Natural Science Foundation of Hunan Province, China [2024JJ5354, 2023JJ40585]; Scientific and Technology Research Projects of Health Commission of Hunan Province [W20243167]; Scientific Research Project of Hunan Provincial Education [21C0300]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Sepsis-associated acute respiratory distress syndrome (ARDS) is a heterogeneous disease with high morbidity and mortality. Lactylation plays a crucial role in sepsis and sepsis-induced lung injury. This study aimed to identify distinct lactylation-based phenotypes in patients with sepsis-associated ARDS and determine relevant molecular biomarkers. We analyzed blood transcriptome and clinical data from patients with sepsis-associated ARDS and calculated the lactylation activity. KEGG pathway analysis, drug sensitivity prediction, and immune cell infiltration analysis were performed. Candidate m...
