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FTO: a critical role in obesity and obesity-related diseases

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成果类型:
期刊论文
作者:
Yin, Dan;Li, Yiyang;Liao, Xingyue;Tian, Dewei;Xu, Yunsi;...
通讯作者:
Peng, C.;Liao, H.
作者机构:
[Tian, Dewei; Peng, Cuiying; Zhou, Cuilan; Yin, Dan; Li, Yiyang; Liao, Xingyue; Liu, Jun; Li, Suyun; Xu, Yunsi] Univ South China, Inst Cytol & Genet, Dept Cell Biol & Genet, Sch Basic Med Sci,Hengyang Med Sch,Dept Educ,Key L, Hengyang 421001, Hunan, Peoples R China.
[Zhou, Jing; Nie, Yulin; Liao, Hongqing] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Hongqing Liao; Cuiying Peng] D
Department of Cell Biology and Genetics, Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Key Laboratory of Hengyang City on Biological Toxicology and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China, Hengyang, Hunan 421001, People’s Republic of China<&wdkj&>Department of Obstetrics and Gynecology, the Second Affiliated Hospital, University of South China, 30# Jiefang Road, Hengyang, Hunan 421001, People’s Republic of China
语种:
英文
关键词:
FTO;SNP;Obesity;PCOS;Cancer;Type 2 diabetes mellitus
期刊:
British Journal of Nutrition
ISSN:
0007-1145
年:
2023
卷:
130
期:
10
页码:
1657-1664
基金类别:
Natural Science Foundation of Hunan Province of China [2021JJ30598, 2021JJ30593, 2020JJ4536]; China Scholarship Council [CSC201708430228]
机构署名:
本校为第一机构
摘要:
In recent years, obesity is a growing pandemic in the world and has likely contributed to increasing the incidence of obesity-related diseases. Fat mass and obesity-associated gene (FTO) is the first gene discovered which has a close connection with fat. Recent studies suggested that FTO gene has played an important role in the molecular mechanisms of many diseases. Obesity is considered to be a hereditary disease and can evoke many kinds of diseases, including polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (T2DM), cancer, etc., whose exact possible molecular mechanisms responsible...

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