Molecular Engineering of NIR-II Excitable Phototheranostic for Mitochondria-Targeted Cancer Photoimmunotherapy

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成果类型：

期刊论文

作者：

Kang, Qiang;Liu, Fen;Tan, Senyou;Wu, Fan;Liu, Yinying;...

通讯作者：

Chen, Guodong;Wu, Gui-long;Tan, Xiaofeng;Yang, QL

作者机构：

[Wu, Fan; Li, Zelong; Liu, Fen; Tan, Xiaofeng; Chen, Guodong; Wu, Gui-long; Xiong, Jian; Huang, Hejin; Yang, Qinglai; Kang, Qiang; Tan, XF; Liu, Yinying; Tan, Senyou] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

[Wu, Fan; Li, Zelong; Liu, Fen; Tan, Xiaofeng; Chen, Guodong; Wu, Gui-long; Xiong, Jian; Huang, Hejin; Yang, Qinglai; Kang, Qiang; Tan, XF; Liu, Yinying; Tan, Senyou] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.

[Wu, Fan; Li, Zelong; Liu, Fen; Tan, Xiaofeng; Chen, Guodong; Wu, Gui-long; Xiong, Jian; Huang, Hejin; Yang, Qinglai; Kang, Qiang; Tan, XF; Liu, Yinying; Tan, Senyou] Univ South China, Hengyang Med Sch, NHC Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.

[Wu, Fan; Li, Zelong; Liu, Fen; Tan, Xiaofeng; Chen, Guodong; Wu, Gui-long; Xiong, Jian; Huang, Hejin; Yang, Qinglai; Kang, Qiang; Tan, XF; Liu, Yinying; Tan, Senyou] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

[Liu, Fen; Xiong, Jian; Huang, Hejin; Liu, Yinying; Tan, Senyou] Univ South China, Affiliated Hosp 2, Dept Radiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tan, XF; Yang, QL ; Chen, GD; Wu, GL] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, NHC Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

JOURNAL OF MEDICINAL CHEMISTRY

ISSN：

0022-2623

年：

2025

卷：

期：

页码：

7707-7719

DOI：

10.1021/acs.jmedchem.5c00314

基金类别：

Scientific Research Foundation of Hunan Provincial Education Department [22374065]; National Science Foundation of China [2024JJ2047]; Outstanding Youth Foundation of Hunan Province; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2024JJ6374]; Natural Science Foundation of Hunan Province of China [24A0606]; Scientific Research Fund of Hunan Province Education Department [4310, 20224310NHYCG01]; University of South China Clinical Research [ZYYD2024CG17]; Central Government Guided Local Science and Technology Development Fund Project in Xinjiang Uygur Autonomous Region [2024WK4008]; Hunan Province Innovation Ecological Construction Plan Science and Technology Assistance Project in Xinjiang Uygur Autonomous Region [SYTG-Y202429]; Health Technology Promotion Project in Xinjiang Uygur Autonomous Region

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

The advancement of mitochondria-targeted near-infrared-II (NIR-II) excitable phototheranostics constitutes a promising strategy for improving fluorescence-image-guided cancer phototherapy. However, developing phototheranostic agents that simultaneously combine high-contrast NIR-II fluorescence imaging with effective multimodal therapeutic techniques remains a substantial challenge. Herein, we reported a shielding-donor–acceptor–donor-shielding structured NIR-II phototheranostic (FCD-T) by a molecular engineering strategy, followed by self-ass...

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Molecular Engineering of NIR-II Excitable Phototheranostic for Mitochondria-Targeted Cancer Photoimmunotherapy

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