Phospholipid metabolism and drug resistance in cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Hu;Xiao, Qian;An, Yangfang;Wang, Mu;Zhong, Jing

通讯作者：

Zhong, J;Wang, M

作者机构：

[Zhong, Jing; Zhao, Hu; Zhong, J; Xiao, Qian] Univ South China, Affiliated Hosp 1, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Qian] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab Med, Hengyang 421001, Hunan, Peoples R China.

[An, Yangfang] Yiyang Cent Hosp, Yiyang 413099, Hunan, Peoples R China.

[Wang, Mu] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Clin Mass Spectrometry Lab, Hengyang, Peoples R China.

[Zhong, Jing] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhong, J ; Wang, M ] U

Univ South China, Affiliated Hosp 1, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Clin Mass Spectrometry Lab, Hengyang, Peoples R China.

语种：

英文

关键词：

Cancer;Drug resistance;Phospholipid metabolism

期刊：

Life Sciences

ISSN：

0024-3205

年：

2025

卷：

372

页码：

123626

DOI：

10.1016/j.lfs.2025.123626

基金类别：

CRediT authorship contribution statement Hu Zhao: Conceptualization, Writing – original draft. Mu Wang: Supervision. Jing Zhong: Supervision, acquisition, Writing – review & editing. Qian Xiao: Writing – review & editing. Yangfang An: Writing – review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Phospholipids, complex lipids prevalent in the human body, play crucial roles in various pathophysiological processes. Beyond their synthesis and degradation, phospholipids can influence chemoresistance by participating in ferroptosis. Extensive evidence highlights the significant link between tumor drug resistance and phospholipids. Therefore, drugs targeting phospholipid metabolism itself or the synthesis of corresponding composite materials will effectively overcome the difficulties of clinical tumor treatment. Phospholipids, complex lipids prevalent in the human body, play crucial roles in...

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