be(II). In simulated wastewater, the Be(II) distribution coefficient of PCH@CDs is 6.56 × 10 5 mL/g, which is significantly higher than that of other coexisting ions. Furthermore, PCH@CDs can reduce the Be(II) concentration to less than 5 µg/L when treating Be(II)-containing solutions with an initial Be(II) concentration of less than 5 mg/L.
摘要：
Postoperative Delirium (POD) has an incidence of up to 65% in older patients undergoing cardiac surgery. We aimed to develop two dynamic nomograms to predict the risk of POD in older patients undergoing cardiac surgery. This was a single-center retrospective cohort study, which included 531 older patients who underwent cardiac surgery from July 2021 to June 2022 at Nanjing First Hospital, China. Univariable and multivariable logistic regression were used to identify the significant predictors used when constructing the models. We evaluated the performances and accuracy, validated, and estimated the clinical utility and net benefit of the models using the receiver operating characteristic (ROC), the 10-fold cross-validation, and decision curve analysis (DCA). A total of 30% of the patients developed POD, the significant predictors in the preoperative model were ASA ( p < 0.001 OR = 3.220), cerebrovascular disease (p < 0.001 OR = 2.326), Alb (p < 0.037 OR = 0.946), and URE (p < 0.001 OR = 1.137), while for the postoperative model they were ASA (p = 0.044, OR = 1.737), preoperative MMSE score (p = 0.005, OR = 0.782), URE (p = 0.017 OR = 1.092), CPB duration (p < 0.001 OR = 1.010) and APACHE II (p < 0.001, OR = 1.353). The preoperative and postoperative models achieved satisfactory predictive performances, with AUC values of 0.731 and 0.799, respectively. The web calculators can be accessed at
https://xxh152.shinyapps.io/Pre-POD/
and
https://xxh152.shinyapps.io/Post-POD/
. We established two nomogram models based on the preoperative and postoperative time points to predict POD risk and guide the flexible implementation of possible interventions at different time points.
通讯机构：
[Gu, YL ] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421000, Hunan, Peoples R China.
关键词：
Composite transparent polyimide film;Flexible display;Finite element analysis
摘要：
Polyimide is a high-performance polymer material that is widely used in the manufacture of printed circuit boards, cable insulation, and other electronic components because of its excellent electrical insulation properties and thermal stability. In this study, a transparent polyimide composite film material (5% CPI/OAPOSS@Al2O3) made from octaaminophenylpolysilsesquioxane (OAPOSS)-modified Al2O3 (in which the OAPOSS-modified Al2O3 filler content is 5%) homogeneously dispersed in a transparent polyimide (CPI) was used, and a foldable screen model made from the polyimide material was designed. A folding screen model made of this polyimide material was designed, and its performance in a complex mechanical environment was analyzed by detailed finite element simulation, to obtain the comprehensive performance of the composite folding screen model in a complex environment, and to try to analyze the law of the material performance in terms of the microscopic molecular structure. The simulation results show that the maximum equivalent stress of the composite CPI material in the folded screen model increases from 33.431 Mpa to 109.640 Mpa under the bending angles of 15 degrees, 45 degrees, 90 degrees, 135 degrees and 180 degrees; the elastic strain increases from 0.010131 mm/mm to 0.033224 mm/mm; and the total deformation increases from 1.762 mm to 71 mm. 1.762 mm to 71.439 mm, indicating that the 5% CPI/OAPOSS@Al2O3 composite CPI material has excellent mechanical strength and toughness, can be reversibly deformed in a wide range, and can withstand a certain degree of plastic deformation in the case of exceeding the elastic limit; the coefficient of safety is reduced from 2.5784 to 0.7862, which indicates that it can absorb enough energy during bending and has a certain plastic deformation ability, and is not prone to brittle fracture; the fatigue life of the composite material is 250,370 times when it is folded for many cycles under the condition that the bending angle is 180 degrees, i.e., the material is able to withstand many times of bending in the model of the folded screen without any significant damage or destruction. The results show that the folding screen model made of the composite material has excellent performance in all aspects, indicating that the 5% CPI/OAPOSS@Al2O3 material is fully capable of being applied in the folding screen cell phone screen, and the application of this series of polyimide-modified materials as flexible displays has a very bright future.
