Synthesis and characterization of functional chitosan-based microspheres as biodegradable yttrium-90 delivery system for radioembolization therapy

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成果类型：

期刊论文

作者：

Zhang, Haoyu;Pan, Xiangni;Wu, Qiang;Wu, Yehuizi;Zheng, Ningchao*;...

通讯作者：

Zheng, Ningchao;Yin, XB

作者机构：

[Wang, Ji; Yin, Xiangbiao; Zheng, Ningchao; Zheng, NC; Wu, Yehuizi; Pan, Xiangni; Li, Wenlong; Wu, Qiang; Zeng, Deqian; Zhang, Haoyu; Ning, Shunyan; Wei, Yuezhou; Jiang, Tianjiao; Chen, Lifeng] Univ South China, Sch Nucl Sci & Technol, 28 Changsheng West Rd, Hengyang 421001, Peoples R China.

[Long, Xizhi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.

[Watabe, Hiroshi] Tohoku Univ, Cyclotron & Radioisotope Ctr, Div Radiat Protect & Safety Control, 6-3 Aoba,Aoba Ku, Sendai, Miyagi 9808578, Japan.

[Wu, Hao; Wei, Yuezhou; Wu, Yan] Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China.

[Yin, Xiangbiao] Univ South China, Key Lab Adv Nucl Energy Design & Safety, Minist Educ, 28 Changsheng West Rd, Hengyang, Peoples R China.

通讯机构：

[Yin, XB ; Zheng, NC] U

Univ South China, Sch Nucl Sci & Technol, 28 Changsheng West Rd, Hengyang 421001, Peoples R China.

Univ South China, Key Lab Adv Nucl Energy Design & Safety, Minist Educ, 28 Changsheng West Rd, Hengyang, Peoples R China.

语种：

英文

关键词：

(90)Y adsorption;Biodegradable microspheres;Functional chitosan;Hepatocellular carcinoma;Transarterial radioembolization

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2025

卷：

312

页码：

144090

DOI：

10.1016/j.ijbiomac.2025.144090

基金类别：

National Natural Science Foundation of China [22206073, 22350710186, U23B20167, U1967218, 22066005, 11975082]; Scientific Research Program of FuRong Laboratory [2023SK2098]

机构署名：

本校为第一且通讯机构

院系归属：

核科学技术学院

公共卫生学院

摘要：

Transarterial radioembolization (TARE) using yttrium-90 ( 90 Y)-labeled glass and resin microspheres is an emerging therapeutic technique for hepatocellular carcinoma (HCC). However, the non-biodegradability and rapid settlement of current commercial microspheres might hinder their even distribution and repetitive administration thus causing unsatisfactory therapeutic effects. In this context, novel functional chitosan-based microspheres (CPIs) that can efficiently label Y as a favorable TARE material were developed for the first time by succes...

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Synthesis and characterization of functional chitosan-based microspheres as biodegradable yttrium-90 delivery system for radioembolization therapy

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