To mitigate the shortage of land uranium (U) resources and environmental pollution caused by uranium mining and smelting, a chitosan/ellagic acid/Cu-metal–organic framework (MOF) material (CEM) was synthesized for U extraction from seawater. CEM, a phenolic salt ligand MOF material, exhibited superior adsorption selectivity for uranium compared to an ellagic acid/Cu-MOF material (EM) according to the experimental results. The K d (distribution coefficient) of CEM for uranium was 16.4 times higher than that of EM, and its stability in water sig...