摘要：
Cervical cancer (CC) is a significant global health issue and remains one of the leading causes of cancer-related mortality in women. Radiotherapy is a crucial treatment modality for CC; however, tumor heterogeneity and resistance to radiotherapy often result in suboptimal outcomes for some patients, including recurrence and metastasis. Periostin (POSTN), a matricellular protein within the tumor microenvironment, has been implicated in the promotion of tumor progression and treatment resistance, particularly through mechanisms such as epithelial-mesenchymal transition (EMT). Despite this, the role of POSTN in radiotherapy resistance in CC patients remains underexplored. Therefore, in this study, we investigated the prognostic significance of POSTN expression in CC patients undergoing radical radiotherapy and explored potential mechanisms underlying radiotherapy resistance. We analyzed data from 92 CC patients in The Cancer Genome Atlas (TCGA) and 153 patients from our institution, assessing POSTN expression levels through mRNA analysis and immunohistochemistry (IHC). Our findings revealed that high POSTN expression was significantly associated with advanced tumor stages, poorer radiotherapy outcomes, and worse overall survival (OS). Additionally, multivariate Cox regression analysis identified POSTN as an independent prognostic factor for CC patients undergoing radical radiotherapy. A prognostic nomogram integrating POSTN expression and clinicopathological features demonstrated superior predictive accuracy for OS. Drug sensitivity analysis suggested that high POSTN expression may be linked to resistance to multiple chemotherapeutic agents. Furthermore, weighted correlation network analysis (WGCNA) and gene set enrichment analysis (GSEA) identified EMT as a top enriched pathway in patients with high POSTN expression, suggesting it may play a critical role in radiotherapy resistance. Subsequently, in vitro experiments confirmed that POSTN knockdown significantly inhibited HeLa cell proliferation, invasion, and enhanced radiosensitivity, while promoting apoptosis. These findings indicate that high POSTN expression is a risk factor for poor prognosis in CC patients undergoing radical radiotherapy, and targeting POSTN may improve radiotherapy efficacy by reducing tumor proliferation and resistance.
摘要：
Exposure to microcysatin-LR (MC-LR) is known to result in kidney damage, however the underlying mechanisms involved in MC-LR-initiated renal injury are not known. Thus, the aim of this study was to examine the effects of exposure to MC-LR on human embryo kidney (HEK 293) cell in vitro and male C57BL/6 in vivo. In the in vitro study, HEK 293 cells were incubated with MC-LR (20 mu M) for 24 hr. Treatment with MC-LR significantly increased the protein expression of RAF and ERK as well as mRNA expression levels of inflammatory cytokines TNF-alpha, IL-6, and IL-1 beta. These findings were confirmed when HEK 293 cells were co-incubated with ERK inhibitor U0126 and MC-LR demonstrating a decrease in protein expression of RAF, ERK, and mRNA levels of pro-inflammatory cytokines. Male C57BL/6 mice were intraperitoneally (ip) injected with MC-LR (20 mu g/kg) daily for 21 days. Histopathological analysis demonstrated significant glomerular and tubular damage with inflammatory infiltration. The expression levels of pro-inflammatory cytokines TNF-alpha, IL-6, and IL-1 beta were significantly elevated following MC-LR treatment. Administration of MC-LR asignificantly enhanced the protein phosphorylation levels of RAF and ERK. Data demonstrated that exposure to MC-LR induced morphological tissue damage and renal inflammatory reactions by activating the RAF/ERK signaling pathway.
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES,2025年88(7):291-300 ISSN：1528-7394
通讯作者：
Yang, Yue;Yang, F;Yang, Y
作者机构：
[Long, Sihong; Yang, F; Yang, Yue; Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;[Wen, Cong] Changsha Yuhua Dist Ctr Dis Control & Prevent, Changsha, Peoples R China.;[Yang, Yue; Zeng, Wen] Cent Hosp Shaoyang, Dept Publ Hlth, Shaoyang, Peoples R China.
通讯机构：
[Yang, F ; Yang, Y] U;[Yang, Y ] C;Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;Cent Hosp Shaoyang, Dept Publ Hlth, Shaoyang, Peoples R China.
关键词：
Microcystin-LR;apoptosis;jejunum;RAF/ERK
摘要：
Microcystin-LR (MC-LR), a class of cyclic heptapeptide compounds synthesized by cyanobacterial species, presents a significant risk to ecological systems and public health. Exposure to MC-LR was found to induce damage to various organs. One of the target organ systems affected by MC-LR is the gastrointestinal tract (GIT). However, the majority of studies regarding GIT focused on colorectal toxicity, with little attention paid to small intestinal toxic injuries, in particular jejunum. Thus, the aim of this study was to investigate the effects attributed to MC-LR exposure on apoptosis and underlying mechanisms utilizing a mouse jejunum injury model following chronic low-dose MC-LR treatment. A total of 40 C57BL/6 male mice were randomly divided into 4 groups with each group receiving drinking water containing 0, 1, 60, or 120 µg/L MC-LR for a duration of 12 months. Results indicated that exposure to MC-LR induced pathological alterations in jejunal tissue as evidenced by abnormal villous serration, crypt disorganization, and lymphocyte infiltration. TUNEL assays demonstrated a significant increase in apoptotic cell count in the 60 and 120 µg/L groups. The 60 and 120 µg/L MC-LR treatment groups exhibited elevated mRNA expression of Bax accompanied by significant reduction in mRNA expression of Bcl-2. The protein levels of cleaved caspase-3 were markedly elevated in the 60 and 120 µg/L MC-LR groups. The protein expression levels of p-RAF and p-ERK were significantly increased in the 60 and 120 µg/L MC-LR treatment groups. Data demonstrated suggest that the RAF/ERK signaling pathway may be involved in MC-LR- induced jejunal apoptosis.
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES,2025年88(9):364-372 ISSN：1528-7394
通讯作者：
Yang, Yue;Yang, F;Yang, Y
作者机构：
[Yang, F; Yang, Yue; Yang, Fei; Yang, Mingjie; Zhan, Chunhua] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.;[Zheng, Shuilin] Changsha Ctr Dis Control & Prevent, Changsha, Peoples R China.;[Yang, Yue; Zeng, Wen] Cent Hosp Shaoyang, Dept Publ Hlth, Shaoyang, Peoples R China.;[Yang, F; Yang, Fei] Univ South China, Nanhua Hosp, Hengyang Med Sch, Nucl Med Dept, Hengyang, Peoples R China.
通讯机构：
[Yang, F ; Yang, Y] U;[Yang, Y ] C;Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.;Cent Hosp Shaoyang, Dept Publ Hlth, Shaoyang, Peoples R China.;Univ South China, Nanhua Hosp, Hengyang Med Sch, Nucl Med Dept, Hengyang, Peoples R China.
摘要：
The global phenomenon of cyanobacterial bloom pollution is spreading globally due to climate change and eutrophication. It is well established that harmful cyanobacteria produce a wide range of toxins including microcystin-LR (MC-LR), a cyclic heptapeptide toxin known to damage various organs. The intestinal tract is the main site of MC-LR absorption and one of the targets susceptible to toxicity. Currently, studies on the enterotoxic effects of MC-LR predominantly focused on the colorectum, with limited investigations addressing the impact of microcystins on the small intestine. Therefore, the aim of our study was to examine the impact of chronic 9-month exposure of mice to low-dose 120 μg/L MC-LR in drinking water on ileal inflammation and potential mechanisms underlying these effects. Our findings showed that in mice chronically administered with low-dose MC-LR disorganized intestinal epithelial cells, lymphocytic infiltration and disturbed crypt arrangement were detected. The results of qPCR and Western blot demonstrated that, in comparison to control, the mRNA expression levels of pro-inflammatory factors IL-6, IL-17, IL-18, and IFN-γ were markedly elevated in the ileal tissue of mice treated with MC-LR, associated with significant increases in protein expression levels of p-PI3K, p-AKT, and p-mTOR. Taken together, evidence indicates that MC-LR induces ileal inflammation and histopathological damage involved activation of the PI3K/AKT/mTOR signaling pathway.
摘要：
The success of graphene oxides has gained extensive research interests in developing novel 2D nanomaterials (NMs). WS(2) nanosheets (NSs) are novel transition metal-based 2D NMs, but their toxicity is unclear. In this study, we investigated the oral toxicity of WS(2) NSs to mouse intestines. Male mice were administrated with vehicles, 1, 10, or 100 mg/kg NSs via intragastric route, once a day, for 5days. The results indicate that the NSs did not induce pathological or ultrastructural changes in intestines. There were minimal changes of trace elements that the exposure did not induce W accumulation, and only Co levels were dose-dependently increased. Lipid droplets were observed in all groups of mice, but lipidomics data indicate that WS(2) NSs only significantly decreased four lipid species, all belonging to phosphatidylcholine (PC). The levels of proteins regulating autophagic lipolysis, namely, LC3, lysosomal associated membrane protein 2 (LAMP2) and perilipin 2 (PLIN2), were increased, but it was only statistically significantly different for LC3. The results of this study suggest that repeated intragastric exposure to WS(2) NSs only induced minimal influences on pathological injury, trace element balance, autophagy, and lipid profiles in mouse intestines, indicating relatively high biocompatibility of WS(2) NSs to mouse intestine via oral route.
摘要：
Bacterial infectious diseases pose a serious threat to the safety of human life. It is urgent to development a simple, rapid, efficient and safe precise diagnostic methods and synergistic therapy techniques for combating bacteria. Herein, we synthesize CuInSe 2 quantum dots with near-infrared (NIR) emission peak at 1190 nm upon excitation at 808 nm and shifted to 1026 nm after the incorporation of ZnS. Then, Vancomycin was modified on the hydrophilic CuInSe 2 /ZnS quantum dots to obtain a fluorescent nano biological probe (Van-CuInSe 2 /ZnS) that can target Staphylococcus aureus, which was used to monitor the bacterial infection process in vivo in real time. Moreover, the nanosystem possesses excellent photothermal conversion properties, and biocompatibility, which enables precise, targeted NIR-II fluorescent imaging of bacterial inflammation in vivo as well as effectively cure subcutaneous bacterial infection and wound bacterial infection in mice. It shows great potential in the treatment of bacterial infectious diseases.
Bacterial infectious diseases pose a serious threat to the safety of human life. It is urgent to development a simple, rapid, efficient and safe precise diagnostic methods and synergistic therapy techniques for combating bacteria. Herein, we synthesize CuInSe 2 quantum dots with near-infrared (NIR) emission peak at 1190 nm upon excitation at 808 nm and shifted to 1026 nm after the incorporation of ZnS. Then, Vancomycin was modified on the hydrophilic CuInSe 2 /ZnS quantum dots to obtain a fluorescent nano biological probe (Van-CuInSe 2 /ZnS) that can target Staphylococcus aureus, which was used to monitor the bacterial infection process in vivo in real time. Moreover, the nanosystem possesses excellent photothermal conversion properties, and biocompatibility, which enables precise, targeted NIR-II fluorescent imaging of bacterial inflammation in vivo as well as effectively cure subcutaneous bacterial infection and wound bacterial infection in mice. It shows great potential in the treatment of bacterial infectious diseases.
期刊：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2025年:118237 ISSN：0165-9936
通讯作者：
Xiangheng Niu
作者机构：
[Qiaoqiao Diao; Zheng Tang; Jinjin Liu; Xiangheng Niu] School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, P. R. China
通讯机构：
[Xiangheng Niu] S;School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, P. R. China
摘要：
Since the revelation of Fe 3 O 4 nanoparticles with enzyme-like characteristics, nanozymes present a promising alternative to traditional bio-enzymes due to their straightforward preparation, good robustness, and adjustable performance. In addition to enzyme-mimetic catalysis, these materials also tend to show optical, electrical, thermal, and magnetic properties. Integrating nanozyme catalysis with these properties into an entity can offer fascinating merits to biochemical sensing. Especially, fluorescent nanozymes, a class of materials combining enzyme-mimicking activity and fluorescence, have been drawing growing interest in the analytical chemistry community in the past five years. To highlight the achievements and progress made in this emerging area, here we, for the first time, present a comprehensive summary on fluorescent nanozymes and their roles in advancing analytical detection. First, a definition of fluorescent nanozymes is given, and their bifunctional features are discussed. Then, common strategies employed to develop different material types of fluorescent nanozymes are introduced. Emphatically, their unique contributions to biochemical analysis are clarified in detail, along with various applications in environmental monitoring, food safety analysis, and biomedical detection. Finally, substantial potential of fluorescent nanozymes in realizing advanced detection as well as existing challenges is spotlighted. Our review provides a comprehensive and up-to-date reference on fluorescent nanozymes, which will attract more attention and guide future efforts to further promote the promising field.
Since the revelation of Fe 3 O 4 nanoparticles with enzyme-like characteristics, nanozymes present a promising alternative to traditional bio-enzymes due to their straightforward preparation, good robustness, and adjustable performance. In addition to enzyme-mimetic catalysis, these materials also tend to show optical, electrical, thermal, and magnetic properties. Integrating nanozyme catalysis with these properties into an entity can offer fascinating merits to biochemical sensing. Especially, fluorescent nanozymes, a class of materials combining enzyme-mimicking activity and fluorescence, have been drawing growing interest in the analytical chemistry community in the past five years. To highlight the achievements and progress made in this emerging area, here we, for the first time, present a comprehensive summary on fluorescent nanozymes and their roles in advancing analytical detection. First, a definition of fluorescent nanozymes is given, and their bifunctional features are discussed. Then, common strategies employed to develop different material types of fluorescent nanozymes are introduced. Emphatically, their unique contributions to biochemical analysis are clarified in detail, along with various applications in environmental monitoring, food safety analysis, and biomedical detection. Finally, substantial potential of fluorescent nanozymes in realizing advanced detection as well as existing challenges is spotlighted. Our review provides a comprehensive and up-to-date reference on fluorescent nanozymes, which will attract more attention and guide future efforts to further promote the promising field.
期刊：
Ecotoxicology and Environmental Safety,2025年290:117580 ISSN：0147-6513
通讯作者：
Cao, Y;Zhou, ZZ
作者机构：
[Cao, Yi; Li, Kuanhang] Univ South China, Hengyang Med Sch, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;[Zhou, Zhengzheng] Southern Med Univ, NMPA Key Lab Safety Evaluat Cosmet, Guangdong Prov Key Lab Trop Dis Res, Dept Hyg Inspection & Quarantine Sci,Sch Publ Hlth, Guangzhou 510515, Guangdong, Peoples R China.
通讯机构：
[Cao, Y ] U;[Zhou, ZZ ] S;Univ South China, Hengyang Med Sch, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;Southern Med Univ, NMPA Key Lab Safety Evaluat Cosmet, Guangdong Prov Key Lab Trop Dis Res, Dept Hyg Inspection & Quarantine Sci,Sch Publ Hlth, Guangzhou 510515, Guangdong, Peoples R China.
关键词：
Autophagy;Lipid profiles;Oral toxicity;SiO(2) nanoparticles (NPs);Trace element balance
摘要：
Recently we proposed the possibility of orally exposed nanoparticles (NPs) to alter metabolite homeostasis by changing metabolism pathways, in addition to intestinal damages, but relatively few studies investigated the changes of metabolite profiles in multi-organs. This study investigated the influences of orally exposed SiO2 NPs on lipid profiles in gut-liver axis. To this end, we treated mice with 16, 160 or 1600 mg/kg bodyweight SiO2 NPs via intragastric route. After 5 days exposure (once a day), we observed that SiO2 NPs induced minimal pathological changes but increased most of the trace elements. Furthermore, lipid staining was gradually decreased in intestines and livers with the increase of NP levels. Consistently, lipidomics results showed that most of the lipid classes in mouse intestines and livers were decreased following SiO2 NP administration. We further identified the lipid classes significantly decreased in both intestines and livers, such as phosphatidylserine (PS), phosphatidylglycerol (PG), and phosphatidylethanolamine (PE). Only a few lipid classes, such as anandamide, showed opposite trends in these organs. For metabolism pathway, SiO2 NPs suppressed autophagy, showing as a significant decrease of microtubule-associated protein 1 A/1B light chain 3 (LC3) and adipose triglyceride lipase (Atgl), accompanying with an accumulation of P62, in both intestines and livers. However, lysosomal-associated membrane protein 2 (Lamp2) showed different trend, that it was significantly increased in intestines but decreased in livers. Combined, our results indicated that intragastric administration of SiO2 NPs altered trace element balance and lipid profiles, accompanying with a change of autophagic lipolysis proteins, in mouse gut-liver axis.
Recently we proposed the possibility of orally exposed nanoparticles (NPs) to alter metabolite homeostasis by changing metabolism pathways, in addition to intestinal damages, but relatively few studies investigated the changes of metabolite profiles in multi-organs. This study investigated the influences of orally exposed SiO2 NPs on lipid profiles in gut-liver axis. To this end, we treated mice with 16, 160 or 1600 mg/kg bodyweight SiO2 NPs via intragastric route. After 5 days exposure (once a day), we observed that SiO2 NPs induced minimal pathological changes but increased most of the trace elements. Furthermore, lipid staining was gradually decreased in intestines and livers with the increase of NP levels. Consistently, lipidomics results showed that most of the lipid classes in mouse intestines and livers were decreased following SiO2 NP administration. We further identified the lipid classes significantly decreased in both intestines and livers, such as phosphatidylserine (PS), phosphatidylglycerol (PG), and phosphatidylethanolamine (PE). Only a few lipid classes, such as anandamide, showed opposite trends in these organs. For metabolism pathway, SiO2 NPs suppressed autophagy, showing as a significant decrease of microtubule-associated protein 1 A/1B light chain 3 (LC3) and adipose triglyceride lipase (Atgl), accompanying with an accumulation of P62, in both intestines and livers. However, lysosomal-associated membrane protein 2 (Lamp2) showed different trend, that it was significantly increased in intestines but decreased in livers. Combined, our results indicated that intragastric administration of SiO2 NPs altered trace element balance and lipid profiles, accompanying with a change of autophagic lipolysis proteins, in mouse gut-liver axis.
作者机构：
[Yue Wang; Xin Zhao; Jiayi Song; Lihao Xiong; Xiayu Zhou; Weichao Zhao] Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China;[Sihan Chen] Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China. 172140411@qq.com;[Le Li] Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China. usclile@126.com;[Deshuai Zhen] Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, People's Republic of China. zhends.1987@163.com
通讯机构：
[Sihan Chen; Le Li; Deshuai Zhen] H;Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, People’s Republic of China<&wdkj&>Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, People’s Republic of China<&wdkj&>Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, People’s Republic of China
摘要：
Three types of carbon dots were synthesized using the same precursor (folic acid and europium nitrate) via different preparation methods (doping and direct coordination). A comprehensive comparison and analysis of the morphology, surface groups, and optical properties of the prepared carbon dots (CD), europium-doped carbon dots (CD-Eu), and europium-functionalized carbon dots (CD@Eu) were conducted. Moreover, due to the higher quantum yield, excellent stability, and outstanding selectivity for UO(2)(2+) exhibited by CD-Eu, we selected CD-Eu as the probe for subsequent applications. CD-Eu showed a sensitive response to UO(2)(2+) within the concentration range 25 ~ 200nM, with a detection limit of 0.84nM (0.42μg·L(-1)). Additionally, CD-Eu demonstrated excellent accuracy and recovery in spiked detection of real water samples. Furthermore, we discovered that this probe could detect UO(2)(2+) both in vitro and in vivo. This strategy provides a promising fluorescent sensor for the detection of UO(2)(2+) in water and biological samples, holding significant implications for addressing UO(2)(2+) contamination issues.
摘要：
Due to the wide uses of plastic products, nanoplastics are ubiquitous contaminants in the environment. Hence, extensive studies used various models to evaluate the toxicity of nanoplastics. In the present study, we developed yellow mealworm (Tenebrio molitor) as an alternative model to investigate the acute toxicity of nanoplastics. Our results showed that microinjection with 500 mg/kg nanoplastics significantly increased death rate of yellow mealworms after 24 or 48 h, with 100 nm particles being more effective compared with 20 nm ones. Meanwhile, dose-dependent increase of death rate was observed in yellow mealworms after injection with 2-200 mg/kg 100 nm nanoplastics. Exposure to 2 mg/kg 100 nm but not 20 nm nanoplastics also led to hyperactivity of yellow mealworms. Both types of nanoplastics altered metabolite profiles, that 20 nm nanoplastics significantly up-regulated and down-regulated 9 and 12 metabolites, whereas 100 nm nanoplastics significantly up-regulated and down-regulated 16 and 25 metabolites, respectively. Enrichment analysis revealed that 100 nm but not 20 nm nanoplastics significantly affected alpha-linolenic acid metabolism (ko00592) and purine metabolism (ko00230). For the metabolites belonging to these pathways, 100 nm nanoplastics significantly up-regulated stearidonic acid but down-regulated guanine. Combined, these results revealed size-dependent effects of nanoplastics on acute toxicity, hyperactivity and metabolite profile changes in yellow mealworms. These results also indicated the potential uses of yellow mealworms as a cheap and simple model to evaluate the toxicity of nanoplastics.
作者机构：
[Cao, Deliang; Wang, Meifang] Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha 410208, China;[Bu, Hongying] School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China;[Luo, Weijia; Zeng, Xi] Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China;[Chen, Guodong] Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, 28 West Changsheng Road, Hengyang, Hunan 421001, China;[He, Yingchun] Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha 410208, China. Electronic address: heyingchun@hnucm.edu.cn
通讯机构：
[He, Yingchun; Cao, Deliang] H;Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha 410208, China. Electronic address:;Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address:
摘要：
Aim This retrospective study was aimed to evaluate the diagnostic value of a combination of carbohydrate antigen 19–9 (CA19-9), carcinoembryonic antigen (CEA) and protein induced by vitamin K absence or antagonist-Ⅱ (PIVKA-II) in pancreatic cancer.
This retrospective study was aimed to evaluate the diagnostic value of a combination of carbohydrate antigen 19–9 (CA19-9), carcinoembryonic antigen (CEA) and protein induced by vitamin K absence or antagonist-Ⅱ (PIVKA-II) in pancreatic cancer.
Methods Clinical data were collected from 111 pancreatic cancer patients and 158 patients with benign pancreatic diseases (BPD). Serum CA19-9, CEA and PIVKA-II were subjected to receiver operating characteristic curve (ROC) analysis alone and in combination for the diagnosis of pancreatic cancer.
Clinical data were collected from 111 pancreatic cancer patients and 158 patients with benign pancreatic diseases (BPD). Serum CA19-9, CEA and PIVKA-II were subjected to receiver operating characteristic curve (ROC) analysis alone and in combination for the diagnosis of pancreatic cancer.
Results Serum CA19-9, CEA, and PIVKA-II were higher in pancreatic cancer patients than in BPD patients ( P < 0.001). ROC analysis indicated that the cutoff values were 99.390 for CA19-9, 3.065 for CEA, and 42.965 for PIVKA-II, at which the positive rate in pancreatic cancer was 78.38 % for CA19-9, 43.24 % for CEA and 48.65 % for PIVKA-Ⅱ. When serum CA19-9, CEA, and PIVKA-II were used alone, the areas under the curves (AUC), sensitivity and specificity were 0.821, 68.47 % and 89.24 % for CA19-9, 0.763, 61.26 % and 85.44 % for CEA, and 0.681, 45.95 % and 87.34 % for PIVKA-II. When serum CA19-9, CEA, and PIVKA-II were used in combination, the positivity rate was 94.59 % in pancreatic cancer with AUC of 0.903, sensitivity of 81.10 % and specificity of 88.00 %.
Serum CA19-9, CEA, and PIVKA-II were higher in pancreatic cancer patients than in BPD patients ( P < 0.001). ROC analysis indicated that the cutoff values were 99.390 for CA19-9, 3.065 for CEA, and 42.965 for PIVKA-II, at which the positive rate in pancreatic cancer was 78.38 % for CA19-9, 43.24 % for CEA and 48.65 % for PIVKA-Ⅱ. When serum CA19-9, CEA, and PIVKA-II were used alone, the areas under the curves (AUC), sensitivity and specificity were 0.821, 68.47 % and 89.24 % for CA19-9, 0.763, 61.26 % and 85.44 % for CEA, and 0.681, 45.95 % and 87.34 % for PIVKA-II. When serum CA19-9, CEA, and PIVKA-II were used in combination, the positivity rate was 94.59 % in pancreatic cancer with AUC of 0.903, sensitivity of 81.10 % and specificity of 88.00 %.
Conclusion PIVKA-II is a potential serum marker of pancreatic cancer and the combination of CA19-9, CEA, and PIVKA-II is a novel panel of serum markers with promising diagnostic value for pancreatic cancer.
PIVKA-II is a potential serum marker of pancreatic cancer and the combination of CA19-9, CEA, and PIVKA-II is a novel panel of serum markers with promising diagnostic value for pancreatic cancer.
期刊：
Journal of Water Process Engineering,2025年71:107416 ISSN：2214-7144
通讯作者：
Wendong Wang
作者机构：
State Key Laboratory of Water Engineering Ecology and Environment in Arid Area, Xi'an University of Technology, Xi'an, Shaanxi Province 710048, China;[Bo Liu] Department of Municipal and Environmental Engineering, School of Water Resources and Hydro-Electric Engineering, Xi'an University of Technology, Xi'an, Shaanxi Province, 710048, China;[Hui Xi; Yingying Sun; Wendong Wang] Technology Innovation Center for Land Engineering and Human Settlements by Shaanxi Land Engineering Construction Group Co., Ltd and Xi'an Jiaotong University, School of Human Settlements and Civil Engineering, Xi'an 710049, China;[Xilin Li] School of Civil Engineering, Liaoning Technical University, Fuxin, Liaoning Province 123000, China;[Xizi Long] School of the Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Basic Medicine, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan Province 421001, China
通讯机构：
[Wendong Wang] T;Technology Innovation Center for Land Engineering and Human Settlements by Shaanxi Land Engineering Construction Group Co., Ltd and Xi'an Jiaotong University, School of Human Settlements and Civil Engineering, Xi'an 710049, China
摘要：
Extracellular electron transfer (EET) plays a crucial role in biogeochemical cycles and energy transformation in microorganisms. Electroactive microorganisms (EAMs) are highly important in environmental pollution remediation, especially in reducing or eliminating extracellular electron acceptors, such as heavy metals with high redox potentials, or producing insoluble metal minerals. There are two mechanisms of microbial EET, such as cytochrome c or conductive cell appendages (nanowires) and electron mediators or shuttles can transfer electrons from microbial cells to outer heavy metal. EPSs, riboflavin, initial concentration of heavy metal ions and pH, and conductive polymers can affect the efficiency of EET and heavy metal reduction. Hence, making full use of conductive minerals, exogenous electron mediators, and biochar to enhance the effectiveness of EET and improve heavy metal removal. Based on the removal mechanisms and strengthening measures, this promising strategy for heavy metal removal has been applied to soil remediation, wastewater treatment, and combined with constructed wetlands. Until now, there are some difficulties to overcome, such as cultivating more EAMs besides Geobacter and Shewanella , improving the tolerance of EAMs through genetic engineering, revealing the complicated EET mechanisms, and applying the strategy to practical implications for environmental remediation, etc.. This review would lead to a renewed awareness of microorganisms' properties and EET in solving energy stagnation and heavy metal pollution treatment problems.
Extracellular electron transfer (EET) plays a crucial role in biogeochemical cycles and energy transformation in microorganisms. Electroactive microorganisms (EAMs) are highly important in environmental pollution remediation, especially in reducing or eliminating extracellular electron acceptors, such as heavy metals with high redox potentials, or producing insoluble metal minerals. There are two mechanisms of microbial EET, such as cytochrome c or conductive cell appendages (nanowires) and electron mediators or shuttles can transfer electrons from microbial cells to outer heavy metal. EPSs, riboflavin, initial concentration of heavy metal ions and pH, and conductive polymers can affect the efficiency of EET and heavy metal reduction. Hence, making full use of conductive minerals, exogenous electron mediators, and biochar to enhance the effectiveness of EET and improve heavy metal removal. Based on the removal mechanisms and strengthening measures, this promising strategy for heavy metal removal has been applied to soil remediation, wastewater treatment, and combined with constructed wetlands. Until now, there are some difficulties to overcome, such as cultivating more EAMs besides Geobacter and Shewanella , improving the tolerance of EAMs through genetic engineering, revealing the complicated EET mechanisms, and applying the strategy to practical implications for environmental remediation, etc.. This review would lead to a renewed awareness of microorganisms' properties and EET in solving energy stagnation and heavy metal pollution treatment problems.
摘要：
With the popularity of health-conscious tea drinking, precise sensing of polyphenols as a main class of antioxidants in tea becomes critical for tea authentication and brewing evaluation. Sensor arrays show great potential for the goal, but currently available sensor arrays always need multiple sensing units and/or multi-dimensional signals, resulting in cumbersome sensor construction and operation as well as data processing. Developing easy-to-fabricate and easy-to-use sensor arrays for efficient discrimination is still challenging. Here we propose a new sensor array that only uses a single signal collected dynamically with oxidase-like MnOOH as a sole sensing material. The synthesized MnOOH nanowires exhibit favorable activity to catalyze the chromogenic oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue oxTMB. By taking gallic acid, tannic acid, L-epicatechin, (−)-epigallocatechin, (−)-epicatechin gallate and (−)-epigallocatechin gallate as models, the six tea polyphenols show discrepant inhibitory effects on the above catalytic system. As a result, these polyphenols, no matter as a single component at various concentrations or multi-component mixtures with different ratios, can be well distinguished by the single-nanozyme single-readout sensor array. Besides, different Chinese tea species, black tea varieties and impacts of brewing methods are accurately identified. Evidently, our sensor array avoids the requirement for multiple sensing units and multi-dimensional signals, greatly simplifying the fabrication of sensor arrays and their use, which provides an efficient yet facile tool for tea authentication and brewing evaluation.
With the popularity of health-conscious tea drinking, precise sensing of polyphenols as a main class of antioxidants in tea becomes critical for tea authentication and brewing evaluation. Sensor arrays show great potential for the goal, but currently available sensor arrays always need multiple sensing units and/or multi-dimensional signals, resulting in cumbersome sensor construction and operation as well as data processing. Developing easy-to-fabricate and easy-to-use sensor arrays for efficient discrimination is still challenging. Here we propose a new sensor array that only uses a single signal collected dynamically with oxidase-like MnOOH as a sole sensing material. The synthesized MnOOH nanowires exhibit favorable activity to catalyze the chromogenic oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue oxTMB. By taking gallic acid, tannic acid, L-epicatechin, (−)-epigallocatechin, (−)-epicatechin gallate and (−)-epigallocatechin gallate as models, the six tea polyphenols show discrepant inhibitory effects on the above catalytic system. As a result, these polyphenols, no matter as a single component at various concentrations or multi-component mixtures with different ratios, can be well distinguished by the single-nanozyme single-readout sensor array. Besides, different Chinese tea species, black tea varieties and impacts of brewing methods are accurately identified. Evidently, our sensor array avoids the requirement for multiple sensing units and multi-dimensional signals, greatly simplifying the fabrication of sensor arrays and their use, which provides an efficient yet facile tool for tea authentication and brewing evaluation.
作者机构：
[Bingjie Wang; Rui Shi; Wanqing Du; HanYu; Hongyu Lu; Liyuan Zhong; Xingli Li; Xiangling Feng] Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Furong Laboratory, Xiangya School of Public Health, Central South University, 172# Tongzipo Road, Changsha, Hunan 410013, China;[Nihan He; Yinghong Zhu; Wen Zhou] Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China;[Jiaojiao Guo] Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;School of Public Health, University of South China, Hengyang, Hunan 421001, China;Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan 410013, China
通讯机构：
[Xiangling Feng] H;Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, Furong Laboratory, Xiangya School of Public Health, Central South University, 172# Tongzipo Road, Changsha, Hunan 410013, China
摘要：
Recurrence of drug-resistant and expensive treatment drugs are major causes of the low survival rate of the multiple myeloma (MM) patients. Exploring a safe, effective, low-cost and novel drug treating MM is a promising strategy to relieve the burden of MM patients. In this study, we found that prodigiosin could inhibit MM cells proliferation and induce MM cell apoptosis, however, it had a lesser cytotoxic effect on normal B cells within the IC50 range of MM cells. In addition, prodigiosin could inhibit the growth of xenograft MM cells in mouse. Transcriptomics and targeted amino acid metabolomics confirmed that prodigiosin could regulate amino acid metabolism, and decrease in amino acid utilization by down-regulated aminoacyl tRNA synthetases expression, resulting in slower growth of MM. In conclusion, prodigiosin exert anticancer effects on MM cells by interfering the use of amino acids, indicating its potential novel therapeutic application in MM.
Recurrence of drug-resistant and expensive treatment drugs are major causes of the low survival rate of the multiple myeloma (MM) patients. Exploring a safe, effective, low-cost and novel drug treating MM is a promising strategy to relieve the burden of MM patients. In this study, we found that prodigiosin could inhibit MM cells proliferation and induce MM cell apoptosis, however, it had a lesser cytotoxic effect on normal B cells within the IC50 range of MM cells. In addition, prodigiosin could inhibit the growth of xenograft MM cells in mouse. Transcriptomics and targeted amino acid metabolomics confirmed that prodigiosin could regulate amino acid metabolism, and decrease in amino acid utilization by down-regulated aminoacyl tRNA synthetases expression, resulting in slower growth of MM. In conclusion, prodigiosin exert anticancer effects on MM cells by interfering the use of amino acids, indicating its potential novel therapeutic application in MM.
作者机构：
[Wang, Yuyan; Yang, F; Zeng, Ying; Pan, Jiafeng; Ren, Xiaoya; Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;[Qiu, Jun] Hunan Childrens Hosp, Pediat Res Inst Hunan Prov, Changsha 410007, Peoples R China.
通讯机构：
[Yang, F ] U;Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
摘要：
Microcystin-lr (MC-LR) is one of the most toxic and ubiquitous microcystins (MCs) released by cyanobacteria. Exposure to MC-LR can cause multiple organ damage and even death of the organism. Therefore, creating highly sensitive and dependable methods for detecting trace MC-LR is crucial. Herein, we developed a novel fluorescence aptasensor aided by exonuclease III (Exo III) for the highly sensitive detection of MC-LR. In the presence of MC-LR, the affinity interaction between MC-LR and aptamer A was triggered, leading to the release of blocker B. This unbound blocker can initiate Exo III-mediated signal amplification to digest the probe H, thereby recovering the fluorescence signal for readout. The proposed Exo III-assisted sensing platform demonstrated remarkable sensitivity and selectivity, achieving a limit of detection (LOD) of 0.37 ng L(-1). Furthermore, it is robust and has been effectively utilized on water samples, achieving acceptable recovery rates (95.04-107.01%). With excellent sensitivity, high selectivity, efficient signal amplification, and fluorescence readout, the proposed biosensor offered a new and reliable alternative for the detection of trace MC-LR in the environment and the early warning of algal toxins.
摘要：
Background The ongoing threat of the monkeypox virus (MPXV) underscores the need for new antiviral treatments, yet drug targets and candidate therapies are limited.
The ongoing threat of the monkeypox virus (MPXV) underscores the need for new antiviral treatments, yet drug targets and candidate therapies are limited.
Methods Calculating the centrality, conservation, and immunogenicity of MPXV proteins in the network to identify viral drug targets. Constructing the MIP-human protein interaction network and identifying key human proteins as potential drug targets through network topology analysis.
Calculating the centrality, conservation, and immunogenicity of MPXV proteins in the network to identify viral drug targets. Constructing the MIP-human protein interaction network and identifying key human proteins as potential drug targets through network topology analysis.
Results We constructed a comprehensive protein–protein interaction (PPI) network between MPXV and humans, using data from the P-HIPSTer database. This network included 113 viral proteins and 2 607 MPXV-interacting human proteins (MIPs). We identified three MPXV proteins (OPG054, OPG084, and OPG190) as key targets for antiviral drugs, as well as 95 critical MIPs (most interacting MIPs, MMIPs) within the MPXV–human PPI network. Further analysis revealed 31 MMIPs as potential targets for broad-spectrum antiviral agents, supported by their involvement in other viral interactions. Functional enrichment of MIPs indicated their roles in infection and immune-related pathways.
We constructed a comprehensive protein–protein interaction (PPI) network between MPXV and humans, using data from the P-HIPSTer database. This network included 113 viral proteins and 2 607 MPXV-interacting human proteins (MIPs). We identified three MPXV proteins (OPG054, OPG084, and OPG190) as key targets for antiviral drugs, as well as 95 critical MIPs (most interacting MIPs, MMIPs) within the MPXV–human PPI network. Further analysis revealed 31 MMIPs as potential targets for broad-spectrum antiviral agents, supported by their involvement in other viral interactions. Functional enrichment of MIPs indicated their roles in infection and immune-related pathways.
Conclusions In total, we identified 112 drugs targeting MPXV proteins and 371 drugs targeting MMIPs, with fostamatinib, trilostane, and raloxifene being able to inhibit both viral and host proteins. This work provides critical insights into MPXV–human interactions and supports the development of targeted antiviral therapies.
In total, we identified 112 drugs targeting MPXV proteins and 371 drugs targeting MMIPs, with fostamatinib, trilostane, and raloxifene being able to inhibit both viral and host proteins. This work provides critical insights into MPXV–human interactions and supports the development of targeted antiviral therapies.
期刊：
Journal of Hazardous Materials,2025年490:137799 ISSN：0304-3894
通讯作者：
Yu, Lijia
作者机构：
[He, Yazhen; Yang, Yina; Meng, Jing; Ding, Chunguang; Zheng, Yuqiao; Tao, Yucun; Zhu, Wenxuan; Yu, Bei; Peng, Fangda; Meng, Qingyu] NHC Key Laboratory for Engineering Control of Dust Hazard, National Center for Occupational Safety and Healthy, NHC, Beijing 102308, China;[Wu, Chengqiu] School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China;[Wang, Chaoyang] The Key Medical Laboratory for Chemical Poison Detection of Henan Province, The Third People's Hospital of Henan Province (Henan Hospital for Occupational Disease), Zhengzhou 45000, China;[Yu, Lijia] NHC Key Laboratory for Engineering Control of Dust Hazard, National Center for Occupational Safety and Healthy, NHC, Beijing 102308, China. Electronic address: yulijia@iccas.ac.cn
通讯机构：
[Yu, Lijia] N;NHC Key Laboratory for Engineering Control of Dust Hazard, National Center for Occupational Safety and Healthy, NHC, Beijing 102308, China. Electronic address:
摘要：
Polycyclic aromatic hydrocarbons (PAHs), especially pyrene, are hazardous pollutants with serious health risks. Effective detection methods for PAHs are essential for environmental monitoring. In this study, we construct a simple, efficient method to detect pyrene derivatives in water. A squaraine dye (J3-Ad) with dual host-guest sites was synthesized and paired with a β-cyclodextrin dimer (H2-CD) to regulate host-guest interactions. In the presence of pyrenes, J3-Ad monomers in the the J3-Ad/H2-CD mixture (JH-AC) are displaced by pyrenes and self-assemble into H-aggregates, resulting in a ~135 nm absorption spectral shift. The transformation was confirmed through Scanning Electron Microscope (SEM), Dynamic Light Scattering (DLS), and Density Functional Theory (DFT) analysis. The system showed high sensitivity, with detection limits of 1.76 nmol/L for pyrene and 60.02 nmol/L for 1-hydroxypyrene (1-OHP), along with strong anti-interference and reliable colorimetric recognition. A smartphone-based, real-time detection platform was developed for visual monitoring of pyrene in soil and vegetables. Pyrene in tap water and river water, as well as 1-OHP in urine, were successfully detected, with recovery rates and a relative standard deviation (RSD) of less than 10.14%. This work provides a sensitive, rapid, and visual method for tracking PAH pollution, offering significant potential for practical, on-site environmental applications.
Polycyclic aromatic hydrocarbons (PAHs), especially pyrene, are hazardous pollutants with serious health risks. Effective detection methods for PAHs are essential for environmental monitoring. In this study, we construct a simple, efficient method to detect pyrene derivatives in water. A squaraine dye (J3-Ad) with dual host-guest sites was synthesized and paired with a β-cyclodextrin dimer (H2-CD) to regulate host-guest interactions. In the presence of pyrenes, J3-Ad monomers in the the J3-Ad/H2-CD mixture (JH-AC) are displaced by pyrenes and self-assemble into H-aggregates, resulting in a ~135 nm absorption spectral shift. The transformation was confirmed through Scanning Electron Microscope (SEM), Dynamic Light Scattering (DLS), and Density Functional Theory (DFT) analysis. The system showed high sensitivity, with detection limits of 1.76 nmol/L for pyrene and 60.02 nmol/L for 1-hydroxypyrene (1-OHP), along with strong anti-interference and reliable colorimetric recognition. A smartphone-based, real-time detection platform was developed for visual monitoring of pyrene in soil and vegetables. Pyrene in tap water and river water, as well as 1-OHP in urine, were successfully detected, with recovery rates and a relative standard deviation (RSD) of less than 10.14%. This work provides a sensitive, rapid, and visual method for tracking PAH pollution, offering significant potential for practical, on-site environmental applications.
作者机构：
[Long, Xizi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Key Lab Typ Environm Pollut & Hlth Hazards Hunan, Hengyang 421001, Peoples R China.;[Li, Wei-Peng; Li, WP; Ho, Chia-Lun; Long, Xizi; Okamoto, Akihiro] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton, Tsukuba, Ibaraki 3050044, Japan.;[Kataoka-Hamai, Chiho; Ho, Chia-Lun; Okamoto, Akihiro] Natl Inst Mat Sci, Res Ctr Macromol & Biomat, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan.;[Ho, Chia-Lun; Okamoto, Akihiro] Hokkaido Univ, Grad Sch Chem Sci & Engn, Sapporo, Hokkaido 0608628, Japan.;[Li, Wei-Peng; Huang, Wei-Lun] Natl Cheng Kung Univ, Ctr Appl Nanomed, Tainan 701, Taiwan.
通讯机构：
[Li, WP; Okamoto, A ] N;Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton, Tsukuba, Ibaraki 3050044, Japan.;Natl Inst Mat Sci, Res Ctr Macromol & Biomat, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan.
关键词：
Liposome;Outer-membrane vesicles;Extracellular electron transport;Cytochrome;Shewanella oneidensis MR-1
摘要：
Extracellular vesicles are pivotal in intercellular communication and hold significant promise for medical applications. However, limitations in their mass production and challenges in replicating their complex functions with artificial liposomes necessitate innovative solutions. We functionalize liposomes by combining the scalable production advantages of artificial liposomes with the vesicle fusion and formation mechanisms of bacteria. By incubating the gram-negative Shewanella oneidensis MR-1, known for its electrochemically active outer membrane cytochromes (OMCs), with liposomes containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine for 24 hours, we achieved a substantial yield of membrane-integrated liposomes (MILs) incorporating OMCs. Circular dichroism spectroscopy confirmed the preservation of redox activity and strong inter-heme exciton coupling in the OMCs. These components were successfully delivered to Escherichia coli K-12 by incubation with MILs, retaining their functionality. Furthermore, the slow membrane exchange process did not result in cellular viability loss or lysis, allowing for the recycling of microbial cells and minimizing contaminants from lysed cells, which is advantageous for scaling up. Building on our previous work where MIL-coated titanium dioxide nanoparticles significantly enhanced radical production and effectively treated orthotopic liver tumors in vivo , our methodology to generate the MIL has promising potential to spearhead novel integrations of synthetic and biological systems for medical technologies.
Extracellular vesicles are pivotal in intercellular communication and hold significant promise for medical applications. However, limitations in their mass production and challenges in replicating their complex functions with artificial liposomes necessitate innovative solutions. We functionalize liposomes by combining the scalable production advantages of artificial liposomes with the vesicle fusion and formation mechanisms of bacteria. By incubating the gram-negative Shewanella oneidensis MR-1, known for its electrochemically active outer membrane cytochromes (OMCs), with liposomes containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine for 24 hours, we achieved a substantial yield of membrane-integrated liposomes (MILs) incorporating OMCs. Circular dichroism spectroscopy confirmed the preservation of redox activity and strong inter-heme exciton coupling in the OMCs. These components were successfully delivered to Escherichia coli K-12 by incubation with MILs, retaining their functionality. Furthermore, the slow membrane exchange process did not result in cellular viability loss or lysis, allowing for the recycling of microbial cells and minimizing contaminants from lysed cells, which is advantageous for scaling up. Building on our previous work where MIL-coated titanium dioxide nanoparticles significantly enhanced radical production and effectively treated orthotopic liver tumors in vivo , our methodology to generate the MIL has promising potential to spearhead novel integrations of synthetic and biological systems for medical technologies.
摘要：
Efficient enrichment and recycling of uranyl ion (UO 2 2+ ) from wastewater are crucial for preventing radioactive contamination and protecting human health. Herein, two novel covalent organic frameworks (Tp-PDAN and Tp-PDAN-AO) were synthesized by a simple two-step method. Tp-PDAN-AO exhibits excellent hydrophilicity, thermal stability, and chemical stability, making it suitable for UO 2 2+ removal from acidic wastewater. The high-density amidoxime chelate groups in Tp-PDAN-AO confer high adsorption capacity and selectivity for UO 2 2+ , with a maximum adsorption capacity of 565.30 mg g −1 , reaching equilibrium within 2 h. Additionally, Tp-PDAN-AO exhibits strong photocatalytic activity under UV irradiation, which further enhances U(VI) reduction, boosting both adsorption kinetics and capacity. The maximum adsorption capacity increases to 757.62 mg g −1 with photocatalytic reduction. Density functional theory (DFT) calculations reveal six distinct COF-U(VI) interaction modes, explaining the chelation mechanism between hydrated uranyl ions and Tp-PDAN-AO (ƞ 2 mode), providing insights into the application of COFs with customizable functional groups for UO 2 2+ adsorption.
Efficient enrichment and recycling of uranyl ion (UO 2 2+ ) from wastewater are crucial for preventing radioactive contamination and protecting human health. Herein, two novel covalent organic frameworks (Tp-PDAN and Tp-PDAN-AO) were synthesized by a simple two-step method. Tp-PDAN-AO exhibits excellent hydrophilicity, thermal stability, and chemical stability, making it suitable for UO 2 2+ removal from acidic wastewater. The high-density amidoxime chelate groups in Tp-PDAN-AO confer high adsorption capacity and selectivity for UO 2 2+ , with a maximum adsorption capacity of 565.30 mg g −1 , reaching equilibrium within 2 h. Additionally, Tp-PDAN-AO exhibits strong photocatalytic activity under UV irradiation, which further enhances U(VI) reduction, boosting both adsorption kinetics and capacity. The maximum adsorption capacity increases to 757.62 mg g −1 with photocatalytic reduction. Density functional theory (DFT) calculations reveal six distinct COF-U(VI) interaction modes, explaining the chelation mechanism between hydrated uranyl ions and Tp-PDAN-AO (ƞ 2 mode), providing insights into the application of COFs with customizable functional groups for UO 2 2+ adsorption.
期刊：
FRONTIERS IN ONCOLOGY,2025年15:1524308 ISSN：2234-943X
作者机构：
[Deng, Yuqi; Zuo, Jianhong; Wang, Yajie; Chen, Lili] Department of Health, Inspection and Quarantine, School of Public Health, University of South China, Hengyang, China;[Zuo, Jianhong; Li, Jiale; Yang, Jinsai] Computer Institute, Hengyang Medical School, University of South China, Hunan, Hengyang, China;[Luo, Xinyu; Zuo, Jianhong; Zhang, Chaohui] The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China;[Qiu, Jieya; Zuo, Jianhong; Long, Rou; Tang, Guiyang] Transformation Research Lab, Hengyang Medical School, University of South China, Hunan, Hengyang, China;[Zuo, Jianhong] The Third Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
关键词：
alcohol use;burden of disease;colorectal cancer;high body mass index (high BMI);smoking
摘要：
BACKGROUND: Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of Colorectal cancer cases and deaths can be attributed to modifiable risk factors, with smoking, alcohol use, and high body mass index (BMI) being the three most prominent. However, the impact of these risk factors on Colorectal cancer across regions, genders, and age groups remains insufficiently characterized. METHODS: Utilizing data from the Global Burden of Disease (GBD) study 2019, restrictive cubic splines (RCS) and quantile regression analyses are applied to explore the relationship between the Socio-Demographic Index (SDI) and ASMR or ASDR. Additionally, gender differences, changes across different SDI levels, and age group trends in smoking, alcohol use, and high BMI over the 30-year period are analyzed. The Bayesian age-period-cohort (BAPC) model is employed to predict mortality trends from 2020 to 2030, aiming to explore the epidemiological and sociodemographic transitions in the Colorectal cancer disease burden attributed to smoking, alcohol use, and high BMI. RESULTS: In 2019, the number of colorectal cancer deaths globally attributable to risk factors as smoking, alcohol consumption, and obesity increased to 142,931, 52,495, and 85,882 cases respectively, collectively accounting for approximately one-third of all Colorectal cancer-related deaths. Notably, there is an upward trend in early-onset Colorectal cancer mortality associated with these factors. DISCUSSION: To reduce the burden of Colorectal cancer, it is recommended to enhance health education, promote smoking cessation and alcohol moderation, and increase the coverage and participation in Colorectal cancer screening, which are crucial for lowering Colorectal cancer mortality rates. These findings are vital for the development of public health policies and intervention measures to reduce the global disease burden. They provide guidance for Colorectal cancer prevention across different regions, genders, and age groups worldwide.
