期刊论文

Xiao, Fubing

英文

Colloids and Surfaces B: Biointerfaces

0927-7765

2025

254

114797

10.1016/j.colsurfb.2025.114797

CRediT authorship contribution statement Shengyuan Yang: Supervision, acquisition. Fubing Xiao: Writing – review & editing, Validation, Supervision, Project administration, acquisition, Conceptualization. Shuangxi Chen: Supervision, Resources. Haibo Huang: Supervision, Data curation. Ying Ding: Methodology, Investigation. Sijia Huang: Methodology, Investigation. Yuxiao Wang: Writing – original draft, Methodology, Investigation, Data curation. Chenyi Deng: Methodology, Investigation.

本校为第一且通讯机构

Effective management of bacterial infection and inflammatory responses is critical for accelerating infected wound healing. Herein, we developed a multifunctional hydrogel microneedle system (GMPL@GC MNs) integrating gelatin methacryloyl (GM) as the matrix material, ε-poly-L-lysine (PL) for enhanced antibacterial properties, and gelatin-curcumin nanoparticles (GC NPs) for inflammation modulation. The system exploits elevated matrix metalloproteinase (MMP) levels at wound sites to trigger specific degradation of GC NPs and controlled curcumin (...