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Synthesis and characterization of functional chitosan-based microspheres as biodegradable yttrium-90 delivery system for radioembolization therapy

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成果类型:
期刊论文
作者:
Zhang, Haoyu;Pan, Xiangni;Wu, Qiang;Wu, Yehuizi;Zheng, Ningchao;...
通讯作者:
Ningchao Zheng<&wdkj&>Xiangbiao Yin
作者机构:
[Zhang, Haoyu; Pan, Xiangni; Wu, Qiang; Wu, Yehuizi; Zheng, Ningchao; Ning, Shunyan; Zeng, Deqian; Chen, Lifeng; Li, Wenlong; Wang, Ji; Jiang, Tianjiao] School of Nuclear Science and Technology, University of South China, 28 Changsheng West Road, Hengyang 421001, China
[Long, Xizhi] Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China
[Watabe, Hiroshi] Division of Radiation Protection and Safety Control, Cyclotron and Radioisotope Center, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan
[Wu, Hao; Wu, Yan] School of Nuclear Science and Engineering, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China
Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, University of South China, 28 Changsheng West Road, Hengyang, China
通讯机构:
[Ningchao Zheng; Xiangbiao Yin] S
School of Nuclear Science and Technology, University of South China, 28 Changsheng West Road, Hengyang 421001, China<&wdkj&>Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, University of South China, 28 Changsheng West Road, Hengyang, China<&wdkj&>School of Nuclear Science and Technology, University of South China, 28 Changsheng West Road, Hengyang 421001, China
语种:
英文
关键词:
(90)Y adsorption;Biodegradable microspheres;Functional chitosan;Hepatocellular carcinoma;Transarterial radioembolization
期刊:
International Journal of Biological Macromolecules
ISSN:
0141-8130
年:
2025
卷:
312
页码:
144090
机构署名:
本校为第一且通讯机构
院系归属:
核科学技术学院
公共卫生学院
摘要:
Transarterial radioembolization (TARE) using yttrium-90 ( 90 Y)-labeled glass and resin microspheres is an emerging therapeutic technique for hepatocellular carcinoma (HCC). However, the non-biodegradability and rapid settlement of current commercial microspheres might hinder their even distribution and repetitive administration thus causing unsatisfactory therapeutic effects. In this context, novel functional chitosan-based microspheres (CPIs) that can efficiently label Y as a favorable TARE material were developed for the first time by succes...

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