Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

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成果类型：

期刊论文

作者：

Yin, Hao;Ruan, Zhe;Wan, Teng-Fei;Lin, Zhi-Rou;Chen, Chun-Yuan;...

通讯作者：

Zhao, Shu-Shan;Zhu, Yong;Xie, H

作者机构：

[Zou, Jing-Tao; Liu, Yi-Wei; Cao, Jia; Zhu, Yong; Zhu, Y; Xie, Hui; Yin, Hao; Gong, Jiang-Shan; Luo, Hao; Long, Cheng; Wang, Yi-Yi; Wan, Teng-Fei; Chen, Chun-Yuan; Liu, Yu-Qi; Zhu, Guo-Qiang; Zhao, Shu-Shan; Jin, Ling; Zhao, SS; Luo, Yi; Wang, Zhen-Xing; Li, Zhao-Hui] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.

[Zou, Jing-Tao; Liu, Yi-Wei; Cao, Jia; Xie, Hui; Yin, Hao; Gong, Jiang-Shan; Wang, Yi-Yi; Wan, Teng-Fei; Chen, Chun-Yuan; Zhu, Guo-Qiang; Jin, Ling; Luo, Yi; Wang, Zhen-Xing] Cent South Univ, Xiangya Hosp, Movement Syst Injury & Repair Res Ctr, Changsha 410008, Hunan, Peoples R China.

[Ruan, Zhe] First Hosp Changsha, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.

[Xie, Hui] Cent South Univ, Xiangya Hosp, Dept Sports Med, Changsha 410008, Hunan, Peoples R China.

[Xie, Hui] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Xie, H ; Zhao, SS; Zhu, Y] C

Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Movement Syst Injury & Repair Res Ctr, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Dept Sports Med, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Metformin;Osteoporosis;YAP1/TAZ;HIF1α;Angiogenesis;Type H vessel

期刊：

MOLECULAR MEDICINE

ISSN：

1076-1551

年：

2025

卷：

期：

页码：

1-16

DOI：

10.1186/s10020-025-01169-7

基金类别：

This work was supported by the National Natural Science Foundation of China ( Grant Nos. 81874006 , 81871822 , 82172399 , 82072504 , 82125023 , 81902222 , 82000845 ) and the Hunan Province Natural Science Foundation of China ( Grant Nos. 2021JJ40492 ).

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摘要：

BackgroundOsteoporosis, resulting from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation, affects millions globally. Recent studies have identified type H vessels (CD31hiEMCNhi) as a specialized subset of bone blood vessels that positively regulate bone formation. This study aims to investigate the effects of metformin on bone mass, strength, and angiogenesis in osteoporotic mice, and to elucidate the underlying molecular mechanisms, particularly focusing on the YAP1/TAZ-HIF1 alpha axis.MethodsOsteoporotic mice were administered metformin, and bone...

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Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

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