Multi-omics analysis revealed the novel role of NQO1 in microenvironment, prognosis and immunotherapy of hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Tang, Ya;Hu, Haihong;Chen, Siyuan;Hao, Bo;Xu, Xuefeng;...

通讯作者：

Zhang, TL;Hu, HJ;Chen, GD

作者机构：

[Tang, Ya] Univ South China, Hengyang Med Coll, Sch Publ Hlth, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Hao, Bo; Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhu, Hongxia; Zhang, TL] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Chen, Siyuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Breast & Thyroid Surg, Hengyang 421001, Hunan, Peoples R China.

[Xu, Xuefeng] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Funct, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Taolan; Zhan, Wendi; Zhu, Hongxia; Zhang, TL] Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhang, TL ; Chen, GD ; Hu, HJ ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Res Ctr Clin Trial, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Publ Hlth Serv, Hengyang 421000, Hunan, Peoples R China.

语种：

英文

关键词：

Hepatocellular carcinoma;Immunotherapy;NQO1;Prognosis;Tumor microenvironment

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2025

卷：

期：

页码：

8591

DOI：

10.1038/s41598-025-92700-7

基金类别：

University of South China Clinical Research 4310 Program [20224310NHYCG01, 20224310NHYCG04]; Central Government Guided Local Science and Technology Development Fund Project in Xinjiang Uygur Autonomous Region [ZYYD2024CG17]; Hunan Province Innovation Ecological Construction Plan Science and Technology Assistance Project in Xinjiang Uygur Autonomous Region [2024WK4008]; Health Technology Promotion Project in Xinjiang Uygur Autonomous Region [SYTG-Y202429]; National Natural Science Foundation of China [82473965]; Scientific Research Project of the Hunan Provincial Department of Education [24B0413]; Natural Science Foundation of Hunan Province [2023JJ50156, 2024JJ7455]; Science and technology innovation Program of Hengyang City [202250045223]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

公共卫生学院

摘要：

NAD(P)H dehydrogenase quinone 1 (NQO1) is overexpressed in various cancers and is strongly associated with an immunosuppressive microenvironment and poor prognosis. In this study, we explored the role of NQO1 in the microenvironment, prognosis and immunotherapy of Hepatocellular carcinoma (HCC) using multi-omics analysis and machine learning. The results revealed that NQO1 was significantly overexpressed in HCC cells. NQO1(+)HCC cells were correlated with poor prognosis and facilitated tumor-associated macrophages (TAMs) polarization to M2 macrophages. We identified core NQO1-related genes (NR...

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Multi-omics analysis revealed the novel role of NQO1 in microenvironment, prognosis and immunotherapy of hepatocellular carcinoma

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