期刊：
Biological Trace Element Research,2024年 ISSN：0163-4984
通讯作者：
Peng, CY;Liao, HQ
作者机构：
[Peng, Cuiying; Wang, Die; Zhou, Cuilan; Yin, Dan; Mao, Rui; Yu, Ping; Liu, Jun; Li, Suyun] Univ South China, Inst Cytol & Genet,Key Lab Typ Environm Pollut & H, Sch Basic Med Sci,Dept Educ,Key Lab Hengyang City, Hengyang Med Sch,Key Lab Ecol Environm & Crit Huma, Hengyang 421001, Hunan, Peoples R China.;[Nie, Yulin; Liao, Hongqing] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Liao, HQ ; Peng, CY ] U;Univ South China, Inst Cytol & Genet,Key Lab Typ Environm Pollut & H, Sch Basic Med Sci,Dept Educ,Key Lab Hengyang City, Hengyang Med Sch,Key Lab Ecol Environm & Crit Huma, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
ART outcomes;Plasma metal levels;Polycystic ovary syndrome;in vitro fertilization
摘要：
The objective of this study is to explore the correlation of metal levels with assisted reproductive technology (ART) outcomes in polycystic ovary syndrome (PCOS) patients. The individuals were recruited who met the research criteria, only tubal factor or male infertility served as the control group (n = 40) and patient group was PCOS patients (n = 35). Individuals (n = 75) were divided into PCOS group (n = 35) and control group (n = 40). The normal body mass index (BMI) group (control) includes women with BMI < 25kg/m(2) in PCOS group (n = 24) and control group (n = 33), and BMI ≥ 25kg/m(2) in PCOS group (n = 11) and control group (n = 7). We performed an analysis of insulin resistance (IR) (n = 15) group and without insulin resistance (NIR) group (n = 20) in PCOS patient and control patients. Comparing difference demographic data, ART outcomes and the metal levels in every group respectively, the correlation of metal levels and ART outcomes in control participants and PCOS patients were analyzed by the Spearman correlation analysis, and multiple linear regression model was used to examine the association between the concentration of 19 metals and ART outcomes in PCOS group and control group. Plasma manganese (Mn), titanium (Ti), sodium (Na), magnesium (Mg), copper (Cu), calcium (Ca)/Mg ratio, and Cu/zinc (Zn) ratio levels in PCOS patients were higher than that in control, while Zn and Ca levels were lower in PCOS patients than that in control. The Mg levels had a positive connection with the number of eggs recovered, and the iron (Fe) levels were positively associated with the number of transplanted embryos in PCOS-IR. In PCOS-NIR, Mn levels positively correlated with the number of follicles and the number of good embryos. Silver (Ag) levels were negatively correlated with the number of follicles, and aluminum (Al) levels were negatively related with the normal fertilization and the number of good embryos. The Spearman analysis in PCOS-BMI ≥ 25 group exhibited that nickel (Ni) levels were negatively associated with the number of follicles. The plasma metal levels seem to affect the clinical manifestations and in vitro fertilization outcomes in assisted reproduction.
摘要：
Conceptual diagram illustrating shielding in polymer composite materials. Abstract Development of shielding materials for 222Rn and γ radiation has crucial implications for ensuring the safety of individuals. This paper reports the synthesis of modified graphene nanosheets (MGNPs) via the reaction of KH560 with graphene nanosheets (GNPs), while melt blending and hot‐press molding technique were used to fabricate a multifunctional polymer composite shielding material, MGNP/WB/PMMA (polymethyl methacrylate). Successful synthesis of MGNP was confirmed by Fourier transform infrared spectroscopy, and scanning electron microscope (SEM) analysis was utilized to assess the distribution of functional fillers within the cross‐section of the polymer composite. Additionally, thermogravimetric analysis (TGA) demonstrated that MGNP and WB particles enhance the thermal stability of the polymer composite materials. Compared to pure PMMA, 98.7% decrease in the radon diffusion coefficient was observed for MGNP1.5 wt%/PMMA composite material. In addition to enhance the radon‐blocking characteristics of the polymer composites, inclusion of WB particles also boosts their shielding capacity against gamma radiation. The 222Rn diffusion coefficient of MGNP1.5 wt%/WB25wt%/PMMA polymer composite material decreased by 99.6% and at energies of 60 KeV, 80 KeV, 122 KeV, 365 KeV, the mass attenuation coefficient (MAC) for the composite material increased by 0.79, 1.97, 0.57, and 0.05 cm2/g, respectively, compared to pure PMMA. Highlights The PMMA composite materials doped with graphene nanosheets demonstrate outstanding resistance to 222Rn. Graphene nanosheets modified by KH560 exhibit favorable dispersion within PMMA. WB can further enhance the radon resistance of MGNP/WB/PMMA composite materials. The polymer composites exhibit excellent 222Rn and gamma ray shielding properties.
关键词：
lung adenocarcinoma;Mendelian randomization;non-small cell lung cancer;serum metabolites;squamous lung cancer
摘要：
This study seeks to understand the causal association between serum metabolites and different lung cancer types, an area yet to be extensively studied. We Used a two-sample Mendelian randomization (TSMR) approach, utilizing 486 blood metabolites as exposures and 3 distinct lung cancer types genome-wide association studies datasets as outcomes. We employed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode to estimate causal effects. We performed sensitivity analyses using Cochran Q test, MR-Egger intercept test, and MR-pleiotropy residual sum and outlier (MR-PRESSO). Linkage disequilibrium score (LDSC) analysis was conducted on the selected metabolites, and common confounding single nucleotide polymorphisms were eliminated using the human genotype-phenotype association Database. Metabolic pathway analysis was performed with MetaboAnalyst 5.0 software. Subsequently, a multivariate Mendelian randomization analysis was conducted to ascertain independent risk exposures. Our findings suggest independent risk factors for specific types of lung cancer: 7-methylxanthine and isoleucine for lung adenocarcinoma, cysteine and 1-arachidonoylglycerophosphocholine are identified as independent protective and risk factors for squamous lung cancer. Undecanoate (11:0) with Linoleate (18:2n6) showed a protective effect for small cell lung cancer. Additionally, 11 metabolic pathways were associated with lung cancer. This novel perspective offers a multidimensional understanding of lung cancer phenotypes, providing valuable guidance for identifying and screening of diverse lung cancer phenotypes.
期刊：
Chemical Communications,2024年60(21):2906-2909 ISSN：1359-7345
通讯作者：
Xie, ZY;Wu, XW;Liao, JJ;Wu, Xiongwei;Ling, W
作者机构：
[Wu, Xuewen; Xie, Zhiyong] Cent South Univ, State Key Lab Powder Met, Changsha 410083, Peoples R China.;[Wu, Xuewen; Xie, Zhiyong] Cent South Univ, Sci & Technol High Strength Struct Mat Lab, Changsha 410083, Peoples R China.;[Wu, Xiongwei; Wu, Xuewen; Wu, Saixiang; Wu, XW; Yin, Xingrong; Liu, Jun] Hunan Prov YinFeng New Energy Co Ltd, Changsha 410000, Peoples R China.;[Liao, Jingjing] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Wu, Xiongwei; Ling, Wei; Wu, XW; Ling, W; Liu, Jun] Hunan Agr Univ, Sch Chem & Mat Sci, Changsha 410128, Peoples R China.
通讯机构：
[Xie, ZY ] C;[Wu, XW; Wu, XW ; Ling, W ] H;[Liao, JJ ] U;Cent South Univ, State Key Lab Powder Met, Changsha 410083, Peoples R China.;Cent South Univ, Sci & Technol High Strength Struct Mat Lab, Changsha 410083, Peoples R China.
摘要：
A phosphoric acid additive with an optimal concentration of 0.1 M can vastly promote the diffusion kinetics of the redox reaction between V(iv) and V(v) without a significant decline in energy efficiency for 300 cycles, and maintain the high-temperature stability (55 degrees C) of an electrolyte at a high state of charge (SOC) of 70% over the course of 30 days. A phosphoric acid additive with an optimal concentration of 0.1 M can maintain the high-temperature stability (55 degrees C) of an electrolyte at a high state of charge (SOC) of 70% over the course of 30 days.
摘要：
Peroxymonosulfate (PMS) advanced oxidation is gaining recognition as a promising method for tackling persistent soil pollutants. However, developing an efficient PMS activator remains a formidable task. This study harnessed Shewanella oneidensis MR-1, a model dissimilatory metal-reducing bacterium (DMRB), to synthesize Mn2O3 nanoparticles by oxidizing Mn(II). These nanoparticles were employed to activate PMS for phenanthrene degradation in soil. Remarkably, biogenic Mn2O3 outperformed chemically synthesized Mn2O3, removing 77.4% of phenanthrene compared to 55.7%. This superior performance is attributed to biogenic Mn2O3's faster electron transfer rate and higher Mn(III) ratio, facilitating electron donation to PMS. Additionally, we assessed the feasibility of PMS advanced oxidation for soil remediation by examining microbial community diversity. Given manganese's prevalence in natural soil and groundwater, in-situ biogenic Mn2O3 synthesis emerges as an innovative soil remediation strategy.
作者机构：
[Li, Xu; Yuan, Jiaying; Liu, Yujing; Zi, Yuheng; Tang, Yuqing; Liao, Haiyan; Liu, Qinru; Shen, Qin; Tan, Changlian; Cai, Sainan; Wang, Min; Liu, Jun] Cent South Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Peoples R China.;[Liu, Jun; Liao, Haiyan] Clin Res Ctr Med Imaging Hunan Prov, Changsha, Peoples R China.;[Zi, Yuheng] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Radiol, Hengyang, Peoples R China.
通讯机构：
[Zi, YH ; Liao, HY] C;Cent South Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Peoples R China.;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Radiol, Hengyang, Peoples R China.
关键词：
depression;Parkinson's disease;structural magnetic resonance imaging;surface-based morphometry (SBM);voxel-based morphometry (VBM)
摘要：
AimsThe aim of this study is to investigate differences in gray matter volume and cortical complexity between Parkinson's disease with depression (PDD) patients and Parkinson's disease without depression (PDND) patients.MethodsA total of 41 PDND patients, 36 PDD patients, and 38 healthy controls (HC) were recruited and analyzed by Voxel-based morphometry (VBM) and surface-based morphometry (SBM). Differences in gray matter volume and cortical complexity were compared using the one-way analysis of variance (ANOVA) and correlated with the Hamilton Depression Scale-17 (HAMD-17) scores.ResultsPDD patients exhibited significant cortical atrophy in various regions, including bilateral medial parietal-occipital-temporal lobes, right dorsolateral temporal lobes, bilateral parahippocampal gyrus, and bilateral hippocampus, compared to HC and PDND groups. A negative correlation between the GMV of left precuneus and HAMD-17 scores in the PDD group tended to be significant (r = -0.318, p = 0.059). Decreased gyrification index was observed in the bilateral insular and dorsolateral temporal cortex. However, there were no significant differences found in fractal dimension and sulcal depth.ConclusionOur research shows extensive cortical structural changes in the insular cortex, parietal-occipital-temporal lobes, and hippocampal regions in PDD. This provides a morphological perspective for understanding the pathophysiological mechanism underlying depression in Parkinson's disease. The first row of pictures shows extensive cortical volume loss in Parkinson's disease with depression patients, primarily concentrated in the parietal-occipital-temporal lobes, parahippocampal gyrus, and hippocampus. The second row of pictures shows decreased gyrification index in the insula.image
作者机构：
[Gong, Yujie; Sheng, Yifa; Liu, Jun; Wang, Qiyou] Univ South China, Sch Elect Engn, Hengyang 421001, Hunan, Peoples R China.;[Tan, Yao; Zi, Xin; Liu, Min; Luo, Tao; Wang, Qiyou; Cai, Chao; Liu, M; Li, Hongmei; Liu, Kang; Fu, Junwei] Cent South Univ, Sch Phys, Hunan Joint Int Res Ctr Carbon Dioxide Resource Ut, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.;[Abazari, Reza] Univ Maragheh, Dept Chem, POB 55181-83111, Maragheh, Iran.;[Li, Wenzhang; Chen, Shanyong] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.;[Zhang, Shiguo] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China.
通讯机构：
[Liu, M ] C;[Liu, J ] U;Univ South China, Sch Elect Engn, Hengyang 421001, Hunan, Peoples R China.;Cent South Univ, Sch Phys, Hunan Joint Int Res Ctr Carbon Dioxide Resource Ut, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.
关键词：
Alkaline hydrogen evolution;Local electric field;Electron localization;Cu doping;CoS 2 nanoneedles
摘要：
Alkaline hydrogen evolution reaction (HER) represents a promising means to store intermittent renewable energy into clean energy. Unfortunately, the sluggish H2O dissociation and difficult *H adsorption-desorption are prominent obstacles to the development of alkaline HER. Herein, we developed a cooperative strategy via nanoneedle inducing local electric field and atomic doping causing electron localization for alkaline HER based on the preparation of Cu doped CoS2 nanoneedles (Cu-CoS2 NNs). Finite element method simulations and density functional theorycalculations demonstrate the local electric field accelerates H2O dissociation and electron localization facilitates *H adsorption, respectively. In situ attenuated total reflection infrared spectroscopy and electro-response measurement experimentally reveal the superior ability to H2O dissociation and *H adsorption for Cu-CoS2 NNs. As a result, the Cu-CoS2 NNs exhibit an ultralow overpotential of 64 mV at -10 mA cm-2 and long-term stability over 100 h at -100 mA cm-2 during alkaline HER, which outperforms most electrocatalysts in recently published works. Published by Elsevier B.V. All rights reserved.
摘要：
BACKGROUND: Neurometabolite concentrations provide a direct index of infarction progression in stroke. However, their relationship with stroke onset time remains unclear. PURPOSE: To assess the temporal dynamics of N-acetylaspartate (NAA), creatine, choline, and lactate and estimate their value in predicting early (<6 hours) vs. late (6-24hours) hyperacute stroke groups. STUDY TYPE: Cross-sectional cohort. POPULATION: A total of 73 ischemic stroke patients scanned at 1.8-302.5 hours after symptom onset, including 25 patients with follow-up scans. FIELD STRENGTH/SEQUENCE: A 3 T/magnetization-prepared rapid acquisition gradient echo sequence for anatomical imaging, diffusion-weighted imaging and fluid-attenuated inversion recovery imaging for lesion delineation, and 3D MR spectroscopic imaging (MRSI) for neurometabolic mapping. ASSESSMENT: Patients were divided into hyperacute (0-24hours), acute (24hours to 1 week), and subacute (1-2 weeks) groups, and into early (<6 hours) and late (6-24hours) hyperacute groups. Bayesian logistic regression was used to compare classification performance between early and late hyperacute groups by using different combinations of neurometabolites as inputs. STATISTICAL TESTS: Linear mixed effects modeling was applied for group-wise comparisons between NAA, creatine, choline, and lactate. Pearson's correlation analysis was used for neurometabolites vs. time. P < 0.05 was considered statistically significant. RESULTS: Lesional NAA and creatine were significantly lower in subacute than in acute stroke. The main effects of time were shown on NAA (F=14.321) and creatine (F= 12.261). NAA was significantly lower in late than early hyperacute patients, and was inversely related to time from symptom onset across both groups (r=-0.440). The decrease of NAA and increase of lactate were correlated with lesion volume (NAA: r=-0.472; lactate: r=0.366) in hyperacute stroke. Discrimination was improved by combining NAA, creatine, and choline signals (area under the curve [AUC]=0.90). DATA CONCLUSION: High-resolution 3D MRSI effectively assessed the neurometabolite changes and discriminated early and late hyperacute stroke lesions. EVIDENCE LEVEL: 1. TECHNICAL EFFICACY: Stage 2.
关键词：
Rice;C-13-N-15-glycine;Absorption and Transport;Mechanism
摘要：
The study was conducted in sterile hydroponics using isotopes tracer technique to demonstrate the posibility for rice seedlings (variety: C Liangyou 266) to directly absorb and utilize molecular organic nitrogen, transport and assimilation of organic/inorganic nitrogen. Further the activity of assimilation-related enzymes i.e Glutamic-oxaloacetic transaminase (GOT), Glutamic-pyruvic transaminase (GPT) and Glutamate dehydrogenase (GDH), in rice seedlings were also studied using isotopic tracing technique. In this regard N-15 -ammonium sulfate, 15N -potassium nitrate and 2-C-13 -N-15 -glycine salts were used to analyzes the abundance of C-13/N-15. The results suggest that the 15N excess and the ratio of N-15 excess in shoot to root under glycine nitrogen treatment (Gly-N) were significantly higher than those under ammonium nitrogen or nitrate nitrogen treatment (p<0.05); the C-13 excess/N-15 excess ratios of rice organs and the whole seedling measured at 24h after Gly-N approximated the theoretical value of 1:1, which showed gradual declines 48h and 72h later. The activities of glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) and glutamate dehydrogenase (GDH), in rice seedlings cultured by organic nitrogen were significantly higher than those by inorganic nitrogen (p<0.05). The findings also showed that rice seedlings are capable for direct absorbing and utilizing molecular glycine nitrogen. The absorption rate of glycine nitrogen was much higher than that of ammonium nitrogen or nitrate nitrogen. The transport capabilities of organic and inorganic nitrogen in rice plants, ranked in descending order are as follows: glycine nitrogen > ammonium nitrogen > nitrate nitrogen.
期刊：
Science of The Total Environment,2023年905:167167 ISSN：0048-9697
通讯作者：
Liu, J
作者机构：
Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Inst Cytol & Genet,Dept Cell Biol & Genet,Key Lab, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Hunan, Peoples R China.;[Liu, Jun] 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Liu, J ] 2;28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
Liver;MCs;Mechanisms;Toxicity
摘要：
Microcystins (MCs) are a class of biologically active cyclic heptapeptide pollutants produced by the freshwater alga Microcystis aeruginosa. With increased environmental pollution, MCs have become a popular research topic. In recent years, the hepatotoxicity of MCs and associated effects and mechanisms have been studied extensively. Current epidemiological data indicate that long-term human exposure to MCs can lead to severe liver toxicity, acute toxicity, and death. In addition, current toxicological studies on the liver, a vital target organ of MCs, indicate that MC contamination is associated with the development of liver cancer, nonalcoholic fatty liver, and liver fibrosis. MCs produce hepatotoxicity that affects the metabolic homeostasis of the liver, induces apoptosis, and acts as a pro-cancer factor, leading to liver lesions. MCs mainly mediate the activation of signaling pathways, such as the ERK/JNK/p38 MAPK and IL-6-STAT3 pathways, which leads to oxidative damage and even carcinogenesis. Moreover, MCs can act synergistically with other pollutants to produce combined toxicity. However, few systematic reviews have been performed on these new findings. This review systematically summarizes the toxic effects and mechanisms of MCs on the liver and discusses the combined liver toxicity effects of MCs and other pollutants to provide reference for subsequent research. The toxicity of different MC isomers deserves further study. The detection methods and limit standards of MCs in agricultural and aquatic products will represent important research directions in the future. Standard protocols for fish sampling during harmful algal blooms or to evaluate the degree of MC toxicity in nature are lacking. In future, bioinformatics can be applied to offer insights into MC toxicology research and potential drug development for MC poisoning. Further research is essential to understand the molecular mechanisms of liver function damage in combined-exposure toxicology studies to establish treatment for MC-induced liver damage.
期刊：
British Journal of Nutrition,2023年130(10):1657-1664 ISSN：0007-1145
通讯作者：
Peng, C.;Liao, H.
作者机构：
[Tian, Dewei; Peng, Cuiying; Zhou, Cuilan; Yin, Dan; Li, Yiyang; Liao, Xingyue; Liu, Jun; Li, Suyun; Xu, Yunsi] Univ South China, Inst Cytol & Genet, Dept Cell Biol & Genet, Sch Basic Med Sci,Hengyang Med Sch,Dept Educ,Key L, Hengyang 421001, Hunan, Peoples R China.;[Zhou, Jing; Nie, Yulin; Liao, Hongqing] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Hongqing Liao; Cuiying Peng] D;Department of Cell Biology and Genetics, Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Key Laboratory of Hengyang City on Biological Toxicology and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China, Hengyang, Hunan 421001, People’s Republic of China<&wdkj&>Department of Obstetrics and Gynecology, the Second Affiliated Hospital, University of South China, 30# Jiefang Road, Hengyang, Hunan 421001, People’s Republic of China
摘要：
In recent years, obesity is a growing pandemic in the world and has likely contributed to increasing the incidence of obesity-related diseases. Fat mass and obesity-associated gene (FTO) is the first gene discovered which has a close connection with fat. Recent studies suggested that FTO gene has played an important role in the molecular mechanisms of many diseases. Obesity is considered to be a hereditary disease and can evoke many kinds of diseases, including polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (T2DM), cancer, etc., whose exact possible molecular mechanisms responsible for the effect of FTO on obesity and obesity-related diseases remain largely unknown. In this review, we comprehensively discuss the correlation between FTO gene and obesity, cancer, PCOS, T2DM, as well as the molecular mechanism involved in these diseases.
摘要：
Pulmonary fibrosis represents the advanced phase of diverse pulmonary ailments, and at present, a definitive cure for these ailments is lacking. Furthermore, underlying mechanisms causative of these ailments remain elusive. Macrophages are immune cells that resist external stimuli in the early stages after birth. These cells can polarize into the classically (M1) and alternatively (M2) activated macrophages. When stimulated owing to the presence of toxic factors, M1 macrophages produce several pro-inflammatory factors, which mediate the inflammatory injury response of the alveolar tissue. The secretion of diverse growth factors by M2 macrophages contributes to the pathogenesis of aberrant alveolar structural fibrosis and remodeling. The abnormal activity of M2 macrophages is considered a critical factor in the formation of pulmonary fibrosis. In this mini-review, to highlight the clinical implications of research studies, we summarize the role and therapeutic targets of polarized subtypes of macrophages in pulmonary fibrosis and the role of targeting macrophages for the treatment of pulmonary fibrosis. M1-type macrophages and M2-type macrophages can transform into each other.M1-type macrophages participate in the early stage of pulmonary fibrosis by producing inflammatory cytokines, ROS and MMP.M2-type macrophages mediate abnormal alveolar tissue repair and tissue remodeling through the production of TGF-& beta;, FGF, and exosomes.Three therapeutic ideas were summarized in this paper: inhibition of the number and activity of lung macrophages, inhibition of M2-type macrophage polarization, inhibition of TGF-& beta; expression and its signalling pathway.
期刊：
World Neurosurgery,2023年174:175-182 ISSN：1878-8750
作者机构：
[Tang, Dan] Department of Neurosurgery, The First People's Hospital of Huaihua, Huaihua, Hunan, China;[Liu, Jun] Department of Neurology, The Second People's Hospital of Huaihua, Huaihua, Hunan, China;[Xiao, Chunwen] Department of Neurosurgery, The Second People's Hospital of Huaihua, Huaihua, Hunan, China;[Xie, Dujie] Department of Neurology, Third Xiangya Hospital, Central South University, Changsha, China;[Fu, Xiaohong] Department of Neurosurgery, The First People's Hospital of Zunyi, ZunYi, Guizhou, China
摘要：
OBJECTIVE: The aim of the article is to introduce a novel laser-based frameless stereotactic device that can locate intracranial lesions quickly and with computed tomograph (CT)/magnetic resonance imaging (MRI) films. Preliminary experiences of application in 416 cases are also summarized. METHODS: From August in 2020 to October in 2022, a total of 416 cases of new minimalist laser stereotactic surgery have been performed on 415 patients. Of the 415 patients, 377 had intracranial hematomas, while the remaining cases were brain tumors or brain abscesses. Postoperative CT was used to evaluate the accuracy of catheterization of 405 patients according to the MISTIE study. The duration time of locating was recorded. Rebleeding refers to the definition: Compared with preoperative CT, the relative volume of postoperative hematoma increases by >33% or absolute volume increase >12.5 mL. RESULTS: According to postoperative CT, the accuracy of 405 stereotactic catheterization cases was good in 346 cases (85.4%) and suboptimal in 59 cases (14.6%), with no poor results. Postoperative rebleeding occurred in 4 spontaneous cerebral hemorrhage cases and 1 brain biopsy case. The average localization time of supratentorial lesions was 13.2 minutes in the supine position, 21.5 minutes in the lateral position, and 27.6 minutes in the prone position. CONCLUSIONS: The new laser-based frameless stereotactic device is simple in principle and convenient in positioning operation of brain hematoma and abscess puncture, brain biopsy and tumor surgery, and appropriate to the precision requirements in most craniocerebral surgery.
期刊：
Journal of Soil Science and Plant Nutrition,2023年23(3):3461-3469 ISSN：0718-9508
通讯作者：
Liu, J
作者机构：
[Ni, Juan; Fan, Xinting; Liu, Jun; Mo, Aili; Jiang, Yuanyuan] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Cell Biol & Genet, Hengyang 421001, Hunan, Peoples R China.;[Ni, Juan; Fan, Xinting; Liu, Jun; Mo, Aili; Jiang, Yuanyuan] Univ South China, Inst Cytol & Genet, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Liu, Jun] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Key Lab Ecol Environm & Crit Human Dis Prevent Hun, Hengyang 421001, Hunan, Peoples R China.;[Liu, Jun] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Key Lab Hengyang City Ecol Impedance Technol Heavy, Hengyang 421001, Hunan, Peoples R China.;[Liu, Jun] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Key Lab Hengyang City Biol Toxicol & Ecol Restorat, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Liu, J ] U;Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Cell Biol & Genet, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Inst Cytol & Genet, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Key Lab Ecol Environm & Crit Human Dis Prevent Hun, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Key Lab Hengyang City Ecol Impedance Technol Heavy, Hengyang 421001, Hunan, Peoples R China.
关键词：
Cd and Se;Rice;Uptake and distribution;Dietary intake risk assessment
摘要：
PurposeCadmium (Cd) is toxic to rice seedlings. Studies showed that selenium (Se) could alleviate Cd toxicity in rice seedlings. However, the effect of Se on the accumulation of Cd in mature rice plants and Se accumulation in grain and the quality and dietary intake risk of brown rice are rarely investigated.MethodsA rice pot experiment was performed with Se-treated Cd-contaminated paddy soil to explore the effect of Se on Cd accumulation of mature rice plants and the yield and quality of the rice grain, as well as the health risks of consuming rice grains.ResultsAdding Se significantly increased the rice grain yield, decreased Cd concentrations in the tissues of rice plants, and significantly decreased protein and amylose concentrations in brown rice, which helped improve the taste and quality of the cooked rice. Adding Se decreased the health risk index of Cd and increased the daily intake of Se for humans by consuming rice; however, excessive Se addition resulted in Se in rice grain exceeding the Tolerable Upper Intake Level.ConclusionAn appropriate dosage of Se can decrease Cd accumulation in rice, increase yield and Se accumulation, and ensure its edible safety.
摘要：
Cadmium (Cd) contamination of rice is an urgent ecological and agricultural problem. Strontium (Sr) has been shown to promote plant growth. However, the effect of Sr on rice seedlings under Cd stress is currently unclear. In this work hydroponic experiments were used to assess the impact of Sr on rice seedling growth under Cd stress. The findings demonstrated that foliar application of 0.5mgL(-1) Sr had no discernible impact on the development of rice seedlings. However, Sr significantly alleviated growth inhibition and toxicity in rice seedlings when threatened by Cd. Compared with the Cd treatment (Cd, 2.5mgL(-1)), the root length, shoot height, and whole plant length of rice seedlings in the Cd+Sr treatment (Cd, 2.5mgL(-1); Sr, 0.5mgL(-1)) increased by 4.96%, 12.47% and 9.60%, respectively. The content of Cd in rice decreased by 23.34% (roots) and 5.79% (shoots). Sr lessened the degree of membrane lipid peroxidation damage (lower MDA concentration) among the seedlings of rice under Cd stress by controlling the activities of antioxidant enzymes and GSH content. By changing the expression of antioxidant enzyme-encoding genes and downregulating the heavy metal transporter gene (OsNramp5), Sr reduced accumulation and the detrimental effects of Cd on rice seedlings. Our study provides a new solution to the problem of Cd contamination in rice, which may promote the safe production of rice and benefit human health.
作者机构：
[Tian, Dewei; Peng, Cuiying; Wu, Liujianxiong; Zhou, Cuilan; Yin, Dan; Liao, Xingyue; Liu, Jun; Li, Suyun] Univ South China, Inst Cytol & Genet, Sch Basic Med Sci, Hengyang Med Sch,Dept Cell Biol & Genet,Dept Educ,, Hengyang 421001, Hunan, Peoples R China.;[Zhou, Jing; Nie, Yulin; Liao, Hongqing] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Hongqing Liao; Cuiying Peng] D;Department of Obstetrics and Gynecology, the Second Affiliated Hospital, University of South China, Hengyang, PR China<&wdkj&>Department of Cell Biology and Genetics, Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of Ecological Environment and Critical Human Dise Ases Prevention of Hunan Province, Department of Education, Key Laboratory of Hengyang City On Biological Toxicology and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China, Hengyang, China
摘要：
Follicles consist of specialized somatic cells that encase a single oocyte. Follicle development is a process regulated by a variety of endocrine, paracrine, and secretory factors that work together to select follicles for ovulation. Zinc is an essential nutrient for the human body and is involved in many physiological processes, such as follicle development, immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. Zinc deficiency can lead to blocked oocyte meiotic process, cumulus expansion, and follicle ovulation. In this mini-review, we summarize the the role of zinc in follicular development.
期刊：
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,2023年26(5):960-964 ISSN：1756-1841
通讯作者：
Jiali Li<&wdkj&>Jiali Li Jiali Li Jiali Li
作者机构：
[Li, Jiali; Liu, Jun; Wen, Rui] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Rheumatol & Immunol, Changsha, Peoples R China.;[Yan, Mingming] Second Xiangya Hosp Cent South Univ, Dept Orthoped Surg, Changsha, Peoples R China.;[Li, Jiali] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Rheumatol & Immunol, 161 South Shaoshan Rd, Changsha 410008, Hunan, Peoples R China.
通讯机构：
[Jiali Li; Jiali Li Jiali Li Jiali Li] D;Department of Rheumatology and Immunology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China
摘要：
Abstract Introduction Thrombotic thrombocytopenia purpura (TTP) associated with systemic lupus erythematous (SLE), features the appearance of inhibitory autoantibodies against ADAMTS13. Rituximab and belimumab (BEL), as both targeting B cells, seem to be an optimal therapy to induce clinical remission, prevent relapse of disease and contribute to glucocorticoid induction. However, the clinical outcome of SLE‐TTP treated with sequential therapy between rituximab and BEL remain elusive. Case Series We reported the clinical outcomes of 4 patients diagnosed with SLE‐TTP who were administrated a combination of corticosteroids, plasma exchange, and rituximab at stage of induction. BEL was utilized to rapidly reduce the reliance on these agents and prevent relapse of TTP at maintenance stage. Ultimately, 4 patients fully recovered with a SLE Disease Activity Index score of 0 and reached the goal at dose of prednisolone <7.5 mg/d without relapse. Conclusion Sequential treatment of rituximab and BEL could be an encouraging approach in treatment of SLE‐TTP and rapid glucocorticoid reduction.
通讯机构：
[Aixiang Wei] S;School of Integrated Circuits, Guangdong University of Technology, Guangzhou 510006, Guangdong, China<&wdkj&>School of Information Science, Guangzhou Xinhua University, Dongguan 523133, Guangdong, China
摘要：
Transition metal doping is an effective method to induce a structural phase transition and improve the electrocatalytic performance of transition metal chalcogenides (TMDs). In this study, MoxRe1-xS2 nanosheets with Mo fraction x from 0 to 1 were grown on a carbon nanotube/carbon cloth (CNT@CC) substrate using a hydrothermal method by changing the molar ratio of Na2MoO4$2H(2)O to NH4ReO4 in the precursor solution. The effect of the Mo fraction x on the phase structure and electrocatalytic performance for the hydrogen evo-lution reaction (HER) of MoxRe1-xS2 nanosheets was studied. The results indicated that MoxRe1-xS2 consists of the 1T' phase (Re, Mo)S-2 and the 2H phase (Mo, Re)S-2, and the proportion of the 1T' phase is in the range of 40-50%. Mo0.5Re0.5S2/CNT@CC shows the best HER catalytic activity with an overpotential of 85 mV at a current density of 10 mAcm(-2), a Tafel slope of 38 mV dec(-1) and a charge transfer resistance of 1.04 U. This excellent HER catalytic activity is attributed to the phase transition, defects and S vacancies on the basal planes, as well as the synergistic effect between the MoxRe1-xS2 nanosheets and CNT. (c) 2022 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
摘要：
Soybean (Glycine max L.), as an oil and protein crop, has attracted interest for its potential in the reclamation/ restoration of barren and contaminated habitats due to its ability to tolerate adverse environments. To investigate the effects of the growth (biomass and plant height), chlorophyll content, antioxidative capacity (per -oxidase and superoxide dismutase activities), and homeostasis of essential elements in soybean plants induced by cadmium (Cd), a pot experiment was performed. Soybean seeds were cultivated in six different levels of Cd-contaminated soil (0, 0.25, 0.50, 1.00, 2.50, 5.00, and 10.00 mg kg(-1)) for 27 days at 60 % humidity and 25-35 C-degrees in a greenhouse with natural light. Soybean seedling growth was stimulated and inhibited at low (<= 1.00 mg kg(-1)) and high (>= 2.50 mg kg(-1)) Cd concentrations, respectively. Essential metal elements (Mg, Fe, and Zn) and chlorophyll contents of leaves were increased and decreased at low and high Cd concentrations, respectively. Exposure to high Cd concentrations interfered with the homeostasis of essential elements in soybean plants. High Cd concentrations reduced antioxidant capacity and chlorophyll content, which inhibited soybean growth. The Cd accumulation level (>100 mg kg(-1)) in soybean plant organs was unsafe for producing soybean products. However, soybean seedlings appear to tolerate moderate Cd contamination.(c) 2023 SAAB. Published by Elsevier B.V. All rights reserved.
作者机构：
School of Mathematics and Physics, University of South China, Hengyang, China;Department of Foundation, Hunan Institute of Traffic Engineering, Hengyang, China;School of Resource Environment and Safety Engineering, University of South China, Hengyang, China;[刘俊; 谭捷] School of Mathematics and Physics,University of South China,Hengyang 421001,China;[胡芳] School of Resource Environment and Safety Engineering,University of South China,Hengyang 421001,China
通讯机构：
[Jie Tan; Fang Hu] S;School of Mathematics and Physics, University of South China, Hengyang, China<&wdkj&>School of Resource Environment and Safety Engineering, University of South China, Hengyang, China
