Integration of Fatty Acid-Targeted Metabolome and Transcriptomics Reveals the Mechanism of Chronic Environmental Microcystin-LR-Induced Hepatic Steatosis

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成果类型：

期刊论文

作者：

Yan, Sisi;Liu, Ying;Zhang, Yin;Wang, Yaqi;Zheng, Shuilin;...

通讯作者：

Yang, F

作者机构：

[Liu, Ying; Zhang, Yin; Yao, Xueqiong; Yang, F; Yang, Yue; Yang, Fei; Tang, Yan; Long, Xizi; Yan, Sisi; Wang, Yaqi] Univ South China, Sch Basic Med, Dept Lab Anim Sci, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.

[Yang, F; Zheng, Shuilin; Yang, Fei] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410083, Peoples R China.

[Luo, Feijun] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Peoples R China.

[Yang, F; Yang, Fei] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Nucl Med Dept, Hengyang 421001, Peoples R China.

通讯机构：

[Yang, F ] U

Univ South China, Sch Basic Med, Dept Lab Anim Sci, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.

Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410083, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Nucl Med Dept, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

fatty acid degradation;fatty acid-targeted metabolome;hepatic steatosis;lipid transport;microcystin-LR;transcriptome

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2025

卷：

期：

页码：

4240–4252

DOI：

10.1021/acs.jafc.4c07085

基金类别：

National Natural Science Foundation of China [42477468]; National Natural Science Foundation of China [2023JJ40539, 2023JJ40568]; Natural Science Foundation of Hunan Province [CX20230987, BZ2023-Q048]; Innovation Project of Postgraduate Research in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

公共卫生学院

摘要：

Microcystin-LR (MC-LR) is a toxin that causes hepatic steatosis. Our previous study found that exposure to 60 μg/L MC-LR for 9 months resulted in liver lipid accumulation, but the underlying mechanisms remain elusive. Herein, for the first time, fatty acid-targeted metabolome and RNA-seq were combined to probe the effect and mechanism of chronic (12-month) MC-LR treatment on mice lipid metabolism at environmental-related levels (1, 60, and 120 μg/L). It was found that MC-LR dose-dependently raised serum and liver lipid levels. The total chole...

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Integration of Fatty Acid-Targeted Metabolome and Transcriptomics Reveals the Mechanism of Chronic Environmental Microcystin-LR-Induced Hepatic Steatosis

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